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Journal Article
FEBS Letters, ISSN 0014-5793, 01/2011, Volume 585, Issue 1, pp. 104 - 110
Protein kinase CK2 (CK2), a constitutively active serine/threonine kinase, is involved in a variety of roles essential to the maintenance of cellular... 
X-ray crystallography | CK2α | Drug discovery | Protein kinase | Cancer | protein kinase CK2 | dithiothreitol | AMPPNP | DMSO | DTT | root mean square deviation | CK2 | adenylyl phosphoramidate | 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole | adenylyl-imidodiphosphate | adenosine-5′-triphosphate | 2-ethanesulfonic acid | dimethyl sulfoxide | HEPES | (2-hydroxyethyl) piperazine | AMPPN | DMAT | ATP | R.M.S.D | COMPLEX | SMALL MOLECULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER GENOME | DIFFRACTION DATA | INDUCTION | DISCOVERY | CELL BIOLOGY | IN-VITRO | BIOPHYSICS | CK2 alpha | INHIBITORS | TUMORIGENESIS | INSIGHTS | Protein Structure, Tertiary | Naphthyridines - chemistry | Catalytic Domain | Temperature | Humans | Casein Kinase II - antagonists & inhibitors | Models, Molecular | Crystallography, X-Ray | Adenylyl Imidodiphosphate - chemistry | Protein Subunits - metabolism | Thermodynamics | Casein Kinase II - chemistry | Adenylyl Imidodiphosphate - metabolism | Protein Binding | Calorimetry | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Binding Sites | Circular Dichroism | Casein Kinase II - metabolism | Naphthyridines - pharmacology | Naphthyridines - metabolism | Enzymes | Care and treatment | Oncology, Experimental | Crystals | Research | Analysis | Dimethyl sulfoxide | Chemical properties | Structure | Protein kinases | Musicians | Protein binding | Index Medicus | MAINTENANCE | DESIGN | HOMEOSTASIS | THERMODYNAMICS | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | TRANSCRIPTION | CRYSTAL STRUCTURE | PHOSPHOTRANSFERASES | CRYSTALLOGRAPHY | PROTEINS | 60 APPLIED LIFE SCIENCES
Journal Article
FEBS Letters, ISSN 0014-5793, 2007, Volume 581, Issue 5, pp. 935 - 938
Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866... 
Mdr1 | Outward-facing conformation | Transport protein | Multidrug ABC transporter | ATP-bound state | AMP-PNP | ABC | TMD | multidrug resistance 1 gene | sodium dodecyl sulfate polyacrylamide electrophoresis | ATP binding cassette | SDS–PAGE | ADP | NBD | nucleotide binding domain | adenosine-5′-(β,γ-imido)triphosphate | transmembrane domain | adenosine diphosphate | adenosine triphosphate | ATP | transport protein | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | STATE | outward-facing conformation | MODEL | ATP-BINDING | ATPASES | CELL BIOLOGY | BIOPHYSICS | multidrug ABC transporter | HUMAN P-GLYCOPROTEIN | Recombinant Proteins - metabolism | Staphylococcus aureus - genetics | Drug Stability | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Crystallography, X-Ray | Recombinant Proteins - genetics | Adenylyl Imidodiphosphate - chemistry | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Adenylyl Imidodiphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | Bacterial Proteins - metabolism | Protein Conformation | Adenosine Triphosphatases - genetics | Staphylococcus aureus - metabolism | Staphylococcus aureus | Television broadcasting industry | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 430 - 435
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2015, Volume 57, Issue 5, pp. 836 - 849
Journal Article
Journal Article
Science, ISSN 0036-8075, 9/2006, Volume 313, Issue 5795, pp. 1968 - 1972
In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves... 
Hydrolysis | Proteins | Molecules | Messenger RNA | Double stranded RNA | RNA | Exons | Adenosine triphosphatases | Reports | Nucleotides | Binding sites | EIF4A | MESSENGER-RNA | DECAY | HELICASE ACTIVITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DISTINCT | MOLECULAR INSIGHTS | TRANSLATION | MAMMALIAN-CELLS | BINDING | RNA Helicases - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | RNA Helicases - chemistry | Drosophila Proteins - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Adenosine Triphosphate - metabolism | Eukaryotic Initiation Factor-4A - chemistry | Nucleic Acid Conformation | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | DEAD-box RNA Helicases | Poly U - chemistry | Protein Structure, Secondary | RNA-Binding Proteins - chemistry | Models, Molecular | Neoplasm Proteins - chemistry | Nuclear Proteins - metabolism | Poly U - metabolism | Drosophila Proteins - chemistry | Nuclear Proteins - chemistry | Adenosine Triphosphate - analogs & derivatives | Amino Acid Motifs | Animals | Hydrogen Bonding | Adenylyl Imidodiphosphate - metabolism | Protein Conformation | RNA, Messenger - chemistry | Mutation | Eukaryotic Initiation Factor-4A - metabolism | RNA-Binding Proteins - metabolism | Exon (Molecular genetics) | Analysis | Research | Eukaryotes | Ribonucleic acid | Molecular biology | Ribonucleic acid--RNA | Adenosine triphosphatase | Crystal structure | Index Medicus | Eukaryotic Initiation Factor-4A | Adenosine Triphosphate | RNA-Binding Proteins | Life Sciences | RNA Helicases | Neoplasm Proteins | Drosophila Proteins | Biochemistry, Molecular Biology | Nuclear Proteins | Adenylyl Imidodiphosphate | Poly U | RNA, Messenger
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2007, Volume 104, Issue 48, pp. 19005 - 19010
ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a wide variety of substrates across cellular membranes and are... 
ATP binding cassette transporters | Molecules | Electrical phases | Maps | Lipids | Dimers | Biochemistry | Nucleotides | Monomers | Cytoplasm | Membrane protein structure | Lipid flippase | Multidrug transport | SUBSTRATE SPECIFICITIES | ATP-BINDING-CASSETTE | RESTING-STATE CONFORMATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | X-RAY-STRUCTURE | membrane protein structure | ESCHERICHIA-COLI MSBA | STRUCTURAL BIOLOGY | lipid flippase | HUMAN P-GLYCOPROTEIN | multidrug transport | MULTIDRUG-RESISTANCE | DISULFIDE CROSS-LINKING | Salmonella typhimurium - chemistry | Amino Acid Sequence | Motion | Species Specificity | Bacterial Proteins - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Escherichia coli Proteins - metabolism | Vibrio cholerae - chemistry | Sequence Homology, Amino Acid | ATP-Binding Cassette Transporters - chemistry | Biological Transport, Active | Sequence Alignment | Adenosine Triphosphate - metabolism | Adenylyl Imidodiphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Protein Binding | Bacterial Proteins - metabolism | Protein Conformation | Escherichia coli Proteins - chemistry | Binding Sites | Substrates (Biochemistry) | Research | Structure | Properties | Biological transport | Membrane proteins | Bacteria | Membranes | Comparative analysis | Flexibility | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, pp. 15091 - 15091
Type IVa pili are protein filaments essential for virulence in many bacterial pathogens; they extend and retract from the surface of bacterial cells to pull... 
MYXOCOCCUS-XANTHUS | DOMAIN MOVEMENTS | RETRACTION MOTOR | COMPLEX | MULTIDISCIPLINARY SCIENCES | PLATFORM PROTEIN | SECRETION | THERMUS-THERMOPHILUS | BINDING | TWITCHING-MOTILITY |