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1. Full Text β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
by Roberts, Lee D and Boström, Pontus and O’Sullivan, John F and Schinzel, Robert T and Lewis, Gregory D and Dejam, Andre and Lee, Youn-Kyoung and Palma, Melinda J and Calhoun, Sondra and Georgiadi, Anastasia and Chen, Ming-Huei and Ramachandran, Vasan S and Larson, Martin G and Bouchard, Claude and Rankinen, Tuomo and Souza, Amanda L and Clish, Clary B and Wang, Thomas J and Estall, Jennifer L and Soukas, Alexander A and Cowan, Chad A and Spiegelman, Bruce M and Gerszten, Robert E
Cell metabolism, ISSN 1550-4131, 01/2014, Volume 19, Issue 1, pp. 96 - 108
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Index Medicus | Medicin och hälsovetenskap
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2. Full Text A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
by Boström, Pontus and Wu, Jun and Jedrychowski, Mark P and Korde, Anisha and Ye, Li and Lo, James C and Rasbach, Kyle A and Boström, Elisabeth Almer and Choi, Jang Hyun and Long, Jonathan Z and Kajimura, Shingo and Zingaretti, Maria Cristina and Vind, Birgitte F and Tu, Hua and Cinti, Saverio and Højlund, Kurt and Gygi, Steven P and Spiegelman, Bruce M
Nature (London), ISSN 0028-0836, 01/2012, Volume 481, Issue 7382, pp. 463 - 468
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Obesity | Biological and medical sciences | Metabolic diseases | Medical sciences | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Adipocytes - drug effects | Obesity - blood | Adipose Tissue, White - cytology | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Models, Animal | Energy Metabolism - physiology | Intracellular Signaling Peptides and Proteins - genetics | Obesity - chemically induced | Mice, Transgenic | Trans-Activators - deficiency | Obesity - prevention & control | Plasma - chemistry | Adipose Tissue, Brown - drug effects | Exercise - physiology | Mice | Mice, Inbred BALB C | Transcription Factors | Energy Metabolism - drug effects | Thermogenesis - genetics | Adipose Tissue, White - metabolism | Adipocytes - cytology | Culture Media, Conditioned - pharmacology | Subcutaneous Fat - metabolism | Insulin Resistance - physiology | Cell Respiration - drug effects | Subcutaneous Fat - drug effects | Trans-Activators - genetics | Energy Metabolism - genetics | Gene Expression Regulation - genetics | Cells, Cultured | Hormones - secretion | Muscle Cells - metabolism | Physical Conditioning, Animal - physiology | Subcutaneous Fat - cytology | Gene Expression Regulation - drug effects | Adipose Tissue, Brown - cytology | Animals | Hormones - metabolism | Ion Channels - metabolism | Adipocytes - metabolism | Trans-Activators - secretion | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Thermogenesis - drug effects | Uncoupling Protein 1 | Adipose Tissue, White - drug effects | Index Medicus | Medicin och hälsovetenskap
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3. Full Text Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
by Mottillo, Emilio P and Desjardins, Eric M and Crane, Justin D and Smith, Brennan K and Green, Alex E and Ducommun, Serge and Henriksen, Tora I and Rebalka, Irena A and Razi, Aida and Sakamoto, Kei and Scheele, Camilla and Kemp, Bruce E and Hawke, Thomas J and Ortega, Joaquin and Granneman, James G and Steinberg, Gregory R
Cell metabolism, ISSN 1550-4131, 07/2016, Volume 24, Issue 1, pp. 118 - 129
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Norepinephrine - pharmacology | AMP-Activated Protein Kinases - metabolism | Lipolysis - drug effects | Fatty Liver - pathology | Adipose Tissue, White - metabolism | Adipocytes - enzymology | Adipocytes - drug effects | Mitochondria - ultrastructure | Adipose Tissue, Beige - enzymology | Liver - drug effects | Diet, High-Fat | Gene Deletion | Fatty Liver - enzymology | Homeostasis - drug effects | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Adipose Tissue, Brown - enzymology | Animals | Adipose Tissue, Beige - drug effects | Adipose Tissue, Brown - drug effects | Thermogenesis - drug effects | Adipose Tissue, White - drug effects | Adipose tissues | Type 2 diabetes | Exercise | Liver diseases | Analysis | Communicable diseases | Liver | Physiological aspects | Insulin resistance | Protein kinases | Index Medicus
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4. Full Text The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat
by Schilperoort, Maaike and Dam, Andrea D and Hoeke, Geerte and Shabalina, Irina G and Okolo, Anthony and Hanyaloglu, Aylin C and Dib, Lea H and Mol, Isabel M and Caengprasath, Natarin and Chan, Yi‐Wah and Damak, Sami and Miller, Anne Reifel and Coskun, Tamer and Shimpukade, Bharat and Ulven, Trond and Kooijman, Sander and Rensen, Patrick CN and Christian, Mark
EMBO molecular medicine, ISSN 1757-4676, 03/2018, Volume 10, Issue 3, p. n/a
GPR120 | brown adipose tissue | Ca2 | mitochondria | lipid metabolism | Adipocytes, White - cytology | Adipocytes, Brown - metabolism | Receptors, G-Protein-Coupled - metabolism | Adipose Tissue, White - metabolism | Body Weight - drug effects | Lipids | Male | Receptors, G-Protein-Coupled - agonists | Adipocytes, White - drug effects | Biphenyl Compounds - pharmacology | Cell Respiration - drug effects | Adiposity - drug effects | Oxidation-Reduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Cell Differentiation - drug effects | Models, Biological | Oxygen Consumption - drug effects | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Adipocytes, Brown - cytology | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Physiological aspects | Obesity | G proteins | Body weight | Membrane proteins | Index Medicus | Pharmacology & Drug Discovery | Metabolism
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5. Full Text Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes
by Krings, A and Rahman, S and Huang, S and Lu, Y and Czernik, P.J and Lecka-Czernik, B
Bone (New York, N.Y.), ISSN 8756-3282, 2011, Volume 50, Issue 2, pp. 546 - 552
Orthopedics | White fat | Brown fat | Bone | Marrow fat | Adipogenesis | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Diabetes Mellitus - pathology | Organ Specificity - drug effects | Bone and Bones - pathology | Diabetes Mellitus - genetics | Cell Count | Aging - drug effects | Male | Adipocytes - drug effects | Thiazolidinediones - administration & dosage | Tibia - pathology | Bone and Bones - drug effects | Organ Specificity - genetics | Aging - genetics | Bone Marrow - metabolism | Bone and Bones - metabolism | Tibia - metabolism | Thiazolidinediones - pharmacology | Bone Marrow - drug effects | Biomarkers - metabolism | Adiposity - drug effects | Mice, Inbred C57BL | Tibia - drug effects | Adipocytes - pathology | Adipose Tissue, Brown - pathology | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Adipocytes - metabolism | Bone Marrow - pathology | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Adipose tissues | Diabetes | Gene expression | Genes | Leptin | Index Medicus | bone | marrow fat | adipogenesis | white fat | brown fat | osteoblastogenesis
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6. Full Text FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
by Schlein, Christian and Talukdar, Saswata and Heine, Markus and Fischer, Alexander W and Krott, Lucia M and Nilsson, Stefan K and Brenner, Martin B and Heeren, Joerg and Scheja, Ludger
Cell metabolism, ISSN 1550-4131, 03/2016, Volume 23, Issue 3, pp. 441 - 453
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Adipose Tissue, White - metabolism | Male | Hepatocytes - metabolism | Adipocytes, White - drug effects | Liver - drug effects | Lipoproteins, VLDL - secretion | Female | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Fibroblast Growth Factors - therapeutic use | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Fibroblast Growth Factors - pharmacology | Hypolipidemic Agents - pharmacology | Mice, Knockout | Animals | Lipoproteins, VLDL - metabolism | Lipid Metabolism - drug effects | Triglycerides - blood | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Hypolipidemic Agents - therapeutic use | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Liver | Insulin resistance | Lipids | Fibroblast growth factors | Genetic engineering | Lipoprotein lipase | Cells | Index Medicus
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7. Full Text Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue
by Véniant, Murielle M and Sivits, Glenn and Helmering, Joan and Komorowski, Renee and Lee, Jae and Fan, Wei and Moyer, Carolyn and Lloyd, David J
Cell metabolism, ISSN 1550-4131, 05/2015, Volume 21, Issue 5, pp. 731 - 738
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Obesity - drug therapy | Diet - adverse effects | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | Obesity - genetics | Anti-Obesity Agents - therapeutic use | Obesity - etiology | Fibroblast Growth Factors - therapeutic use | Hypoglycemic Agents - therapeutic use | Adipocytes, Brown - pathology | Adipocytes, Brown - drug effects | Mice, Inbred C57BL | Adipose Tissue, White - physiopathology | Obesity - physiopathology | Gene Expression Regulation - drug effects | Animals | Glucose - metabolism | Mice, Obese | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - physiopathology | Mice | Thermogenesis - drug effects | Uncoupling Protein 1 | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | Adipose tissues | Fibroblast growth factors | Blood lipids | Glucose | Body weight | Dextrose | Index Medicus
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8. Full Text Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system
by Kim, Minji and Goto, Tsuyoshi and Yu, Rina and Uchida, Kunitoshi and Tominaga, Makoto and Kano, Yuriko and Takahashi, Nobuyuki and Kawada, Teruo
Scientific reports, ISSN 2045-2322, 12/2015, Volume 5, Issue 1, pp. 18013 - 18013
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gene Expression - drug effects | Body Temperature - drug effects | Sympathetic Nervous System - drug effects | Humans | Adipose Tissue, White - metabolism | Ion Channels - genetics | Male | Catecholamines - urine | Mitochondrial Proteins - genetics | Insulin - blood | TRPV Cation Channels - deficiency | Adipose Tissue, Brown - innervation | Rectum - physiology | Sympathetic Nervous System - physiology | Mitochondrial Proteins - metabolism | Fish Oils - administration & dosage | Energy Metabolism - physiology | Mice, Inbred C57BL | Receptors, Adrenergic, beta-3 - metabolism | Fish Oils - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Adipose Tissue, White - innervation | Blotting, Western | TRPV Cation Channels - genetics | Mice, Knockout | Up-Regulation - drug effects | Animals | Ion Channels - metabolism | Oxygen Consumption - drug effects | Triglycerides - blood | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Uncoupling Protein 1 | Blood Glucose - metabolism | Fish Oils - chemistry | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | Adipose tissue | Fish oils | Homeostasis | Energy expenditure | Nervous system | Capsaicin receptors | Oxygen consumption | Catecholamines | Adipocytes | Sympathetic nervous system | Energy balance | Transient receptor potential proteins | Mitochondria | Thermogenesis | Temperature effects | Uncoupling protein 1 | Rodents | Norepinephrine | Adrenergic receptors | Lipid metabolism | Adipose tissue (brown) | Index Medicus
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9. Full Text 3D brown adipogenesis to create “Brown-Fat-in-Microstrands”
by Unser, Andrea M and Mooney, Bridget and Corr, David T and Tseng, Yu-Hua and Xie, Yubing
Biomaterials, ISSN 0142-9612, 2015, Volume 75, pp. 123 - 134
Advanced Basic Science | Dentistry | Adipocyte | Brown fat | Alginate | Hydrogel | Adipose tissue engineering | Stem cell | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Alginates - pharmacology | Adipogenesis - drug effects | Adipose Tissue, Brown - physiology | Adipocytes - cytology | Mouse Embryonic Stem Cells - cytology | Adipocytes - drug effects | Cell Culture Techniques - methods | Mouse Embryonic Stem Cells - drug effects | Mouse Embryonic Stem Cells - metabolism | Gene Expression Regulation - drug effects | Cell Differentiation - genetics | Microscopy, Confocal | Glucuronic Acid - pharmacology | Animals | Cell Differentiation - drug effects | Polymerase Chain Reaction | Cell Proliferation - drug effects | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology | Mice | Adipogenesis - genetics | Microfluidics - methods | Hexuronic Acids - pharmacology | Obesity | Analysis | Cell differentiation | Gene expression | Embryonic stem cells | Microfluidics | Biomedical engineering | Tissue engineering | Index Medicus | Biotechnology | Stem cells | Disorders | Markers | Differentiation | Arenas | Three dimensional | Stem Cell | Brown Fat | Adipose Tissue Engineering
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