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1. Full Text A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
by Boström, Pontus and Wu, Jun and Jedrychowski, Mark P and Korde, Anisha and Ye, Li and Lo, James C and Rasbach, Kyle A and Boström, Elisabeth Almer and Choi, Jang Hyun and Long, Jonathan Z and Kajimura, Shingo and Zingaretti, Maria Cristina and Vind, Birgitte F and Tu, Hua and Cinti, Saverio and Højlund, Kurt and Gygi, Steven P and Spiegelman, Bruce M
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7382, pp. 463 - 468
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional... 
SKELETAL-MUSCLE | COACTIVATOR | PHOSPHORYLATION | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | DISEASE | MYOBLAST | EXPRESSION | EXERCISE | ADIPOSE-TISSUE | PROTECTS | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Adipocytes - drug effects | Obesity - blood | Adipose Tissue, White - cytology | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Models, Animal | Energy Metabolism - physiology | Intracellular Signaling Peptides and Proteins - genetics | Obesity - chemically induced | Mice, Transgenic | Trans-Activators - deficiency | Obesity - prevention & control | Plasma - chemistry | Adipose Tissue, Brown - drug effects | Exercise - physiology | Mice | Mice, Inbred BALB C | Transcription Factors | Energy Metabolism - drug effects | Thermogenesis - genetics | Adipose Tissue, White - metabolism | Adipocytes - cytology | Culture Media, Conditioned - pharmacology | Subcutaneous Fat - metabolism | Insulin Resistance - physiology | Cell Respiration - drug effects | Subcutaneous Fat - drug effects | Trans-Activators - genetics | Energy Metabolism - genetics | Gene Expression Regulation - genetics | Cells, Cultured | Hormones - secretion | Muscle Cells - metabolism | Physical Conditioning, Animal - physiology | Subcutaneous Fat - cytology | Gene Expression Regulation - drug effects | Adipose Tissue, Brown - cytology | Animals | Hormones - metabolism | Ion Channels - metabolism | Adipocytes - metabolism | Trans-Activators - secretion | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Thermogenesis - drug effects | Uncoupling Protein 1 | Adipose Tissue, White - drug effects | Index Medicus
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2. Full Text β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
by Roberts, Lee D and Boström, Pontus and O’Sullivan, John F and Schinzel, Robert T and Lewis, Gregory D and Dejam, Andre and Lee, Youn-Kyoung and Palma, Melinda J and Calhoun, Sondra and Georgiadi, Anastasia and Chen, Ming-Huei and Ramachandran, Vasan S and Larson, Martin G and Bouchard, Claude and Rankinen, Tuomo and Souza, Amanda L and Clish, Clary B and Wang, Thomas J and Estall, Jennifer L and Soukas, Alexander A and Cowan, Chad A and Spiegelman, Bruce M and Gerszten, Robert E
Cell Metabolism, ISSN 1550-4131, 01/2014, Volume 19, Issue 1, pp. 96 - 108
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and... 
SKELETAL-MUSCLE | PPAR-ALPHA | MITOCHONDRIAL UNCOUPLING PROTEIN | INSULIN-RESISTANCE | COACTIVATOR PGC-1 | IN-VIVO | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | LIVER-DISEASE | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | CELL BIOLOGY | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Index Medicus
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3. Full Text Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
by Mottillo, Emilio P and Desjardins, Eric M and Crane, Justin D and Smith, Brennan K and Green, Alex E and Ducommun, Serge and Henriksen, Tora I and Rebalka, Irena A and Razi, Aida and Sakamoto, Kei and Scheele, Camilla and Kemp, Bruce E and Hawke, Thomas J and Ortega, Joaquin and Granneman, James G and Steinberg, Gregory R
Cell Metabolism, ISSN 1550-4131, 07/2016, Volume 24, Issue 1, pp. 118 - 129
Brown (BAT) and white (WAT) adipose tissues play distinct roles in maintaining whole-body energy homeostasis, and their dysfunction can contribute to... 
GLUCOSE-HOMEOSTASIS | CYCLIC-AMP | ACTIVATED PROTEIN-KINASE | HORMONE-SENSITIVE LIPASE | LIPOLYSIS | FATTY-ACID | IN-VIVO | ENDOCRINOLOGY & METABOLISM | HUMAN SKELETAL-MUSCLE | PHOSPHORYLATION SITES | MITOCHONDRIAL FISSION | CELL BIOLOGY | Norepinephrine - pharmacology | AMP-Activated Protein Kinases - metabolism | Lipolysis - drug effects | Fatty Liver - pathology | Adipose Tissue, White - metabolism | Adipocytes - enzymology | Adipocytes - drug effects | Mitochondria - ultrastructure | Adipose Tissue, Beige - enzymology | Liver - drug effects | Diet, High-Fat | Gene Deletion | Fatty Liver - enzymology | Homeostasis - drug effects | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Adipose Tissue, Brown - enzymology | Animals | Adipose Tissue, Beige - drug effects | Adipose Tissue, Brown - drug effects | Thermogenesis - drug effects | Adipose Tissue, White - drug effects | Adipose tissues | Type 2 diabetes | Exercise | Liver diseases | Analysis | Communicable diseases | Liver | Physiological aspects | Insulin resistance | Protein kinases | Index Medicus
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4. Full Text BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
by Shu-Wen Qian and Yan Tang and Xi Li and Yuan Liu and You-You Zhang and Hai-Yan Huang and Rui-Dan Xue and Hao-Yong Yu and Liang Guo and Hui-Di Gao and Yan Liu and Xia Sun and Yi-Ming Li and Wei-Ping Jia and Qi-Qun Tang
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 9, pp. 3223 - 3224
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces “white adipocytes” with characteristics of brown fat and... 
PNAS PLUS: AUTHOR SUMMARIES | Brown adipose tissue | Mitochondria | Metabolism | Adipocyte terminal differentiation | Adipocytes, Brown - metabolism | Bone Morphogenetic Protein 4 - genetics | Humans | Adipose Tissue, White - metabolism | Adipocytes, White - enzymology | Fatty Acid-Binding Proteins - metabolism | Bone Morphogenetic Protein 4 - metabolism | Mitochondria - ultrastructure | Thinness - metabolism | Thinness - pathology | Adipocytes, White - drug effects | Adipose Tissue, White - ultrastructure | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adipose Tissue, Brown - ultrastructure | p38 Mitogen-Activated Protein Kinases - metabolism | Homeostasis - drug effects | Adipocytes, Brown - pathology | Insulin - pharmacology | Adipocytes, Brown - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Mitochondria - metabolism | 3T3-L1 Cells | Activating Transcription Factor 2 - metabolism | Adipose Tissue, Brown - pathology | Gene Expression Regulation - drug effects | Organ Size - drug effects | Phenotype | Adipocytes, White - pathology | Animals | Oxygen Consumption - drug effects | Adipose Tissue, White - enzymology | Glucose - metabolism | Trans-Activators - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Transcription Factors | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | OBESITY | MULTIDISCIPLINARY SCIENCES | Proteins | Tissue | Rodents | Homeostasis | Glucose | Gene expression | Cells | Index Medicus | Biological Sciences | metabolism | PNAS Plus | adipocyte terminal differentiation | brown adipose tissue | mitochondria
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5. Full Text Berberine activates thermogenesis in white and brown adipose tissue
by Zhang, Zhiguo and Zhang, Huizhi and Li, Bo and Meng, Xiangjian and Wang, Jiqiu and Zhang, Yifei and Yao, Shuangshuang and Ma, Qinyun and Jin, Lina and Yang, Jian and Wang, Weiqing and Ning, Guang
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5493 - 5493
Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue formation and function increases energy expenditure and hence... 
SKELETAL-MUSCLE | ENERGY-EXPENDITURE | PROTEIN-KINASE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | HYPOTHALAMIC AMPK | ADIPOCYTE DIFFERENTIATION | AMP-KINASE | GLUCOSE-UPTAKE | FAT-CELL | Berberine - administration & dosage | Obesity - drug therapy | Humans | Mice, Inbred C57BL | Adipose Tissue, White - physiopathology | Male | Obesity - physiopathology | Mice, Inbred C3H | Obesity - metabolism | Animals | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - physiopathology | Mice | Drugs, Chinese Herbal - administration & dosage | Thermogenesis - drug effects | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | Index Medicus
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6. Full Text Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes
by Krings, A and Rahman, S and Huang, S and Lu, Y and Czernik, P.J and Lecka-Czernik, B
Bone, ISSN 8756-3282, 2011, Volume 50, Issue 2, pp. 546 - 552
Abstract Fat occupies a significant portion of bone cavity however its function is largely unknown. Marrow fat expands during aging and in conditions which... 
Orthopedics | White fat | Brown fat | Bone | Marrow fat | Adipogenesis | FOXC2 | ADIPOCYTES | MUSCLE | OBESITY | THERAPY | GENE | MITOCHONDRIAL UNCOUPLING PROTEIN | BIOLOGY | ENDOCRINOLOGY & METABOLISM | TRANSCRIPTION FACTOR | EXPRESSION | Diabetes Mellitus - pathology | Organ Specificity - drug effects | Bone and Bones - pathology | Diabetes Mellitus - genetics | Cell Count | Aging - drug effects | Male | Adipocytes - drug effects | Thiazolidinediones - administration & dosage | Tibia - pathology | Bone and Bones - drug effects | Organ Specificity - genetics | Aging - genetics | Bone Marrow - metabolism | Bone and Bones - metabolism | Tibia - metabolism | Thiazolidinediones - pharmacology | Bone Marrow - drug effects | Biomarkers - metabolism | Adiposity - drug effects | Mice, Inbred C57BL | Tibia - drug effects | Adipocytes - pathology | Adipose Tissue, Brown - pathology | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Adipocytes - metabolism | Bone Marrow - pathology | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Adipose tissues | Diabetes | Gene expression | Genes | Leptin | Index Medicus | bone | marrow fat | adipogenesis | white fat | brown fat | osteoblastogenesis
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7. Full Text PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
by Ohno, Haruya and Shinoda, Kosaku and Spiegelman, Bruce M and Kajimura, Shingo
Cell Metabolism, ISSN 1550-4131, 03/2012, Volume 15, Issue 3, pp. 395 - 404
Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning... 
OLIGONUCLEOTIDE ARRAYS | GENE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | ACTIVATED-RECEPTOR-GAMMA | TRANSCRIPTIONAL CONTROL | ADIPOCYTE DIFFERENTIATION | ADULT HUMANS | LIGAND | EXPRESSION | ADIPOSE-TISSUE | CELL BIOLOGY | Mice, Inbred C57BL | Adipose Tissue, White - metabolism | Male | Transcription Factors - genetics | DNA-Binding Proteins - genetics | PPAR gamma - metabolism | Blotting, Western | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Oxygen Consumption - drug effects | Protein Stability - drug effects | PPAR gamma - agonists | Indoles - pharmacology | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Thiazolidinediones - pharmacology | Adipose Tissue, White - drug effects | Sulfides - pharmacology | Index Medicus
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8. Full Text The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity
by Broeders, Evie P.M and Nascimento, Emmani B.M and Havekes, Bas and Brans, Boudewijn and Roumans, Kay H.M and Tailleux, Anne and Schaart, Gert and Kouach, Mostafa and Charton, Julie and Deprez, Benoit and Bouvy, Nicole D and Mottaghy, Felix and Staels, Bart and van Marken Lichtenbelt, Wouter D and Schrauwen, Patrick
Cell Metabolism, ISSN 1550-4131, 09/2015, Volume 22, Issue 3, pp. 418 - 426
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In... 
THERMOGENESIS | ACTIVATION | ENERGY-EXPENDITURE | GLUCOSE | Y GASTRIC BYPASS | ENDOCRINOLOGY & METABOLISM | FAT | ADULT HUMANS | COLD | IDENTIFICATION | METABOLIC-RATE | CELL BIOLOGY | Adipocytes, Brown - metabolism | Receptors, G-Protein-Coupled - metabolism | Adipocytes, Brown - drug effects | Administration, Oral | Humans | Cells, Cultured | Chenodeoxycholic Acid - administration & dosage | Chenodeoxycholic Acid - blood | Young Adult | Signal Transduction - drug effects | Chenodeoxycholic Acid - pharmacology | Adult | Female | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Energy Metabolism - drug effects | Adipose tissues | Physiological aspects | Analysis | Deoxycholic acid | Index Medicus
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9. Full Text Microbiota depletion promotes browning of white adipose tissue and reduces obesity
by Suárez-Zamorano, Nicolas and Fabbiano, Salvatore and Chevalier, Claire and Stojanović, Ozren and Colin, Didier J and Stevanović, Ana and Veyrat-Durebex, Christelle and Tarallo, Valentina and Rigo, Dorothée and Germain, Stéphane and Ilievska, Miroslava and Montet, Xavier and Seimbille, Yann and Hapfelmeier, Siegfried and Trajkovski, Mirko
Nature Medicine, ISSN 1078-8956, 12/2015, Volume 21, Issue 12, pp. 1497 - 1501
Brown adipose tissue (BAT) promotes a lean and healthy phenotype and improves insulin sensitivity(1). In response to cold or exercise, brown fat cells also... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | ADIPOCYTES | ADAPTIVE THERMOGENESIS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICE | GUT MICROBIOTA | INSULIN SENSITIVITY | BEIGE FAT | CELL | CELL BIOLOGY | Microbiota - drug effects | Adipose Tissue, White - metabolism | Adipocytes - cytology | Adipocytes - drug effects | RNA, Messenger - metabolism | Obesity - microbiology | Subcutaneous Fat - metabolism | Subcutaneous Fat - drug effects | Intra-Abdominal Fat - drug effects | Insulin - pharmacology | Glucose Tolerance Test | Cytokines - metabolism | Cell Size - drug effects | Mice, Inbred C57BL | RNA, Messenger - genetics | Intra-Abdominal Fat - metabolism | Obesity - pathology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Adipocytes - metabolism | Germ-Free Life | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice, Inbred BALB C | Adipose Tissue, White - drug effects | Adipose tissues | Pregnancy | Obesity | Care and treatment | Microbiota (Symbiotic organisms) | Research | Health aspects | Risk factors | Index Medicus
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10. Full Text The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
by Lynes, Matthew D and Leiria, Luiz O and Lundh, Morten and Bartelt, Alexander and Shamsi, Farnaz and Huang, Tian Lian and Takahashi, Hirokazu and Hirshman, Michael F and Schlein, Christian and Lee, Alexandra and Baer, Lisa A and May, Francis J and Gao, Fei and Narain, Niven R and Chen, Emily Y and Kiebish, Michael A and Cypess, Aaron M and Blüher, Matthias and Goodyear, Laurie J and Hotamisligil, Gökhan S and Stanford, Kristin I and Tseng, Yu-Hua
Nature Medicine, ISSN 1078-8956, 05/2017, Volume 23, Issue 5, pp. 631 - 637
Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADIPOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | EPOXIDE HYDROLASE | CELL BIOLOGY | THERMOGENESIS | TARGETED DISRUPTION | WHITE FAT | METABOLISM | GENE | IN-VIVO | EXPOSURE | PLASMA TRIGLYCERIDES | Humans | Male | RNA, Messenger - metabolism | Oleic Acids - metabolism | Overweight - metabolism | Fatty Acid Transport Proteins - metabolism | Oleic Acids - biosynthesis | CD36 Antigens - metabolism | Fatty Acid Transport Proteins - drug effects | Female | Biological Transport - drug effects | Cell Membrane - metabolism | Oleic Acids - pharmacology | Radiopharmaceuticals | Fatty Acids - metabolism | Cell Membrane - drug effects | Cold Temperature | Insulin Resistance | CD36 Antigens - drug effects | Obesity - metabolism | Triglycerides - metabolism | Positron Emission Tomography Computed Tomography | Animals | Thermogenesis | Fluorodeoxyglucose F18 | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Energy Metabolism - drug effects | Index Medicus
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11. Full Text Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
by Wang, S and Liang, X and Yang, Q and Fu, X and Rogers, C.J and Zhu, M and Rodgers, B.D and Jiang, Q and Dodson, M.V and Du, M
International Journal of Obesity, ISSN 0307-0565, 06/2015, Volume 39, Issue 6, pp. 967 - 976
Development of brown-like/beige adipocytes in white adipose tissue (WAT) helps to reduce obesity. Thus we investigated the effects of resveratrol, a dietary... 
Eating | AMP-Activated Protein Kinases - metabolism | Adipocytes, Brown - metabolism | Adipocytes, Brown - drug effects | Adipogenesis - drug effects | Adipose Tissue, White - metabolism | Antioxidants - pharmacology | Stilbenes - pharmacology | Gene Expression Regulation - drug effects | Animals | Ion Channels - metabolism | Mitochondrial Proteins - metabolism | Diet, High-Fat | Resveratrol | Female | Mice | Uncoupling Protein 1 | Cyclic AMP - metabolism | Adipose Tissue, White - drug effects | Index Medicus | uncoupling protein 1 | stromal vascular cells | white adipose tissue | beige adipocytes | resveratrol | obesity
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