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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 258 - 262
In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes(1). Adipose-specific knockout or overexpression of... 
METABOLISM | MULTIDISCIPLINARY SCIENCES | MOUSE | LIVER | RESISTANCE | MICE | CDNA CLONING | EXPRESSION | SIRT1 | CANCER | ADIPOSE-TISSUE | Sirtuin 1 - metabolism | Acetyltransferases - metabolism | Adipocytes - secretion | Ornithine Decarboxylase - metabolism | Liver - enzymology | Glucose Transporter Type 4 - metabolism | Adipose Tissue, White - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | Nicotinamide N-Methyltransferase - metabolism | Glucose Intolerance | Glucose Transporter Type 4 - deficiency | Obesity - genetics | Thinness - metabolism | Gene Knockdown Techniques | Adipose Tissue - metabolism | Nicotinamide N-Methyltransferase - deficiency | Obesity - etiology | NAD - metabolism | Spermine - analogs & derivatives | Nicotinamide N-Methyltransferase - genetics | Thinness - enzymology | Glucose Transporter Type 4 - genetics | Niacinamide - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Oxidoreductases Acting on CH-NH Group Donors - metabolism | Fatty Liver | Animals | Diet | Energy Metabolism | Adipocytes - metabolism | Obesity - prevention & control | Spermine - metabolism | Adipose Tissue, White - enzymology | Adipose Tissue - enzymology | Mice | Obesity - enzymology | S-Adenosylmethionine - metabolism | Adipose tissues | Type 2 diabetes | Obesity | Care and treatment | Analysis | Transferases | Physiological aspects | Genetic aspects | Research | Gene expression | Enzymes | Body fat | Adipocytes | Polyamines | Variance analysis | Proteins | Weight control | Metabolites | Rodents | Insulin resistance | Diabetes | Mass spectrometry | Food
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 9, pp. 3223 - 3224
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces “white adipocytes” with characteristics of brown fat and... 
PNAS PLUS: AUTHOR SUMMARIES | Brown adipose tissue | Mitochondria | Metabolism | Adipocyte terminal differentiation | Adipocytes, Brown - metabolism | Bone Morphogenetic Protein 4 - genetics | Humans | Adipose Tissue, White - metabolism | Adipocytes, White - enzymology | Fatty Acid-Binding Proteins - metabolism | Bone Morphogenetic Protein 4 - metabolism | Mitochondria - ultrastructure | Thinness - metabolism | Thinness - pathology | Adipocytes, White - drug effects | Adipose Tissue, White - ultrastructure | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adipose Tissue, Brown - ultrastructure | p38 Mitogen-Activated Protein Kinases - metabolism | Homeostasis - drug effects | Adipocytes, Brown - pathology | Insulin - pharmacology | Adipocytes, Brown - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Mitochondria - metabolism | 3T3-L1 Cells | Activating Transcription Factor 2 - metabolism | Adipose Tissue, Brown - pathology | Gene Expression Regulation - drug effects | Organ Size - drug effects | Phenotype | Adipocytes, White - pathology | Animals | Oxygen Consumption - drug effects | Adipose Tissue, White - enzymology | Glucose - metabolism | Trans-Activators - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Transcription Factors | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | OBESITY | MULTIDISCIPLINARY SCIENCES | Biological Sciences | metabolism | PNAS Plus | adipocyte terminal differentiation | brown adipose tissue | mitochondria
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 04/2016, Volume 310, Issue 7, pp. G526 - G538
Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt(-/-) mice are protected... 
Phosphatidylcholine | Nonalcoholic fatty liver disease | Peroxisomal proliferator-activated receptor-γ | Steatohepatitis | Fibrosis | steatohepatitis | PHYSIOLOGY | ACTIVATED RECEPTOR-GAMMA | peroxisomal proliferator-activated receptor-gamma | TRIACYLGLYCEROL HYDROLASE | STELLATE CELLS | NONALCOHOLIC STEATOHEPATITIS | DIET-INDUCED OBESITY | INDUCED INSULIN-RESISTANCE | nonalcoholic fatty liver disease | LOW-DENSITY LIPOPROTEINS | phosphatidylcholine | GENE-EXPRESSION | PLASMA HIGH-DENSITY | PPAR-GAMMA | fibrosis | GASTROENTEROLOGY & HEPATOLOGY | Liver - pathology | Hepatitis - enzymology | Anti-Infective Agents - pharmacology | PPAR gamma - metabolism | Liver Cirrhosis, Experimental - prevention & control | Collagen Type I - genetics | Liver - drug effects | Phosphatidylethanolamine N-Methyltransferase - deficiency | Time Factors | Diet, High-Fat | Hepatitis - genetics | Thiazolidinediones - pharmacology | Genetic Predisposition to Disease | Adiposity - drug effects | Mice, Knockout | Phenotype | Signal Transduction - drug effects | Obesity - prevention & control | Oxidative Stress - drug effects | Non-alcoholic Fatty Liver Disease - pathology | Liver - enzymology | Actins - metabolism | Adipocytes, White - enzymology | Obesity - genetics | Phosphatidylethanolamine N-Methyltransferase - genetics | Actins - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Hepatitis - prevention & control | Liver Cirrhosis, Experimental - enzymology | Adipocytes, White - drug effects | Non-alcoholic Fatty Liver Disease - enzymology | Liver Cirrhosis, Experimental - pathology | Adipose Tissue, White - pathology | Collagen Type I - metabolism | Non-alcoholic Fatty Liver Disease - genetics | Mice, Inbred C57BL | Insulin Resistance | Hepatitis - pathology | Liver Cirrhosis, Experimental - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | Adipocytes, White - pathology | Animals | Transforming Growth Factor beta - genetics | Adipose Tissue, White - enzymology | Non-alcoholic Fatty Liver Disease - prevention & control | PPAR gamma - agonists | Cell Proliferation - drug effects | Obesity - enzymology | Transforming Growth Factor beta - metabolism | Adipose Tissue, White - drug effects | Prevention | Liver diseases | Health aspects | Transferases
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7716, pp. 102 - 106
Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease(1). Thermogenic respiration is... 
ENERGY-EXPENDITURE | NONSHIVERING THERMOGENESIS | METABOLISM | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | LACTATE | FAT | UCP1 | DYSFUNCTION | BROWN-ADIPOCYTES | DEFICIENCY | Metabolomics | Reactive Oxygen Species - metabolism | Adipose Tissue, White - metabolism | Adipocytes - enzymology | Male | Adipocytes - drug effects | Thermogenesis - physiology | Adipose Tissue, White - cytology | Oxidation-Reduction - drug effects | Female | Uncoupling Protein 1 - metabolism | Adipose Tissue, Brown - enzymology | Obesity - metabolism | Adipose Tissue, Brown - cytology | Animals | Succinic Acid - pharmacology | Succinic Acid - metabolism | Adipocytes - metabolism | Obesity - prevention & control | Adipose Tissue, White - enzymology | Succinate Dehydrogenase - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Thermogenesis - drug effects | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Control | Thermogenesis | Succinates | Protein kinase A | Tricarboxylic acid cycle | Reactive oxygen species | Succinate dehydrogenase | Dehydrogenases | Adipose tissue | Body fat | Activation | Adipocytes | Kinases | Dehydrogenase | Accumulation | Proteins | Signal transduction | Energy | Metabolites | Rodents | Oxidation | Adipose tissue (brown) | Oxygen | Cyclic AMP | Pharmacology | Metabolism | Lipolysis | Glucose tolerance | Signaling | Hypotheses | External stimuli | Respiration
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157644
Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to... 
THERMOGENESIS | MITOCHONDRIAL DYNAMICS | OBESITY | ENERGY-EXPENDITURE | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PPAR-GAMMA | METABOLIC-REGULATION | ADIPOGENESIS | SIRT1 | BROWN FAT | AMP-Activated Protein Kinases - metabolism | Adipocytes, Beige - drug effects | Humans | Adipocytes, Beige - cytology | Adipocytes, White - enzymology | Mitochondria - metabolism | Stem Cells - cytology | Mitochondria - drug effects | Enzyme Activation - drug effects | Pericardium - cytology | Aminoimidazole Carboxamide - pharmacology | Cell Shape - drug effects | Ribonucleotides - pharmacology | Phenotype | Adipose Tissue, White - cytology | Mitochondrial Dynamics - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Stem Cells - enzymology | Stem Cells - drug effects | Adipocytes, Beige - enzymology | Fat cells | Mitochondrial biogenesis | Research | Cell differentiation | Analysis | Adipose tissue | Mesenchyme | Body fat | Laboratories | Heart surgery | Activation | Biosynthesis | Biology | Adipocytes | Kinases | AMP-activated protein kinase | Proteins | Mitochondria | Energy | Cell cycle | Oxidation | Cardiology | Phenotypes | AMP | Oxygen consumption | Biophysics | Metabolism | Gene expression | SIRT1 protein | Lipolysis | Medicine | Musculoskeletal system | Thermogenesis | Deacetylation | Stem cells | Diabetes | Differentiation | Tbx1 protein
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