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EMBO Molecular Medicine, ISSN 1757-4676, 03/2018, Volume 10, Issue 3, p. n/a
Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related disorders... 
GPR120 | brown adipose tissue | Ca2 | mitochondria | lipid metabolism | Ca | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | PROTEIN | INSULIN-SECRETION | THERMOGENESIS | POTENT | GLUCOSE-METABOLISM | GENE-EXPRESSION | ACID RECEPTOR GPR40 | ADIPOSE-TISSUE | Adipocytes, White - cytology | Adipocytes, Brown - metabolism | Receptors, G-Protein-Coupled - metabolism | Adipose Tissue, White - metabolism | Body Weight - drug effects | Lipids | Male | Receptors, G-Protein-Coupled - agonists | Adipocytes, White - drug effects | Biphenyl Compounds - pharmacology | Cell Respiration - drug effects | Adiposity - drug effects | Oxidation-Reduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Cell Differentiation - drug effects | Models, Biological | Oxygen Consumption - drug effects | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Adipocytes, Brown - cytology | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Physiological aspects | Obesity | G proteins | Body weight | Membrane proteins | Pharmacology & Drug Discovery | Metabolism
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 9, pp. E798 - E807
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces “white adipocytes... 
PNAS PLUS: AUTHOR SUMMARIES | Brown adipose tissue | Mitochondria | Metabolism | Adipocyte terminal differentiation | Adipocytes, Brown - metabolism | Bone Morphogenetic Protein 4 - genetics | Humans | Adipose Tissue, White - metabolism | Adipocytes, White - enzymology | Fatty Acid-Binding Proteins - metabolism | Bone Morphogenetic Protein 4 - metabolism | Mitochondria - ultrastructure | Thinness - metabolism | Thinness - pathology | Adipocytes, White - drug effects | Adipose Tissue, White - ultrastructure | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adipose Tissue, Brown - ultrastructure | p38 Mitogen-Activated Protein Kinases - metabolism | Homeostasis - drug effects | Adipocytes, Brown - pathology | Insulin - pharmacology | Adipocytes, Brown - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Mitochondria - metabolism | 3T3-L1 Cells | Activating Transcription Factor 2 - metabolism | Adipose Tissue, Brown - pathology | Gene Expression Regulation - drug effects | Organ Size - drug effects | Phenotype | Adipocytes, White - pathology | Animals | Oxygen Consumption - drug effects | Adipose Tissue, White - enzymology | Glucose - metabolism | Trans-Activators - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Transcription Factors | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | OBESITY | MULTIDISCIPLINARY SCIENCES | Biological Sciences | metabolism | PNAS Plus | adipocyte terminal differentiation | brown adipose tissue | mitochondria
Journal Article
Cell metabolism, ISSN 1550-4131, 2014, Volume 19, Issue 1, pp. 96 - 108
...-mediated response to exercise in muscle conveys signals to other tissues remains incompletely defined... 
SKELETAL-MUSCLE | PPAR-ALPHA | ACTIVATION | MITOCHONDRIAL UNCOUPLING PROTEIN | PGC-1-ALPHA | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MICE | EXPRESSION | EXERCISE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 481, Issue 7382, pp. 463 - 468
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-gamma co-activator-1 alpha (PGC1-alpha... 
SKELETAL-MUSCLE | COACTIVATOR | PHOSPHORYLATION | ROLES | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | SWITCH | MYOBLAST | EXPRESSION | EXERCISE | PROTECTS | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Adipocytes - drug effects | Obesity - blood | Adipose Tissue, White - cytology | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Models, Animal | Energy Metabolism - physiology | Intracellular Signaling Peptides and Proteins - genetics | Obesity - chemically induced | Mice, Transgenic | Trans-Activators - deficiency | Obesity - prevention & control | Plasma - chemistry | Adipose Tissue, Brown - drug effects | Exercise - physiology | Mice | Mice, Inbred BALB C | Transcription Factors | Energy Metabolism - drug effects | Thermogenesis - genetics | Adipose Tissue, White - metabolism | Adipocytes - cytology | Culture Media, Conditioned - pharmacology | Subcutaneous Fat - metabolism | Insulin Resistance - physiology | Cell Respiration - drug effects | Subcutaneous Fat - drug effects | Trans-Activators - genetics | Energy Metabolism - genetics | Gene Expression Regulation - genetics | Cells, Cultured | Hormones - secretion | Muscle Cells - metabolism | Physical Conditioning, Animal - physiology | Subcutaneous Fat - cytology | Gene Expression Regulation - drug effects | Adipose Tissue, Brown - cytology | Animals | Hormones - metabolism | Ion Channels - metabolism | Adipocytes - metabolism | Trans-Activators - secretion | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Thermogenesis - drug effects | Uncoupling Protein 1 | Adipose Tissue, White - drug effects
Journal Article
Cell metabolism, ISSN 1550-4131, 2016, Volume 24, Issue 1, pp. 118 - 129
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2014, Volume 63, Issue 10, pp. 3346 - 3358
... for these interactions remain largely unknown. We found that central injection of a clinically used GLP-1R agonist, liraglutide, in mice stimulates brown adipose tissue (BAT... 
NERVOUS-SYSTEM | GLUCOSE-HOMEOSTASIS | ENERGY-EXPENDITURE | GLUCAGON-LIKE PEPTIDE-1 | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | RAT-BRAIN | DIET-INDUCED OBESITY | RECEPTORS | TYPE-2 DIABETES-MELLITUS | Protein Kinases - metabolism | Metformin - therapeutic use | Obesity - drug therapy | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Eating - physiology | Young Adult | Glucagon-Like Peptide 1 - agonists | Aged, 80 and over | Adult | Female | Hypothalamus - drug effects | Drug Therapy, Combination | Energy Metabolism - physiology | Hypoglycemic Agents - therapeutic use | Glucagon-Like Peptide 1 - analogs & derivatives | Metformin - pharmacology | Glucagon-Like Peptide 1 - pharmacology | Rats | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Peptides - pharmacology | Eating - drug effects | Animals | Hypothalamus - metabolism | Venoms - therapeutic use | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Aged | Mice | Venoms - pharmacology | Thermogenesis - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Energy Metabolism - drug effects | Liraglutide | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Type 2 diabetes | Complications and side effects | Thermogenesis | Body weight | Brown adipose tissue | Development and progression | Research | Risk factors
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7656, pp. 107 - 112
.... The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis... 
WHITE | OBESITY | ENERGY-EXPENDITURE | BROWN-FAT | OSTEOCLAST FORMATION | MULTIDISCIPLINARY SCIENCES | FOLLICLE-STIMULATING-HORMONE | RECEPTOR | BONE MASS | MENOPAUSAL TRANSITION | OVARIECTOMIZED MICE | Obesity - drug therapy | Receptors, FSH - genetics | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Follicle Stimulating Hormone, beta Subunit - antagonists & inhibitors | Male | Osteoporosis - drug therapy | Adipocytes - drug effects | Uncoupling Protein 1 - biosynthesis | Adipose Tissue - metabolism | Antibodies - immunology | Female | Receptors, FSH - metabolism | Adiposity - drug effects | Ovariectomy | Mitochondria - metabolism | Mitochondria - drug effects | Receptors, FSH - antagonists & inhibitors | Haploinsufficiency | Antibodies - pharmacology | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Obesity - prevention & control | Follicle Stimulating Hormone, beta Subunit - immunology | Adipose Tissue, Beige - drug effects | Mice | Thermogenesis - drug effects | Adipose Tissue - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Physiological research | Follicle-stimulating hormone | Thermogenesis | Research | Binding | Obesity | Immunoglobulins | Adipose tissue | Pituitary hormones | Body fat | Menopause | Blocking | Adipocytes | Hormones | Metabolism | Density | Osteoporosis | Mitochondria | Biomedical materials | Bone mass | Pituitary | Biocompatibility | Bone loss | Adipose tissue (brown)
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 18013
Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis, and may provide novel strategies for the treatment of human obesity... 
CAPSAICIN RECEPTOR | COLD-EXPOSURE | ELEMENT-BINDING PROTEIN-1 | UNCOUPLING PROTEIN | MULTIDISCIPLINARY SCIENCES | DIET-INDUCED THERMOGENESIS | DOWN-REGULATION | POLYUNSATURATED FATTY-ACIDS | POSSIBLE MECHANISM | MARINE ORIGIN | OMEGA-3-FATTY-ACID SUPPLEMENTATION | Gene Expression - drug effects | Body Temperature - drug effects | Sympathetic Nervous System - drug effects | Humans | Adipose Tissue, White - metabolism | Ion Channels - genetics | Male | Catecholamines - urine | Mitochondrial Proteins - genetics | Insulin - blood | TRPV Cation Channels - deficiency | Adipose Tissue, Brown - innervation | Rectum - physiology | Sympathetic Nervous System - physiology | Mitochondrial Proteins - metabolism | Fish Oils - administration & dosage | Energy Metabolism - physiology | Mice, Inbred C57BL | Receptors, Adrenergic, beta-3 - metabolism | Fish Oils - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Adipose Tissue, White - innervation | Blotting, Western | TRPV Cation Channels - genetics | Mice, Knockout | Up-Regulation - drug effects | Animals | Ion Channels - metabolism | Oxygen Consumption - drug effects | Triglycerides - blood | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Uncoupling Protein 1 | Blood Glucose - metabolism | Fish Oils - chemistry | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | Adipose tissue | Fish oils | Homeostasis | Energy expenditure | Nervous system | Capsaicin receptors | Oxygen consumption | Catecholamines | Adipocytes | Sympathetic nervous system | Energy balance | Transient receptor potential proteins | Mitochondria | Thermogenesis | Temperature effects | Uncoupling protein 1 | Rodents | Norepinephrine | Adrenergic receptors | Lipid metabolism | Adipose tissue (brown)
Journal Article