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Cell metabolism, ISSN 1550-4131, 2014, Volume 19, Issue 1, pp. 96 - 108
.... Muscle PGC-1α transgenic expression and exercise both increase the expression of thermogenic genes within white adipose. How the PGC-1α... 
SKELETAL-MUSCLE | PPAR-ALPHA | ACTIVATION | MITOCHONDRIAL UNCOUPLING PROTEIN | PGC-1-ALPHA | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MICE | EXPRESSION | EXERCISE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2018, Volume 10, Issue 3, p. n/a
Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related disorders... 
GPR120 | brown adipose tissue | Ca2 | mitochondria | lipid metabolism | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | PROTEIN | INSULIN-SECRETION | UCP1 | POTENT | GLUCOSE-METABOLISM | GENE-EXPRESSION | ACID RECEPTOR GPR40 | ADIPOSE-TISSUE | Adipocytes, White - cytology | Adipocytes, Brown - metabolism | Receptors, G-Protein-Coupled - metabolism | Adipose Tissue, White - metabolism | Body Weight - drug effects | Lipids | Male | Receptors, G-Protein-Coupled - agonists | Adipocytes, White - drug effects | Biphenyl Compounds - pharmacology | Cell Respiration - drug effects | Adiposity - drug effects | Oxidation-Reduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Cell Differentiation - drug effects | Models, Biological | Oxygen Consumption - drug effects | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Adipocytes, Brown - cytology | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Physiological aspects | Obesity | G proteins | Body weight | Membrane proteins | Pharmacology & Drug Discovery | Metabolism
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 9, pp. E798 - E807
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces “white adipocytes... 
PNAS PLUS: AUTHOR SUMMARIES | Brown adipose tissue | Mitochondria | Metabolism | Adipocyte terminal differentiation | Adipocytes, Brown - metabolism | Bone Morphogenetic Protein 4 - genetics | Humans | Adipose Tissue, White - metabolism | Adipocytes, White - enzymology | Fatty Acid-Binding Proteins - metabolism | Bone Morphogenetic Protein 4 - metabolism | Mitochondria - ultrastructure | Thinness - metabolism | Thinness - pathology | Adipocytes, White - drug effects | Adipose Tissue, White - ultrastructure | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adipose Tissue, Brown - ultrastructure | p38 Mitogen-Activated Protein Kinases - metabolism | Homeostasis - drug effects | Adipocytes, Brown - pathology | Insulin - pharmacology | Adipocytes, Brown - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Mitochondria - metabolism | 3T3-L1 Cells | Activating Transcription Factor 2 - metabolism | Adipose Tissue, Brown - pathology | Gene Expression Regulation - drug effects | Organ Size - drug effects | Phenotype | Adipocytes, White - pathology | Animals | Oxygen Consumption - drug effects | Adipose Tissue, White - enzymology | Glucose - metabolism | Trans-Activators - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Transcription Factors | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | OBESITY | MULTIDISCIPLINARY SCIENCES | Biological Sciences | metabolism | PNAS Plus | adipocyte terminal differentiation | brown adipose tissue | mitochondria
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 2007, Volume 27, Issue 13, pp. 4953 - 4967
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
CELLS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | DIFFERENTIATION | MICROARRAY DATA | TRANSGENIC MICE | CELL BIOLOGY | Gene Expression Regulation, Enzymologic - drug effects | Acetyltransferases - metabolism | Multienzyme Complexes - metabolism | Adipocytes - drug effects | Glucose Intolerance | AMP-Activated Protein Kinases | Oxidative Phosphorylation - drug effects | Adipose Tissue, White - cytology | Body Composition - drug effects | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Food Deprivation | p38 Mitogen-Activated Protein Kinases - metabolism | Homeostasis - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Isoenzymes - genetics | Hydrogen Peroxide - pharmacology | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Multienzyme Complexes - genetics | Macrophages - cytology | Mitochondria - drug effects | Feeding Behavior - drug effects | Polyamines - metabolism | Macrophages - metabolism | Organ Size - drug effects | Animals | Adipocytes - metabolism | Fibroblasts - drug effects | Adipose Tissue, White - enzymology | Adipose Tissue, White - growth & development | Glucose - metabolism | Macrophages - drug effects | Trans-Activators - metabolism | Mice | Transcription Factors | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | White/cytology/drug effects/enzymology/growth | Hydrogen Peroxide/pharmacology | Macrophages/cytology/drug effects/metabolism | Mitochondria/drug effects/metabolism | Fibroblasts/drug effects/metabolism | p38 Mitogen-Activated Protein Kinases/metabolism | MEDICIN OCH HÄLSOVETENSKAP | Homeostasis/drug effects | Multienzyme Complexes/genetics/metabolism | Protein-Serine-Threonine Kinases/genetics/metabolism | Trans-Activators/genetics/metabolism | Enzymologic/drug effects | Glucose/metabolism | Adipose Tissue | Feeding Behavior/drug effects | Organ Size/drug effects | Oxidative Phosphorylation/drug effects | MEDICAL AND HEALTH SCIENCES | development | Acetyltransferases/metabolism | Adipocytes/drug effects/metabolism | Gene Expression Regulation | Adenosine Triphosphate/metabolism | Body Composition/drug effects | Polyamines/metabolism | Energy Metabolism/drug effects | Isoenzymes/genetics/metabolism | Phosphorylation/drug effects
Journal Article
Nature medicine, ISSN 1546-170X, 2015, Volume 21, Issue 12, pp. 1497 - 1501
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7656, pp. 107 - 112
...) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr... 
WHITE | OBESITY | ENERGY-EXPENDITURE | BROWN-FAT | OSTEOCLAST FORMATION | MULTIDISCIPLINARY SCIENCES | FOLLICLE-STIMULATING-HORMONE | RECEPTOR | BONE MASS | MENOPAUSAL TRANSITION | OVARIECTOMIZED MICE | Obesity - drug therapy | Receptors, FSH - genetics | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Follicle Stimulating Hormone, beta Subunit - antagonists & inhibitors | Male | Osteoporosis - drug therapy | Adipocytes - drug effects | Uncoupling Protein 1 - biosynthesis | Adipose Tissue - metabolism | Antibodies - immunology | Female | Receptors, FSH - metabolism | Adiposity - drug effects | Ovariectomy | Mitochondria - metabolism | Mitochondria - drug effects | Receptors, FSH - antagonists & inhibitors | Haploinsufficiency | Antibodies - pharmacology | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Obesity - prevention & control | Follicle Stimulating Hormone, beta Subunit - immunology | Adipose Tissue, Beige - drug effects | Mice | Thermogenesis - drug effects | Adipose Tissue - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Physiological research | Follicle-stimulating hormone | Thermogenesis | Research | Binding | Obesity | Immunoglobulins | Adipose tissue | Pituitary hormones | Body fat | Menopause | Blocking | Adipocytes | Hormones | Metabolism | Density | Osteoporosis | Mitochondria | Biomedical materials | Bone mass | Pituitary | Biocompatibility | Bone loss | Adipose tissue (brown)
Journal Article
Cell metabolism, ISSN 1550-4131, 2017, Volume 26, Issue 3, pp. 493 - 508.e4
Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT... 
adipose remodeling | macrophages | adipocyte precursor cells | beiging | adaptive thermogenesis | eotaxin | eosinophils | type 2 immunity | ANTIDIABETIC ACTIONS | CELLS | ENERGY-EXPENDITURE | ADIPOCYTES | ADIPONECTIN | EOSINOPHILS | ENDOCRINOLOGY & METABOLISM | INSULIN SENSITIVITY | EOTAXIN | GROWTH-FACTOR 21 | FGF21 | CELL BIOLOGY | Eosinophils - metabolism | Eosinophils - drug effects | Sympathetic Nervous System - drug effects | Adaptation, Physiological - drug effects | Glucuronidase - metabolism | Adipose Tissue, White - metabolism | Adipocytes - cytology | Male | Autocrine Communication - drug effects | Stem Cells - cytology | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Stem Cells - metabolism | Sympathetic Nervous System - metabolism | Immunity - drug effects | Fibroblast Growth Factors - metabolism | Cold Temperature | Chemokine CCL11 - metabolism | Mice, Inbred C57BL | Fibroblast Growth Factors - deficiency | Recombinant Proteins - pharmacology | Mice, Knockout | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Adipocytes - metabolism | Stem Cells - drug effects | Adipose Tissue, Beige - drug effects | Macrophages - drug effects | Cell Proliferation - drug effects | Thermogenesis - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Fibroblast growth factors | Immune response | Macrophages | Pharmaceutical biotechnology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 15, pp. 5874 - 5879
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 18013
Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis, and may provide novel strategies for the treatment of human obesity... 
CAPSAICIN RECEPTOR | COLD-EXPOSURE | ELEMENT-BINDING PROTEIN-1 | UNCOUPLING PROTEIN | MULTIDISCIPLINARY SCIENCES | DIET-INDUCED THERMOGENESIS | DOWN-REGULATION | POLYUNSATURATED FATTY-ACIDS | POSSIBLE MECHANISM | MARINE ORIGIN | OMEGA-3-FATTY-ACID SUPPLEMENTATION | Gene Expression - drug effects | Body Temperature - drug effects | Sympathetic Nervous System - drug effects | Humans | Adipose Tissue, White - metabolism | Ion Channels - genetics | Male | Catecholamines - urine | Mitochondrial Proteins - genetics | Insulin - blood | TRPV Cation Channels - deficiency | Adipose Tissue, Brown - innervation | Rectum - physiology | Sympathetic Nervous System - physiology | Mitochondrial Proteins - metabolism | Fish Oils - administration & dosage | Energy Metabolism - physiology | Mice, Inbred C57BL | Receptors, Adrenergic, beta-3 - metabolism | Fish Oils - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Adipose Tissue, White - innervation | Blotting, Western | TRPV Cation Channels - genetics | Mice, Knockout | Up-Regulation - drug effects | Animals | Ion Channels - metabolism | Oxygen Consumption - drug effects | Triglycerides - blood | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Uncoupling Protein 1 | Blood Glucose - metabolism | Fish Oils - chemistry | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | Adipose tissue | Fish oils | Homeostasis | Energy expenditure | Nervous system | Capsaicin receptors | Oxygen consumption | Catecholamines | Adipocytes | Sympathetic nervous system | Energy balance | Transient receptor potential proteins | Mitochondria | Thermogenesis | Temperature effects | Uncoupling protein 1 | Rodents | Norepinephrine | Adrenergic receptors | Lipid metabolism | Adipose tissue (brown)
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 560, Issue 7716, pp. 102 - 106
Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease(1... 
ENERGY-EXPENDITURE | METABOLISM | BEIGE | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | LIVER | FAT | MICE | COLD | BROWN | CYCLE | Metabolomics | Reactive Oxygen Species - metabolism | Adipose Tissue, White - metabolism | Adipocytes - enzymology | Male | Adipocytes - drug effects | Thermogenesis - physiology | Adipose Tissue, White - cytology | Oxidation-Reduction - drug effects | Female | Uncoupling Protein 1 - metabolism | Adipose Tissue, Brown - enzymology | Obesity - metabolism | Adipose Tissue, Brown - cytology | Animals | Succinic Acid - pharmacology | Succinic Acid - metabolism | Adipocytes - metabolism | Obesity - prevention & control | Adipose Tissue, White - enzymology | Succinate Dehydrogenase - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Thermogenesis - drug effects | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Control | Thermogenesis | Succinates | Protein kinase A | Tricarboxylic acid cycle | Reactive oxygen species | Succinate dehydrogenase | Dehydrogenases | Adipose tissue | Body fat | Activation | Adipocytes | Kinases | Dehydrogenase | Accumulation | Proteins | Signal transduction | Energy | Metabolites | Rodents | Oxidation | Adipose tissue (brown) | Oxygen | Cyclic AMP | Pharmacology | Metabolism | Lipolysis | Glucose tolerance | Signaling | Hypotheses | External stimuli | Respiration
Journal Article