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PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 4, pp. e0191926 - e0191926
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with... 
UNTREATED MELANOMA | CYTOKINE RELEASE ASSAYS | LUNG-CANCER | IN-VITRO | MEDIATED CYTOTOXICITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | CTLA-4 | ANTITUMOR ACTIVITIES | NIVOLUMAB PLUS IPILIMUMAB | Antineoplastic Agents, Immunological - toxicity | Epitope Mapping | Adjuvants, Immunologic - pharmacology | Antineoplastic Agents, Immunological - pharmacokinetics | Cricetulus | Cancer Vaccines - pharmacology | Humans | Immunoglobulin G - toxicity | Macaca fascicularis | Antineoplastic Agents, Immunological - chemistry | T-Lymphocytes, Regulatory - immunology | Adjuvants, Immunologic - pharmacokinetics | Neoplasms - therapy | Immunity, Cellular - drug effects | Adjuvants, Immunologic - chemistry | Immunoglobulin G - pharmacology | CHO Cells | Amino Acid Sequence | Immunoglobulin G - chemistry | Cells, Cultured | Models, Molecular | Adjuvants, Immunologic - toxicity | CTLA-4 Antigen - immunology | Antineoplastic Agents, Immunological - pharmacology | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | Neoplasms - immunology | Antibody Formation - drug effects | CTLA-4 Antigen - antagonists & inhibitors | Toxicology | Pharmacology, Experimental | Research | Immunoglobulin G | Analysis | CD86 antigen | PD-1 protein | Lung cancer | Antibodies | Biochemistry | Lymphocytes T | CD28 antigen | Immunity | CTLA-4 protein | Lymphocytes | Immunotherapy | Combined vaccines | Primates | Repressing | Medical research | Immunoglobulins | Cytokines | Immunoregulation | Immunomodulation | Research & development--R&D | CD80 antigen | Pharmacology | T cell receptors | Chemical compounds | Signaling | Antigen-presenting cells | Biomarkers | Index Medicus | Research & development | R&D
Journal Article
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 1954 - 15
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 3, pp. 870 - 875
Journal Article
Carbohydrate polymers, ISSN 0144-8617, 01/2016, Volume 135, pp. 110 - 120
•The antioxidative and immunological activities of OPL were studied.•OPL possessed the better antioxidative and immunoregulatory activities... 
Immunoregulatory activity | Antioxidative activity | Ophiopogon polysaccharide liposome | MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide | Abbreviations OP ophiopogon polysaccharide | PBS phosphate buffered saline | VC vitamin | PHA phytohemagglutinin | DMSO dimethyl sulfoxide | OVA ovalbumin | OPL ophiopogon polysaccharide liposome | SOD superoxide dismutase | DPPH 2,2-diphenyl-1-picrylhydrazyl | XOD xanthine oxidase | LPS lipopolysaccharide | MDA malondialdehyde | BC blank control | GSH-Px glutathione peroxidase | MPO myeloperoxidase | IMMUNE-RESPONSE | CELLS | OXIDATIVE STRESS | POLYMER SCIENCE | REHMANNIA-GLUTINOSA POLYSACCHARIDE | ADJUVANT ACTIVITY | VACCINE | CHEMISTRY, ORGANIC | CHICKENS | EXTRACTION | ENHANCE | OPTIMIZATION | CHEMISTRY, APPLIED | Antioxidants - chemistry | Immunoglobulin G - blood | Ovalbumin - immunology | Oxidoreductases - blood | Ophiopogon | Plant Roots | Hydroxyl Radical - chemistry | Picrates - chemistry | Polysaccharides - chemistry | Polysaccharides - administration & dosage | Biphenyl Compounds - chemistry | Cytokines - blood | Immunologic Factors - chemistry | Immunologic Factors - administration & dosage | Spleen - cytology | Antioxidants - pharmacology | Mice, Inbred ICR | Polysaccharides - pharmacology | Animals | CD8-Positive T-Lymphocytes - drug effects | Antioxidants - administration & dosage | Antigens - immunology | Cell Proliferation - drug effects | Liposomes | CD4-Positive T-Lymphocytes - drug effects | Immunologic Factors - pharmacology | Polysaccharides | Oxidases | Superoxide | T cells | Functional foods | Mitogens
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2017, Volume 37, Issue 7, pp. 1772 - 1784
Triggering Receptor Expressed on Myeloid cells 2 (TREM2), which is expressed on myeloid cells including microglia in the CNS, has recently been identified as a... 
Akt/GSK3β signaling pathway | TREM2 | Cell survival | Alzheimer’s disease | Wnt/β-catenin signaling pathway | Microglia | NEURODEGENERATIVE DISEASE | NERVOUS-SYSTEM | CELLS | cell survival | ALZHEIMERS-DISEASE | AMYLOID PLAQUES | PROLIFERATION | BETA-CATENIN | NEUROSCIENCES | Wnt/beta-catenin signaling pathway | SIGNALING PATHWAY | PSEUDOMONAS-AERUGINOSA | Akt/GSK3 beta signaling pathway | IN-VIVO | Alzheimer's disease | microglia | Cell Cycle - genetics | Cyclin D1 - metabolism | Microglia - metabolism | Adjuvants, Immunologic - pharmacology | Membrane Glycoproteins - metabolism | Caspase 3 - metabolism | Cell Survival - genetics | Wnt Signaling Pathway - physiology | Male | Proteolysis - drug effects | Lithium Chloride - pharmacology | Thiadiazoles - pharmacology | Animals, Newborn | Cell Survival - drug effects | Brain - cytology | Microglia - drug effects | Gene Expression Regulation - genetics | Kainic Acid - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Agonists - pharmacology | beta Catenin - metabolism | Membrane Glycoproteins - genetics | Gene Expression Regulation - drug effects | Animals | Wnt Signaling Pathway - drug effects | Cyclin D1 - genetics | Mice | Cell Cycle - drug effects | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | β-catenin signaling pathway | GSK3β signaling pathway | s | Akt | Wnt
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 21, pp. 5917 - 5923
Journal Article
Expert Opinion on Biological Therapy, ISSN 1744-7682, 2005, Volume 4, Issue 7, pp. 1129 - 1138
Toll-like receptor (TLR) agonists are being developed for use as vaccine adjuvants and as stand-alone immunomodulators because of their ability to stimulate... 
vaccine | innate immunity | adjuvant | MPL | immunomodulators | AGP | lipid A mimetics | TLR4 | Toll-like receptor | Innate immunity | Adjuvant | Vaccine | Immunomodulators | Lipid A mimetics | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATITIS-B-VACCINE | HUMAN DENDRITIC CELLS | GLUCOSAMINIDE 4-PHOSPHATES AGPS | INNATE | CUTTING EDGE | MONOPHOSPHORYL-LIPID-A | IMMUNOTHERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMMUNE-RESPONSES | GENE-EXPRESSION | RECEPTORS | Adjuvants, Immunologic - administration & dosage | Toll-Like Receptor 4 | Humans | Lipid A - analogs & derivatives | Male | Protozoan Infections - drug therapy | Toll-Like Receptors | Membrane Glycoproteins - physiology | Lipid A - immunology | Virus Diseases - drug therapy | Antiviral Agents - chemistry | Respiratory Syncytial Virus Infections - drug therapy | Receptors, Cell Surface - physiology | Adjuvants, Immunologic - therapeutic use | Child | Virus Replication - drug effects | Antiviral Agents - pharmacology | Lipid A - administration & dosage | Virus Diseases - immunology | Antiviral Agents - therapeutic use | Bacterial Infections - drug therapy | Respiratory Syncytial Viruses - drug effects | Glycolipids - therapeutic use | Antiviral Agents - administration & dosage | Viral Vaccines - administration & dosage | Bacterial Infections - prevention & control | Glycolipids - immunology | Lipid A - pharmacology | Mice | Mice, Inbred BALB C | Immunologic Factors - pharmacology | Virus Diseases - prevention & control | Adjuvants, Immunologic - pharmacology | Respiratory Syncytial Viruses - physiology | Adjuvants, Immunologic - chemistry | Bacterial Infections - immunology | Drug Design | Female | Glycolipids - chemistry | Molecular Structure | Drug Evaluation, Preclinical | Lipid A - chemistry | Immunologic Factors - chemistry | Immunologic Factors - administration & dosage | Membrane Glycoproteins - agonists | Receptors, Cell Surface - agonists | Clinical Trials as Topic | Protozoan Infections - prevention & control | Lipid A - therapeutic use | Animals | Bacterial Vaccines - administration & dosage | Lymphocyte Activation - drug effects | Aged | Immunologic Factors - therapeutic use
Journal Article
Carbohydrate polymers, ISSN 0144-8617, 11/2016, Volume 153, pp. 663 - 678
•This review presented naturally occurring polysaccharides from tea materials (TPS).•Main methods for extraction and purification were... 
Extraction | Bioactivity | Future perspectives | Purification | Structure | Tea polysaccharide | PU-ERH TEA | DIABETIC MICE | POLYMER SCIENCE | CHEMICAL-CHARACTERIZATION | CHEMISTRY, ORGANIC | OOLONG TEA | VITRO ANTIOXIDANT ACTIVITY | ACIDIC POLYSACCHARIDE | CAMELLIA-SINENSIS FLOWER | ZIYANG GREEN TEA | ACTIVITY IN-VITRO | CHEMISTRY, APPLIED | WATER-SOLUBLE POLYSACCHARIDE | Camellia sinensis - chemistry | Plant Extracts - chemistry | Anti-Infective Agents - isolation & purification | Adjuvants, Immunologic - pharmacology | Antioxidants - chemistry | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Humans | Adjuvants, Immunologic - chemistry | Polysaccharides - isolation & purification | Anti-Infective Agents - chemistry | Polysaccharides - chemistry | Adjuvants, Immunologic - isolation & purification | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Anti-Obesity Agents - isolation & purification | Polysaccharides - pharmacology | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Anti-Obesity Agents - chemistry | Animals | Antioxidants - isolation & purification | Chemical Fractionation | Antineoplastic Agents, Phytogenic - pharmacology | Anti-Obesity Agents - pharmacology | Tea - chemistry | Antineoplastic Agents, Phytogenic - isolation & purification | Polysaccharides | Polyphenols | Yuan (China) | Functional foods
Journal Article