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1. Full Text Absence of Effect of Intravaginal Miconazole, Clindamycin, Nonoxynol‐9, and Tampons on the Pharmacokinetics of an Anastrozole/Levonorgestrel Intravaginal Ring
by Nave, Rüdiger and Klein, Stefan and Müller, André and Chang, Xinying and Höchel, Joachim
The Journal of Clinical Pharmacology, ISSN 0091-2700, 01/2018, Volume 58, Issue 1, pp. 97 - 106
A study was performed to investigate the effect of an intravaginally administered antimycotic, an antibiotic, and a spermicide plus the co‐usage of tampons on... 
gynecology | clinical pharmacology | pharmacokinetics and drug metabolism | drug delivery | drug‐drug interaction | women's health | drug-drug interaction | LEVONORGESTREL | CHRONIC PELVIC PAIN | CONTRACEPTIVE VAGINAL RING | NUVARING(R) | HORMONE-BINDING GLOBULIN | ENDOMETRIOSIS | CO-MEDICATION | ANASTROZOLE | WOMEN | PHARMACOLOGY & PHARMACY | AROMATASE EXPRESSION | Care and treatment | Clindamycin | Analysis | Endometriosis | Dosage and administration | Miconazole | Pharmacokinetics | Confidence intervals | Tampons | Antibiotics | Anastrozole | Plasma levels | Pharmacology | Nonoxynol | Women's Health
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2. Full Text Induction of labor in prolonged pregnancy with unfavorable cervix: comparison of sequential intracervical Foley catheter–intravaginal misoprostol and intravaginal misoprostol alone
by Ande, A Babatunde and Ezeanochie, C Michael and Olagbuji, N Biodun
Archives of Gynecology and Obstetrics, ISSN 0932-0067, 4/2012, Volume 285, Issue 4, pp. 967 - 971
To compare the outcome of induced labor at term using sequential intracervical Foley catheter with intravaginal misoprostol versus intravaginal misoprostol... 
Human Genetics | Medicine & Public Health | Gynecology | Foley catheter | Obstetrics/Perinatology | Prolonged pregnancy | Misoprostol | Endocrinology | Induction of labor | RANDOMIZED-CONTROLLED-TRIAL | WOMEN | TERM | PROSTAGLANDIN E-2 | ORAL MISOPROSTOL | OBSTETRICS & GYNECOLOGY | Cervical Ripening - drug effects | Prospective Studies | Catheterization | Humans | Misoprostol - administration & dosage | Administration, Intravaginal | Cervix Uteri | Pregnancy, Prolonged - drug therapy | Case-Control Studies | Pregnancy | Labor, Induced - methods | Oxytocics - administration & dosage | Pregnancy, Prolonged - therapy | Adult | Female | Term Birth | Pituitary hormones | Pregnant women | Analysis | Comparative analysis | Childbirth | Catheters | Induced labor
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3. Full Text Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses
by Çuburu, Nicolas and Graham, Barney S and Buck, Christopher B and Kines, Rhonda C and Pang, Yuk-Ying S and Day, Patricia M and Lowy, Douglas R and Schiller, John T
Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4606 - 4620
The induction of persistent intraepithelial CD8(+) T cell responses may be key to the development of Vaccines against mucosally transmitted pathogens,... 
VAGINAL MUCOSA | MEDICINE, RESEARCH & EXPERIMENTAL | HERPES-SIMPLEX-VIRUS | NONLYMPHOID TISSUE | MEDIATED-IMMUNITY | DENDRITIC CELLS | HUMAN-PAPILLOMAVIRUS | VACCINIA VIRUS | MEMORY CELLS | CERVICAL INTRAEPITHELIAL NEOPLASIA | VIRAL-INFECTION | Tumor Necrosis Factor-alpha - metabolism | Cell Proliferation | Spleen - immunology | Papillomavirus Vaccines - genetics | Humans | Respiratory Syncytial Viruses - immunology | Vaccination | Vagina - immunology | Administration, Intravaginal | Human papillomavirus 16 - immunology | Interferon-gamma - metabolism | Vaccinia virus - genetics | Vaccinia virus - immunology | Immunization, Secondary | HEK293 Cells | Respiratory Syncytial Virus Infections - prevention & control | Statistics, Nonparametric | CD8-Positive T-Lymphocytes - metabolism | Female | Antigens, Viral - biosynthesis | Papillomavirus Vaccines - administration & dosage | Genes, Reporter | Mucous Membrane - virology | Vaccines, Synthetic - genetics | Lymph Nodes - immunology | CD8-Positive T-Lymphocytes - physiology | Luciferases, Firefly - biosynthesis | Animals | Mucous Membrane - immunology | Vagina - virology | Immunologic Memory | Luciferases, Firefly - genetics | Mice | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Genetic Vectors | Human papillomavirus 16 - genetics | Cytotoxicity, Immunologic
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4. Full Text Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges
by James M. Smith and Rachna Rastogi and Ryan S. Teller and Priya Srinivasan and Pedro M. M. Mesquita and Umadevi Nagaraja and Janet M. McNicholl and R. Michael Hendry and Chuong T. Dinh and Amy Martina and Betsy C. Herold and Patrick F. Kiser
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 40, pp. 16145 - 16150
Topical preexposure prophylaxis interrupts HIV transmission at the site of mucosal exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse... 
Antiretrovirals | Shivs | Gels | HIV | Lymphocytes | Antivirals | Viruses | Sexual transmission | Infections | Drug design | Controlled drug delivery | PrEP | Pharmacokinetics | Nonhuman primate | controlled drug delivery | NONHUMAN-PRIMATES | DAPIVIRINE | MULTIDISCIPLINARY SCIENCES | PREVENTION | nonhuman primate | HUMAN-IMMUNODEFICIENCY-VIRUS | ADHERENCE | DELIVERY | GEL | PROPHYLAXIS | pharmacokinetics | INFECTION | Lentivirus Infections - prevention & control | Adenine - analogs & derivatives | Administration, Intravaginal | Adenine - pharmacology | Macaca mulatta | HIV - drug effects | Adenine - administration & dosage | Tenofovir | Organophosphonates - administration & dosage | Organophosphonates - pharmacology | Animals | Female | Delayed-Action Preparations | Drug Delivery Systems - methods | Simian Immunodeficiency Virus - drug effects | Macaques | Physiological aspects | Host-parasite relationships | Research | Simian immunodeficiency virus | Health aspects | HIV infection | Biological Sciences
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5. Full Text Tenofovir Disoproxil Fumarate Intravaginal Ring Protects High-Dose Depot Medroxyprogesterone Acetate–Treated Macaques From Multiple SHIV Exposures
by Smith, James M and Srinivasan, Priya and Teller, Ryan S and Lo, Yungtai and Dinh, Chuong T and Kiser, Patrick F and Herold, Betsy C
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 01/2015, Volume 68, Issue 1, pp. 1 - 5
Preclinical HIV prevention models use either a single high-dose viral challenge in depot medroxyprogesterone acetate–treated macaques or repeated viral... 
macaque | PrEP | Depo-Provera | Intravaginal ring | TDF | HIV PREVENTION | INFECTIOUS DISEASES | EFFICACY | SAFETY | IMMUNOLOGY | CHALLENGES | ANIMAL-MODELS | intravaginal ring | INFECTION | PREEXPOSURE PROPHYLAXIS | TECHNOLOGY | HIV Infections - prevention & control | Macaca nemestrina | Adenine - analogs & derivatives | Vagina | Phosphorous Acids - administration & dosage | Adenine - administration & dosage | Anti-HIV Agents - administration & dosage | Simian Acquired Immunodeficiency Syndrome - prevention & control | Animals | Adenine - therapeutic use | Phosphorous Acids - therapeutic use | Placebos | Anti-HIV Agents - therapeutic use | Female | HIV Infections - transmission | Simian Acquired Immunodeficiency Syndrome - transmission | Medroxyprogesterone Acetate - administration & dosage | Delayed-Action Preparations | Macaque
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6. Full Text Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy
by Labrie, Fernand and Archer, David and Bouchard, Céline and Fortier, Michel and Cusan, Leonello and Gomez, José-Luis and Girard, Ginette and Baron, Mira and Ayotte, Normand and Moreau, Michèle and Dubé, Robert and Côté, Isabelle and Labrie, Claude and Lavoie, Lyne and Berger, Louise and Gilbert, Lucy and Martel, Céline and Balser, John
Menopause, ISSN 1072-3714, 09/2009, Volume 16, Issue 5, pp. 907 - 922
OBJECTIVE:Because the secretion of dehydroepiandrosterone (DHEA), the exclusive source of sex steroids in postmenopausal women, is already decreased by 60% and... 
Androgens | Dehydroepiandrosterone | Tissuespecific prohormone replacement therapy | Prasterone | Vaginal atrophy | Intracrinology | UROGENITAL SYMPTOMS | ESTROGEN THERAPY | LOCAL ESTROGEN | RANDOMIZED CONTROLLED-TRIAL | OVARIAN-CANCER | ENDOMETRIAL CANCER | OBSTETRICS & GYNECOLOGY | BREAST-CANCER RISK | HORMONE-REPLACEMENT THERAPY | HEALTHY POSTMENOPAUSAL WOMEN | Tissue-specific prehormone replacement therapy | ANDROGENIC ACTIVITY | Severity of Illness Index | Postmenopause - drug effects | Prospective Studies | Double-Blind Method | Vagina - drug effects | Humans | Middle Aged | Dehydroepiandrosterone - administration & dosage | Administration, Intravaginal | Treatment Outcome | Vaginal Smears | Atrophy | Dose-Response Relationship, Drug | Analysis of Variance | Dehydroepiandrosterone - deficiency | Adult | Female | Hormone Replacement Therapy - methods | Dehydroepiandrosterone - metabolism | Postmenopause - physiology | Vagina - pathology | Hydrogen-Ion Concentration
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7. Full Text A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis
by Todd J. Johnson and Meredith R. Clark and Theodore H. Albright and Joel S. Nebeker and Anthony L. Tuitupou and Justin T. Clark and Judit Fabian and R. Tyler McCabe and Neelima Chandra and Gustavo F. Doncel and David R. Friend and Patrick F. Kiser
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2012, Volume 56, Issue 12, pp. 6272 - 6283
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
TRANSMISSION | DRUG-DELIVERY | SAFETY | PREVENTION | SYSTEMS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | SUSTAINED DELIVERY | RELEASE | PREEXPOSURE PROPHYLAXIS | VAGINAL RING | GEL | HIV Infections - prevention & control | Adenine - analogs & derivatives | Organophosphonates - therapeutic use | Administration, Intravaginal | Chromatography, High Pressure Liquid | Adenine - pharmacokinetics | Equipment Design | Irritants | Polyurethanes | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Anti-HIV Agents - administration & dosage | Tenofovir | Organophosphonates - administration & dosage | Animals | Delayed-Action Preparations - adverse effects | Adenine - therapeutic use | Anti-HIV Agents - pharmacokinetics | Anti-HIV Agents - therapeutic use | Female | Sheep | Vagina - metabolism | Vaginal Creams, Foams, and Jellies | Vagina - pathology | Index Medicus | Antiviral Agents
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8. Full Text Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis
by Verstraete, G and Vandenbussche, L and Kasmi, S and Nuhn, L and Brouckaert, D and Van Renterghem, J and Grymonpré, W and Vanhoorne, V and Coenye, T and De Geest, B.G and De Beer, T and Remon, J.P and Vervaet, C
International Journal of Pharmaceutics, ISSN 0378-5173, 08/2017, Volume 529, Issue 1-2, pp. 218 - 226
The aim of the present study was to develop thermoplastic polyurethane (TPU)-based intravaginal rings (IVRs) for prophylaxis and treatment of bacterial... 
Hot melt extrusion | Bacterial vaginosis | Intravaginal rings | Lactic acid | Metronidazole | Thermoplastic polyurethanes | DRUG | LOCAL TOLERANCE | CONTRACEPTIVE VAGINAL RING | DAPIVIRINE | RELEASE | ADHERENCE | DELIVERY | FORMULATIONS | MATRICES | PHARMACOLOGY & PHARMACY | Lactic Acid - chemistry | Polyurethanes - chemistry | Humans | Drug Liberation | Administration, Intravaginal | Female | Vaginosis, Bacterial - drug therapy | Drug Delivery Systems | Metronidazole - pharmacology | Drug therapy | Polyurethanes | Vaginosis
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9. Full Text Simultaneous Delivery of Tenofovir and Acyclovir via an Intravaginal Ring
by John A. Moss and Amanda M. Malone and Thomas J. Smith and Sean Kennedy and Etana Kopin and Cali Nguyen and Josh Gilman and Irina Butkyavichene and Kathleen L. Vincent and Massoud Motamedi and David R. Friend and Meredith R. Clark and Marc M. Baum
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2012, Volume 56, Issue 2, pp. 875 - 882
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
UNITED-STATES | HIV PREVENTION | VAGINAL RINGS | WOMEN | SIMPLEX-VIRUS TYPE-2 | MICROBICIDES | ACQUISITION | RISK | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | COHABITING COUPLES | HIV Infections - prevention & control | Herpes Genitalis - transmission | Antiviral Agents - pharmacokinetics | Humans | Acyclovir - adverse effects | Administration, Intravaginal | Equipment Design | Drug Delivery Systems | Anti-HIV Agents - administration & dosage | Tenofovir | Adenine - adverse effects | Herpes Genitalis - prevention & control | Female | HIV Infections - transmission | Herpesvirus 2, Human - drug effects | Disease Models, Animal | Rabbits | Adenine - analogs & derivatives | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | HIV Infections - virology | Organophosphonates - adverse effects | Treatment Outcome | Adenine - pharmacokinetics | Antiviral Agents - administration & dosage | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Acyclovir - pharmacokinetics | Organophosphonates - administration & dosage | Sexually Transmitted Diseases, Viral - transmission | Animals | Sexually Transmitted Diseases, Viral - virology | Anti-HIV Agents - pharmacokinetics | Antiviral Agents - adverse effects | Herpes Genitalis - virology | Sexually Transmitted Diseases, Viral - prevention & control | Delayed-Action Preparations | Drug Combinations | Acyclovir - administration & dosage | Pharmacology
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10. Full Text An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission
by Ugaonkar, Shweta R and Clark, Justin T and English, Lexie B and Johnson, Todd J and Buckheit, Robert W and Buckheit, Karen W and Bahde, Robert J and Appella, Daniel H and Kiser, Patrick F
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2015, Volume 104, Issue 10, pp. 3426 - 3439
Nucleocapsid 7 (NCp7) inhibitors have been investigated extensively for their role in impeding the function of HIV-1 replication machinery and their ability to... 
epithelial delivery/permeability | HIV/AIDS | controlled release | physicochemical properties | polymeric drug delivery system | biocompatibility | mucosal drug delivery | extrusion | stability | preformulation | permeability | MICROBICIDES | IN-VITRO | PHARMACOLOGY & PHARMACY | TENOFOVIR GEL | INFECTION | ZINC-FINGER INHIBITORS | CHEMISTRY, MEDICINAL | CONTRACEPTIVE VAGINAL RING | epithelial delivery | PREVENTION | AIDS | CHEMISTRY, MULTIDISCIPLINARY | HIV | IMMUNODEFICIENCY-VIRUS TYPE-1 | NUCLEOCAPSID PROTEIN | PREEXPOSURE PROPHYLAXIS | HIV Infections - prevention & control | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | Humans | Solubility | Administration, Intravaginal | HIV-1 - genetics | Reverse Transcriptase Inhibitors - administration & dosage | Chemistry, Pharmaceutical | Drug Delivery Systems | Anti-HIV Agents - administration & dosage | Benzamides - administration & dosage | Benzamides - therapeutic use | Differential Thermal Analysis | Anti-HIV Agents - therapeutic use | Female | HIV Infections - transmission | Pyrimidinones - pharmacology | Pyrimidinones - administration & dosage | Reverse Transcriptase Inhibitors - therapeutic use | Benzamides - adverse effects | Delayed-Action Preparations | Organ Culture Techniques | Drugs | Antiviral agents | Drug delivery systems | Analysis | Pharmacists | HIV (Viruses) | Drug therapy | Health aspects | Vehicles | Index Medicus
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11. Full Text An Intravaginal Ring for the Simultaneous Delivery of Multiple Drugs
by Baum, Marc M and Butkyavichene, Irina and Gilman, Joshua and Kennedy, Sean and Kopin, Etana and Malone, Amanda M and Nguyen, Cali and Smith, Thomas J and Friend, David R and Clark, Meredith R and Moss, John A
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 08/2012, Volume 101, Issue 8, pp. 2833 - 2843
Intravaginal delivery of microbicide combinations is a promising approach for the prevention of sexually transmitted infections, but requires a method of... 
HIV/AIDS | drug delivery systems | silicone | sustained release | in vitro models | formulation | microbicide delivery | intravaginal ring | combination delivery device | mechanical properties | Drug delivery systems | In vitro models | Formulation | Silicone | Mechanical properties | Combination delivery device | Sustained release | Microbicide delivery | Intravaginal ring | UNITED-STATES | CHEMISTRY, MEDICINAL | SIMPLEX-VIRUS TYPE-2 | SUSTAINED-RELEASE GANCICLOVIR | HERPES | CYTOMEGALOVIRUS RETINITIS | AIDS | CHEMISTRY, MULTIDISCIPLINARY | REVERSE-TRANSCRIPTASE INHIBITOR | VAGINAL RINGS | IN-VITRO | HIV | HIV-NEGATIVE WOMEN | PHARMACOLOGY & PHARMACY | INFECTION | Tensile Strength | HIV Infections - prevention & control | Adenine - analogs & derivatives | Drug Delivery Systems - instrumentation | Humans | Administration, Intravaginal | Delayed-Action Preparations - chemistry | Reverse Transcriptase Inhibitors - administration & dosage | Antiviral Agents - administration & dosage | Equipment Design | HIV - drug effects | Adenine - administration & dosage | Tenofovir | Organophosphonates - administration & dosage | Animals | Female | Silicon - chemistry | Acyclovir - administration & dosage
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