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Lancet neurology, ISSN 1474-4422, 2009, Volume 8, Issue 9, pp. 802 - 809
Summary Background The efficacy of intravenous (IV) alteplase is restricted by the speed of recanalisation and the site of the occlusion... 
Neurology | CONTROLLED-TRIAL | INTRAARTERIAL | INTERVENTIONAL MANAGEMENT | THERAPY | TISSUE-PLASMINOGEN-ACTIVATOR | CLINICAL RECOVERY | PREDICTORS | ACUTE ISCHEMIC-STROKE | THROMBOLYSIS | INFUSION | CLINICAL NEUROLOGY | Intracranial Thrombosis - complications | Postoperative Complications - etiology | Prospective Studies | Injections, Intra-Arterial - statistics & numerical data | Recovery of Function - drug effects | Humans | Middle Aged | Clinical Protocols | Male | Stroke - physiopathology | Tissue Plasminogen Activator - adverse effects | Cerebral Arteries - drug effects | Fibrinolytic Agents - adverse effects | Thrombolytic Therapy - methods | Aged, 80 and over | Recovery of Function - physiology | Female | Intracranial Thrombosis - drug therapy | Drug Administration Routes | Intracranial Thrombosis - physiopathology | Cerebral Arteries - diagnostic imaging | Injections, Intra-Arterial - adverse effects | Thrombolytic Therapy - statistics & numerical data | Tissue Plasminogen Activator - administration & dosage | Treatment Outcome | Stroke - drug therapy | Radiography | Stroke - etiology | Cerebral Arteries - pathology | Aged | Fibrinolytic Agents - administration & dosage | Injections, Intravenous - statistics & numerical data | Thrombolytic Therapy - adverse effects | Cohort Studies | Stroke (Disease) | Medicine, Experimental | Medical research | Care and treatment | Comparative analysis | Tissue plasminogen activator | Index Medicus
Journal Article
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 05/2011, Volume 305, Issue 18, pp. 1863 - 1872
Journal Article
Stroke (1970), ISSN 1524-4628, 2016, Volume 47, Issue 9, pp. 2331 - 2338
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 10/2010, Volume 107, Issue 42, pp. 18143 - 18148
Effective treatment of brain neurological disorders such as Alzheimer’s disease, multiple sclerosis, or tumors should be possible with drug delivery through... 
Glioma | Antineoplastics | Brain neoplasms | Cell membranes | Drug design | Liposomes | Polymers | Blood brain barrier | Tumors | Endosomes | Glioma treatment | Blood-brain barrier | Laminin-411 | Endosomal escape | Polymalic acid | blood-brain barrier | laminin-411 | GENE DELIVERY | ANGIOGENESIS | PERMEABILITY | MULTIDISCIPLINARY SCIENCES | BARRIER | endosomal escape | glioma treatment | PEPTIDE | CHEMOTHERAPY | LAMININ-8 | polymalic acid | IN-VIVO | MALIGNANT GLIOMAS | HPMA COPOLYMER | Polymers - administration & dosage | Brain Neoplasms - pathology | Brain Neoplasms - drug therapy | Endosomes - metabolism | Nanoparticles | Polymers - therapeutic use | Animals | Mice, Nude | Malates - pharmacokinetics | Polymers - pharmacokinetics | Mice | Infusions, Intravenous | Malates - administration & dosage | Malates - therapeutic use | Blood-Brain Barrier | Hydrogen-Ion Concentration | Drugs | Care and treatment | Drug delivery systems | Brain tumors | Malic acid | Dosage and administration | Research | Vehicles | Multiple sclerosis | Intravenous administration | Neurodegenerative diseases | Biodegradability | Tumor cells | Antisense oligonucleotides | Esters | endosomes | Drug delivery | Leucine | Drug development | pH effects | Neurological diseases | Angiogenesis | Glioma cells | Monoclonal antibodies | nanotechnology | Alzheimer's disease | Cytoplasm | Biological Sciences | Physical Sciences | blood–brain barrier
Journal Article