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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 04/2012, Volume 97, Issue 4, pp. 1311 - 1319
Context: Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA). Objective: Our objective was to... 
DIAGNOSIS | PLASMA | HYPERALDOSTERONISM | ENDOCRINOLOGY & METABOLISM | METANEPHRINES | PREVALENCE | HYPERTENSIVE PATIENTS | CORTISOL | Humans | Middle Aged | Molecular Sequence Data | Male | Adrenal Cortex Neoplasms - physiopathology | Cushing Syndrome - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Hyperaldosteronism - etiology | Base Sequence | Adrenocortical Adenoma - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Adult | Female | Retrospective Studies | Neoplasm Proteins - genetics | Adrenal Cortex Neoplasms - metabolism | Pheochromocytoma - metabolism | Cross-Sectional Studies | Genetic Association Studies | Cushing Syndrome - genetics | Japan | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Neoplasm Proteins - chemistry | Adrenal Cortex Neoplasms - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Adrenal Gland Neoplasms - metabolism | Pheochromocytoma - genetics | Aged | Adrenocortical Adenoma - physiopathology | Mutation | Adrenal Gland Neoplasms - genetics | Immunohistochemistry | Hospitals | Pheochromocytoma | Cell membranes | Cushing's syndrome | mRNA | Adenoma | Gene expression | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2011, Volume 331, Issue 6018, pp. 768 - 772
Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and... 
Depolarization | Hypertension | Somatic mutation | Cell growth | Hyperaldosteronism | REPORTS | Loss of heterozygosity | Adenoma | Genetic mutation | Sequencing | Tumors | REMEDIABLE ALDOSTERONISM | HUMAN BREAST | COLORECTAL CANCERS | ADRENOCORTICAL-CELLS | MULTIDISCIPLINARY SCIENCES | CONDUCTION | GLOMERULOSA CELLS | IDENTIFICATION | MOLECULAR-BASIS | SELECTIVITY | POTASSIUM CHANNEL | Adrenal Glands - pathology | Potassium - metabolism | Cell Proliferation | Humans | Hyperaldosteronism - pathology | Hyperplasia | Protein Multimerization | Zona Glomerulosa - pathology | Male | Hyperaldosteronism - metabolism | Sodium - metabolism | Aldosterone - metabolism | Adrenocortical Adenoma - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Female | Hypertension - genetics | Adrenal Cortex Neoplasms - metabolism | Cell Line | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Hyperaldosteronism - genetics | Mutant Proteins - genetics | Mutant Proteins - metabolism | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Hypertension - metabolism | Adrenal Cortex Neoplasms - genetics | Mutant Proteins - chemistry | Mutation | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Hypertension, ISSN 0194-911X, 08/2014, Volume 64, Issue 2, pp. 354 - 361
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2013, Volume 45, Issue 9, pp. 1050 - 1054
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 12/2015, Volume 22, Issue S3, pp. 714 - 720
Adrenocortical carcinoma (ACC) is a rare but lethal malignancy with few reliable prognostic markers. FDG-PET metabolic parameters have been shown to predict... 
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | Bone Neoplasms - mortality | Fluorodeoxyglucose F18 - pharmacokinetics | Prognosis | Prospective Studies | Bone Neoplasms - therapy | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Middle Aged | Adrenocortical Carcinoma - diagnosis | Bone Neoplasms - secondary | Tomography, X-Ray Computed - methods | Male | Liver Neoplasms - therapy | Liver Neoplasms - mortality | Neoplasm Recurrence, Local - mortality | Bone Neoplasms - metabolism | Tissue Distribution | Young Adult | Adrenal Cortex Neoplasms - diagnosis | Lung Neoplasms - secondary | Adrenocortical Carcinoma - metabolism | Multimodal Imaging - methods | Adult | Female | Adrenocortical Carcinoma - mortality | Retrospective Studies | Liver Neoplasms - secondary | Whole Body Imaging - methods | Adrenal Cortex Neoplasms - metabolism | Adrenal Cortex Neoplasms - mortality | Radiopharmaceuticals - pharmacokinetics | Neoplasm Recurrence, Local - metabolism | Neoplasm Recurrence, Local - therapy | Survival Rate | Combined Modality Therapy | Lung Neoplasms - therapy | Neoplasm Recurrence, Local - diagnosis | Positron-Emission Tomography - methods | Tumor Burden | Adrenocortical Carcinoma - therapy | Adrenal Cortex Neoplasms - therapy | Adolescent | Liver Neoplasms - metabolism | Glycolysis | Aged | Neoplasm Staging | Glucose metabolism | Medical colleges | Medical research | Carcinoma | PET imaging | Patient outcomes | Medicine, Experimental | Sport-utility vehicles | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 06/2010, Volume 70, Issue 11, pp. 4666 - 4675
MicroRNAs (miRNAs) act at the posttranscriptional level to control gene expression in virtually every biological process, including oncogenesis. Here, we... 
OVEREXPRESSION | FACTOR-II | ONCOLOGY | UPSTREAM | RECEPTOR | CELL-PROLIFERATION | EXPRESSION PROFILES | CARCINOMA | CONTRIBUTES | HUMAN OVARIAN-CANCER | MTOR | Humans | Cell Growth Processes - physiology | MicroRNAs - metabolism | Transplantation, Heterologous | Intracellular Signaling Peptides and Proteins - metabolism | Adrenocortical Carcinoma - pathology | Adrenocortical Carcinoma - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adrenocortical Adenoma - genetics | Female | Everolimus | Adrenal Cortex Neoplasms - metabolism | Protein-Serine-Threonine Kinases - metabolism | Somatomedins - metabolism | Sirolimus - analogs & derivatives | Adrenocortical Carcinoma - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Adrenal Cortex Neoplasms - pathology | Mice, SCID | Adrenocortical Adenoma - pathology | Sirolimus - pharmacology | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Animals | Mice, Inbred NOD | Mice | MicroRNAs - genetics | TOR Serine-Threonine Kinases | Index Medicus | Somatomedins | Sirolimus | Protein-Serine-Threonine Kinases | Biochemistry, Molecular Biology | Adrenocortical Adenoma | Adrenocortical Carcinoma | Intracellular Signaling Peptides and Proteins | Cell Growth Processes | Life Sciences | Adrenal Cortex Neoplasms | MicroRNAs
Journal Article
Hypertension, ISSN 0194-911X, 11/2010, Volume 56, Issue 5, pp. 885 - 892
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2017, Volume 102, Issue 6, pp. 1792 - 1796
Context: Whether primary aldosteronism (PA) is the consequence of a monoclonal or multiclonal process is unclear. Case Description: A 48-year-old man with... 
ADENOMA | COMMON | SOMATIC MUTATIONS | ENDOCRINOLOGY & METABOLISM | Immunohistochemistry | Neoplasms, Multiple Primary - surgery | Neoplasms, Multiple Primary - metabolism | Humans | Hyperaldosteronism - pathology | Middle Aged | Zona Glomerulosa - pathology | Male | Hyperaldosteronism - metabolism | Zona Reticularis - pathology | Adrenocortical Adenoma - genetics | Zona Fasciculata - pathology | Sulfotransferases - metabolism | Adrenal Cortex Neoplasms - metabolism | Cytochrome P-450 CYP11B2 - metabolism | Adrenocortical Adenoma - surgery | Neoplasms, Multiple Primary - genetics | Adrenal Cortex Neoplasms - surgery | Hyperaldosteronism - genetics | Adrenal Cortex Neoplasms - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Neoplasms, Multiple Primary - pathology | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Calcium Channels, L-Type - genetics | Hyperaldosteronism - surgery | Steroid 17-alpha-Hydroxylase - metabolism | Adrenal glands | Cortex | Aldosterone synthase | Histology | Adenoma | Hydrocortisone | Aldosterone | Pigmentation | Nodules | Adrenalectomy | Heterogeneity | Histopathology | Computed tomography | Genetic analysis | Genetics | Steroidogenesis | Mutation | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, pp. 19546 - 19546
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 3895 - 3908
Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of... 
ADJUVANT MITOTANE | ACTIVATION | UNFOLDED PROTEIN RESPONSE | CHOLESTERYL ESTER | METABOLISM | QUANTIFICATION | MITOCHONDRIA | ENDOCRINOLOGY & METABOLISM | ACAT | CANCER | EXPRESSION | Immunohistochemistry | Transcription Factor CHOP - genetics | Gas Chromatography-Mass Spectrometry | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Humans | Immunoblotting | Endoplasmic Reticulum Stress - genetics | Mitotane - pharmacology | Adrenocortical Carcinoma - drug therapy | Antineoplastic Agents, Hormonal - therapeutic use | Adrenocortical Carcinoma - metabolism | HEK293 Cells | Sterol O-Acyltransferase - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Adrenal Cortex Neoplasms - metabolism | Cell Survival - drug effects | Antineoplastic Agents, Hormonal - pharmacology | Endoplasmic Reticulum Stress - drug effects | Adrenocortical Carcinoma - genetics | Transcriptome - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Mitotane - therapeutic use | Hep G2 Cells | Adrenal Cortex Neoplasms - drug therapy | Adrenal Cortex Neoplasms - genetics | Disease-Free Survival | Cell Line, Tumor | Sterol O-Acyltransferase - genetics | HeLa Cells | Lipids - analysis | Transcription Factor CHOP - metabolism | Sterol O-Acyltransferase - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Hypertension, ISSN 0194-911X, 11/2015, Volume 66, Issue 5, pp. 1014 - 1022
Journal Article
Journal Article
Science, ISSN 0036-8075, 2014, Volume 344, Issue 6186, pp. 913 - 917
Journal Article