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Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 08/2017, Volume 56, Issue 8, pp. 893 - 913
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2014, Volume 370, Issue 16, pp. 1504 - 1513
Journal Article
Anesthesia & Analgesia, ISSN 0003-2999, 05/2016, Volume 122, Issue 5, pp. 1556 - 1566
BACKGROUND:Dexmedetomidine is a highly selective α2-agonist with hypnotic, analgesic, and anxiolytic properties. Despite off-label administration,... 
DRUG | ANESTHESIA | PHARMACOKINETICS | PEDIATRIC-PATIENTS | GLUCURONIDATION | CARDIAC-CATHETERIZATION | ANESTHESIOLOGY | EXPRESSION | INTENSIVE-CARE | DEVELOPMENTAL ASPECTS | CHILDREN | Age Factors | Analgesics, Non-Narcotic - pharmacokinetics | Hypnotics and Sedatives - adverse effects | Heart Defects, Congenital - surgery | Adrenergic alpha-2 Receptor Agonists - pharmacokinetics | Humans | Hypnotics and Sedatives - administration & dosage | Child, Preschool | Infant | Metabolic Clearance Rate | Chromatography, High Pressure Liquid | Drug Monitoring - methods | Tandem Mass Spectrometry | Adrenergic alpha-2 Receptor Agonists - administration & dosage | Cardiac Surgical Procedures | Drug Dosage Calculations | Adrenergic alpha-2 Receptor Agonists - adverse effects | Analgesics, Non-Narcotic - adverse effects | Computer Simulation | Infant, Newborn | Term Birth | Dexmedetomidine - administration & dosage | Analgesics, Non-Narcotic - blood | Drug Administration Schedule | Hypnotics and Sedatives - pharmacokinetics | Dexmedetomidine - pharmacokinetics | Treatment Outcome | Analgesics, Non-Narcotic - administration & dosage | Respiration, Artificial | Dexmedetomidine - adverse effects | Adrenergic alpha-2 Receptor Agonists - blood | Models, Biological | Dexmedetomidine - blood | Heart Defects, Congenital - diagnosis | Hypnotics and Sedatives - blood | Infusions, Intravenous | Nonlinear Dynamics | Monte Carlo Method | Index Medicus | Abridged Index Medicus
Journal Article
JAMA, ISSN 0098-7484, 12/2014, Volume 312, Issue 21, pp. 2254 - 2264
Journal Article
American Journal of Ophthalmology, ISSN 0002-9394, 2011, Volume 151, Issue 4, pp. 671 - 681
Purpose To compare the alpha2-adrenergic agonist brimonidine tartrate 0.2% to the beta-adrenergic antagonist timolol maleate 0.5% in preserving visual function... 
Ophthalmology | OPEN-ANGLE GLAUCOMA | OPTIC-NERVE | TARTRATE 0.2-PERCENT | RISK-FACTORS | GANGLION-CELLS | OCULAR HYPERTENSION | OPHTHALMOLOGY | FIELD PROGRESSION | INTRAOCULAR-PRESSURE | PERFUSION-PRESSURE | RAT MODEL | Quinoxalines - adverse effects | Visual Fields - physiology | Intraocular Pressure - drug effects | Follow-Up Studies | Humans | Middle Aged | Male | Vision Disorders - physiopathology | Adrenergic alpha-2 Receptor Agonists - therapeutic use | Adrenergic alpha-2 Receptor Agonists - adverse effects | Tonometry, Ocular | Adrenergic beta-Antagonists - adverse effects | Female | Timolol - therapeutic use | Visual Acuity - physiology | Adrenergic beta-Antagonists - therapeutic use | Quinoxalines - therapeutic use | Timolol - adverse effects | Double-Blind Method | Ophthalmic Solutions - therapeutic use | Treatment Outcome | Brimonidine Tartrate | Low Tension Glaucoma - drug therapy | Aged | Gonioscopy | Administration, Topical | Low Tension Glaucoma - physiopathology | Glaucoma | Care and treatment | Patient outcomes | Brimonidine | Dosage and administration | Timolol maleate | Research | Therapy | Diabetic retinopathy | Heart attacks | Optic nerve | Disease | Review boards | Colleges & universities | Clinical trials | Manuscripts | Confidence intervals | Health Insurance Portability & Accountability Act 1996-US | Neurodegeneration
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2018, Volume 13, Issue 11, p. e0207427
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2012, Volume 18, Issue 38, pp. 6257 - 6265
The alpha-2 agonist dexmedetomidine is being increasingly used for sedation and as an adjunctive agent during general and regional anesthesia. It is used in a... 
Anesthesia | Surgery | Dexmedetomidine | dexmedetomidine | ALPHA-AGONIST DEXMEDETOMIDINE | INTRAVENOUS REGIONAL ANESTHESIA | RANDOMIZED CONTROLLED-TRIAL | ALPHA-ADRENOCEPTOR AGONIST DEXMEDETOMIDINE | CARBON-DIOXIDE RESPONSE | CARDIAC-SURGERY | PHARMACOLOGY & PHARMACY | AWAKE FIBEROPTIC INTUBATION | LONG-TERM SEDATION | CEREBRAL-BLOOD-FLOW | CRITICALLY-ILL PATIENTS | surgery | Critical Care - methods | Neuroprotective Agents - therapeutic use | Anesthesia - methods | Hypnotics and Sedatives - adverse effects | Adrenergic alpha-2 Receptor Agonists - pharmacokinetics | Humans | Hypnotics and Sedatives - administration & dosage | Critical Illness | Hypnotics and Sedatives - therapeutic use | Adrenergic alpha-2 Receptor Agonists - administration & dosage | Adrenergic alpha-2 Receptor Agonists - therapeutic use | Drug Interactions | Hypotension - physiopathology | Neuroprotective Agents - pharmacokinetics | Adrenergic alpha-2 Receptor Agonists - adverse effects | Neuroprotective Agents - adverse effects | Neuroprotective Agents - administration & dosage | Dexmedetomidine - administration & dosage | Drug Administration Routes | Dexmedetomidine - therapeutic use | Hypnotics and Sedatives - pharmacokinetics | Cerebrovascular Circulation - drug effects | Dexmedetomidine - pharmacokinetics | Bradycardia - physiopathology | Endoscopy, Gastrointestinal | Anesthesia - adverse effects | Hypotension - chemically induced | Dexmedetomidine - adverse effects | Bradycardia - chemically induced | Animals
Journal Article
Journal Article