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1. Full Text Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization- activated cation current
by Brummett, Chad M and Hong, Elizabeth K and Janda, Allison M and Amodeo, Francesco S and Lydic, Ralph
Anesthesiology, ISSN 0003-3022, 2011, Volume 115, Issue 4, pp. 836 - 843
Background: The current study was designed to test the hypothesis that the increased duration of analgesia caused by adding dexmedetomidine to local anesthetic... 
PERIPHERAL-NERVE | CLONIDINE | FIBERS | INHIBITION | LIDOCAINE | BRACHIAL-PLEXUS BLOCK | BUPIVACAINE | MEPIVACAINE | ANESTHESIOLOGY | ANTINOCICEPTION | EPINEPHRINE | Nerve Block | Male | Adrenergic alpha-Antagonists - pharmacology | Anesthetics, Local - pharmacology | Dose-Response Relationship, Drug | Idazoxan - pharmacology | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Prazosin - pharmacology | Behavior, Animal - drug effects | Dexmedetomidine - pharmacology | Sciatic Nerve - drug effects | Potassium Channel Blockers | Amides - pharmacology | Colforsin - pharmacology | Cyclic Nucleotide-Gated Cation Channels - antagonists & inhibitors | Rats | Pain Measurement - drug effects | Pyrimidines - pharmacology | Adrenergic alpha-2 Receptor Antagonists - pharmacology | Rats, Sprague-Dawley | Potassium Channels | Analgesia | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels | Animals | Adrenergic alpha-Agonists - pharmacology | Hypnotics and Sedatives - pharmacology
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2. Full Text Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease
by Ahles, Andrea and Ahles, Andrea and Engelhardt, Stefan
Pharmacological reviews, ISSN 0031-6997, 07/2014, Volume 66, Issue 3, pp. 598 - 637
The human genome encodes nine different adrenoceptor genes. These are grouped into three families, namely, the α1-, α2-, and β-adrenoceptors, with three family... 
Genome-Wide Association Study | Receptors, Adrenergic - metabolism | Humans | Gene Expression Regulation | Adrenergic alpha-Antagonists - pharmacology | Polymorphism, Genetic | Genetic Variation | Animals | Norepinephrine - metabolism | Receptors, Adrenergic - drug effects | Receptors, Adrenergic - genetics | Adrenergic alpha-Agonists - pharmacology | Signal Transduction - physiology | Genome, Human | Epinephrine - metabolism
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3. Full Text Glucocorticoid Enhancement of Memory Requires Arousal-Induced Noradrenergic Activation in the Basolateral Amygdala
by Benno Roozendaal and Shoki Okuda and Eddy A. Van der Zee and James L. McGaugh
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2006, Volume 103, Issue 17, pp. 6741 - 6746
Considerable evidence indicates that glucocorticoid hormones enhance the consolidation of long-term memories for emotionally arousing experiences but not that... 
Glucocorticoids | Amygdala | Corticosterone | Memory | Norepinephrine | Object recognition | Behavioral neuroscience | Hippocampus | Habituation | Vehicles | Memory consolidation | Emotional arousal | norepinephrine | object recognition | EMOTIONAL MATERIAL | OBJECT RECOGNITION MEMORY | memory consolidation | TYROSINE-HYDROXYLASE | MULTIDISCIPLINARY SCIENCES | PERIRHINAL CORTEX | ELEMENT-BINDING PROTEIN | NOREPINEPHRINE RELEASE | INHIBITORY AVOIDANCE | DORSAL HIPPOCAMPUS | emotional arousal | RECEPTOR ACTIVATION | LONG-TERM POTENTIATION | corticosterone | Memory - drug effects | Amygdala - drug effects | Phosphorylation | Amygdala - anatomy & histology | Corticosterone - pharmacology | Cyclic AMP Response Element-Binding Protein - chemistry | Norepinephrine - physiology | Rats | Male | Adrenergic alpha-Antagonists - pharmacology | Rats, Sprague-Dawley | Arousal - drug effects | Yohimbine - pharmacology | Adrenergic beta-Antagonists - pharmacology | Arousal - physiology | Propranolol - pharmacology | Animals | Habituation, Psychophysiologic - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Amygdala - physiology | Memory - physiology | Biological Sciences
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4. Full Text Local anesthetics: review of pharmacological considerations
by Becker, Daniel E and Reed, Kenneth L
Anesthesia progress, ISSN 0003-3006, 2012, Volume 59, Issue 2, pp. 90 - 103
Local anesthetics have an impressive history of efficacy and safety in medical and dental practice. Their use is so routine, and adverse effects are so... 
Vasoconstrictor Agents - pharmacology | Lidocaine - pharmacology | Anesthetics, Local - chemistry | Humans | Carticaine - pharmacology | Drug Hypersensitivity | Adrenergic alpha-Antagonists - pharmacology | Phentolamine - pharmacology | Anesthetics, Local - toxicity | Anesthetics, Local - pharmacology | Maximum Tolerated Dose | Drug Interactions | Anesthesia, Local | Anesthesia Recovery Period | Anesthesia, Dental - methods | Continuing Education | Pharmacology | Dentistry | Drug toxicity | Local anesthetics
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5. Full Text Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats
by Richards, Jemma K and Simms, Jeffrey A and Steensland, Pia and Taha, Sharif A and Borgland, Stephanie L and Bonci, Antonello and Bartlett, Selena E
Psychopharmacology, ISSN 0033-3158, 7/2008, Volume 199, Issue 1, pp. 109 - 117
Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol... 
Neurosciences | Operant self administration | Biomedicine | Yohimbine | Ethanol | Reinstatement | Pharmacology/Toxicology | Psychiatry | Orexin | Hypocretin | Stress | SB334867 | operant self administration | stress | PSYCHIATRY | COCAINE-SEEKING | BEHAVIOR | STRESS-INDUCED RELAPSE | yohimbine | OREXIN NEURONS | MODEL | ethanol | NEUROSCIENCES | CORTICOTROPIN-RELEASING-FACTOR | ALCOHOL-SEEKING | reinstatement | DRUG-ADDICTION | hypocretin | NORADRENERGIC MECHANISMS | PHARMACOLOGY & PHARMACY | orexin | FOOD SEEKING | Sucrose - administration & dosage | Benzoxazoles - pharmacology | Rats, Long-Evans | Receptors, Neuropeptide - antagonists & inhibitors | Extinction, Psychological - drug effects | Motor Activity - drug effects | Rats | Male | Adrenergic alpha-Antagonists - pharmacology | Orexin Receptors | Taste - physiology | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Self Administration | Animals | Taste - drug effects | Conditioning, Operant - drug effects | Motivation | Urea - analogs & derivatives | Receptors, G-Protein-Coupled - antagonists & inhibitors | Alcoholism - physiopathology | Urea - pharmacology | Psychotropic drugs | Neurotransmitters | Animal behavior | Rodents | Psychopharmacology | Sugar | Food | Index Medicus | Original Investigation
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6. Full Text Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
by Minokoshi, Yasuhiko and Müller, Corinna and Kahn, Barbara B and Carling, David and Fryer, Lee G. D and Peroni, Odile D and Kim, Young-Bum
Nature, ISSN 0028-0836, 01/2002, Volume 415, Issue 6869, pp. 339 - 343
Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function. Leptin... 
SKELETAL-MUSCLE | MECHANISM | COA | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | STRESS | CELL | Catalytic Domain | Muscle, Skeletal - enzymology | Phosphorylation | Oxidation-Reduction | Signal Transduction | Adrenergic beta-Agonists - pharmacology | Multienzyme Complexes - metabolism | Lipid Metabolism | Male | Muscle, Skeletal - metabolism | Adrenergic alpha-Antagonists - pharmacology | Phentolamine - pharmacology | AMP-Activated Protein Kinases | Leptin - physiology | Animals | Sympathetic Nervous System - physiology | Isoproterenol - pharmacology | Leptin - administration & dosage | Mice | Enzyme Activation | Fatty Acids - metabolism | Acetyl-CoA Carboxylase - antagonists & inhibitors | Acetyl-CoA Carboxylase - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proteins | Obesity | Enzymes | Hormones | Diabetes | Metabolism | Fatty acids
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7. Full Text Concurrent glucocorticoid and noradrenergic activity shifts instrumental behavior from goal-directed to habitual control
by Schwabe, Lars and Tegenthoff, Martin and Höffken, Oliver and Wolf, Oliver T
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 24, pp. 8190 - 8196
Stress modulates instrumental action in favor of habitual stimulus-response processes that are insensitive to changes in outcome value and at the expense of... 
REINFORCER DEVALUATION | ACTIVATION | MEMORY CONSOLIDATION | BASOLATERAL AMYGDALA | MEDIAL PREFRONTAL CORTEX | HUMANS | STRESS | NEUROSCIENCES | STRIATUM | LESIONS | BRAIN | Memory - drug effects | Humans | Conditioning, Operant - physiology | Hydrocortisone - metabolism | Male | Adrenergic alpha-Antagonists - pharmacology | Yohimbine - pharmacology | Motivation - drug effects | Young Adult | Drug Interactions | Motivation - physiology | Norepinephrine - metabolism | Analysis of Variance | Conditioning, Operant - drug effects | Glucocorticoids - metabolism | Saliva - metabolism | Reaction Time - drug effects | Adult | Female | Blood Pressure - drug effects | Hydrocortisone - pharmacology | Norepinephrine - analogs & derivatives | Goals
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8. Full Text 6-Methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 Discovery of a potent and selective α1D-adrenoceptor antagonist
by Fumagalli, Laura and Pallavicini, Marco and Budriesi, Roberta and Bolchi, Cristiano and Canovi, Mara and Chiarini, Alberto and Chiodini, Giuseppe and Gobbi, Marco and Laurino, Paola and Micucci, Matteo and Straniero, Valentina and Valoti, Ermanno
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2013, Volume 56, Issue 16, pp. 6402 - 6412
Previous results have shown that replacement of one of the two o-methoxy groups at the phenoxy residue of the potent, but not subtype-selective, α1-AR... 
Cricetinae | Animals | Cricetulus | Magnetic Resonance Spectroscopy | Receptors, Adrenergic, alpha-1 - drug effects | Adrenergic alpha-Antagonists - pharmacology | Dioxanes - pharmacology | Adrenergic alpha-Antagonists - chemistry | CHO Cells
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9. Full Text The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats
by Marinelli, Peter W and Funk, Douglas and Juzytsch, Walter and Harding, Stephen and Rice, Kenner C and Shaham, Yavin and Lê, A D
Psychopharmacology, ISSN 0033-3158, 12/2007, Volume 195, Issue 3, pp. 345 - 355
Yohimbine is an alpha-2 adrenoreceptor antagonist that provokes stress- and anxiety-like responses in both humans and laboratory animals. In rats, yohimbine... 
Alcohol self-administration | Relapse | Biomedicine | Corticosterone | CRF | Reinstatement | Pharmacology/Toxicology | Psychiatry | CRF 1 receptor | Noradrenaline | Alpha-2 adrenoceptors | Stress | receptor | ANXIOGENIC DRUG YOHIMBINE | stress | PRIMING-INDUCED REINSTATEMENT | CRF1 receptor | relapse | PSYCHIATRY | COCAINE-SEEKING | STRESS-INDUCED RELAPSE | alcohol self administration | ANXIETY-LIKE BEHAVIOR | NEUROSCIENCES | alpha-2 adrenoceptors | ETHANOL-DEPENDENT RATS | CORTICOTROPIN-RELEASING-FACTOR | STRIA TERMINALIS | reinstatement | NORADRENERGIC MECHANISMS | PHARMACOLOGY & PHARMACY | noradrenaline | corticosterone | FOOD-SEEKING | Rats, Wistar | Ethanol - administration & dosage | Rats | Male | Adrenergic alpha-Antagonists - pharmacology | Alcoholism - prevention & control | Pyrimidines - pharmacology | Yohimbine - pharmacology | Behavior, Addictive - prevention & control | Dose-Response Relationship, Drug | Ethanol - pharmacology | Pyrroles - pharmacology | Self Administration | Animals | Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors | Conditioning, Operant - drug effects | Alcoholism - psychology | Neurosciences | Inhibitor drugs | Antagonist drugs | Rodents | Pharmacology | Addictions | Alcohol use
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10. Full Text The role of α‐adrenergic receptors in mediating beat‐by‐beat sympathetic vascular transduction in the forearm of resting man
by Fairfax, Seth T and Holwerda, Seth W and Credeur, Daniel P and Zuidema, Mozow Y and Medley, John H and Dyke II, Peter C and Wray, D. Walter and Davis, Michael J and Fadel, Paul J
The Journal of Physiology, ISSN 0022-3751, 07/2013, Volume 591, Issue 14, pp. 3637 - 3649
Key points •  Sympathetic support of blood pressure demands the efficient control of vascular tone; however, little is known regarding how spontaneously... 
Vasoconstrictor Agents - pharmacology | Angiotensin II - pharmacology | Humans | Male | Adrenergic alpha-Antagonists - pharmacology | Phentolamine - pharmacology | Rest - physiology | Young Adult | Regional Blood Flow - drug effects | Receptors, Adrenergic, alpha - physiology | Forearm - blood supply | Adult | Forearm - physiology | Integrative
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11. Full Text Systems pharmacology identifies drug targets for Stargardt disease-Associated retinal degeneration
by Chen, Yu and Palczewska, Grazyna and Mustafi, Debarshi and Golczak, Marcin and Dong, Zhiqian and Sawada, Osamu and Maeda, Tadao and Maeda, Akiko and Palczewski, Krzysztof
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human... 
MEDICINE, RESEARCH & EXPERIMENTAL | VISUAL CYCLE | PHAGOCYTOSIS | OPTICAL COHERENCE TOMOGRAPHY | ABCA4 | RHODOPSIN | MECHANISMS | MICE | DOXAZOSIN | LONG-TERM TREATMENT | CLINICAL-EXPERIENCE | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology
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12. Full Text Effects of anesthetics on systemic hemodynamics in mice
by Ben J. A. Janssen and Tijl De Celle and Jacques J. M. Debets and Agnieszka E. Brouns and Michael F. Callahan and Thomas L. Smith
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2004, Volume 287, Issue 4, pp. 1618 - 1624
The aim of this study was to compare the systemic hemodynamic effects of four commonly used anesthetic regimens in mice that were chronically instrumented for... 
Analgesia | Ketamine | Buprenorphine | Pentobarbital | Xylazine | Anesthesia | Urethane | Isoflurane | urethane | CARDIAC-FUNCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | xylazine | analgesia | MOUSE | RATS | ECHOCARDIOGRAPHIC-ASSESSMENT | anesthesia | THERMONEUTRALITY | buprenorphine | ketamine | pentobarbital | IN-VIVO | VOLATILE ANESTHETICS | PERIPHERAL VASCULAR DISEASE | isoflurane | K+ CHANNELS | TRANSGENIC MICE | Anesthetics, Inhalation - pharmacology | Adjuvants, Anesthesia - pharmacology | Anesthetics, Dissociative - pharmacology | Isoflurane - pharmacology | Cardiac Output - drug effects | Mice, Inbred C57BL | Analgesics, Opioid - pharmacology | Pentobarbital - pharmacology | Male | Adrenergic alpha-Antagonists - pharmacology | Imidazoles - pharmacology | Buprenorphine - pharmacology | Anesthetics, Intravenous - pharmacology | Animals | Xylazine - pharmacology | Adrenergic alpha-Agonists - pharmacology | Female | Blood Pressure - drug effects | Mice | Urethane - pharmacology | Ketamine - pharmacology
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