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1. Full Text A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists
by Stroebel, David and Buhl, Derek L and Knafels, John D and Chanda, Pranab K and Green, Michael and Sciabola, Simone and Mony, Laetitia and Paoletti, Pierre and Pandit, Jayvardhan
Molecular pharmacology, ISSN 0026-895X, 05/2016, Volume 89, Issue 5, pp. 541 - 551
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Membrane Transport Modulators - chemistry | Expert Systems | Humans | Molecular Conformation | Imidazoles - chemistry | Receptors, N-Methyl-D-Aspartate - metabolism | Pyrimidines - metabolism | Piperidines - pharmacology | Oxadiazoles - pharmacology | Receptors, N-Methyl-D-Aspartate - chemistry | Binding Sites | Imidazoles - metabolism | Protein Subunits - genetics | Piperidines - metabolism | Computational Biology | Models, Molecular | Imidazoles - pharmacology | Pyrimidines - pharmacology | Recombinant Fusion Proteins - chemistry | Pyridazines - chemistry | Adrenergic alpha-Antagonists - metabolism | Ligands | Molecular Docking Simulation | Protein Subunits - antagonists & inhibitors | Mutation | Oxadiazoles - metabolism | Drugs, Investigational - pharmacology | Xenopus Proteins - genetics | Adrenergic alpha-Antagonists - pharmacology | Drugs, Investigational - metabolism | Pyridazines - pharmacology | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | Pyrimidines - chemistry | Receptors, N-Methyl-D-Aspartate - genetics | Xenopus Proteins - chemistry | Drugs, Investigational - chemistry | Membrane Transport Modulators - pharmacology | Pyridazines - metabolism | Protein Interaction Domains and Motifs | Oxadiazoles - chemistry | Allosteric Regulation - drug effects | Piperidines - chemistry | Adrenergic alpha-Antagonists - chemistry | Xenopus Proteins - antagonists & inhibitors | Membrane Transport Modulators - metabolism | Animals | Xenopus Proteins - metabolism | Protein Subunits - chemistry | Amino Acid Substitution | Index Medicus | Neuroscience | Cognitive science
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2. Full Text The Effect of Alpha Antagonists on Pupil Dynamics: Implications for the Diagnosis of Intraoperative Floppy Iris Syndrome
by Theodossiadis, Panagiotis G and Achtsidis, Vasilis and Theodoropoulou, Sofia and Tentolouris, Nicholas and Komninos, Christos and Fountas, Kostas N
American journal of ophthalmology, ISSN 0002-9394, 2012, Volume 153, Issue 4, pp. 620 - 626
Ophthalmology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Miscellaneous | Medical sciences | Iris Diseases - chemically induced | Prospective Studies | Cataract Extraction | Humans | Male | Muscle Hypotonia - chemically induced | Iris Diseases - diagnosis | Sulfonamides - pharmacology | Case-Control Studies | Muscle Hypotonia - diagnosis | Muscle, Smooth - drug effects | Diagnostic Techniques, Ophthalmological - instrumentation | Intraoperative Complications | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Pupil - drug effects | Quinazolines - pharmacology | Prostatic Hyperplasia - drug therapy | Medical colleges | Cataracts | Hospitals | Eye surgery | Surgery | Index Medicus | Abridged Index Medicus
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3. Full Text Biologically active dihydropyrimidones of the Biginelli-type — a literature survey
by Kappe, C.Oliver
2000, Volume 35, Issue 12, 10
calcium channel modulators | cardiovascular disease | dihydropyridines | dihydropyrimidones | benign prostatic hyperplasia | mitotic machinery | Benign prostatic hyperplasia | Cardiovascular disease | Dihydropyridines | Dihydropyrimidones | Mitotic machinery | Calcium channel modulators | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Cardiovascular system | Miscellaneous | General aspects | Neurotransmitters. Neurotransmission. Receptors | Pharmacology. Drug treatments | Biological and medical sciences | Catecholaminergic system | Medical sciences | Neuropharmacology | Antineoplastic agents | Calcium Channels - drug effects | Adrenergic alpha-Antagonists - chemical synthesis | Mitosis | Humans | Molecular Conformation | Pyrimidinones - pharmacology | Adrenergic alpha-Antagonists - pharmacology | Adrenergic alpha-1 Receptor Antagonists | Pyrimidinones - chemical synthesis | Adrenergic alpha-Antagonists - chemistry | Kinesin - antagonists & inhibitors | Pyrimidinones - chemistry | Index Medicus
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4. Full Text Spinal mechanism of micturition reflex inhibition by naftopidil in rats
by Sugaya, Kimio and Nishijima, Saori and Kadekawa, Katsumi and Ashitomi, Katsuhiro and Ueda, Tomoyuki and Yamamoto, Hideyuki
Life sciences (1973), ISSN 0024-3205, 10/2014, Volume 116, Issue 2, pp. 106 - 111
Micturition reflex | Strychnine | Noradrenaline | Naftopidil | Bicuculline | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Piperazines - administration & dosage | Norepinephrine - pharmacology | Glycine - metabolism | Spinal Cord - drug effects | Spinal Cord - metabolism | gamma-Aminobutyric Acid - metabolism | Norepinephrine - administration & dosage | Reflex - drug effects | Adrenergic alpha-Antagonists - pharmacology | Adrenergic alpha-Antagonists - administration & dosage | Dose-Response Relationship, Drug | Tissue Distribution | Amino Acids - metabolism | Urination - drug effects | Female | Naphthalenes - pharmacokinetics | Adrenergic alpha-Antagonists - pharmacokinetics | Piperazines - pharmacokinetics | Injections, Spinal | Administration, Oral | Rats | Strychnine - pharmacology | Bicuculline - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Naphthalenes - pharmacology | Animals | Muscle Contraction - drug effects | Naphthalenes - administration & dosage | Serotonin - metabolism | Index Medicus
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5. Full Text Young rats exhibit an age- and sex-dependent bladder response to alpha-antagonists but not beta-agonists
by Chien, China and Wu, Hsi-Yang
Journal of pediatric urology, ISSN 1477-5131, 2015, Volume 12, Issue 2, pp. 92.e1 - 92.e8
Pediatrics | Urology | Bladder | External urethral sphincter | Beta adrenergic receptors | Neonate | Rat | Alpha adrenergic receptors | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Animals, Newborn | Age Factors | Aging - drug effects | Rats | Male | Adrenergic beta-1 Receptor Agonists - pharmacology | Rats, Sprague-Dawley | Urinary Bladder, Overactive - drug therapy | Animals | Urinary Bladder, Overactive - physiopathology | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Urination - drug effects | Sex Factors | Urinary Bladder - physiopathology | Female | Urinary Bladder - drug effects | Electromyography | Disease Models, Animal | Index Medicus
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6. Full Text Systems pharmacology identifies drug targets for Stargardt disease-Associated retinal degeneration
by Chen, Yu and Palczewska, Grazyna and Mustafi, Debarshi and Golczak, Marcin and Dong, Zhiqian and Sawada, Osamu and Maeda, Tadao and Maeda, Akiko and Palczewski, Krzysztof
The Journal of clinical investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology | Index Medicus | Abridged Index Medicus
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7. Full Text The Effect of Alpha Antagonists on Pupil Dynamics: Implications for the Diagnosis of Intraoperative Floppy Iris Syndrome
by Carifi, Gianluca and Theoulakis, Panagiotis
American journal of ophthalmology, ISSN 0002-9394, 2012, Volume 154, Issue 3, pp. 611 - 612
Ophthalmology | Life Sciences & Biomedicine | Science & Technology | Intraoperative Complications | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Humans | Pupil - drug effects | Male | Iris Diseases - diagnosis | Muscle Hypotonia - diagnosis | Cataracts | Confidence intervals | Eye surgery | Index Medicus | Abridged Index Medicus
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8. Pharmacology of Sedative-Analgesic Agents: Dexmedetomidine, Remifentanil, Ketamine, Volatile Anesthetics, and the Role of Peripheral Mu Antagonists
by Panzer, Oliver and Moitra, Vivek and Sladen, Robert N
Critical care clinics, ISSN 0749-0704, 07/2009, Volume 25, Issue 3, pp. 451 - 469
Analgesia | Ketamine | Sedation | Volatile anesthetics | Remifentanil | Dexmedetomidine | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Analgesics - pharmacology | Hypnotics and Sedatives - adverse effects | Humans | Hypnotics and Sedatives - administration & dosage | Adrenergic alpha-Antagonists - pharmacology | Anesthetics, Inhalation - adverse effects | Adrenergic alpha-Antagonists - administration & dosage | Ketamine - administration & dosage | Receptors, Adrenergic, alpha-2 - drug effects | Ketamine - adverse effects | Adrenergic alpha-Antagonists - adverse effects | Piperidines - pharmacology | Dexmedetomidine - pharmacology | Analgesics - adverse effects | Anesthetics, Inhalation - pharmacology | Dexmedetomidine - administration & dosage | Piperidines - administration & dosage | Anesthetics, Inhalation - administration & dosage | Analgesics - administration & dosage | Cardiovascular System - drug effects | Receptors, Opioid, mu - antagonists & inhibitors | Dexmedetomidine - adverse effects | Piperidines - adverse effects | Hypnotics and Sedatives - pharmacology | Ketamine - pharmacology | Peripheral Nervous System - drug effects | Index Medicus
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9. Full Text Effects of Acute Treatment With Tamsulosin Versus Alfuzosin on Ejaculatory Function in Normal Volunteers
by Hellstrom, Wayne J.G and Sikka, Suresh C
The Journal of urology, ISSN 0022-5347, 2006, Volume 176, Issue 4, pp. 1529 - 1533
ejaculation | urinary tract | adrenergic alpha-antagonists | prostatic hyperplasia | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Male genital diseases | Tumors | Sperm Count | Drug Administration Schedule | Urine - cytology | Humans | Male | Adrenergic alpha-Antagonists - pharmacology | Adrenergic alpha-Antagonists - administration & dosage | Sulfonamides - pharmacology | Cross-Over Studies | Ejaculation - physiology | Adult | Quinazolines - administration & dosage | Ejaculation - drug effects | Quinazolines - pharmacology | Sulfonamides - administration & dosage | Tamsulosin hydrochloride | Sexual disorders | Analysis | Index Medicus | Abridged Index Medicus
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10. Full Text In vitro, and in vivo, evaluation of dihydropyrimidinone C-5 amides as potent and selective α(1A) receptor antagonists for the treatment of benign prostatic hyperplasia
by Barrow, James C and Nantermet, Philippe G and Selnick, Harold G and Glass, Kristen L and Rittle, Kenneth E and Gilbert, Kevin F and Steele, Thomas G and Homnick, Carl F and Freidinger, Roger M and Ransom, Rick W and Kling, Paul and Reiss, Duane and Broten, Theodore P and Schorn, Terry W and Chang, Raymond S. L and O'Malley, Stacey S and Olah, Timothy V and Ellis, Joan D and Barrish, Andrea and Kassahun, Kelem and Leppert, Paula and Nagarathnam, Dhanapalan and Forray, Carlos
Journal of medicinal chemistry, ISSN 0022-2623, 07/2000, Volume 43, Issue 14, pp. 2703 - 2718
Caco-2 Cells | Receptors, Adrenergic, alpha-1 - metabolism | Adrenergic alpha-Antagonists - chemical synthesis | Receptors, Adrenergic, alpha-1 - drug effects | Humans | Rats | Biological Availability | Crystallography, X-Ray | Male | Adrenergic alpha-Antagonists - pharmacology |