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Journal Article
Nature Communications, ISSN 2041-1723, 04/2017, Volume 8, Issue 1, p. 14780
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2014, Volume 63, Issue 22, pp. 2356 - 2362
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 3, pp. 528 - 538
Background and Purpose PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle... 
inotropism and lusitropism | human heart failure | phosphodiesterases 3 and 4 | noradrenaline and adrenaline | metoprolol | β1 and β2 adrenoceptors | and β | adrenoceptors | Adrenergic beta-1 Receptor Antagonists - adverse effects | Heart Failure - surgery | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Norepinephrine - pharmacology | Adrenergic alpha-Agonists - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Middle Aged | Adrenergic beta-1 Receptor Antagonists - pharmacology | Heart Failure - physiopathology | Myocardial Contraction - drug effects | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Adrenergic beta-Agonists - chemistry | Epinephrine - agonists | Receptors, Adrenergic, beta-2 - chemistry | Cardiotonic Agents - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Adrenergic beta-2 Receptor Antagonists - pharmacology | Adrenergic beta-Agonists - pharmacology | Heart Transplantation | Metoprolol - therapeutic use | Receptors, Adrenergic, beta-1 - metabolism | Drug Resistance - drug effects | Heart Failure - metabolism | Anti-Arrhythmia Agents - therapeutic use | Cardiotonic Agents - pharmacology | Metoprolol - adverse effects | Norepinephrine - agonists | Phosphodiesterase 4 Inhibitors - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Heart Failure - drug therapy | Heart Ventricles - physiopathology | Anti-Arrhythmia Agents - adverse effects | Adrenergic alpha-Agonists - pharmacology | Heart Ventricles - metabolism | In Vitro Techniques | Epinephrine - pharmacology | Heart Ventricles - drug effects | Research Paper with
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 7, pp. 668 - 680
Abstract Background Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting... 
Cardiovascular | Internal Medicine | β-blocker | nebivolol | inflammation | endothelial dysfunction | pulmonary hypertension | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | beta-blocker | RATS | CROSS-TALK | THERAPY | SMOOTH-MUSCLE HYPERPLASIA | ARTERIAL-HYPERTENSION | ANIMAL-MODELS | BLOCKADE | PROGRESSION | Ethanolamines - pharmacology | Benzopyrans - therapeutic use | Cell Proliferation | Rats, Wistar | Metoprolol - pharmacology | Humans | Monocrotaline | Adrenergic beta-1 Receptor Antagonists - pharmacology | Hypertension, Pulmonary - physiopathology | Endothelium, Vascular - drug effects | Male | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Hypertension, Pulmonary - drug therapy | Cell Culture Techniques | Vascular Remodeling - drug effects | Benzopyrans - pharmacology | Disease Models, Animal | Nebivolol | Endothelium, Vascular - physiopathology | Rats | Metoprolol - therapeutic use | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Animals | Myocytes, Smooth Muscle | Cell Communication - drug effects | Endothelium, Vascular - pathology | Ethanolamines - therapeutic use | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Endothelial Cells - drug effects | Heart | Sects | Pulmonary hypertension | Endothelium | Studies | Cell growth | Pulmonary arteries | Mortality | Smooth muscle | Veins & arteries | Life Sciences
Journal Article
Journal Article
Drugs, ISSN 0012-6667, 3/2018, Volume 78, Issue 3, pp. 377 - 388
Intravenous landiolol [Rapibloc® (EU)], an ultra short-acting highly cardioselective β1-blocker, is approved in the EU for the rapid short-term control of... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | TRACHEAL INTUBATION | LEFT-VENTRICULAR DYSFUNCTION | LOW-DOSE LANDIOLOL | PHARMACOLOGY & PHARMACY | POSTOPERATIVE ATRIAL-FIBRILLATION | ACTING BETA-BLOCKER | DECOMPENSATED HEART-FAILURE | SUPRAVENTRICULAR TACHYARRHYTHMIAS | TOXICOLOGY | BETA-1-SELECTIVE BLOCKER | RAPID ATRIAL | BISPECTRAL INDEX | Adrenergic beta-1 Receptor Antagonists - adverse effects | Tachycardia, Supraventricular - drug therapy | Humans | Adrenergic beta-1 Receptor Antagonists - pharmacology | Drug Approval | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Dose-Response Relationship, Drug | Heart Rate - drug effects | Urea - analogs & derivatives | Adrenergic beta-1 Receptor Antagonists - administration & dosage | Morpholines - adverse effects | Morpholines - therapeutic use | Tachycardia - drug therapy | Urea - administration & dosage | Atrial Fibrillation - drug therapy | Japan | Morpholines - administration & dosage | Morpholines - pharmacology | Treatment Outcome | Heart Failure - drug therapy | Administration, Intravenous | Urea - therapeutic use | Ventricular Dysfunction, Left - drug therapy | Urea - adverse effects | Urea - pharmacology | Short term | Cardiac arrhythmia | Intensive care | Intravenous administration | Digoxin | Heart surgery | Weaning | Clinical trials | Powder | Sinuses | Fibrillation | Electrocardiography | Flutter | Blood pressure | Formulations | Medical research | Electroconvulsive therapy | Pharmacology | Diltiazem | Hypotension | Heart rate | Studies | Tachycardia | Bradycardia | ECS | Comparative studies | Adrenergic receptors | Intubation | Hemodynamics | Cancer
Journal Article
Circulation. Heart Failure, ISSN 1941-3289, 2012, Volume 5, Issue 1, pp. 97 - 105
Background-In pulmonary arterial hypertension (PH), sympathetic adrenergic activity is highly elevated. Sympathetic overactivity is a compensatory mechanism at... 
β-adrenergic receptor blocker | Wistar rats | Pressure-volume relationship | Pulmonary hypertension | Right ventricular dysfunction | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | SYMPATHETIC-NERVOUS-SYSTEM | pulmonary hypertension | RATS | pressure-volume relationship | VENTRICULAR HYPERTROPHY | ARTERIAL-HYPERTENSION | PERSPECTIVES | right ventricular dysfunction | beta-adrenergic receptor blocker | ADRENERGIC-RECEPTOR BLOCKADE | DYSFUNCTION | SYSTOLIC PRESSURE-VOLUME | INDEXES | Antihypertensive Agents - pharmacology | Rats, Wistar | Bisoprolol - therapeutic use | Adrenergic beta-1 Receptor Antagonists - pharmacology | Male | Monocrotaline - adverse effects | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Heart Ventricles - diagnostic imaging | Hypertension, Pulmonary - chemically induced | Vascular Resistance - physiology | Dose-Response Relationship, Drug | Heart Failure - prevention & control | Vascular Resistance - drug effects | Hypertension, Pulmonary - drug therapy | Heart Failure - diagnostic imaging | Heart Failure - etiology | Heart Ventricles - pathology | Disease Models, Animal | Echocardiography | Rats | Antihypertensive Agents - therapeutic use | Disease Progression | Animals | Heart Ventricles - physiopathology | Signal Transduction - drug effects | Fibrosis | Signal Transduction - physiology | Bisoprolol - pharmacology | Hypertension, Pulmonary - complications
Journal Article
Journal Article