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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2007, Volume 320, Issue 1, pp. 1 - 13
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 9865 - 9881
The glucagon receptor (GCGR) belongs to the secretin-like (class B) family of G protein-coupled receptors (GPCRs... 
BETA ADRENERGIC-RECEPTOR | LIGAND-BINDING | GLUCAGON RECEPTOR | IONIC LOCK | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING STRATEGY | METAPHYSEAL CHONDRODYSPLASIA | BETA-ADRENERGIC RECEPTOR | PEPTIDE | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptors, Corticotropin-Releasing Hormone - metabolism | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Receptors, Corticotropin-Releasing Hormone - agonists | Receptors, Corticotropin-Releasing Hormone - genetics | Receptor, Parathyroid Hormone, Type 1 - agonists | Recombinant Fusion Proteins - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - chemistry | Conserved Sequence | Protein Interaction Domains and Motifs | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Protein Stability | Binding Sites | Peptide Fragments - genetics | Second Messenger Systems | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Receptors, Vasoactive Intestinal Polypeptide, Type I - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Models, Molecular | Receptors, Glucagon - metabolism | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Peptide Fragments - chemistry | Peptide Fragments - agonists | Receptors, Glucagon - chemistry | Hydrophobic and Hydrophilic Interactions | Receptor, Parathyroid Hormone, Type 1 - genetics | Ligands | Protein Conformation | Structural Homology, Protein | Mutation | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Receptors, Corticotropin-Releasing Hormone - chemistry | Amino Acid Substitution | Index Medicus | Editors' Picks | 7-helix receptor | G protein-coupled receptor (GPCR) | parathyroid hormone | glucagon | arrestin
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 05/2015, Volume 55, Issue 5, pp. 1045 - 1061
The spectacular advances in G-protein-coupled receptor (GPCR) structure determination have opened up new possibilities for structure-based GPCR ligand discovery... 
Adrenergic beta-2 Receptor Antagonists | Humans | Computational Biology | Library and Information Sciences | Chemistry(all) | Crystallography, X-Ray | Receptors, Adrenergic, beta-2 | Adrenergic beta-2 Receptor Agonists | Journal Article | Adrenergic beta-1 Receptor Antagonists | Animals | Computer Science Applications | Research Support, Non-U.S. Gov't | Receptors, Adrenergic, beta-1 | Adrenergic beta-1 Receptor Agonists | Chemical Engineering(all) | Ligands | Protein Conformation | Medicine(all) | Molecular Docking Simulation | Drug Evaluation, Preclinical | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | COMPUTER SCIENCE, INFORMATION SYSTEMS | HUMAN P2Y RECEPTOR | ADRENERGIC-RECEPTOR | 2 SERINE RESIDUES | CHEMISTRY, MULTIDISCIPLINARY | A(2A) ADENOSINE RECEPTOR | MOLECULAR INTERACTION FINGERPRINTS | MUSCARINIC ACETYLCHOLINE-RECEPTOR | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | STRUCTURE-BASED DISCOVERY | BETA-ADRENERGIC RECEPTOR | PARTIAL AGONIST ACTIVITY | Computational Biology - methods | Adrenergic beta-1 Receptor Antagonists - pharmacology | Adrenergic beta-2 Receptor Agonists - metabolism | Receptors, Adrenergic, beta-1 - metabolism | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - chemistry | Adrenergic beta-2 Receptor Antagonists - metabolism | Adrenergic beta-1 Receptor Antagonists - metabolism | Adrenergic beta-1 Receptor Agonists - metabolism | Adrenergic beta-2 Receptor Antagonists - pharmacology
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2015, Volume 388, Issue 8, pp. 883 - 903
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today... 
Neurosciences | CXCR 1 , CXCR 2 , CCR 4 and CCR 5 , chemokine receptors | TM, trans-membrane helix | β 2 AR, β 2 -adrenergic receptor | ProS, pairwise protein similarity method | CRF1, corticotropin releasing factor receptor 1 | T4L, T4-lysozyme | ECL, extracellular loop | GLP-1, Glucagon-like peptide-1 receptor | hM 3 R, human muscarinic M3 receptor | α1B Adrenergic receptor | Pharmacology/Toxicology | 7TM, seven-transmembrane domain | HGMP, hierarchical GPCR modelling protocol | PDB, Protein Data Bank | XFELs, x-ray free electron lasers | 5-HT 2B and 5-HT 2C , human 5-hydroxytryptamine receptors 2B and 2C, respectively | GLAS, GPCR-likeness assessment score | H 1 , histamine receptor 1 | 3D, three-dimensional | Biomedicine | CCK 2 R, cholecystokinin receptor-2 | MD, molecular dynamic simulations | GPCRs, G-protein coupled receptors | Dopamine D 2 receptor | BRIL, apocytochrome b 562 RIL | δ-OR, delta-opioid receptor | SDM, site-directed mutagenesis | CCK2R, cholecystokinin receptor-2 | PEPTIDE-1 RECEPTOR | DESIGN | CXCR1, CXCR2, CCR4, and CCR5, chemokine receptors | beta 2AR, beta 2-adrenergic receptor | hMR, human muscarinic M3 receptor | HUMAN OREXIN-1 | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Dopamine D-2 receptor | PROTEIN-COUPLED RECEPTORS | SITE-DIRECTED MUTAGENESIS | alpha 1B Adrenergic receptor | LIPIDIC CUBIC PHASE | delta-OR, delta-opioid receptor | 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively | H-1, histamine receptor 1 | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | BINDING | SELECTIVITY | BRIL, apocytochrome bRIL | Animals | Receptors, G-Protein-Coupled - metabolism | Computer Simulation | Drug Industry | Humans | Cooperative Behavior | Models, Molecular | Crystallography | Drug Discovery | Universities | Drug discovery | BRIL, apocytochrome b562RIL | Meeting Report | H1, histamine receptor 1 | β2AR, β2-adrenergic receptor | CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors | hM3R, human muscarinic M3 receptor | Dopamine D2 receptor
Journal Article
Circulation, ISSN 0009-7322, 09/2003, Volume 108, Issue 13, pp. 1611 - 1618
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0213792
Journal Article
Journal of Neural Transmission, ISSN 0300-9564, 1/2007, Volume 114, Issue 1, pp. 49 - 75
In 1980/81 Agnati and Fuxe introduced the concept of intramembrane receptor–receptor interactions and presented the first experimental observations for their existence in crude membrane preparations... 
Neurology | Medicine & Public Health | Pharmacology/Toxicology | A2A receptors, D2-like receptors, metabotropic glutamate receptor 5, neuropeptide receptors, receptor heteromers, receptor mosaics, basal ganglia, novel treatment strategies in neuropsychopharmacology, learning and memory | Psychiatry | Learning and memory | Receptor heteromers | Receptor mosaics | Basal ganglia | D2-like receptors | Neuropeptide receptors | Novel treatment strategies in neuropsychopharmacology | Metabotropic glutamate receptor 5 | A2A receptors | GALANIN BINDING-SITES | basal ganglia | BETA-ADRENERGIC-RECEPTORS | receptor mosaics | METABOTROPIC GLUTAMATE RECEPTORS | ANGIOTENSIN-II | neuropeptide receptors | NEUROSCIENCES | INTEGRATIVE MECHANISM | CLINICAL NEUROLOGY | learning and memory | ADENOSINE A(2A) RECEPTORS | DOPAMINE D2 RECEPTORS | metabotropic glutamate receptor 5 | HEPTASPANNING MEMBRANE-RECEPTORS | CENTRAL-NERVOUS-SYSTEM | receptor heteromers | novel treatment strategies in neuropsychopharmacology | C-FOS EXPRESSION | Neurons - chemistry | Humans | Receptors, Neurotransmitter - chemistry | Cell Membrane - ultrastructure | Cell Membrane - physiology | Receptors, Neurotransmitter - physiology | Brain - physiology | Receptor Cross-Talk - physiology | Cell Membrane - chemistry | Animals | Neurons - ultrastructure | Neurons - physiology | Receptors, Cell Surface - chemistry | Signal Transduction - physiology | Protein Subunits - chemistry | Receptors, Cell Surface - physiology | Protein Subunits - physiology | Neurotransmitter Agents - physiology
Journal Article
Europace, ISSN 1099-5129, 07/2017, Volume 19, Issue 7, pp. 1211 - 1219
...) and beta 1/2-adrenergic receptors (beta 1/2AR). Immunoglobulin G (IgG) derived from 17 POTS patients, 7 with recurrent vasovagal syncope (VVS... 
Autoimmunity | Adrenergic receptors | Postural tachycardia syndrome | Allosteric activation | Vasovagal syncope | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | SYNCOPE | INAPPROPRIATE SINUS TACHYCARDIA | ORTHOSTATIC INTOLERANCE | NITROGLYCERIN | HYPOTENSION | CONSENSUS STATEMENT | Receptors, Adrenergic, alpha-1 - metabolism | Cricetulus | Immunoglobulin G - blood | Autoantibodies - blood | Humans | Male | Receptors, Adrenergic, beta-2 - immunology | Receptors, Adrenergic, beta-2 - drug effects | Adrenergic beta-1 Receptor Agonists - pharmacology | Case-Control Studies | Adrenergic alpha-1 Receptor Agonists - pharmacology | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, alpha-1 - immunology | Dose-Response Relationship, Drug | Young Adult | Transfection | Receptors, Adrenergic, beta-1 - immunology | Adult | Female | Receptors, Adrenergic, beta-1 - drug effects | CHO Cells | Postural Orthostatic Tachycardia Syndrome - immunology | Receptors, Adrenergic, alpha-1 - drug effects | Receptors, Adrenergic, beta-2 - genetics | Rats | Receptors, Adrenergic, beta-1 - metabolism | Abdominal Muscles - blood supply | Arterioles - drug effects | Vasoconstriction - drug effects | Postural Orthostatic Tachycardia Syndrome - blood | Receptors, Adrenergic, beta-2 - metabolism | Animals | Arterioles - metabolism | Postural Orthostatic Tachycardia Syndrome - diagnosis | Receptors, Adrenergic, alpha-1 - genetics | Adolescent | Receptors, Adrenergic, beta-1 - genetics | In Vitro Techniques | Clinical Research | Editor's Choice | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Immunologi inom det medicinska området | Immunology in the medical area
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 01/2003, Volume 50, Issue 1, pp. 5 - 25
The aim of the current study is to investigate whether homology models of G‐Protein‐Coupled Receptors (GPCRs) that are based on bovine rhodopsin are reliable enough to be used for virtual screening of chemical database... 
docking | scoring | homology modeling | GPCRs | structure‐based ligand design | Docking | Scoring | Structure-based ligand design | Homology modeling | BETA ADRENERGIC-RECEPTOR | AGONIST ACTIVATION | LIGAND-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-based ligand design | MUSCARINIC RECEPTOR | DELTA-OPIOID RECEPTOR | INDUCED CONFORMATIONAL-CHANGES | TRANSMEMBRANE REGIONS | BIOPHYSICS | SCORING FUNCTIONS | 3-DIMENSIONAL MODELS | BETA-ADRENERGIC RECEPTOR | Humans | Molecular Sequence Data | Heterotrimeric GTP-Binding Proteins - metabolism | Adrenergic beta-2 Receptor Agonists | Receptors, Cell Surface - antagonists & inhibitors | Drug Delivery Systems | Receptors, Adrenergic, beta-2 - chemistry | Receptors, Vasopressin - chemistry | Cattle | Computer Simulation | Receptors, Dopamine D2 - chemistry | Receptors, Cell Surface - chemistry | Databases, Factual | Rhodopsin - chemistry | Amino Acid Sequence | Computational Biology - methods | Receptors, Opioid, delta - chemistry | Receptors, Dopamine D2 - agonists | Receptors, Cell Surface - agonists | Models, Molecular | Receptor, Muscarinic M1 | Receptors, Muscarinic - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Algorithms | Animals | Receptors, Dopamine D3 | Ligands | Antidiuretic Hormone Receptor Antagonists | Dopamine D2 Receptor Antagonists | Receptors, Opioid, delta - agonists
Journal Article