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adrenodoxin (130) 130
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mitochondria - metabolism (42) 42
crystal-structure (41) 41
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saccharomyces-cerevisiae (37) 37
sequence homology, amino acid (36) 36
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human adrenodoxin (25) 25
sequence alignment (25) 25
steroid hydroxylases - genetics (25) 25
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side-chain cleavage (23) 23
steroid 11-beta-hydroxylase - metabolism (23) 23
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Molecular Biotechnology, ISSN 1073-6085, 10/2017, Volume 59, Issue 9, pp. 394 - 406
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12754 - 12763
The biogenesis of iron-sulfur (Fe/S) proteins in eukaryotes is a multistage, multicompartment process that is essential for a broad range of cellular... 
4FE-4S CLUSTERS | acyl carrier protein (ACP) | cysteine desulfurase | fatty acid metabolism | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOTHIOL GLUTAREDOXINS FUNCTION | FUNCTIONAL-CHARACTERIZATION | glutaredoxin | mitochondrial disease | frataxin | ACYL CARRIER PROTEIN | ferredoxin | metal biology | chaperone | INTERACTING PROTEIN | ASSEMBLY MACHINERY | AZOTOBACTER-VINELANDII (NIF)ISCA | FE-S PROTEINS | SCAFFOLD PROTEIN | lipoic acid | Mitochondria - enzymology | Adrenodoxin - genetics | Species Specificity | Humans | Protein Multimerization | Adrenodoxin - metabolism | Iron-Sulfur Proteins - genetics | Iron-Binding Proteins - chemistry | Mitochondrial Proteins - genetics | Iron-Sulfur Proteins - chemistry | Iron-Binding Proteins - metabolism | Mitochondrial Proteins - metabolism | Apoenzymes - metabolism | Sulfurtransferases - chemistry | Acyl Carrier Protein - metabolism | Models, Molecular | Sulfurtransferases - genetics | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | Protein Transport | Gene Expression Regulation, Enzymologic | Acyl Carrier Protein - chemistry | Animals | Models, Biological | Acyl Carrier Protein - genetics | Apoenzymes - genetics | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Apoenzymes - chemistry | Adrenodoxin - chemistry | Iron-Binding Proteins - genetics | Protein Conformation | Iron-Sulfur Proteins - metabolism | Sulfurtransferases - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Minireviews
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 10/2017, Volume 101, Issue 4, pp. 630 - 637
Hearing loss and visual impairment in childhood have mostly genetic origins, some of them being related to sensorial neuronal defects. Here, we report on eight... 
optic atrophy | iron overload | ARH1 | Auditory neuropathy | iron-sulfur cluster | mitochondria | FDXR | Fe-S cluster synthesis | CLUSTER BIOGENESIS | FRATAXIN | DOMINANT OPTIC ATROPHY | PROTEIN | ADRENODOXIN REDUCTASE | IRON HOMEOSTASIS | GENE | GENETICS & HEREDITY | MECHANISMS | AUDITORY NEUROPATHY | FERREDOXINS | Ferredoxin-NADP Reductase - metabolism | Mitochondrial Diseases - pathology | Mitochondria - enzymology | Saccharomyces cerevisiae - genetics | Humans | Child, Preschool | Iron-Sulfur Proteins - genetics | Male | Hearing Loss, Central - genetics | Genetic Complementation Test | Optic Atrophy - pathology | Saccharomyces cerevisiae - metabolism | Young Adult | Hearing Loss, Central - enzymology | Mitochondria - genetics | Ferredoxin-NADP Reductase - genetics | Adult | Female | Optic Atrophy - genetics | Mitochondrial Diseases - genetics | Amino Acid Sequence | Mitochondria - pathology | Saccharomyces cerevisiae Proteins - genetics | Iron - metabolism | Mitochondrial Diseases - enzymology | Sequence Alignment | Pedigree | Adolescent | Saccharomyces cerevisiae Proteins - metabolism | Iron-Sulfur Proteins - metabolism | Ferredoxin-NADP Reductase - chemistry | Mutation | Hearing Loss, Central - pathology | Optic Atrophy - enzymology | Saccharomyces cerevisiae - growth & development | Usage | Gene mutations | Analysis | Genetic aspects | Nucleotide sequencing | Research | Children | Gene expression | Health aspects | DNA sequencing | Hearing loss | Report
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 26, pp. 11775 - 11780
Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid hormones in adrenal glands. As a member of the [2Fe-2S]... 
Yeasts | Mitochondria | Transfection | Iron sulfur proteins | Ferredoxins | HeLa cells | Small interfering RNA | Cytochromes | Biosynthesis | Steroidogenesis | IRP1 | Iron | Iron-sulfur cluster | Adrenodoxin | Cytochrome P450 | iron-sulfur cluster | MULTIDISCIPLINARY SCIENCES | DEFECT | CARDIOMYOPATHY | BOVINE ADRENODOXIN | cytochrome P450 | SACCHAROMYCES-CEREVISIAE | adrenodoxin | YEAST | SULFUR PROTEIN BIOGENESIS | S CLUSTER | ELECTRON-TRANSFER | IRON HOMEOSTASIS | iron | FRIEDREICH ATAXIA | RNA, Small Interfering - genetics | Ferredoxins - genetics | Adrenodoxin - genetics | Species Specificity | Humans | Ferredoxins - chemistry | Adrenodoxin - metabolism | Mitochondrial Proteins - genetics | Iron-Sulfur Proteins - chemistry | Protein Isoforms - metabolism | RNA Interference | Heme - biosynthesis | Mitochondrial Proteins - metabolism | Protein Isoforms - chemistry | Steroids - biosynthesis | Ferredoxins - metabolism | Mitochondrial Proteins - antagonists & inhibitors | Ferredoxins - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - genetics | Iron - metabolism | Models, Biological | Adrenodoxin - antagonists & inhibitors | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Adrenodoxin - chemistry | HeLa Cells | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Biological transport | Cytochrome P-450 | Protein biosynthesis | Genetic aspects | Research | Properties | Biological Sciences
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 12/2017, Volume 26, Issue 24, pp. 4937 - 4950
Journal Article
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 05/2017, Volume 56, Issue 17, pp. 2282 - 2293
The mitochondrial cytochromes P450 11B1 and P450 11B2 are responsible for the final stages of cortisol and aldosterone synthesis, respectively. Dysregulation... 
11-BETA-HYDROXYLASE INHIBITOR | REDUCTASE-ADRENODOXIN COMPLEX | 17,20-LYASE ACTIVITY | HADDOCK | CYP11B1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | ALDOSTERONE | MUTATIONS | RESIDUES | STEROIDOGENIC ELECTRON-TRANSPORT | Ferredoxin-NADP Reductase - metabolism | Mitochondria - enzymology | Ferredoxins - genetics | Adrenodoxin - genetics | Cross-Linking Reagents - pharmacology | Humans | Ferredoxins - chemistry | Adrenodoxin - metabolism | Steroid 11-beta-Hydroxylase - genetics | Recombinant Fusion Proteins - metabolism | Adrenal Cortex Hormones - biosynthesis | Steroid 11-beta-Hydroxylase - chemistry | Biocatalysis - drug effects | Ferredoxin-NADP Reductase - genetics | Cytochrome P-450 CYP11B2 - chemistry | Protein Interaction Domains and Motifs | Binding Sites | Peptide Fragments - genetics | Cytochrome P-450 CYP11B2 - metabolism | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Ferredoxins - metabolism | Models, Molecular | Mitochondria - metabolism | Recombinant Fusion Proteins - chemistry | Static Electricity | Peptide Fragments - chemistry | Steroid 11-beta-Hydroxylase - metabolism | Hydrophobic and Hydrophilic Interactions | Adrenodoxin - chemistry | Protein Conformation | Molecular Docking Simulation | Ferredoxin-NADP Reductase - chemistry | Mutation | Amino Acid Substitution | Cytochrome P-450 CYP11B2 - genetics | Proteins | Crosslinking | Mitochondrial DNA | Research | Gene mutations | Cytochrome P-450
Journal Article
Journal Article
Journal Article
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 03/2018, Volume 28, Issue 9, pp. 76 - 772
Significance: Psychosocial stress is associated with alterations in serum glucocorticoids and cytokines, such as interleukin-6 (IL-6) and IL-1β, which... 
Forum Review Articles | electron transfer reactions | IL-6 signaling | redox signaling | psychosocial stress | oxidative respiration | STAT3 | steroidogenesis | HPA axis | glucocorticoids | OXIDATIVE STRESS | VITAL EXHAUSTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SALIVARY CORTISOL | INFLAMMATORY MARKERS | ELECTRON-TRANSPORT CHAIN | CORTICOTROPIN-RELEASING-FACTOR | GLUCOCORTICOID-RECEPTOR | ENDOCRINOLOGY & METABOLISM | PITUITARY-ADRENAL AXIS | IRON PROTEIN ADRENODOXIN | ACUTE PSYCHOLOGICAL STRESS | Adrenal Glands - pathology | Cytokines - metabolism | Interleukin-6 - genetics | Oxidation-Reduction | Signal Transduction | Pituitary-Adrenal System - metabolism | Humans | Adrenal Cortex - metabolism | Oxidative Stress - genetics | Pituitary-Adrenal System - pathology | Mitochondria - metabolism | Adrenal Cortex - pathology | Mitochondria - pathology | Stress, Psychological - pathology | Stress, Psychological - genetics | Adrenal Glands - metabolism | Mitochondria - genetics | Glucocorticoids - metabolism | Stress, Psychological - metabolism | Cytokines - genetics | STAT3 Transcription Factor - genetics | Mitochondria | Corticosteroids | Research | Cytokines | Stress (Psychology) | Phosphorylation | Glucocorticoids | Adrenal glands | Interleukin | Electron transfer | Biosynthesis | Hypothalamus | Hydrocortisone | Interleukin 6 | Social interactions | Adrenal gland | Stresses | Tyrosine | Adrenal cortex | Stat3 protein | Hypothalamic-pituitary-adrenal axis | Stress | Signaling | Molecular modelling | Pituitary | Steroidogenesis | Electron transport | Respiration | Nuclear reactions
Journal Article
Journal Article