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mAbs, ISSN 1942-0862, 05/2015, Volume 7, Issue 3, pp. 562 - 570
Accurate measurement and functional characterization of antibody Fc domain N-linked glycans is critical to successful biosimilar development. Here, we describe... 
effector function | Fc domain | antibody | CDC | glycosylation | ADCC | biosimilar | mAb | N-linked carbohydrates | Antibody | Glycosylation | Effector function | Biosimilar | MS, mass spectrometry | MEDICINE, RESEARCH & EXPERIMENTAL | CHO, Chinese hamster ovary | SGs, sialylated glycans | mAb, monoclonal antibody | HPLC, high performance liquid chromatography | FT, flow-through | ACN, acetonitrile | THERAPY | TRIS, tris(hydroxymethyl)aminomethane | HILIC, hydrophilic interaction liquid chromatography | HIGH-MANNOSE | ADCC, antibody-dependent cell-mediated cytotoxicity | CDC, complement-dependent cytotoxicity | ANTIINFLAMMATORY ACTIVITY | OLIGOSACCHARIDES | AHGs, afucosylated hybrid glycans | HMGs, high-mannose glycans | Con A, concanavalin A lectin | CQA, critical quality attribute | GLYCANS | MS/MS, tandem mass spectrometry | HGs, hybrid glycans | AMBGs, afucosylated monoantennary and biantennary glycans | BGGs, beta-galactosylated glycans | LC, light chain | PQA, product quality attribute | EIC, extracted ion current | FC | BINDING | HC, heavy chain | SM, starting material | Cell Line | Antibody-Dependent Cell Cytotoxicity | Humans | Immunoglobulin G - chemistry | Polysaccharides - chemistry | Biological Assay | Biosimilar Pharmaceuticals - chemistry | Immunoglobulin Fc Fragments - chemistry | Antibodies, Monoclonal - chemistry
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2014, Volume 111, Issue 16, pp. 5992 - 5997
Respiratory syncytial virus (RSV) can cause devastating lower respiratory tract infections in preterm infants or when other serious health problems are... 
Human respiratory syncytial virus | Respiratory syncytial virus infections | Polysaccharides | Receptors | Isotypes | Respiratory syncytial viruses | Antibodies | Rats | Monoclonal antibodies | Viruses | ADCC | Immunotherapy | Afucosylated | Glycoengineering | COST-EFFECTIVENESS | afucosylated | PREMATURE-INFANTS | MULTIDISCIPLINARY SCIENCES | MONOCLONAL-ANTIBODY | FUCOSE | PROPHYLAXIS | glycoengineering | ECONOMIC-EVALUATION | RSV | immunotherapy | PALIVIZUMAB | PLANTS | INFECTION | Humans | Receptors, Fc - metabolism | Respiratory Syncytial Viruses - immunology | Antibodies, Monoclonal - therapeutic use | Male | Neutralization Tests | Complement C1q - metabolism | Respiratory Syncytial Virus Infections - immunology | Lung - virology | Respiratory Syncytial Virus Infections - drug therapy | Protein Binding - drug effects | Female | Lung - pathology | Sigmodontinae - immunology | Antibodies, Viral - therapeutic use | Enzyme-Linked Immunosorbent Assay | Respiratory Syncytial Viruses - drug effects | Antibodies, Neutralizing - pharmacology | Treatment Outcome | Polysaccharides - metabolism | Animals | Lung - drug effects | Sigmodontinae - virology | Antibodies, Viral - chemistry | Lung - immunology | Viral antibodies | Microbiological research | Respiratory syncytial virus | Viral proteins | Genetic variation | Host-parasite relationships | Genetic research | Genetic aspects | Research | Health aspects | Biological Sciences
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 133, Issue 5, pp. 1439 - 1447.e8
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 03/2017, Volume 114, Issue 3, pp. 632 - 644
Journal Article
Journal Article
Journal Article
OncoImmunology, ISSN 2162-4011, 06/2015, Volume 4, Issue 6, p. e1009288
Journal Article
Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, ISSN 1871-5222, 2011, Volume 11, Issue 1, pp. 21 - 32
Journal Article
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