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Blood, ISSN 0006-4971, 2015, Volume 125, Issue 10, pp. 1643 - 1652
Erythrocyte possesses high sphingosine kinase 1 (SphK1) activity and is the major cell type supplying plasma sphingosine-1-phosphate, a signaling lipid... 
CELL-DISEASE | ACTIVATION | INTERNATIONAL UNION | SPHINGOSINE-1-PHOSPHATE | AIRWAY INFLAMMATION | LUNG-DISEASE | RELEASE | HEMATOLOGY | DEAMINASE-DEFICIENT MICE | PULMONARY-FIBROSIS | 1-PHOSPHATE | Cyclic AMP-Dependent Protein Kinases - blood | Agammaglobulinemia - genetics | Erythrocytes, Abnormal - drug effects | Adenosine-5'-(N-ethylcarboxamide) - pharmacology | Humans | Anemia, Sickle Cell - enzymology | Receptor, Adenosine A2B - blood | Receptor, Adenosine A2B - genetics | Erythrocytes, Abnormal - metabolism | MAP Kinase Signaling System | Adenosine Deaminase - blood | Agammaglobulinemia - enzymology | Severe Combined Immunodeficiency - blood | Erythrocytes - enzymology | Adenosine Deaminase - deficiency | Severe Combined Immunodeficiency - enzymology | Signal Transduction | Adenosine Deaminase - genetics | Receptor, Adenosine A2B - deficiency | Cells, Cultured | Mice, Transgenic | Hemoglobin, Sickle - genetics | Erythrocytes - drug effects | Hemoglobin, Sickle - metabolism | Mice, Knockout | Severe Combined Immunodeficiency - genetics | Agammaglobulinemia - blood | Animals | Adenosine - blood | Models, Biological | Erythrocytes - metabolism | Phosphotransferases (Alcohol Group Acceptor) - blood | Mice | Anemia, Sickle Cell - blood | Anemia, Sickle Cell - genetics | Erythrocytes, Abnormal - enzymology | Index Medicus | Abridged Index Medicus | 103 | Red Cells, Iron, and Erythropoiesis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 29, pp. 13075 - 13080
Activation of the B-cell antigen receptor (BCR) signaling pathway contributes to the initiation and maintenance of B-cell malignancies and autoimmune diseases.... 
T lymphocytes | Animal models | Disease models | Gels | B lymphocytes | B cell lymphoma | Arthritis | Mice | Autoimmune diseases | Tumors | X-linked agammaglobulinemia | Lymphoma | COLLAGEN-INDUCED ARTHRITIS | THERAPY | RITUXIMAB | MULTIDISCIPLINARY SCIENCES | lymphoma | DOGS | FAMILY KINASES | BTK | RECEPTOR | DEPLETION | MICE | Arthritis, Experimental - drug therapy | Pyrazoles - therapeutic use | Humans | Benzofurans - administration & dosage | Benzofurans - pharmacology | Autoantibodies - biosynthesis | Pyrimidines - chemistry | Benzofurans - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Lymphoma, B-Cell - enzymology | Autoimmune Diseases - drug therapy | Disease Models, Animal | Lymphoma, B-Cell - drug therapy | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Benzofurans - therapeutic use | Autoimmune Diseases - enzymology | Administration, Oral | Pyrimidines - administration & dosage | Treatment Outcome | Pyrimidines - pharmacology | Receptors, Antigen, B-Cell - immunology | B-Lymphocytes - drug effects | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Animals | B-Lymphocytes - immunology | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Dogs | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Cell receptors | Models | Lymphomas | Research | Properties | Antigens | Biochemistry | Mutation | Kinases | Cells | Cancer | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e85834 - e85834
Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1... 
SYSTEM | GAMMA | BRUTONS TYROSINE KINASE | DENDRITIC CELLS | CELL-DEVELOPMENT | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | X-LINKED AGAMMAGLOBULINEMIA | GENE-EXPRESSION | NF-KAPPA-B | ALTERNATIVE ACTIVATION | Inflammation - pathology | Transcription, Genetic - drug effects | Hypersensitivity - enzymology | Protein-Tyrosine Kinases - metabolism | Hypersensitivity - complications | Protein-Tyrosine Kinases - deficiency | Macrophages, Peritoneal - cytology | Inflammation - complications | Cell Polarity - drug effects | Phosphorylation - drug effects | Macrophages, Peritoneal - drug effects | Mice, Inbred C57BL | Macrophages, Peritoneal - enzymology | Macrophages - cytology | Toll-Like Receptor 4 - metabolism | Macrophages - enzymology | Phenotype | Animals | Signal Transduction - drug effects | Hypersensitivity - pathology | Models, Biological | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Inflammation - enzymology | Inflammation | Genetic transcription | DNA binding proteins | Macrophages | Mitogens | Polarization | Animal models | Transcription factors | Phosphorylation | Disease | Genes | AKT protein | Infections | Activation | Kinases | Eggs | Lipopolysaccharides | Recruitment | Proteins | Genotype & phenotype | Rodents | Transcription activation | Toll-like receptors | Bacteria | Stat1 protein | NF-κB protein | Cytokines | Dendritic cells | Hypersensitivity | Chitin | TLR4 protein | Dentistry | Gene expression | Bruton's tyrosine kinase | Nitric-oxide synthase | Studies | Immunosuppression | Stat6 protein | Inositol-1,4,5-trisphosphate 5-phosphatase | Regulatory proteins | Stimuli | Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 01/2011, Volume 26, Issue 1, pp. 182 - 192
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2014, Volume 124, Issue 9, pp. 4067 - 4081
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2011, Volume 187, Issue 2, pp. 817 - 827
Heme oxygenase (HO)-1 is the inducible isoform of the rate-limiting enzyme of heme degradation and provides cytoprotection against oxidative stress by its... 
SIGNALING PATHWAYS | ANTIOXIDANT RESPONSIVE ELEMENTS | THERAPEUTIC TARGET | X-LINKED AGAMMAGLOBULINEMIA | LIPOPOLYSACCHARIDE | ANTIGEN-PRESENTING CELLS | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | T-CELLS | TEC FAMILY KINASES | NF-E2-Related Factor 2 - physiology | Gene Expression Regulation, Enzymologic - drug effects | Agammaglobulinemia - immunology | Transcriptional Activation - genetics | Agammaglobulinemia - genetics | Genetic Diseases, X-Linked - enzymology | Nitriles - pharmacology | Transcriptional Activation - drug effects | Transcriptional Activation - immunology | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - physiology | Heme Oxygenase-1 - genetics | Signal Transduction - immunology | Agammaglobulinemia - enzymology | Toll-Like Receptors - physiology | Genetic Diseases, X-Linked - genetics | Lipopolysaccharides - physiology | Macrophages, Alveolar - immunology | Amides - pharmacology | Cell Line | Heme Oxygenase-1 - biosynthesis | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Heme Oxygenase-1 - antagonists & inhibitors | Macrophages, Alveolar - enzymology | Mice, Knockout | Genetic Diseases, X-Linked - immunology | Membrane Proteins - biosynthesis | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Macrophages, Alveolar - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Enzymologic - immunology | Mutation | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 131, Issue 2, pp. 477 - 485.e1
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2006, Volume 177, Issue 10, pp. 7203 - 7210
Bruton's tyrosine kinase (Btk) is a critical signaling mediator downstream of the B cell Ag receptor. X-linked agammaglobulinemia is caused by mutations in Btk... 
KAPPA-B ACTIVATION | EFFECTOR FUNCTIONS | INNATE IMMUNE-RESPONSES | X-LINKED AGAMMAGLOBULINEMIA | TOLL-LIKE RECEPTORS | LIPOPOLYSACCHARIDE | STIMULATED MACROPHAGES | DEFICIENT MICE | IMMUNOLOGY | CELL DEVELOPMENT | PROINFLAMMATORY CYTOKINE BIOSYNTHESIS | Spleen - immunology | Bone Marrow Cells - enzymology | Protein-Tyrosine Kinases - metabolism | Protein-Tyrosine Kinases - deficiency | Bacteria, Aerobic - growth & development | Protein-Tyrosine Kinases - physiology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Spleen - enzymology | Bone Marrow Cells - immunology | Toll-Like Receptors - antagonists & inhibitors | Interleukin-10 - metabolism | Toll-Like Receptors - physiology | Toll-Like Receptors - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Macrophages, Peritoneal - enzymology | Homeostasis - immunology | Macrophages, Peritoneal - immunology | Up-Regulation - genetics | Signal Transduction - genetics | Spleen - cytology | Down-Regulation - genetics | Macrophages - enzymology | Mice, Knockout | Toll-Like Receptor 4 - physiology | Macrophages - metabolism | Animals | Up-Regulation - immunology | Down-Regulation - immunology | Agammaglobulinaemia Tyrosine Kinase | Interleukin-10 - antagonists & inhibitors | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Mice | Macrophages, Peritoneal - metabolism | Bacteria, Aerobic - immunology | Bone Marrow Cells - metabolism | Homeostasis - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2017, Volume 127, Issue 5, pp. 1689 - 1699
BACKGROUND. Autologous hematopoietic stem cell transplantation (HSCT) of gene-modified cells is an alternative to enzyme replacement therapy (ERT) and... 
MEDICINE, RESEARCH & EXPERIMENTAL | THERAPY | SCID PATIENTS | RETROVIRAL VECTORS | RECONSTITUTION | EXPRESSION | ADA | TRANSPLANTATION | Autografts | Genetic Therapy | Severe Combined Immunodeficiency - enzymology | Transduction, Genetic | Agammaglobulinemia - genetics | Adenosine Deaminase - genetics | Agammaglobulinemia - therapy | Humans | Adenosine Deaminase - biosynthesis | Child, Preschool | Hematopoietic Stem Cell Transplantation | Retroviridae | Severe Combined Immunodeficiency - therapy | Infant | Male | Gene Expression Regulation, Enzymologic | Severe Combined Immunodeficiency - genetics | Agammaglobulinemia - enzymology | Adolescent | Female | Adenosine Deaminase - deficiency | Genetic Vectors | Child | Treatment outcome | Care and treatment | Usage | Safety and security measures | Analysis | Adenosine deaminase deficiency | Genetic aspects | Genetic engineering | Transplantation | Research | Hematopoietic stem cells | Pediatrics | Intravenous administration | Severe combined immunodeficiency | Transplants & implants | ADA gene | Copy number | Stem cell transplantation | Clinical trials | Genomes | Immunology | Lymphocytes | Peripheral blood mononuclear cells | Genetics | Busulfan | Research centers | Age | CD34 antigen | Enzymes | Adenosine | Enrollments | Research & development--R&D | Immunodeficiency | Immune reconstitution | Data processing | Adenosine deaminase | Gene expression | Medical screening | Hemopoiesis | Children & youth | Medicine | Studies | Hospitals | Stem cells | Product development | Gene therapy | Leukocytes (granulocytic) | Mitogens | Index Medicus | Abridged Index Medicus
Journal Article