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Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 2015, Volume 11, Issue 5, pp. 1227 - 1236
Abstract We are investigating an imaging agent that detects early-stage primary colorectal cancer on the mucosal surface in real time under colonoscopic... 
Internal Medicine | Toxicity study | Good Laboratory Practice | Colonoscopic imaging agent | Nanosphere | Colorectal cancer | IMMOBILIZED FLUORESCENT NANOSPHERES | THOMSEN-FRIEDENREICH ANTIGEN | DRUG | MEDICINE, RESEARCH & EXPERIMENTAL | NANOSCIENCE & NANOTECHNOLOGY | AMPHOTERICIN-B | DELIVERY | CURRENT STATE | NANOPARTICLES | HYDROPHILIC POLYMERIC CHAINS | EARLY COLORECTAL-CANCER | NANOTECHNOLOGY | Cricetulus | Peanut Agglutinin - administration & dosage | Rectum - pathology | Humans | Nanospheres - chemistry | Colon - drug effects | Body Weight - drug effects | Coumarins - chemistry | Male | Thiazoles - administration & dosage | Polystyrenes - toxicity | Colorectal Neoplasms - diagnosis | Polystyrenes - chemistry | Rectum - drug effects | Polystyrenes - administration & dosage | Colonoscopy | Acetamides - toxicity | Fluorescent Dyes - administration & dosage | Coumarins - toxicity | CHO Cells | Caco-2 Cells | Fluorescent Dyes - chemistry | Peanut Agglutinin - chemistry | Colon - pathology | Coumarins - administration & dosage | Rats | Nanospheres - toxicity | Peanut Agglutinin - toxicity | Eating - drug effects | Thiazoles - toxicity | Acetamides - chemistry | Animals | Polyvinyls - administration & dosage | Fluorescent Dyes - toxicity | Thiazoles - chemistry | Drinking - drug effects | Polyvinyls - toxicity | Polyvinyls - chemistry | Acetamides - administration & dosage | Nanospheres - administration & dosage | Imaging systems | Index Medicus
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2011, Volume 251, Issue 1, pp. 79 - 84
Biodegradable polymer-based nanoparticles have been widely studied to deliver therapeutic agents to the brain after intranasal administration. However,... 
WGA | Brain | Poly(ethylene glycol)-poly(lactic acid) nanoparticle | Immunogenicity | Intranasal | Toxicity | IMMUNE-RESPONSE | OXIDATIVE STRESS | GLUTAMATE RELEASE | RATS | ALPHA | NEUROTOXICITY | MEDIATED DRUG-DELIVERY | DISEASE | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | TOXICOLOGY | PLANT-LECTINS | L-Lactate Dehydrogenase - metabolism | Tumor Necrosis Factor-alpha - metabolism | Polymers - administration & dosage | Glutathione - metabolism | Male | Acetylcholine - metabolism | Olfactory Bulb - metabolism | Olfactory Bulb - immunology | Drug Carriers | Brain - metabolism | Nanoparticles | Amino Acids - metabolism | Time Factors | Drug Compounding | Polyesters | Interleukin-8 - metabolism | Lactic Acid - administration & dosage | Enzyme-Linked Immunosorbent Assay | Rats | Wheat Germ Agglutinins - toxicity | Wheat Germ Agglutinins - immunology | Polyethylene Glycols - toxicity | Administration, Intranasal | Rats, Sprague-Dawley | Chemistry, Pharmaceutical | Polyethylene Glycols - administration & dosage | Wheat Germ Agglutinins - administration & dosage | Brain - drug effects | Particle Size | Animals | Polymers - toxicity | Antibodies - blood | Lactic Acid - toxicity | Mice | Mice, Inbred BALB C | Brain - immunology | Lactic Acid - immunology | Olfactory Bulb - drug effects | Acetylcholinesterase - metabolism | Index Medicus | ANTIBODIES | POLYMERS | NERVOUS SYSTEM | POLYETHYLENE GLYCOLS | 60 APPLIED LIFE SCIENCES | ORGANIC POLYMERS | AMINO ACIDS | QUATERNARY AMMONIUM COMPOUNDS | GLYCOLS | VERTEBRATES | BRAIN | ORGANIC ACIDS | AUTONOMIC NERVOUS SYSTEM AGENTS | TOXICITY | CENTRAL NERVOUS SYSTEM | WHEAT | LACTIC ACID | PARASYMPATHOMIMETICS | RESPIRATORY SYSTEM | ENZYME IMMUNOASSAY | CARBOXYLIC ACIDS | PLANTS | IMMUNOASSAY | BODY | LILIOPSIDA | HEAD | PARTICLES | AMMONIUM COMPOUNDS | BIOASSAY | HYDROXY COMPOUNDS | ENZYMES | DRUGS | ESTERS | MAGNOLIOPHYTA | MICE | MAMMALS | ANIMALS | RODENTS | ACETYLCHOLINE | ORGANIC COMPOUNDS | HYDROXY ACIDS | NEUROREGULATORS | OLFACTORY BULBS | AGGLUTININS | NANOSTRUCTURES | IN VIVO | HEMIACETAL DEHYDROGENASES | LACTATE DEHYDROGENASE | ALCOHOLS | CEREALS | ORGANS | GRAMINEAE | NOSE | PROTEINS | FACE | OXIDOREDUCTASES
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 2011, Volume 413, Issue 1, pp. 184 - 193
Journal Article
Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1531 - 1543
We have investigated delivery of protein therapeutics from the bloodstream into the brain using a mouse model of late-infantile neuronal ceroid lipofuscinosis... 
blood brain barrier | intravenous | enzyme replacement therapy | tripeptidyl peptidase 1 | MEDICINE, RESEARCH & EXPERIMENTAL | WHEAT-GERM-AGGLUTININ | HORSERADISH-PEROXIDASE | LYSOSOMAL-ENZYME | TRANSPORT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ADSORPTIVE TRANSCYTOSIS | MOUSE MODEL | I ACTIVITY | GENETICS & HEREDITY | MANNOSE 6-PHOSPHATE RECEPTOR | POLYCATIONS | NEURONAL CEROID-LIPOFUSCINOSIS | Neuronal Ceroid-Lipofuscinoses - enzymology | Serine Proteases - genetics | Injections, Intravenous | Humans | Peptides - pharmacokinetics | Brain - enzymology | Infant | Apolipoproteins E - pharmacokinetics | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - deficiency | Neuronal Ceroid-Lipofuscinoses - pathology | Drug Carriers | Endocytosis | Neuronal Ceroid-Lipofuscinoses - genetics | Serine Proteases - deficiency | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Disease Models, Animal | Amino Acid Sequence | Neuronal Ceroid-Lipofuscinoses - therapy | Aminopeptidases - genetics | Peptides - chemistry | Endothelial Cells - metabolism | Gene Expression Regulation | Treatment Outcome | Aminopeptidases - deficiency | Blood-Brain Barrier - drug effects | Apolipoproteins E - chemistry | Blood-Brain Barrier - metabolism | Brain - drug effects | Enzyme Replacement Therapy - methods | Animals | Survival Analysis | Brain - pathology | Mice | Endothelial Cells - pathology | Endothelial Cells - drug effects | Animal models | Intravenous administration | Disease | Peptides | Toxicity | Liver | Experiments | Proteins | Blood-brain barrier | Apolipoprotein E | Neuronal ceroid lipofuscinosis | Drug dosages | Enzymes | Peptidase | Kidneys | Biotin | Grants | Endothelial cells | Studies | Brain research | Life span | Morphology | Scientific imaging | Mass spectrometry | Cancer | Index Medicus | Original
Journal Article
Proceedings of the Royal Society B: Biological Sciences, ISSN 0962-8452, 07/2014, Volume 281, Issue 1787, pp. 20140619 - 20140619
Journal Article