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Journal of molecular biology, ISSN 0022-2836, 06/2019
The selective degradation of protein aggregates is called aggrephagy. Misfolded proteins are thought to form aggregates, which are then surrounded by selective... 
Journal Article
Autophagy, ISSN 1554-8627, 08/2019, Volume 15, Issue 8, pp. 1475 - 1477
Macroautophagy/autophagy mediates the degradation of ubiquitinated aggregated proteins within lysosomes in a process known as aggrephagy. The cargo receptor... 
phase separation | autophagy | Aggrephagy | protein quality control | ULK1 | Atg8 | autophagosome | cargo receptor | CELL BIOLOGY
Journal Article
Autophagy, ISSN 1554-8627, 07/2018, Volume 14, Issue 7, pp. 1280 - 1282
The degradation of misfolded, ubiquitinated proteins is essential for cellular homeostasis. These proteins are primarily degraded by the ubiquitin-proteasome... 
quality control | aggrephagy | Selective autophagy | phase transition | p62 | LC3 | cargo receptor | ubiquitin | CELL BIOLOGY
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 193 - 224
Autophagy and the ubiquitin-proteasome system are the two major quality control pathways responsible for cellular homeostasis. As such, they provide protection... 
xenophagy | proteasome | mitophagy | autophagy | chaperone | ubiquitination | aggrephagy | organelle homeostasis | UPS | p62-Keap1-Nrf2 | proteostasis | P62-Keap1-Nrf2 | Ubiquitination | Xenophagy | Proteostasis | Aggrephagy | Chaperone | Organelle homeostasis | Mitophagy | Autophagy | Proteasome | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | YEAST 26S PROTEASOME | QUALITY-CONTROL | SELECTIVE AUTOPHAGY | TRANSCRIPTION FACTOR NRF1 | MITOCHONDRIAL DYNAMICS | SYNUCLEIN IMPAIRS MACROAUTOPHAGY | N-TERMINAL DOMAIN | UBIQUITIN LIGASE MARCH5 | Molecular Chaperones - metabolism | Humans | Ubiquitin - metabolism | Homeostasis | Eukaryotic Cells - metabolism | Kelch-Like ECH-Associated Protein 1 - chemistry | Mitochondrial Degradation - genetics | Kelch-Like ECH-Associated Protein 1 - genetics | Proteolysis | NF-E2-Related Factor 2 - genetics | Autophagy - genetics | Sequestosome-1 Protein - chemistry | Sequestosome-1 Protein - metabolism | Signal Transduction | Gene Expression Regulation | Molecular Chaperones - genetics | Kelch-Like ECH-Associated Protein 1 - metabolism | Ubiquitin - genetics | Sequestosome-1 Protein - genetics | NF-E2-Related Factor 2 - metabolism | Protein Conformation | Eukaryotic Cells - cytology | NF-E2-Related Factor 2 - chemistry | Proteasome Endopeptidase Complex - metabolism | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Ubiquitin-proteasome system
Journal Article
Autophagy, ISSN 1554-8627, 05/2019, Volume 15, Issue 5, pp. 924 - 926
The formation of protein aggregates is linked to several diseases collectively called proteinopathies. The mechanisms and the molecular players that control... 
NFE2L2/NRF2 | SQSTM1/p62 | autophagy | Aggrephagy | protein homeostasis | neurodegeneration | protein quality control | cancer | protein aggregates | TRIM16 | oxidative stress | CELL BIOLOGY
Journal Article
Journal of cell science, ISSN 0021-9533, 10/2018, Volume 131, Issue 19, p. jcs214304
The degradation of misfolded proteins is essential for cellular homeostasis. Misfolded proteins are normally degraded by the ubiquitin-proteasome system (UPS),... 
Degradation | Proteostasis | Aggrephagy | Cargo receptor | Lysosome | Quality control | Selective autophagy | SQSTM1 | AMYOTROPHIC-LATERAL-SCLEROSIS | DEFICIENT MICE | SYNTAXIN 17 | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | PROTEIN CONJUGATION | TARGETING PATHWAY | ENDOPLASMIC-RETICULUM | HOPS COMPLEX | SQSTM1 MUTATIONS
Journal Article
Autophagy, ISSN 1554-8627, 01/2019, Volume 15, Issue 1, pp. 180 - 181
During macroautophagy/autophagy, SQSTM1/p62 plays dual roles as a key mediator of cargo selection and as an autophagic substrate. SQSTM1 links N-degrons and/or... 
N-end rule | autophagy adaptor | pH-dependent oligomerization | Aggrephagy | UBR box | HSPA5/BiP/GRP78 | CELL BIOLOGY
Journal Article
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35, ISSN 1081-0706, 10/2019, Volume 35, Issue 1, pp. 477 - 500
Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are... 
neuronal homeostasis | ERphagy | neurodegeneration | mitophagy | autophagy | aggrephagy | CYTOSKELETAL COMPONENTS | ENDOPLASMIC-RETICULUM TURNOVER