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Plant Physiology, ISSN 0032-0889, 12/2005, Volume 139, Issue 4, pp. 1635 - 1648
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e79977 - e79977
We previously demonstrated that mitochondrial bioenergetic deficits in the female brain accompanied reproductive senescence and was accompanied by a shift from... 
MECHANISM | ASTROCYTE | MULTIDISCIPLINARY SCIENCES | LACTATE | DISEASE | HIPPOCAMPAL | ESTRADIOL | COGNITIVE IMPAIRMENT | ENERGY-METABOLISM | EXPRESSION | OLIGODENDROCYTES | Adaptation, Physiological | Ketone Oxidoreductases - metabolism | Neurons - pathology | Humans | Ketone Bodies - metabolism | Astrocytes - pathology | Glucose Transporter Type 1 - metabolism | Alzheimer Disease - pathology | Biological Transport, Active | Monocarboxylic Acid Transporters - metabolism | Aging - genetics | Female | Neurons - metabolism | Hexokinase - genetics | Disease Models, Animal | Gene Expression | Lactic Acid - metabolism | Mice, Transgenic | Hippocampus - pathology | Mitochondria - metabolism | Ketone Oxidoreductases - genetics | Aging - pathology | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Animals | Energy Metabolism | Glucose Transporter Type 1 - genetics | Alzheimer Disease - metabolism | Glucose - metabolism | Mice | Monocarboxylic Acid Transporters - genetics | Alzheimer Disease - genetics | Hexokinase - metabolism | Aging - metabolism | Astrocytes - metabolism | Lactates | Glucose metabolism | Enzymes | Brain | Neurons | Glucose | Alzheimer's disease | Dextrose | Neurosciences | Senescence | Adaptive systems | Dehydrogenases | Pyruvic acid | Ketone bodies | Fuels | Mitochondria | Bioenergetics | Blood-brain barrier | Rodents | Aging | Pharmaceutical sciences | Age | Glucose transporter | Phenotypes | Medical imaging | Neurodegenerative diseases | Ketones | Astrocytes | Pharmacology | Metabolism | Glucose transport | Fatty acids | Hexokinase | Utilization | Pharmacy | Glycolysis | Lactic acid | Laboratory animals | Transport | Alzheimers disease | Axonal transport | Transporter | Hippocampus | Animal cognition | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, pp. e19194 - e19194
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as an... 
Biomarkers - metabolism | Sirtuin 1 - metabolism | Protein Carbonylation | Electron Transport | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Mitochondria - metabolism | Aldehydes - metabolism | Organ Specificity | Brain - metabolism | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Intracellular Space - metabolism | Female | Acetylation | DNA Damage | Enzyme Activation | Lipid Peroxidation | NAD - metabolism | Aging - metabolism | Antioxidants | Tyrosine | Niacinamide | Purines | Enzymes | Ionizing radiation | DNA damage | Tumor proteins | Sugars | Monosaccharides | Apoptosis | Dehydrogenases | Syngeneic grafts | Oxidative metabolism | Liver | p53 Protein | Lung | Neurobiology | Poly(ADP-ribose) | Lipid peroxidation | ADP | Proteins | Electron transport chain | Signal transduction | Mitochondria | Animal tissues | Aging | Physiology | Chronic obstructive pulmonary disease | Deoxyribonucleic acid--DNA | Peroxidation | Liver diseases | Longevity | Metabolism | Gene expression | Overexpression | Nicotinamide adenine dinucleotide | Nicotinamide | NADPH | Oxidative stress | Carbonyl compounds | Neurosciences | Senescence | Biosynthesis | DNA repair | NADH | Ribose | Rodents | Cell cycle | Age | Carbonyls | Kidneys | Organs | Poly(ADP-ribose) polymerase | Adenine | Histology | Pharmacology | Polymerase | NAD | Lungs | Intracellular | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Neuron, ISSN 0896-6273, 01/2015, Volume 85, Issue 2, pp. 296 - 302
Journal Article
Nature, ISSN 0028-0836, 10/2010, Volume 467, Issue 7318, pp. 972 - 976
Reciprocity of inflammation, oxidative stress and neovascularization is emerging as an important mechanism underlying numerous processes from tissue healing... 
SYSTEM | TOLL-LIKE RECEPTOR-2 | CELLS | PATTERN-RECOGNITION | MULTIDISCIPLINARY SCIENCES | MACULAR DEGENERATION | CD36 | CHRONIC INFLAMMATION | CANCER | INNATE IMMUNITY | Neovascularization, Physiologic - drug effects | Toll-Like Receptor 2 - agonists | Melanoma - blood supply | Humans | Oxidative Stress - physiology | Vascular Endothelial Growth Factor A - metabolism | Inflammation - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Wound Healing - drug effects | Receptors, Scavenger - metabolism | Melanoma - metabolism | Cell Line | Pyrroles - metabolism | Oxidation-Reduction | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Ischemia - metabolism | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Immunity, Innate - immunology | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Propionates | Pyrroles - chemistry | Ligands | Mice | Neovascularization, Pathologic - metabolism | Wound Healing - physiology | Aorta - cytology | Hindlimb - metabolism | Myeloid Differentiation Factor 88 - metabolism | rac1 GTP-Binding Protein - metabolism | Aging - metabolism | Cell Movement | Oxidative stress | Complications and side effects | Cell receptors | Physiological aspects | Genetic aspects | Research | Neovascularization | Vascular endothelial growth factor | Angiogenesis | Wound healing | Rodents | Atherosclerosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 448 - 454
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are... 
LIFE-SPAN | CAENORHABDITIS-ELEGANS | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ANALYSIS | NEURONS | MILD COGNITIVE IMPAIRMENT | SEL-12 PRESENILIN | REPRESSOR | C. ELEGANS | Neurons - pathology | Up-Regulation | Humans | Oxidative Stress - physiology | Caenorhabditis elegans Proteins - metabolism | Phagosomes | Neurons - cytology | Cognition | Autophagy | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Brain - metabolism | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Young Adult | Cell Nucleus - metabolism | Aging - genetics | Cell Death - genetics | Chromatin Immunoprecipitation | Repressor Proteins - deficiency | Aged, 80 and over | Neurons - metabolism | Repressor Proteins - metabolism | Wnt Signaling Pathway | Frontotemporal Dementia - pathology | Brain - cytology | Amyloid beta-Peptides - toxicity | Cognitive Dysfunction - metabolism | Down-Regulation | Gene Expression Regulation | Lewy Body Disease - pathology | Oxidative Stress - genetics | Repressor Proteins - genetics | Longevity | Aging - pathology | Lewy Body Disease - metabolism | Transcription Factors - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Alzheimer Disease - metabolism | Brain - pathology | Aged | Mice | Alzheimer Disease - genetics | Aging - metabolism | Oxidative stress | Control | Transcription factors | Neurons | Aging | Physiological aspects | Genetic aspects | Research | Alzheimer's disease | Studies | Pathology | Cognitive ability | Epigenetics | Kinases | Stress response | Gene expression | Alzheimers disease | Age | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 119 - 123
Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the hydrolysis of triglycerides(1), declines with age(2,3). The... 
MONOAMINE-OXIDASE | CELLS | OBESITY | ACTIVATION | MULTIDISCIPLINARY SCIENCES | ACCUMULATION | IDENTIFICATION | GENE ONTOLOGY | DEFICIENCY | ADIPOSE-TISSUE | AGE | Inflammasomes - metabolism | Lipolysis - drug effects | Catecholamines - metabolism | Growth Differentiation Factor 3 - metabolism | Sterol Esterase - metabolism | Aging - drug effects | Adipose Tissue - cytology | Caspase 1 - metabolism | Gene Expression Profiling | Growth Differentiation Factor 3 - deficiency | Lipolysis - genetics | Adipose Tissue - metabolism | Aging - genetics | Monoamine Oxidase Inhibitors - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Lipase - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Norepinephrine - metabolism | Growth Differentiation Factor 3 - genetics | Adipocytes - metabolism | Mice | Adipose Tissue - drug effects | Catecholamines - pharmacology | Aging - metabolism | Monoamine Oxidase - metabolism | Aging | Observations | Catecholamine metabolism | Health aspects | Elderly people | Adipose tissue | Oxidase | Genomes | Adipocytes | Kinases | Macrophages | Lipase | Caspase-1 | Reduction | Energy resources | Clonal deletion | Deletion | Noradrenaline | Age | Enzymes | Starvation | Fasting | Body temperature | Aging (artificial) | Glycerol | Caspase | Principal components analysis | Triglycerides | Inflammation | Bioavailability | Metabolism | Gene expression | Sympathetic nervous system | Catecholamine | Fatty acids | Substrates | Lipolysis | Amine oxidase (flavin-containing) | Signaling | Catabolism | Norepinephrine | Elderly | Geriatrics | Index Medicus
Journal Article
Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | 3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | PI3K delta | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Index Medicus | Original
Journal Article