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agrin (538) 538
mice (393) 393
agrin - metabolism (356) 356
neurosciences (340) 340
humans (332) 332
receptors, cholinergic - metabolism (323) 323
biochemistry & molecular biology (214) 214
cell biology (210) 210
neuromuscular junction (210) 210
rats (205) 205
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neuromuscular junction - metabolism (178) 178
skeletal-muscle (163) 163
agrin - genetics (157) 157
receptor protein-tyrosine kinases - metabolism (147) 147
proteins (141) 141
extracellular-matrix (131) 131
cell line (130) 130
expression (130) 130
animal structures (123) 123
phosphorylation (122) 122
in-vivo (121) 121
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muscle, skeletal - metabolism (114) 114
molecular sequence data (112) 112
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neurons (104) 104
basal lamina (102) 102
female (101) 101
amino acid sequence (99) 99
muscle fibers, skeletal - metabolism (96) 96
muscle (94) 94
synapses (94) 94
immunohistochemistry (93) 93
research (92) 92
acetylcholine receptor (89) 89
protein (88) 88
signal transduction (87) 87
neuromuscular junction - physiology (86) 86
laminin (85) 85
synapse formation (84) 84
synapses - metabolism (84) 84
protein binding (82) 82
synaptogenesis (82) 82
acetylcholine-receptor (80) 80
heparan-sulfate proteoglycan (80) 80
torpedo electric organ (80) 80
agrin - physiology (79) 79
membrane glycoproteins - metabolism (79) 79
alpha-dystroglycan (78) 78
article (78) 78
chick embryo (78) 78
dystroglycans (77) 77
laminin - metabolism (77) 77
muscle proteins - metabolism (77) 77
synapses - physiology (76) 76
cytoskeletal proteins - metabolism (73) 73
dystroglycan (72) 72
physiological aspects (72) 72
receptors, cholinergic - genetics (71) 71
analysis (70) 70
acetylcholine-receptors (69) 69
mice, knockout (68) 68
agrin - chemistry (67) 67
extracellular matrix (67) 67
acetylcholine (66) 66
receptor protein-tyrosine kinases - genetics (64) 64
synapse (64) 64
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developmental biology (62) 62
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neurology (59) 59
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rodents (58) 58
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multidisciplinary sciences (57) 57
neurons - metabolism (57) 57
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mutation (56) 56
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agrin receptor (55) 55
mice, inbred c57bl (54) 54
musculoskeletal system (54) 54
tyrosine phosphorylation (53) 53
neuromuscular-junctions (52) 52
gene-expression (51) 51
muscle, skeletal - innervation (51) 51
mutant mice (51) 51
antibodies (50) 50
motor neurons (50) 50
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The American Journal of Human Genetics, ISSN 0002-9297, 08/2009, Volume 85, Issue 2, pp. 155 - 167
We report the case of a congenital myasthenic syndrome due to a mutation in , the gene encoding agrin, an extracellular matrix molecule released by the nerve... 
MUTANT MICE | PROTEIN | DEFICIENT | GENETICS & HEREDITY | MUSCULAR-DYSTROPHY | SKELETAL-MUSCLE FIBERS | DIFFERENTIATION | NEUROMUSCULAR-JUNCTION | DYSTROGLYCAN | BINDING | ACETYLCHOLINE-RECEPTOR | Agrin - chemistry | Models, Chemical | Neuromuscular Junction - metabolism | Humans | Dystroglycans - metabolism | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - metabolism | Mutation, Missense | Agrin - metabolism | Muscle, Skeletal - surgery | Synapses - metabolism | DNA Mutational Analysis | Neuromuscular Junction - genetics | Adult | Female | Myasthenic Syndromes, Congenital - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Agrin - genetics | Cell Line | Receptors, Cholinergic - metabolism | Muscle, Skeletal - ultrastructure | Rats | Recombinant Proteins - chemistry | Neuromuscular Junction - ultrastructure | Receptors, Cholinergic - physiology | Animals | Biopsy | Pedigree | Muscle Fibers, Skeletal - cytology | Muscle, Skeletal - pathology | Neuromuscular Junction - physiology | Receptors, Cholinergic - genetics | Myasthenia gravis | Gene mutations | Analysis | Physiological aspects | Genetic aspects | Research | Neuromuscular junction | Synapses | Cell culture | Glycoproteins | Genetic disorders | Mutation | Muscular system | Rodents | Index Medicus | Life Sciences | Genetics | Neurons and Cognition
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2005, Volume 168, Issue 2, pp. 193 - 199
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective degeneration of motor neurons, atrophy, and... 
Protein isoforms | Motor neurons | Nervous system diseases | Spinal cord | Muscular diseases | Transgenic animals | Motor neuron disease | Muscles | Amyotrophic lateral sclerosis | Reports | Skeletal muscle | SKELETAL-MUSCLE | HYPERTROPHY | REGENERATION | DISEASE | CALCINEURIN | MICE | ASSOCIATION | GROWTH-FACTOR-I | GATA-2 | CELL BIOLOGY | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Superoxide Dismutase - genetics | Central Nervous System - metabolism | Gene Expression - genetics | Neuromuscular Junction - metabolism | Homeodomain Proteins - metabolism | Humans | PAX7 Transcription Factor | Central Nervous System - pathology | Muscle, Skeletal - metabolism | Insulin-Like Growth Factor I - genetics | Glial Fibrillary Acidic Protein - metabolism | Myosin Heavy Chains - metabolism | Motor Neurons - pathology | Calcineurin - genetics | Muscle, Skeletal - chemistry | Central Nervous System - chemistry | Superoxide Dismutase - metabolism | Disease Models, Animal | Agrin - genetics | Receptors, Cholinergic - metabolism | Mice, Transgenic | Satellite Cells, Skeletal Muscle - metabolism | Survival Rate | Blotting, Western | Protein Isoforms - physiology | Amyotrophic Lateral Sclerosis - mortality | Motor Neurons - metabolism | Walking | Amyotrophic Lateral Sclerosis - pathology | Blotting, Northern | Animals | Insulin-Like Growth Factor I - physiology | Desmin - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Satellite Cells, Skeletal Muscle - chemistry | Muscle Fibers, Skeletal - cytology | Mice | Muscle, Skeletal - pathology | Superoxide Dismutase-1 | Calcineurin - metabolism | Astrocytes - metabolism | Protein Isoforms - genetics | Receptors, Cholinergic - genetics | Neurons | Rodents | Motor ability | Models | Muscular system | Gene expression | Index Medicus | s
Journal Article
Nature Communications, ISSN 2041-1723, 01/2015, Volume 6, Issue 1, pp. 6184 - 6184
Journal Article
Neuron, ISSN 0896-6273, 2008, Volume 60, Issue 2, pp. 285 - 297
Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by... 
CELLBIO | MOLNEURO | SIGNALING | ADULT-RAT BRAIN | POSTSYNAPTIC DIFFERENTIATION | TYROSINE PHOSPHORYLATION | ACETYLCHOLINE-RECEPTOR AGGREGATION | IN-VIVO | SYNAPSE FORMATION | NEUROMUSCULAR-JUNCTION | BETA-CATENIN | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | MUSCLE-SPECIFIC KINASE | Phosphorylation | Synaptic Transmission - genetics | Neuromuscular Junction - metabolism | Humans | Muscle Fibers, Skeletal - metabolism | Presynaptic Terminals - ultrastructure | Agrin - metabolism | Motor Neurons - ultrastructure | Neuromuscular Junction - embryology | Receptor Aggregation - genetics | Muscle Fibers, Skeletal - ultrastructure | Neuromuscular Junction - genetics | Agrin - genetics | Cell Line | Receptors, LDL - genetics | Receptors, Cholinergic - metabolism | Receptors, LDL - metabolism | Signal Transduction - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Synaptic Membranes - ultrastructure | Motor Neurons - metabolism | Tyrosine - metabolism | Animals | Receptor Protein-Tyrosine Kinases - genetics | Receptors, Cholinergic - ultrastructure | Presynaptic Terminals - metabolism | Mice | Synaptic Membranes - metabolism | Protein Binding - physiology | Receptors, Cholinergic - genetics | Synaptic Membranes - genetics | Tyrosine | Neurons | Autonomic drugs | Low density lipoproteins | Proteins | Software | Epidermal growth factor | Muscular system | Index Medicus
Journal Article
NATURE, ISSN 0028-0836, 07/2017, Volume 547, Issue 7662, pp. 179 - 179
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2018, Volume 27, Issue 8, pp. 1434 - 1446
Abstract Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterized by compromised function of the neuromuscular junction,... 
MARIE-TOOTH-DISEASE | PROTEIN | NEURITE OUTGROWTH | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOSIN IXA | GENETICS & HEREDITY | ACTIN-FILAMENTS | CONGENITAL MYASTHENIC SYNDROME | AMYOTROPHIC-LATERAL-SCLEROSIS | MUTATIONS | ZEBRAFISH EMBRYO | Intermediate Filaments - genetics | Enzyme Inhibitors | Neuromuscular Junction - metabolism | Humans | Actins - metabolism | Amides | Tubulin - genetics | Agrin - metabolism | Intermediate Filaments - metabolism | Muscle Weakness - genetics | Motor Neurons - ultrastructure | Actins - genetics | Myosins - deficiency | Tubulin - metabolism | Muscle Weakness - pathology | Myasthenic Syndromes, Congenital - pathology | Membrane Proteins - metabolism | Disease Models, Animal | Myasthenic Syndromes, Congenital - genetics | Agrin - genetics | Pyridines | Actin Cytoskeleton - metabolism | Nerve Growth Factor - metabolism | Membrane Proteins - genetics | rho GTP-Binding Proteins - genetics | Gene Expression Regulation | Nerve Growth Factor - genetics | Zebrafish | Myosins - genetics | Neuromuscular Junction - ultrastructure | Protein Transport | Motor Neurons - metabolism | Myasthenic Syndromes, Congenital - metabolism | Animals | rho GTP-Binding Proteins - metabolism | Embryo, Nonmammalian | Muscle Weakness - metabolism | Mice | Actin Cytoskeleton - ultrastructure | Cell Movement | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 11/2010, Volume 24, Issue 21, pp. 2451 - 2461
Agrin, released by motor neurons, promotes neuromuscular synapse formation by stimulating MuSK, a receptor tyrosine kinase expressed in skeletal muscle.... 
Receptor tyrosine kinase | Synapse formation | Neuromuscular synapse | Acetylcholine receptor | Congenital myasthenia | Mouse development | congenital myasthenia | AGRIN | MUSK | TYROSINE KINASE | MUSCLE | RECEPTOR | DEVELOPMENTAL BIOLOGY | ABL | synapse formation | JUNCTION | CELL BIOLOGY | acetylcholine receptor | GENETICS & HEREDITY | receptor tyrosine kinase | MICE | mouse development | MUTATIONS | ADAPTER PROTEIN | Neuromuscular Junction - metabolism | Humans | Muscle, Skeletal - metabolism | Green Fluorescent Proteins - genetics | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Synapses - metabolism | Time Factors | HEK293 Cells | Muscle Proteins - metabolism | Proto-Oncogene Proteins c-crk - metabolism | Muscle, Skeletal - embryology | Phosphorylation - drug effects | Nuclear Proteins - genetics | Cell Line | Green Fluorescent Proteins - metabolism | Receptors, Cholinergic - metabolism | Agrin - pharmacology | Nuclear Proteins - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins c-crk - genetics | Blotting, Western | Mice, Knockout | Muscle Proteins - genetics | Microscopy, Confocal | Tyrosine - metabolism | Animals | Receptor Protein-Tyrosine Kinases - genetics | Adaptor Proteins, Signal Transducing - genetics | Muscle Fibers, Skeletal - cytology | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Receptors, Cholinergic - genetics | Tyrosine - genetics | Research | Gene mutations | Phosphotransferases | Analysis | Synapses | Index Medicus | Research Paper
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2011, Volume 25, Issue 12, pp. 4378 - 4393
Journal Article
Brain Research, ISSN 0006-8993, 2009, Volume 1301, pp. 152 - 162
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2005, Volume 94, Issue 6, pp. 1488 - 1499
Glial cell line‐derived neurotrophic factor (GDNF), a known survival factor for neurons, has recently been shown to stimulate the migration of Schwann cells... 
myelination | glial cells | glial cell line‐derived neurotrophic factor | growth factors | signal transduction | neural cell adhesion molecule | Signal transduction | Glial cell line-derived neurotrophic factor | Myelination | Neural cell adhesion molecule | Glial cells | Growth factors | PROTEIN-KINASE-C | INDEPENDENT MECHANISMS | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | MYELIN-ASSOCIATED GLYCOPROTEIN | glial cell line-derived neurotrophic factor | N-CAM | CYCLIC-AMP | ADHESION MOLECULE | SCIATIC-NERVE | NUCLEAR FACTOR CREB | NEURONAL CELLS | Membrane Microdomains - metabolism | Nerve Regeneration - physiology | Cell Communication - physiology | Nerve Growth Factors - metabolism | Agrin - metabolism | Myelin Sheath - metabolism | Protein Kinase C - metabolism | Glial Cell Line-Derived Neurotrophic Factor | Up-Regulation - physiology | Proto-Oncogene Proteins c-ret | Animals, Newborn | Cyclic AMP-Dependent Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Axons - metabolism | Rats | Schwann Cells - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Up-Regulation - drug effects | Animals | Glial Cell Line-Derived Neurotrophic Factor Receptors | Cyclic AMP Response Element-Binding Protein - metabolism | Neural Cell Adhesion Molecules - metabolism | Signal Transduction - physiology | Neurons, Afferent - metabolism | Cell Line, Transformed | Ganglia, Spinal - metabolism | Cell division | Tissue | Glycosylation | Neurons | Index Medicus
Journal Article