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Nature Medicine, ISSN 1078-8956, 11/2010, Volume 16, Issue 11, pp. 1299 - 1304
Bitter taste receptors (TAS2Rs) on the tongue probably evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CONTRACTILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELAXATION | CELL BIOLOGY | HETEROGENEITY | LACTONES | ASTHMA | CHANNELS | MAMMALIAN TASTE | EXPRESSION | SPARKS | Asthma - metabolism | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Bronchi - physiopathology | Myocytes, Smooth Muscle - pathology | RNA, Messenger - metabolism | Airway Obstruction - metabolism | Bronchi - drug effects | Dose-Response Relationship, Drug | Muscle, Smooth - drug effects | Muscle Relaxation - physiology | Bronchoconstriction - drug effects | Bronchi - metabolism | Bronchi - pathology | Myocytes, Smooth Muscle - metabolism | Membrane Potentials - drug effects | Bronchoconstriction - physiology | Asthma - physiopathology | Cell Separation | RNA, Messenger - genetics | Airway Obstruction - physiopathology | Muscle, Smooth - metabolism | Membrane Potentials - physiology | Taste - physiology | Gene Expression Regulation - drug effects | Animals | Taste - drug effects | Asthma - complications | Calcium Signaling - drug effects | Airway Obstruction - pathology | Muscle, Smooth - physiopathology | Mice | Receptors, G-Protein-Coupled - genetics | Muscle Relaxation - drug effects | Muscle, Smooth - pathology | Saccharin - pharmacology | Taste buds | Care and treatment | Usage | Animal models in research | Physiological aspects | Smooth muscle | Genetic aspects | Airway obstruction (Medicine) | Research | Risk factors | Signal transduction | Taste | Calcium | Cellular biology | Respiratory diseases
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 11/2014, Volume 51, Issue 5, pp. 709 - 720
Whereas cigarette smoking remains the main risk factor for emphysema, recent studies in beta-epithelial Na+ channel-transgenic (beta ENaC-Tg) mice demonstrated... 
Airway surface liquid | Cystic fibrosis | Chronic obstructive pulmonary disease | Inflammation | Mucus | SURFACE DEHYDRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBROSIS LUNG-DISEASE | LESSONS | mucus | CELL BIOLOGY | PATHOGENESIS | inflammation | RESPIRATORY SYSTEM | cystic fibrosis | CHANNEL-OVEREXPRESSING MICE | ELASTASE | GENE-EXPRESSION | airway surface liquid | CYSTIC-FIBROSIS | PULMONARY-DISEASE | chronic obstructive pulmonary disease | Genomics | Bronchoalveolar Lavage Fluid - immunology | Matrix Metalloproteinase 12 - genetics | Pulmonary Emphysema - metabolism | STAT6 Transcription Factor - genetics | Airway Obstruction - metabolism | Cystic Fibrosis - immunology | Signal Transduction - immunology | Airway Obstruction - immunology | Mucus - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Macrophages, Alveolar - immunology | Cystic Fibrosis - metabolism | Macrophage Activation - immunology | Dehydration - immunology | Matrix Metalloproteinase 12 - immunology | Matrix Metalloproteinase 12 - metabolism | STAT6 Transcription Factor - metabolism | STAT6 Transcription Factor - immunology | Pulmonary Emphysema - immunology | Mice, Knockout | Animals | Cystic Fibrosis - genetics | Polymorphism, Single Nucleotide - genetics | Mucus - immunology | Macrophages, Alveolar - metabolism | Pulmonary Disease, Chronic Obstructive - immunology | Dehydration - metabolism | Studies | Lungs | Microscopy | Pathogenesis | Rodents | Lung diseases | Genomes | Cigarettes | Gene expression | Emphysema
Journal Article
Mediators of Inflammation, ISSN 0962-9351, 2015, Volume 2015, pp. 408935 - 11
Journal Article
Respiratory Medicine, ISSN 0954-6111, 08/2018, Volume 141, pp. 159 - 164
Airflow limitation in COPD is caused by a mixture of small airways obstruction and alveolar destruction. To evaluate the contributions of these factors to... 
Chronic obstructive pulmonary disease | Small airway | Alveolar destruction | Vascular endothelial growth factor | Induced sputum | Pentosidine | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPUTED-TOMOGRAPHY | PATHOGENESIS | RESPIRATORY SYSTEM | EMPHYSEMA | ASTHMATIC-PATIENTS | RAT LUNG COLLAGEN | ENDOTHELIAL GROWTH-FACTOR | GLYCATION END-PRODUCTS | COPD | Severity of Illness Index | Lysine - analogs & derivatives | Nitrogen - metabolism | Pulmonary Alveoli - pathology | Humans | Middle Aged | Airway Obstruction - physiopathology | Tomography, X-Ray Computed - methods | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Vascular Endothelial Growth Factor A - metabolism | Pulmonary Disease, Chronic Obstructive - pathology | Airway Obstruction - metabolism | Arginine - analogs & derivatives | Sputum - metabolism | Smoking - metabolism | Airway Obstruction - complications | Female | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Aged | Lysine - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Arginine - metabolism | Lung diseases, Obstructive | Endothelial growth factors | Analysis | Endothelium | Correlation | Destruction | Editing | Respiratory tract | Airway management | Computed tomography | Measurement methods | Extracellular matrix | Attenuation | Physiology | Alveoli | Evaluation | Lung diseases | Nitrogen | Disease control | Patients | Pathology | Air flow | Lungs | Obstructive lung disease | Sputum | Biomarkers | Data collection | Emphysema
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 1, pp. 68 - 74.e4
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 3, pp. 767 - 773.e6
Journal Article