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Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 2, pp. 231 - 241
AS 160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4) translocation, but is widely expressed in insulin-insensitive... 
14-3-3 | Akt/protein kinase B (PKB) | GTPase-activating protein (GAP) | p90 ribosomal S6 kinase (RSK) | Akt substrate of 160 kDa (AS160) | Serum- and glucocorticoid-induced protein kinase (SGK) | MOUSE SKELETAL-MUSCLE | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | Akt substrate of 160kDa (AS160) | AKT SUBSTRATE | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | INSULIN-STIMULATED PHOSPHORYLATION | GLUT4 TRANSLOCATION | S6 KINASE | PROTEOMIC ANALYSIS | RAB-GAP | serum- and glucocorticoid-induced protein kinase (SGK) | Cell Line | Insulin-Like Growth Factor I - pharmacology | Phosphorylation | Humans | GTPase-Activating Proteins - metabolism | Insulin | Amino Acids | Aminoimidazole Carboxamide - pharmacology | Hypoglycemic Agents - pharmacology | 14-3-3 Proteins - metabolism | Ribonucleotides - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Protein Binding | Epidermal Growth Factor - pharmacology | Binding Sites | Index Medicus | ACC, acetyl-CoA carboxylase | AGC kinase, protein kinase A | AICAR, 5-amino-4-imidazolecarboxamide1-β-D-ribofuranoside | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | TOS motif, mTOR signalling motif | PAS, phospho-Akt substrate | pSer, phosphorylated serine | TSC, tuberous sclerosis complex | AS160, Akt substrate of 160 kDa | PKB, protein kinase B (also known as Akt) | AMPK, AMP-activated protein kinase | RSK, p90 ribosomal S6 kinase | DSP, dithiobis(succinimidyl propionate) | protein kinase C-family | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase B (PKB) | IGF-1, insulin-like growth factor-1 | Akt substrate of 160 kDa (AS160) | GLUT4, glucose transporter 4 | protein kinase G | mTOR, mammalian target of rapamycin | TORC1, mTOR–raptor (regulatory associated protien of mTOR) complex | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | GST, glutathione S-transferase | PKC, protein kinase C | PP2A, protein phosphatase 2A | Akt | SGK, serum- and glucocorticoid-induced protein kinase | HA, haemagglutinin | GSV, GLUT4 storage vesicle | p70S6K, p70 S6 kinase | PTB, phosphotyrosine binding domain | pThr, phosphorylated threonine | GAP, GTPase-activating protein | HEK-293, human embryonic kidney-293 | IRAP, insulin-responsive aminopeptidase | Rheb, Ras enriched in brain | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7497, pp. 541 - 545
Journal Article
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 14, pp. 5295 - 5303
ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and endometrioid carcinomas, endometrial, and breast carcinomas. They... 
BAF250a | Endometriosis associated ovarian carcinomas | Endometrial cancer | Perifosine | AKT-inhibitor | Buparlisib (BKM120) | Breast cancer | ARID1A | PI3K/AKT pathway | PIK3CA | SWI/SNF | MK-2206 | PI3K-inhibitor | AKT phosphorylation | Ovarian clear cell carcinomas | Apoptosis | RNA, Small Interfering - genetics | Phosphorylation | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Transcription Factors - deficiency | Phosphatidylinositol 3-Kinases - metabolism | Phosphorylcholine - analogs & derivatives | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Breast Neoplasms - therapy | Breast Neoplasms - enzymology | Transfection | MCF-7 Cells | Nuclear Proteins - biosynthesis | Nuclear Proteins - deficiency | Phosphorylcholine - pharmacology | Female | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Morpholines - pharmacology | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Transcription Factors - metabolism | Breast Neoplasms - pathology | Aminopyridines - pharmacology | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | RNA, Small Interfering - administration & dosage | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2017, Volume 118, Issue 12, pp. 4498 - 4507
Journal Article
ISSN 0950-1991, 08/2017, Volume 144, Issue 15, pp. e1.2 - e1.2
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 11, pp. e0207285 - e0207285
TGF beta promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. Both mTORC1 and mTORC2 are... 
FIBRONECTIN EXPRESSION | MESANGIAL CELL HYPERTROPHY | GROWTH-FACTOR-BETA | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | TUBULAR EPITHELIAL-CELL | HIGH GLUCOSE | GENE-EXPRESSION | KINASE-B-GAMMA | DIABETIC-NEPHROPATHY | RENAL-DISEASE | Cell Line | Fibronectins - biosynthesis | Phosphorylation | Podocytes - metabolism | Down-Regulation | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Rats | Phosphatidylinositol 3-Kinases - metabolism | Podocytes - pathology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Rats, Sprague-Dawley | Mechanistic Target of Rapamycin Complex 1 - biosynthesis | Gene Expression Regulation, Enzymologic | Transforming Growth Factor beta - pharmacology | Animals | TOR Serine-Threonine Kinases - biosynthesis | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Transforming Growth Factor beta - metabolism | Mechanistic Target of Rapamycin Complex 2 - biosynthesis | Hypertrophy | TOR protein | AKT protein | Activation | Kinases | Fibronectin | Proteins | Signal transduction | Cell growth | Rodents | Inhibition | Matrix protein | Veterans health care | Immunoglobulins | Kidneys | Diabetes mellitus | AKT2 protein | Pharmacology | siRNA | Diseases | Medicine | Signaling | Inhibitors | Nephropathy | Insects | Fibrosis | Insulin resistance | Protein expression | Diabetes | Mutation | Kidney diseases | Renal cortex | Deficient mutant | PTEN protein | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e85116 - e85116
In the current study, we showed that the combination of mammalian target of rapamycin (mTOR) inhibitor RAD001 (everolimus) and Akt inhibitor MK-2206 exerted... 
MAMMALIAN TARGET | BREAST-CANCER | INHIBITION | THERAPY | SIGNALING PATHWAY | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | AKT | PI3K/AKT/MTOR PATHWAY | MTOR | Cyclin D1 - metabolism | Microtubule-Associated Proteins - genetics | Nitriles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Gastric Mucosa - pathology | Gastric Mucosa - metabolism | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | PTEN Phosphohydrolase - antagonists & inhibitors | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Gastric Mucosa - drug effects | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Everolimus | Beclin-1 | PTEN Phosphohydrolase - genetics | Butadienes - pharmacology | Sirolimus - analogs & derivatives | Adenine - analogs & derivatives | Signal Transduction | Membrane Proteins - genetics | PTEN Phosphohydrolase - metabolism | Adenine - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Sirolimus - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Cyclin D1 - genetics | Membrane Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Biochemistry | Phosphatases | Stomach cancer | Cancer cells | Cancer | TOR protein | Toxicity | Chloroquine | Cytotoxicity | Oncology | Homology | AKT protein | Cyclin D1 | Kinases | Cancer therapies | Autophagy | Proteins | Cell growth | Cell cycle | Inhibition | Growth factors | Gastric cancer | Tensin | Mortality | Extracellular signal-regulated kinase | MAP kinase | Rapamycin | Inhibitors | Cell death | PTEN protein | Phagocytosis | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 06/2011, Volume 30, Issue 26, pp. 2954 - 2963
Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth, differentiation and cell migration. In... 
mTOR | Akt | invasion | metastasis | P-Rex1 | PROTEIN-KINASE-B | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | BREAST-CANCER | INHIBITION | ONCOLOGY | INSULIN-RESISTANCE | GROWTH | GENETICS & HEREDITY | ACTIN CYTOSKELETON | FACTOR-I RECEPTOR | MOTILITY | Neoplasms - metabolism | Guanine Nucleotide Exchange Factors - physiology | Insulin-Like Growth Factor I - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Substrate Specificity | Cell Movement - genetics | Proto-Oncogene Proteins c-akt - genetics | Neoplasm Metastasis | Neoplasms - genetics | Guanine Nucleotide Exchange Factors - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Neoplasm Invasiveness | RNA, Small Interfering - pharmacology | Cells, Cultured | Enzyme Activation - drug effects | Cell Movement - drug effects | rac1 GTP-Binding Protein - physiology | Proto-Oncogene Proteins c-akt - agonists | Enzyme Activation - genetics | Neoplasms - pathology | Enzyme Activation - physiology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | rac1 GTP-Binding Protein - metabolism | Genetic aspects | Rapamycin | Research | Drug therapy | Gene expression | Health aspects | Cancer | Proteins | Signal transduction | Metastasis | Cell adhesion & migration | Index Medicus
Journal Article