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British journal of clinical pharmacology, ISSN 0306-5251, 2016, Volume 82, Issue 4, pp. 943 - 956
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 407, Issue 2, pp. 231 - 241
AS160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4) translocation, but is widely expressed in insulin-insensitive... 
14-3-3 | Akt/protein kinase B (PKB) | GTPase-activating protein (GAP) | p90 ribosomal S6 kinase (RSK) | Akt substrate of 160 kDa (AS160) | Serum- and glucocorticoid-induced protein kinase (SGK) | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | Akt substrate of 160kDa (AS160) | AKT SUBSTRATE | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | SKELETAL-MUSCLE | INSULIN-STIMULATED PHOSPHORYLATION | GLUT4 TRANSLOCATION | S6 KINASE | PROTEOMIC ANALYSIS | RAB-GAP | serum- and glucocorticoid-induced protein kinase (SGK) | Cell Line | Insulin-Like Growth Factor I - pharmacology | Phosphorylation | Humans | GTPase-Activating Proteins - metabolism | Insulin | Amino Acids | Aminoimidazole Carboxamide - pharmacology | Hypoglycemic Agents - pharmacology | 14-3-3 Proteins - metabolism | Ribonucleotides - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Protein Binding | Epidermal Growth Factor - pharmacology | Binding Sites | ACC, acetyl-CoA carboxylase | AGC kinase, protein kinase A | AICAR, 5-amino-4-imidazolecarboxamide1-β-D-ribofuranoside | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | TOS motif, mTOR signalling motif | PAS, phospho-Akt substrate | pSer, phosphorylated serine | TSC, tuberous sclerosis complex | AS160, Akt substrate of 160 kDa | PKB, protein kinase B (also known as Akt) | AMPK, AMP-activated protein kinase | RSK, p90 ribosomal S6 kinase | DSP, dithiobis(succinimidyl propionate) | protein kinase C-family | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase B (PKB) | IGF-1, insulin-like growth factor-1 | Akt substrate of 160 kDa (AS160) | GLUT4, glucose transporter 4 | protein kinase G | mTOR, mammalian target of rapamycin | TORC1, mTOR–raptor (regulatory associated protien of mTOR) complex | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | GST, glutathione S-transferase | PKC, protein kinase C | PP2A, protein phosphatase 2A | Akt | SGK, serum- and glucocorticoid-induced protein kinase | HA, haemagglutinin | GSV, GLUT4 storage vesicle | p70S6K, p70 S6 kinase | PTB, phosphotyrosine binding domain | pThr, phosphorylated threonine | GAP, GTPase-activating protein | HEK-293, human embryonic kidney-293 | IRAP, insulin-responsive aminopeptidase | Rheb, Ras enriched in brain | MAPK, mitogen-activated protein kinase
Journal Article
PLoS biology, ISSN 1545-7885, 2009, Volume 7, Issue 6, p. e1000121
Journal Article
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 14, pp. 5295 - 5303
ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and endometrioid carcinomas, endometrial, and breast carcinomas. They... 
BAF250a | Endometriosis associated ovarian carcinomas | Endometrial cancer | Perifosine | AKT-inhibitor | Buparlisib (BKM120) | Breast cancer | ARID1A | PI3K/AKT pathway | PIK3CA | SWI/SNF | MK-2206 | PI3K-inhibitor | AKT phosphorylation | Ovarian clear cell carcinomas | Apoptosis | RNA, Small Interfering - genetics | Phosphorylation | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Transcription Factors - deficiency | Phosphatidylinositol 3-Kinases - metabolism | Phosphorylcholine - analogs & derivatives | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Breast Neoplasms - therapy | Breast Neoplasms - enzymology | Transfection | MCF-7 Cells | Nuclear Proteins - biosynthesis | Nuclear Proteins - deficiency | Phosphorylcholine - pharmacology | Female | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Morpholines - pharmacology | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Transcription Factors - metabolism | Breast Neoplasms - pathology | Aminopyridines - pharmacology | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | RNA, Small Interfering - administration & dosage | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article
Cell Cycle, ISSN 1551-4005, 2014, Volume 8, Issue 16, pp. 2502 - 2508
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 1, p. e85116
In the current study, we showed that the combination of mammalian target of rapamycin (mTOR) inhibitor RAD001 (everolimus) and Akt inhibitor MK-2206 exerted... 
MAMMALIAN TARGET | BREAST-CANCER | INHIBITION | THERAPY | SIGNALING PATHWAY | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | AKT | PI3K/AKT/MTOR PATHWAY | MTOR | Cyclin D1 - metabolism | Microtubule-Associated Proteins - genetics | Nitriles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Gastric Mucosa - pathology | Gastric Mucosa - metabolism | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | PTEN Phosphohydrolase - antagonists & inhibitors | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Gastric Mucosa - drug effects | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Everolimus | Beclin-1 | PTEN Phosphohydrolase - genetics | Butadienes - pharmacology | Sirolimus - analogs & derivatives | Adenine - analogs & derivatives | Signal Transduction | Membrane Proteins - genetics | PTEN Phosphohydrolase - metabolism | Adenine - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Sirolimus - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Cyclin D1 - genetics | Membrane Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Biochemistry | Phosphatases | Stomach cancer | Cancer cells | Cancer | TOR protein | Toxicity | Chloroquine | Cytotoxicity | Oncology | Homology | AKT protein | Cyclin D1 | Kinases | Cancer therapies | Autophagy | Proteins | Cell growth | Cell cycle | Inhibition | Growth factors | Gastric cancer | Tensin | Mortality | Extracellular signal-regulated kinase | MAP kinase | Rapamycin | Inhibitors | Cell death | PTEN protein | Phagocytosis
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, p. e39520
Background: Accumulating evidence suggested that epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) characteristics, both of which contribute... 
INVASION | ACTIVATION | METASTASIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TUMOR-SUPPRESSOR GENE | MICRORNA-21 TARGETS | AKT | IDENTIFICATION | EXPRESSION | EMT | PTEN Phosphohydrolase - genetics | MAP Kinase Signaling System - physiology | Cadherins - metabolism | Vimentin - metabolism | Humans | Actins - metabolism | PTEN Phosphohydrolase - metabolism | MicroRNAs - metabolism | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Proto-Oncogene Proteins c-akt - genetics | Actins - genetics | Breast Neoplasms - metabolism | Phenotype | Breast Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Vimentin - genetics | Cell Line, Tumor | Female | MicroRNAs - genetics | Cadherins - genetics | Proto-Oncogene Proteins c-akt - metabolism | MicroRNA | Stem cells | Development and progression | Genetic aspects | Metastasis | Intermediate filament proteins | Cancer | Vimentin | Phosphorylation | Leukocyte migration | Mesenchyme | Laboratories | Epithelial cells | Colorectal cancer | AKT protein | Biochemistry | Kinases | Inactivation | E-cadherin | Metastases | Genotype & phenotype | Cell growth | N-Cadherin | Pathways | CD44 antigen | Education | Surgery | miRNA | Tumorigenesis | Deactivation | Markers | Extracellular signal-regulated kinase | Breast cancer | Gene expression | 1-Phosphatidylinositol 3-kinase | Studies | Molecular modelling | MicroRNAs | Surface markers | Cell migration | PTEN protein | Tumors | Reversing
Journal Article
Oncogene, ISSN 0950-9232, 06/2011, Volume 30, Issue 26, pp. 2954 - 2963
Journal Article