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BBA - Biomembranes, ISSN 0005-2736, 12/2017, Volume 1859, Issue 12, pp. 2461 - 2466
Journal Article
Kidney International, ISSN 0085-2538, 12/2012, Volume 82, Issue 12, pp. 1284 - 1296
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has significant morbidity and mortality as 20–40% of patients progress to... 
IgA deposition | IgA | IgA nephropathy | KIDNEY-DISEASE | POLYMERIC IGA1 | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | FACTOR-KAPPA-B | ABERRANT GLYCOSYLATION | PREDICTING PROGRESSION | RESONANCE MASS-SPECTROMETRY | TRANSFERRIN RECEPTOR | HINGE REGION | GALACTOSE-DEFICIENT IGA1 | UROLOGY & NEPHROLOGY | Blood Pressure | Antigen-Antibody Complex | Phosphorylation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Calcium - metabolism | Humans | Middle Aged | Glomerulonephritis, IGA - immunology | Podocytes - enzymology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Antigens, CD - metabolism | Mesangial Cells - drug effects | Glomerulonephritis, IGA - enzymology | Young Adult | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Renin-Angiotensin System | Time Factors | Inflammation Mediators - metabolism | Mesangial Cells - enzymology | Adult | Female | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Glomerulonephritis, IGA - pathology | Glomerulonephritis, IGA - physiopathology | Immunoglobulin A - metabolism | Angiotensin II - metabolism | Proteinuria - immunology | Mesangial Cells - immunology | Cells, Cultured | Podocytes - pathology | Receptors, Transferrin - metabolism | Proteinuria - enzymology | MAP Kinase Signaling System - drug effects | Podocytes - drug effects | Biopsy | Podocytes - immunology | Cell Communication - drug effects | Mesangial Cells - pathology | Aged | Enzyme Activation | Glomerulonephritis | End-stage renal disease | Renal function | Cytokines | Immunoglobulin G | Mortality | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Morbidity | Signal transduction | Molecular modelling | Mesangial cells | Blood pressure | Antigen-antibody complexes | Mesangium | Proteinuria
Journal Article
Cellular Signalling, ISSN 0898-6568, 03/2006, Volume 18, Issue 3, pp. 391 - 399
Our previous studies demonstrated that high glucose-induced apoptosis in human umbilical vein endothelial cells (HUVECs) is mediated by sequential activation... 
NF-κB | Endothelial cell | eNOS | Reactive oxygen species | JNK | Akt | Apoptosis | High glucose | SURVIVAL | ACTIVATION | endothelial cell | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | apoptosis | TRANSDUCTION | INDUCTION | CELL BIOLOGY | NF-kappa B | high glucose | reactive oxygen species | GROWTH-FACTOR | TRANSCRIPTION FACTOR | ATHEROSCLEROTIC LESION
Journal Article
Cancer Research, ISSN 0008-5472, 09/2002, Volume 62, Issue 17, pp. 4929 - 4937
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/APO-2L is a member of the TNF superfamily and has been shown to have selective antitumor... 
SURVIVAL | ONCOLOGY | SUPPRESSOR PROTEIN | PHOSPHORYLATION | NEGATIVE REGULATION | PROSTATE-CANCER | PTEN | AKT | CYTOCHROME-C RELEASE | INDEPENDENT PATHWAYS | PHOSPHOINOSITIDE 3-KINASE | Lung Neoplasms - drug therapy | Caspase 9 | Intracellular Membranes - physiology | Apoptosis - drug effects | Humans | Protein-Serine-Threonine Kinases | Lung Neoplasms - pathology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Membrane Glycoproteins - antagonists & inhibitors | TNF-Related Apoptosis-Inducing Ligand | PTEN Phosphohydrolase | Caspases - biosynthesis | Tumor Cells, Cultured | Carcinoma, Non-Small-Cell Lung - pathology | Membrane Potentials - drug effects | Cell Survival - drug effects | Lung Neoplasms - enzymology | Caspases - genetics | Down-Regulation | Membrane Glycoproteins - pharmacology | Mitochondria - drug effects | Phosphoric Monoester Hydrolases - physiology | Caspase Inhibitors | Proto-Oncogene Proteins c-akt | Tumor Necrosis Factor-alpha - pharmacology | Tumor Suppressor Proteins - physiology | Apoptosis Regulatory Proteins | Signal Transduction - drug effects | Proto-Oncogene Proteins - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Intracellular Membranes - drug effects | Apoptosis - physiology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mitochondria - physiology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e78788
Chicoric acid (CA) is a caffeoyl derivative previously described as having potential anti-diabetic properties. As similarities in cellular mechanism... 
ACTIVATED PROTEIN-KINASE | MITOCHONDRIAL BIOGENESIS | CAFFEIC ACID | FREE FATTY-ACIDS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | METABOLIC-DISORDERS | SUPEROXIDE-DISMUTASE | GLUCOSE-PRODUCTION | STRESS RESISTANCE | Citrate (si)-Synthase - biosynthesis | Gene Expression Regulation, Enzymologic - drug effects | Caenorhabditis elegans - genetics | Longevity - drug effects | Oxidoreductases - genetics | Caffeic Acids - pharmacology | Transcription Factors - biosynthesis | Antioxidants - pharmacology | Transcription Factors - genetics | Animals | Gene Expression Regulation, Enzymologic - genetics | Adenylate Kinase - metabolism | Citrate (si)-Synthase - genetics | Adenylate Kinase - genetics | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Succinates - pharmacology | Caenorhabditis elegans - enzymology | Caenorhabditis elegans Proteins - biosynthesis | Muscle Fibers, Skeletal - enzymology | Oxidoreductases - biosynthesis | Antioxidants | Enzymes | Caenorhabditis elegans | RNA | Polyphenols | Biosynthesis | Superoxide | Hypoglycemic agents | TOR protein | Oxidative stress | Reactive oxygen species | Phosphorylation | AKT protein | Superoxide dismutase | Glucose | Kinases | Proteins | Stimulators | Mitochondria | Rodents | Aging | Peroxidase | Glutathione peroxidase | Obesity | Myotubes | AMP | Diabetes mellitus | Gene expression | Insulin | Analogies | Life span | Acids | Insects | Quercetin | Nematodes | Diabetes | Electron transport | Metabolic disorders | Life Sciences | Animal biology | Agricultural sciences
Journal Article
Cardiovascular Research, ISSN 0008-6363, 10/2006, Volume 72, Issue 1, pp. 152 - 162
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 47, pp. 33966 - 33977
Mitogen-activated protein kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial role in the deactivation of... 
MAMMALIAN TARGET | DUAL-SPECIFICITY PHOSPHATASE-1 | Signal Transduction | PHOSPHORYLATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | Akt PKB | MTOR | CROSS-TALK | MAP Kinases (MAPKs) | mTOR Complex (mTORC) | IMMUNE-RESPONSES | Dual Specificity Phosphoprotein Phosphatase | INFLAMMATORY RESPONSE | T-CELLS | Antibiotics, Antineoplastic - pharmacology | TOR Serine-Threonine Kinases - metabolism | Bone Marrow Cells - enzymology | Activating Transcription Factor 2 - genetics | Proto-Oncogene Proteins c-akt - genetics | CREB-Binding Protein - genetics | Dose-Response Relationship, Drug | MAP Kinase Kinase 1 - genetics | CREB-Binding Protein - metabolism | Phosphorylation - genetics | MAP Kinase Signaling System - genetics | TOR Serine-Threonine Kinases - genetics | Enzyme Induction - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Dual Specificity Phosphatase 1 - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | MAP Kinase Kinase 2 - genetics | Activating Transcription Factor 1 - genetics | Cell Line | Dual Specificity Phosphatase 1 - genetics | Lipopolysaccharides - toxicity | Interleukin-6 - genetics | Bone Marrow Cells - cytology | Activating Transcription Factor 1 - metabolism | Morpholines - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Macrophages - cytology | Enzyme Activation - drug effects | Sirolimus - pharmacology | Activating Transcription Factor 2 - metabolism | Macrophages - enzymology | Mice, Knockout | Enzyme Induction - genetics | Animals | MAP Kinase Signaling System - drug effects | Nitric Oxide - genetics | Mice | Enzyme Activation - genetics | Nitric Oxide - metabolism | Immunology
Journal Article