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Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7484, pp. 564 - 568
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2004, Volume 23, Issue 13, pp. 2544 - 2553
Bach1 is a transcriptional repressor of heme oxygenase‐1 and β‐globin genes, both of which are known to be transcriptionally induced by heme. To test the... 
heme oxygenase | Maf | globin | heme | oxidative stress | Globin | Oxidative stress | Heme | Heme oxygenase | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | OXYGENASE-1 GENE | LEUCINE ZIPPER PROTEIN | CELL BIOLOGY | CADMIUM | SMALL MAF | TRANSCRIPTION FACTOR NF-E2 | BINDING | Immunohistochemistry | Heme - metabolism | Transcription Factors - chemistry | Humans | Leucine Zippers | Molecular Sequence Data | Globins - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Chromatin Immunoprecipitation | Heme Oxygenase-1 | Transcription, Genetic | Active Transport, Cell Nucleus | Hemin - pharmacology | Heme Oxygenase (Decyclizing) - metabolism | Dimerization | Heme Oxygenase (Decyclizing) - genetics | Genes, Reporter | Repressor Proteins - metabolism | Fibroblasts - metabolism | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins - metabolism | Zinc Fingers | Gene Expression Regulation | Glutathione Transferase - metabolism | Alanine - metabolism | Nuclear Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Fanconi Anemia Complementation Group Proteins | Amino Acid Motifs | MafK Transcription Factor | Membrane Proteins | Transcription Factors - metabolism | Karyopherins - metabolism | Escherichia coli - genetics | Plasmids | Fibroblasts - drug effects | Erythroid-Specific DNA-Binding Factors | Spectrophotometry | Basic-Leucine Zipper Transcription Factors | Amino Acid Substitution | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0161803 - e0161803
We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for... 
OVEREXPRESSION | STEM-CELLS | ACTIVATION | MULTIPARAMETRIC OPTIMIZATION | MULTIDISCIPLINARY SCIENCES | NMR SPECTROSCOPIC ANALYSIS | MULTIDRUG-RESISTANCE | ENERGY-METABOLISM | HYPOXIA | CANCER | P-31 | Melanoma - metabolism | Magnetic Resonance Spectroscopy | Humans | Gene Expression Regulation, Neoplastic | Alanine - metabolism | Melanoma - pathology | Metabolomics - methods | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Amino Acids - metabolism | Pilot Projects | Lactates - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Melanoma - genetics | Glycerylphosphorylcholine - metabolism | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Glucose - metabolism | Biomarkers, Tumor - genetics | Cell Membrane - metabolism | Phosphatidylethanolamines - metabolism | Phospholipids - metabolism | Cell metabolism | Physiological aspects | Genetic aspects | Research | Binding proteins | Melanoma | Energy metabolism | Nuclear magnetic resonance--NMR | Lung cancer | Amino acids | Lipids | Phospholipids | Glucose | Drug resistance | Cell surface | Magnetic resonance spectroscopy | Metabolites | Energy | Spectrum analysis | Interleukin 1 | Inhibition | Lipid metabolism | Water chemistry | Alanine | Degradation products | Statistical analysis | Cold | Phosphorus | Breast cancer | Metabolism | Gene expression | Acids | Stem cells | Glycolysis | Monoclonal antibodies | Hypoxia | Lactic acid | NMR spectroscopy | Surface markers | Tumors | Index Medicus | Life Sciences | Cellular Biology | Nuclear magnetic resonance | NMR
Journal Article
Gut, ISSN 0017-5749, 04/2017, Volume 66, Issue 4, pp. 620 - 632
ObjectiveTo examine the role of hepatocyte myeloid differentiation primary-response gene 88 (MyD88) on glucose and lipid metabolism.DesignTo study the impact... 
INTESTINAL MICROBIOTA | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | MICE | PROLIFERATOR-ACTIVATED-RECEPTOR | DIET-INDUCED OBESITY | LARGE GENE LISTS | GASTROENTEROLOGY & HEPATOLOGY | EPOXYEICOSATRIENOIC ACIDS | FARNESOID X-RECEPTOR | ADIPOSE-TISSUE | Body Weight | Humans | Immunity, Innate - genetics | Cytochrome P-450 Enzyme System - metabolism | Alanine Transaminase - blood | Hepatocytes - metabolism | Obesity - genetics | Adiposity | Diet, High-Fat | Myeloid Differentiation Factor 88 - immunology | Lipid Metabolism - genetics | STAT3 Transcription Factor - metabolism | Gene Expression | Non-alcoholic Fatty Liver Disease - genetics | Liver - metabolism | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Bile Acids and Salts - metabolism | Liver X Receptors - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Gastrointestinal Microbiome - genetics | Metabolome - genetics | Mice, Knockout | Obesity - metabolism | Animals | Aspartate Aminotransferases - blood | Insulin Resistance - genetics | Cytochrome P-450 Enzyme System - genetics | Glucose - metabolism | Mice | PPAR alpha - metabolism | Myeloid Differentiation Factor 88 - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Research | Lipid metabolism | Microbiota (Symbiotic organisms) | Liver cells | Index Medicus | Abridged Index Medicus | LIPID METABOLISM | Gut Microbiota | BILE ACID METABOLISM | GLUCOSE METABOLISM | DIABETES MELLITUS | 1506 | INTESTINAL BACTERIA | liver-disease | Gastroenterologi | adipose-tissue | mice | diet-induced obesity | farnesoid x-receptor | epoxyeicosatrienoic acids | Gastroenterology & Hepatology | intestinal microbiota | insulin-resistance | fatty | proliferator-activated-receptor | large gene lists | Gastroenterology and Hepatology
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2009, Volume 11, Issue 10, pp. 1241 - 1246
Journal Article
by Peng, JH and Cui, T and Huang, F and Chen, L and Zhao, Y and Xu, L and Xu, LL and Feng, Q and Hu, YY
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 646 - 654
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined... 
HEPATITIS | LIPOPOLYSACCHARIDE-BINDING PROTEIN | DISEASE | BARRIER | FATTY LIVER | RATS | ETHANOL | PHARMACOLOGY & PHARMACY | MICE | KAPPA-B | INTESTINAL PERMEABILITY | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Tight Junctions - genetics | Isoflavones - pharmacology | Male | Alanine Transaminase - blood | Alcohol-Related Disorders - genetics | Antigens, CD - genetics | Receptors, Immunologic - antagonists & inhibitors | Antigens, CD - metabolism | Liver Diseases, Alcoholic - drug therapy | Zonula Occludens-1 Protein - metabolism | Neutrophil Infiltration - drug effects | Disease Models, Animal | Tight Junctions - drug effects | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Fatty Liver - metabolism | Portal Vein - metabolism | Liver - metabolism | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 2 - metabolism | Neutrophil Infiltration - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Fatty Liver - drug therapy | Triglycerides - metabolism | Microvilli - genetics | Aspartate Aminotransferases - blood | Diet | Microvilli - metabolism | Receptors, Immunologic - genetics | Intestines - drug effects | Tumor Necrosis Factor-alpha - metabolism | Liver - enzymology | Intestines - metabolism | Acute-Phase Proteins - genetics | Alcohol-Related Disorders - drug therapy | Lipopolysaccharide Receptors - metabolism | Alcohol-Related Disorders - metabolism | Liver Diseases, Alcoholic - genetics | Receptors, Immunologic - biosynthesis | Kupffer Cells - metabolism | Endotoxins - metabolism | Fatty Liver - genetics | Portal Vein - drug effects | Acute-Phase Proteins - metabolism | Endotoxins - genetics | gamma-Glutamyltransferase - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Liver Diseases, Alcoholic - metabolism | Kupffer Cells - drug effects | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Microvilli - drug effects | Endotoxins - antagonists & inhibitors | Animals | Carrier Proteins - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Lipopolysaccharide Receptors - genetics | Receptors, Immunologic - metabolism | Index Medicus
Journal Article
Journal of Gastroenterology and Hepatology (Australia), ISSN 0815-9319, 2009, Volume 24, Issue 3, pp. 443 - 452
We examined extrinsic and intrinsic (endogenous) mitochondrial apoptosis pathways in experimental non-alcoholic steatohepatitis (NASH). To assess extrinsic... 
Cell death pathways | TRAIL-R killer/DR5 | Methionine and choline deficiency | Mitochondria | Insulin-like growth factor-1 | TNF receptors | P53 | HEPATOCYTE APOPTOSIS | ACIDS | DR5 | mitochondria | FATTY LIVER-DISEASE | insulin-like growth factor-1 | NONALCOHOLIC STEATOHEPATITIS | cell death pathways | p53 | PATHOGENESIS | HEPATIC INFLAMMATION | NECROSIS | methionine and choline deficiency | MICE | TNF-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | TRAIL-R killer | NF-KAPPA-B | Liver - pathology | Liver - enzymology | Fatty Liver - pathology | Mitochondria, Liver - metabolism | Caspase 3 - metabolism | Choline Deficiency - complications | Male | Alanine Transaminase - blood | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | RNA, Messenger - metabolism | fas Receptor - metabolism | Tumor Suppressor Protein p53 - genetics | Time Factors | Receptors, Tumor Necrosis Factor, Type II - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Nutritional Status | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | Disease Models, Animal | Methionine - deficiency | Receptors, Tumor Necrosis Factor - metabolism | Fatty Liver - metabolism | Mitochondria, Liver - pathology | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Mitochondria, Liver - enzymology | Animals | Mice | bcl-X Protein - metabolism | Insulin-Like Growth Factor I - metabolism | Apoptosis | Fatty Liver - etiology | BH3 Interacting Domain Death Agonist Protein, metabolism | Receptors, Tumor Necrosis Factor, Type II, metabolism | Fatty Liver, pathology | Mitochondria, Liver, metabolism | Receptors, Tumor Necrosis Factor, metabolism | Cyclin-Dependent Kinase Inhibitor p21, metabolism | Insulin-Like Growth Factor I, metabolism | Caspase 3, metabolism | Antigens, CD95, metabolism | RNA, Messenger, metabolism | Tumor Suppressor Protein p53, metabolism | Methionine, deficiency | Choline Deficiency, complications | Tumor Suppressor Protein p53, genetics | bcl-X Protein, metabolism | Mitochondria, Liver, pathology | Liver, pathology | Alanine Transaminase, blood | Liver, metabolism | Fatty Liver, metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand, metabolism | Liver, enzymology | Fatty Liver, etiology | Mitochondria, Liver, enzymology | Receptors, Tumor Necrosis Factor, Type I, metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand, genetics | Messenger RNA | Choline | Methionine | Mitochondrial DNA | Tumor proteins | Peptide hormones | Growth factors | Index Medicus
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 12/2011, Volume 15, Issue 11, pp. 2837 - 2854
Hepatic energy depletion has been described in severe sepsis, and lipopolysaccharide (LPS) has been shown to cause mitochondrial DNA (mtDNA) damage. To clarify... 
Original Research Communications | OXIDATIVE STRESS | LIVER-INJURY | PEROXYNITRITE | MANGANESE SUPEROXIDE-DISMUTASE | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | ETHANOL | MICE | TRANSCRIPTION-FACTOR | RESPIRATORY FACTOR-I | EXPRESSION | Aconitate Hydratase - metabolism | Electron Transport Complex III - metabolism | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Humans | Tumor Necrosis Factor-alpha - blood | Alanine Transaminase - blood | Electron Transport Complex I - metabolism | Tyrosine - analogs & derivatives | Electron Transport Complex IV - metabolism | DNA-Binding Proteins - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Sepsis - metabolism | Adenosine Triphosphate - metabolism | ATP Synthetase Complexes - metabolism | Nitrites - blood | Transcription, Genetic | Superoxide Dismutase - metabolism | Iron - blood | Nitrates - blood | DNA, Mitochondrial - metabolism | High Mobility Group Proteins - metabolism | Liver - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Thiobarbituric Acid Reactive Substances - metabolism | Iron - metabolism | Toll-Like Receptor 4 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Tyrosine - metabolism | Animals | Interferon-beta - pharmacology | Nitric Oxide Synthase Type II - genetics | Lipopolysaccharides - pharmacology | Interferon-beta - blood | Mice | Nitric Oxide Synthase Type II - metabolism | DNA damage | Physiological aspects | Septic shock | Mitochondrial DNA | Genetic aspects | Research | Health aspects | Risk factors | Lipopolysaccharides | Index Medicus
Journal Article
Journal Article