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Journal Article
Therapeutic Drug Monitoring, ISSN 0163-4356, 12/2012, Volume 34, Issue 6, pp. 660 - 670
Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2010, Volume 328, Issue 5981, pp. 1031 - 1035
Poor penetration of anticancer drugs into tumors can be an important factor limiting their effícacy. We studied mouse tumor models to show that a previously... 
Molecules | Intravenous injections | Medical treatment | REPORTS | Antineoplastics | Antibodies | Liposomes | Dosage | Prostate cancer | Tumors | Cancer | NANOPARTICLES | INTEGRINS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | IN-VIVO | DOXORUBICIN | PHAGE DISPLAY | VASCULAR-PERMEABILITY FACTOR | CELL | ENDOTHELIAL GROWTH-FACTOR | DELIVERY | Neoplasms - metabolism | Doxorubicin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Neuropilin-1 - metabolism | Albumin-Bound Paclitaxel | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Capillary Permeability - drug effects | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Paclitaxel - pharmacokinetics | Antineoplastic Agents - administration & dosage | Albumins - therapeutic use | Antibodies, Monoclonal, Humanized | Antineoplastic Agents - pharmacokinetics | Paclitaxel - administration & dosage | Doxorubicin - administration & dosage | Oligopeptides - pharmacokinetics | Antibodies, Monoclonal - pharmacokinetics | Albumins - administration & dosage | Neoplasms - blood supply | Oligopeptides - metabolism | Permeability | Paclitaxel - therapeutic use | Doxorubicin - pharmacokinetics | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Albumins - pharmacokinetics | Animals | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice | Oligopeptides - administration & dosage | Oligopeptides - pharmacology | Trastuzumab | Antimitotic agents | Peptides | Research | Antineoplastic agents | Drug therapy | Health aspects | Chemotherapy | Index Medicus | Drugs | Nanoparticles | Side effects | Doxorubicin | Constraining
Journal Article
Biomacromolecules, ISSN 1525-7797, 09/2014, Volume 15, Issue 9, pp. 3246 - 3252
Multifunctional injectable thermo-/pH-responsive hydrogels as release systems for the oral delivery of small molecule drugs and the local delivery of protein... 
BIODEGRADABLE HYDROGELS | IN-VITRO | POLYMER SCIENCE | CHITOSAN MATERIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | RECENT PROGRESS | SYSTEMS | BIOMEDICAL APPLICATIONS | ORAL DELIVERY | COENZYME-A | MECHANICAL-PROPERTIES | Diclofenac - pharmacology | Adipose Tissue - cytology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Delayed-Action Preparations - chemistry | Hydrogels - pharmacokinetics | Hydrogels - chemical synthesis | Hexuronic Acids - pharmacokinetics | Methacrylates - chemistry | Diclofenac - chemistry | Drug Carriers - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Adipose Tissue - metabolism | Mesenchymal Stromal Cells - cytology | Cattle | Delayed-Action Preparations - pharmacology | Delayed-Action Preparations - pharmacokinetics | Delayed-Action Preparations - chemical synthesis | Serum Albumin, Bovine - chemistry | Hexuronic Acids - chemical synthesis | Glucuronic Acid - chemistry | Alginates - pharmacokinetics | Glucuronic Acid - chemical synthesis | Alginates - pharmacology | Rabbits | Serum Albumin, Bovine - pharmacology | Mesenchymal Stromal Cells - metabolism | Drug Carriers - chemical synthesis | Glucuronic Acid - pharmacokinetics | Hexuronic Acids - chemistry | Diclofenac - pharmacokinetics | Drug Carriers - pharmacology | Glucuronic Acid - pharmacology | Serum Albumin, Bovine - pharmacokinetics | Animals | Alginates - chemical synthesis | Alginates - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Drug Carriers - pharmacokinetics | Hydrogels - pharmacology | Hydrogels - chemistry | Hexuronic Acids - pharmacology | Hydrogen-Ion Concentration | Index Medicus
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2017, Volume 45, Issue 7, pp. 855 - 866
In vitro hepatocyte culture systems have inherent limitations in capturing known human drug toxicities that arise from complex immune responses. Therefore, we... 
HUMAN HEPATOCYTES | SERUM-ALBUMIN | IN-VITRO MODEL | PHARMACOLOGY & PHARMACY | BILE-ACID SYNTHESIS | METABOLIC-CLEARANCE | KUPFFER CELL | HEPATOTOXICITY | PARAMETERS | BINDING | PREDICTION | Lipopolysaccharides - toxicity | Kupffer Cells - cytology | Acute-Phase Proteins - secretion | Coculture Techniques | Humans | Liver - metabolism | Inflammation | Diclofenac - toxicity | Hepatocytes - metabolism | Anti-Inflammatory Agents, Non-Steroidal - toxicity | Diclofenac - pharmacokinetics | Kupffer Cells - drug effects | Dose-Response Relationship, Drug | Hepatocytes - cytology | Liver - immunology | Liver - drug effects | Models, Biological | Biotransformation | Proteomics | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Protein Binding | Kupffer Cells - metabolism | Hepatocytes - drug effects | Cytokines - immunology | Cell culture | Toxicity | Liver | Interleukin | Immune clearance | Inflammatory response | Lymphocytes T | Interleukin 1 receptors | Glycine | Macrophages | Diclofenac | Interleukin 6 | Proteins | Cell activation | Interleukin 5 | Metabolites | Granulocyte colony-stimulating factor | IP-10 protein | Biocompatibility | Colony-stimulating factor | Bioindicators | Nonsteroidal anti-inflammatory drugs | Interleukin 8 | Bile acids | Immune response | Cytokines | Granulocyte-macrophage colony-stimulating factor | Colonies | Interleukin 1 receptor antagonist | Liquid chromatography | Pharmacology | Metabolism | Acute phase substances | Acids | Biomarkers | Pharmacokinetics | Mass spectrometry | Bile | Index Medicus
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2008, Volume 62, Issue 5, pp. 779 - 786
Journal Article