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1. Full Text Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children
by Ducharme, Francine M and Ni Chroinin, Muireann and Greenstone, Ilana and Lasserson, Toby J
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2010, Volume 5, Issue 5, p. CD005535
Background Long-acting inhaled beta(2)-adrenergic agonists (LABAs) are recommended as 'add-on' medication to inhaled corticosteroids (ICS) in the maintenance... 
Adrenal Cortex Hormones [therapeutic use] | TO-MODERATE ASTHMA | Humans | Administration, Inhalation | RANDOMIZED CONTROLLED-TRIAL | Adrenergic beta-Agonists [therapeutic use] | SURROGATE INFLAMMATORY MARKERS | Randomized Controlled Trials as Topic | MEDICINE, GENERAL & INTERNAL | FLUTICASONE PROPIONATE/SALMETEROL COMBINATION | LEUKOTRIENE RECEPTOR ANTAGONIST | Asthma [drug therapy] | Adult | SALMETEROL/FLUTICASONE PROPIONATE COMBINATION | FORMOTEROL OXIS(R) TURBUHALER(R) | QUALITY-OF-LIFE | MILD PERSISTENT ASTHMA | Chronic Disease | Child | OBSTRUCTIVE AIRWAYS DISEASE | Anti-Asthmatic Agents [therapeutic use] | Beclomethasone - administration & dosage | Formoterol Fumarate | Salmeterol Xinafoate | Albuterol - analogs & derivatives | Child, Preschool | Asthma - drug therapy | Ethanolamines - administration & dosage | Drug Therapy, Combination - methods | Adolescent | Adrenergic beta-Agonists - administration & dosage | Albuterol - administration & dosage | Anti-Asthmatic Agents - administration & dosage | Adrenal Cortex Hormones - administration & dosage
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2. Full Text Step-up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids
by Lemanske, Robert F and Mauger, David T and Sorkness, Christine A and Jackson, Daniel J and Boehmer, Susan J and Martinez, Fernando D and Strunk, Robert C and Szefler, Stanley J and Zeiger, Robert S and Bacharier, Leonard B and Covar, Ronina A and Guilbert, Theresa W and Larsen, Gary and Morgan, Wayne J and Moss, Mark H and Spahn, Joseph D and Taussig, Lynn M and Natl Heart Lung Blood Inst and Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute
The New England Journal of Medicine, ISSN 0028-4793, 03/2010, Volume 362, Issue 11, pp. 975 - 985
Many children have uncontrolled asthma symptoms when treated with low-dose inhaled corticosteroids (ICS). In this three-way crossover trial, the investigators... 
MEDICINE, GENERAL & INTERNAL | PERSISTENT ASTHMA | BRONCHODILATOR RESPONSIVENESS | CHILDHOOD ASTHMA | Eczema - complications | Glucocorticoids - administration & dosage | Bronchodilator Agents - administration & dosage | Forced Expiratory Volume - drug effects | Asthma - ethnology | Humans | Male | Fluticasone | Quinolines - administration & dosage | Dose-Response Relationship, Drug | Leukotriene Antagonists - administration & dosage | Adrenergic beta-Agonists - administration & dosage | Albuterol - administration & dosage | Female | Bronchodilator Agents - adverse effects | Drug Therapy, Combination | Child | Prednisone - administration & dosage | Salmeterol Xinafoate | Asthma - physiopathology | Double-Blind Method | Administration, Oral | Administration, Inhalation | Albuterol - analogs & derivatives | Logistic Models | Treatment Outcome | Asthma - drug therapy | Cross-Over Studies | Androstadienes - administration & dosage | Acetates - administration & dosage | Asthma - complications | Adolescent | Usage | Corticosteroids | Drug therapy | Asthma in children | Health aspects | Inhaled medication | Medical research | Drug dosages | Asthma
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3. Full Text Inhaled corticosteroids versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease
by Spencer, Sally and Spencer, Sally and Evans, David J and Karner, Charlotta and Karner, Charlotta and Cates, Christopher J and Cates, Christopher J and Evans, David J
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2011, Volume 2011, Issue 12, p. CD007033
Background Long-acting beta(2)-agonists and inhaled corticosteroids can be used as maintenance therapy by patients with moderate to severe chronic obstructive... 
Adrenergic beta-2 Receptor Agonists [administration & dosage] | COST-EFFECTIVENESS | STABLE COPD | Budesonide [administration & dosage] | SAFETY | Humans | FLUTICASONE PROPIONATE/SALMETEROL IMPROVES | BUDESONIDE | Ethanolamines [administration & dosage] | Pulmonary Disease, Chronic Obstructive [drug therapy] | RANDOMIZED CONTROLLED-TRIAL | Randomized Controlled Trials as Topic | BETA-AGONISTS | SALMETEROL | COPD HEALTH TORCH | PROPIONATE | MEDICINE, GENERAL & INTERNAL | Androstadienes [administration & dosage] | Bronchodilator Agents [administration & dosage] | Albuterol [administration & dosage; analogs & derivatives] | Adrenal Cortex Hormones [administration & dosage] | Formoterol Fumarate | Salmeterol Xinafoate | Bronchodilator Agents - administration & dosage | Albuterol - analogs & derivatives | Fluticasone | Ethanolamines - administration & dosage | Androstadienes - administration & dosage | Albuterol - administration & dosage | Adrenergic beta-2 Receptor Agonists - administration & dosage | Budesonide - administration & dosage | Adrenal Cortex Hormones - administration & dosage | Pulmonary Disease, Chronic Obstructive - drug therapy
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4. Full Text Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy
by Yamasmit, Waralak and Yamasmit, Waralak and Chaithongwongwatthana, Surasith and Chaithongwongwatthana, Surasith and Tolosa, Jorge E and Tolosa, Jorge E and Limpongsanurak, Sompop and Limpongsanurak, Sompop and Pereira, Leonardo and Pereira, Leonardo and Lumbiganon, Pisake and Lumbiganon, Pisake
The Cochrane database of systematic reviews, ISSN 1469-493X, 2015, Volume 12, Issue 12, p. CD004733
Background Twin pregnancies are associated with a high risk of neonatal mortality and morbidity due to an increased rate of preterm birth. Betamimetics can... 
Ritodrine [administration & dosage] | RITODRINE | Adrenergic beta-Agonists [administration & dosage] | PLACEBO | Administration, Oral | Tocolytic Agents [administration & dosage] | PREVENTION | Isoxsuprine [administration & dosage] | Fenoterol [administration & dosage] | Gestational Age | Pregnancy, Twin | Randomized Controlled Trials as Topic | Albuterol [administration & dosage] | MEDICINE, GENERAL & INTERNAL | TOCOLYSIS | DOUBLE-BLIND TRIAL | Premature Birth [prevention & control] | CEREBRAL-PALSY | LABOR | Terbutaline [administration & dosage] | Humans | Ritodrine - administration & dosage | Fetal Membranes, Premature Rupture - prevention & control | Fenoterol - administration & dosage | Isoxsuprine - administration & dosage | Pregnancy | Terbutaline - administration & dosage | Tocolytic Agents - administration & dosage | Adrenergic beta-Agonists - administration & dosage | Albuterol - administration & dosage | Adult | Female | Premature Birth - prevention & control
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5. Full Text Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus inhaled corticosteroids alone for chronic obstructive pulmonary disease
by Nannini, Luis Javier and Nannini, Luis Javier and Poole, Phillippa and Poole, Phillippa and Milan, Stephen J and Milan, Stephen J and Kesterton, Annabel and Kesterton, Annabel
The Cochrane database of systematic reviews, ISSN 1469-493X, 2013, Volume 8, Issue 12, p. CD006826
Background Both long-acting beta(2)-agonists and inhaled corticosteroids have been recommended in guidelines for the treatment of chronic obstructive pulmonary... 
Adrenal Cortex Hormones [administration & dosage; adverse effects] | COST-EFFECTIVENESS | Adrenergic beta-Agonists [administration & dosage; adverse effects] | EFFICACY | Humans | SALMETEROL/FLUTICASONE PROPIONATE | Steroids [administration & dosage; adverse effects] | Pneumonia [chemically induced] | Randomized Controlled Trials as Topic | SALMETEROL | Bronchodilator Agents [administration & dosage; adverse effects] | Pulmonary Disease, Chronic Obstructive [drug therapy; mortality] | MEDICINE, GENERAL & INTERNAL | FLUTICASONE PROPIONATE | COMBINED MOMETASONE FUROATE | FIXED-DOSE COMBINATION | Drug Therapy, Combination | CHINESE PATIENTS | Drug Combinations | Nebulizers and Vaporizers | HEALTH-STATUS | COPD | Pulmonary Disease, Chronic Obstructive - mortality | Steroids - administration & dosage | Ethanolamines - adverse effects | Formoterol Fumarate | Bronchodilator Agents - administration & dosage | Ethanolamines - administration & dosage | Drug Therapy, Combination - adverse effects | Adrenergic beta-2 Receptor Agonists - adverse effects | Pneumonia - chemically induced | Albuterol - administration & dosage | Bronchodilator Agents - adverse effects | Steroids - adverse effects | Albuterol - analogs & derivatives | Adrenal Cortex Hormones - adverse effects | Drug Therapy, Combination - methods | Androstadienes - administration & dosage | Budesonide - adverse effects | Adrenergic beta-2 Receptor Agonists - administration & dosage | Budesonide - administration & dosage | Fluticasone-Salmeterol Drug Combination | Androstadienes - adverse effects | Albuterol - adverse effects | Adrenal Cortex Hormones - administration & dosage | Pulmonary Disease, Chronic Obstructive - drug therapy
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6. Full Text Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease
by Nannini, Luis Javier and Nannini, Luis Javier and Lasserson, Toby J and Lasserson, Toby J and Poole, Phillippa and Poole, Phillippa
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2012, Volume 2012, Issue 9, p. CD006829
Background Both inhaled steroids (ICS) and long-acting beta(2)-agonists (LABA) are used in the management of chronic obstructive pulmonary disease (COPD). This... 
Adrenal Cortex Hormones [administration & dosage; adverse effects] | COST-EFFECTIVENESS | Adrenergic beta-Agonists [administration & dosage; adverse effects] | CLINICAL-TRIAL | Humans | FLUTICASONE PROPIONATE/SALMETEROL 250/50 | SALMETEROL/FLUTICASONE PROPIONATE | COPD EXACERBATIONS | LUNG-FUNCTION | RANDOMIZED CONTROLLED-TRIAL | Pneumonia [chemically induced] | Randomized Controlled Trials as Topic | SALMETEROL | Bronchodilator Agents [administration & dosage; adverse effects] | Pulmonary Disease, Chronic Obstructive [drug therapy; mortality] | MEDICINE, GENERAL & INTERNAL | METERED-DOSE INHALER | Quality of Life | Adult | Drug Therapy, Combination | 50 MU-G | Drug Combinations | Nebulizers and Vaporizers | Pulmonary Disease, Chronic Obstructive - mortality | Ethanolamines - adverse effects | Formoterol Fumarate | Bronchodilator Agents - administration & dosage | Fluticasone | Ethanolamines - administration & dosage | Pneumonia - chemically induced | Adrenergic beta-Agonists - administration & dosage | Albuterol - administration & dosage | Bronchodilator Agents - adverse effects | Adrenergic beta-Agonists - adverse effects | Salmeterol Xinafoate | Albuterol - analogs & derivatives | Adrenal Cortex Hormones - adverse effects | Drug Therapy, Combination - methods | Androstadienes - administration & dosage | Budesonide - adverse effects | Budesonide - administration & dosage | Androstadienes - adverse effects | Albuterol - adverse effects | Adrenal Cortex Hormones - administration & dosage | Pulmonary Disease, Chronic Obstructive - drug therapy
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7. Full Text Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease
by Welsh, Emma J and Welsh, Emma J and Cates, Christopher J and Cates, Christopher J and Poole, Phillippa and Poole, Phillippa
The Cochrane database of systematic reviews, ISSN 1469-493X, 2013, Volume 5, Issue 5, p. CD007891
Background Combination therapy (inhaled corticosteroids and long-acting beta2-agonists) and tiotropium are both used in the treatment of chronic obstructive... 
MODERATE | Adrenergic beta-Agonists [administration & dosage] | Patient Dropouts [statistics & numerical data] | Humans | SALMETEROL/FLUTICASONE PROPIONATE | Administration, Inhalation | BUDESONIDE/FORMOTEROL | FLUTICASONE PROPIONATE/SALMETEROL | PNEUMONIA | Pneumonia [drug therapy] | SALMETEROL | Pulmonary Disease, Chronic Obstructive [drug therapy; mortality] | MEDICINE, GENERAL & INTERNAL | Drug Therapy, Combination [methods] | Scopolamine Derivatives [administration & dosage] | Albuterol [administration & dosage; analogs & derivatives] | TRIPLE THERAPY | PLUS FLUTICASONE | BROMIDE | Androstadienes [administration & dosage]; Bronchodilator Agents [administration & dosage] | COPD | Pulmonary Disease, Chronic Obstructive - mortality | Patient Dropouts - statistics & numerical data | Salmeterol Xinafoate | Bronchodilator Agents - administration & dosage | Albuterol - analogs & derivatives | Fluticasone | Drug Therapy, Combination - methods | Androstadienes - administration & dosage | Pneumonia - drug therapy | Adrenergic beta-Agonists - administration & dosage | Albuterol - administration & dosage | Scopolamine Derivatives - administration & dosage | Pulmonary Disease, Chronic Obstructive - drug therapy | Tiotropium Bromide
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8. Full Text Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events
by Cates, Christopher J and Cates, Christopher J and Lasserson, Toby J and Lasserson, Toby J
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2010, Volume 2010, Issue 1, p. CD007694
Background An increase in serious adverse events with both regular formoterol and regular salmeterol in chronic asthma has been demonstrated in comparison with... 
MODERATE | MEDICINE, GENERAL & INTERNAL | METERED-DOSE INHALER | COST-EFFECTIVENESS | MANAGEMENT | SALMETEROL/FLUTICASONE PROPIONATE | EXACERBATIONS | PERSISTENT ASTHMA | RELIEVER THERAPY | COMBINATION | BUDESONIDE/FORMOTEROL MAINTENANCE
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9. Full Text Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol–fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study
by Vogelmeier, Claus F, Prof and Bateman, Eric D, Prof and Pallante, John, BS and Alagappan, Vijay KT, MD and D'Andrea, Peter, MD and Chen, Hungta, PhD and Banerji, Donald, MD
Lancet Respiratory Medicine, The, ISSN 2213-2600, 2013, Volume 1, Issue 1, pp. 51 - 60
Summary Background QVA149 is an inhaled fixed-dose combination therapy under development for the treatment of chronic obstructive pulmonary disease (COPD). It... 
Pulmonary/Respiratory | FORMOTEROL | MANAGEMENT | RESPIRATORY SYSTEM | SALMETEROL/FLUTICASONE PROPIONATE | INHALED CORTICOSTEROIDS | EXACERBATIONS | PREVENTION | TIOTROPIUM | OUTCOMES | COMBINATION | COPD | Bronchodilator Agents - therapeutic use | Indans - adverse effects | Sympathomimetics - administration & dosage | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Bronchodilator Agents - administration & dosage | Humans | Middle Aged | Male | Indans - therapeutic use | Quinolones - adverse effects | Quinolones - therapeutic use | Female | Indans - administration & dosage | Glucocorticoids - adverse effects | Sympathomimetics - adverse effects | Glycopyrrolate - adverse effects | Sympathomimetics - therapeutic use | Double-Blind Method | Drug Administration Schedule | Glycopyrrolate - therapeutic use | Administration, Inhalation | Albuterol - analogs & derivatives | Treatment Outcome | Glycopyrrolate - analogs & derivatives | Quinolones - administration & dosage | Glycopyrrolate - administration & dosage | Albuterol - therapeutic use | Androstadienes - therapeutic use | Fluticasone-Salmeterol Drug Combination | Androstadienes - adverse effects | Albuterol - adverse effects | Drug Combinations | Pulmonary Disease, Chronic Obstructive - drug therapy
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