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NATURE, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 241 - 244
beta-adrenergic receptors (beta ARs) are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins upon binding catecholamine agonist ligands... 
CRYSTALLIZATION | AMINO-ACID | ACTIVATION | LIGAND-BINDING | BETA-ADRENERGIC-RECEPTORS | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CRYSTALLOGRAPHY | HIGH-AFFINITY BINDING | BETA-ADRENERGIC RECEPTOR | Dobutamine - metabolism | Hydroxyquinolines - chemistry | Catecholamines - metabolism | Albuterol - pharmacology | Amphetamines - pharmacology | Adrenergic beta-1 Receptor Antagonists - pharmacology | Crystallography, X-Ray | Adrenergic beta-1 Receptor Agonists - chemistry | Structure-Activity Relationship | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Agonists - pharmacology | Turkeys | Adrenergic beta-1 Receptor Antagonists - chemistry | Drug Design | Adrenergic beta-1 Receptor Antagonists - metabolism | Dobutamine - chemistry | Isoproterenol - chemistry | Binding Sites | Hydroxyquinolines - pharmacology | Amphetamines - chemistry | Drug Partial Agonism | Albuterol - metabolism | Hydroxyquinolines - metabolism | Isoproterenol - metabolism | Models, Molecular | Receptors, Adrenergic, beta-1 - metabolism | Serine - chemistry | Serine - metabolism | Dobutamine - pharmacology | Animals | Hydrogen Bonding | Amphetamines - metabolism | Isoproterenol - pharmacology | Protein Stability - drug effects | Albuterol - chemistry | Ligands | Protein Conformation | Adrenergic beta-1 Receptor Agonists - metabolism
Journal Article
Journal Article
Journal Article
AAPS PharmSciTech, ISSN 1530-9932, 6/2013, Volume 14, Issue 2, pp. 712 - 718
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 6/2012, Volume 403, Issue 8, pp. 2385 - 2395
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 07/2011, Volume 100, Issue 7, pp. 2665 - 2684
It has been shown that dry powder inhaler (DPI) formulations typically achieve low fine particle fractions (poor performance). A commonly held theory is that... 
particle size | precipitation | crystallized lactose | pulmonary delivery | particle shape | aerosolization performance | crystallization | salbutamol sulfate | dry powder inhalers | solid state | Dry powder inhalers | Solid state | Particle size | Precipitation | Aerosolization performance | Crystallization | Crystallized lactose | Pulmonary delivery | Particle shape | Salbutamol sulfate | CHEMISTRY, MEDICINAL | PARTICLE-SIZE DISTRIBUTION | EXCIPIENT PARTICLES | DRUG-DELIVERY | FINE LACTOSE | CHEMISTRY, MULTIDISCIPLINARY | SALMETEROL XINAFOATE | DRY POWDER INHALER | ENGINEERED MANNITOL | INTERACTIVE MIXTURES | PHARMACOLOGY & PHARMACY | IN-VITRO DEPOSITION | ALPHA-LACTOSE | Bronchodilator Agents - administration & dosage | Solvents - chemistry | Spectroscopy, Fourier Transform Infrared | Drug Carriers | Bronchodilator Agents - chemistry | Surface Properties | Albuterol - administration & dosage | Drug Compounding | Microscopy, Atomic Force | Acetone - chemistry | Dry Powder Inhalers | Microscopy, Electron, Scanning | Powders | Rheology | Adhesiveness | Adrenergic beta-2 Receptor Agonists - chemistry | Administration, Inhalation | Technology, Pharmaceutical - methods | Chemistry, Pharmaceutical | Particle Size | Ethanol - chemistry | Aerosols | Adrenergic beta-2 Receptor Agonists - administration & dosage | Albuterol - chemistry | Calorimetry, Differential Scanning | Lactose - chemistry
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