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European Journal of Pharmacology, ISSN 0014-2999, 2003, Volume 462, Issue 1, pp. 193 - 198
The cytokine interleukin-17 may play a role in the recruitment of airway neutrophils, and interleukin-17 protein is increased in the airways of patients with... 
C-X-C chemokine | Interleukin-17 | Bronchial epithelial cell | human | Human | ACTIVATION | PROTEIN | MECHANISMS | CYTOKINE | NEUTROPHIL RECRUITMENT | bronchial epithelial cell, human | interleukin-17 | IN-VITRO | IL-17 | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | AIRWAYS | CYCLOSPORINE | Epithelial Cells - metabolism | Albuterol - pharmacology | Cyclosporine - pharmacology | Epithelial Cells - drug effects | Humans | Receptors, Glucocorticoid - metabolism | Interleukin-17 - pharmacology | Bronchi - drug effects | Dose-Response Relationship, Drug | Calcineurin Inhibitors | Intercellular Signaling Peptides and Proteins - metabolism | Chemotactic Factors - metabolism | Bronchi - metabolism | Flavonoids - pharmacology | Interleukin-8 - metabolism | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Receptors, Glucocorticoid - drug effects | Bronchi - cytology | p38 Mitogen-Activated Protein Kinases | Enzyme Inhibitors - pharmacology | Adrenergic beta-Agonists - pharmacology | Imidazoles - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Chemokines, CXC - metabolism | Chemokine CXCL1 | Chemokines - metabolism | Hydrocortisone - pharmacology | Pyridines - pharmacology | Chemokine CXCL6 | Cell Line, Transformed | Chemokines/secretion | Albuterol/pharmacology | Flavonoids/pharmacology | Adrenergic | beta/drug effects/metabolism | Epithelial Cells/drug effects/metabolism | Enzyme Inhibitors/pharmacology | Transformed | Adrenergic beta-Agonists/pharmacology | Ca(2+)-Calmodulin Dependent Protein Kinase/antagonists & inhibitors | Receptors | Imidazoles/pharmacology | Chemotactic Factors/secretion | Cyclosporine/pharmacology | Lungmedicin och allergi | Respiratory Medicine and Allergy | Bronchi/cytology/drug effects/metabolism | Drug | Intercellular Signaling Peptides and Proteins/secretion | Cell Line | P-Glycoprotein/antagonists & inhibitors | Interleukin-8/secretion | Hydrocortisone/pharmacology | Glucocorticoid/drug effects/metabolism | CXC/secretion | Interleukin-17/pharmacology | Mitogen-Activated Protein Kinases/antagonists & inhibitors | Calcineurin/antagonists & inhibitors | Dose-Response Relationship | Chemokines | Pyridines/pharmacology
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2012, Volume 167, Issue 4, pp. 775 - 786
BACKGROUND AND PURPOSE Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids, which has been linked to oxidative... 
salmeterol | corticosteroid | severe asthma | PI3Kδ | formoterol | oxidative stress | COPD | CELLS | COMBINATION THERAPY | INHALED CORTICOSTEROIDS | AIRWAY INFLAMMATION | BUDESONIDE | ADRENERGIC AGONISTS | INTERLEUKIN-8 | ASTHMA CONTROL | OBSTRUCTIVE PULMONARY-DISEASE | PHARMACOLOGY & PHARMACY | PI3Kd | Ethanolamines - pharmacology | Asthma - metabolism | Formoterol Fumarate | Albuterol - pharmacology | Humans | Middle Aged | Oxidative Stress - physiology | Male | Fluticasone | Adrenergic beta-2 Receptor Agonists - pharmacology | 1-Phosphatidylinositol 4-Kinase - metabolism | Young Adult | Dexamethasone - pharmacology | U937 Cells | Adult | Female | Interleukin-8 - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Chromones - pharmacology | Salmeterol Xinafoate | Adenine - analogs & derivatives | Leukocytes, Mononuclear - drug effects | Hydrogen Peroxide - pharmacology | Adrenal Cortex Hormones - pharmacology | Albuterol - analogs & derivatives | Morpholines - pharmacology | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | Adenine - pharmacology | Drug Resistance - drug effects | Receptors, Adrenergic, beta-2 - metabolism | Budesonide - pharmacology | Androstadienes - pharmacology | Aged | Quinazolines - pharmacology | Hydrogen peroxide | Dexamethasone | Asthma | Steroids | Oxidative stress | Chronic obstructive pulmonary disease | Research Papers
Journal Article
NATURE, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 241 - 244
beta-adrenergic receptors (beta ARs) are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins upon binding catecholamine agonist ligands... 
CRYSTALLIZATION | AMINO-ACID | ACTIVATION | LIGAND-BINDING | BETA-ADRENERGIC-RECEPTORS | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CRYSTALLOGRAPHY | HIGH-AFFINITY BINDING | BETA-ADRENERGIC RECEPTOR | Dobutamine - metabolism | Hydroxyquinolines - chemistry | Catecholamines - metabolism | Albuterol - pharmacology | Amphetamines - pharmacology | Adrenergic beta-1 Receptor Antagonists - pharmacology | Crystallography, X-Ray | Adrenergic beta-1 Receptor Agonists - chemistry | Structure-Activity Relationship | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Agonists - pharmacology | Turkeys | Adrenergic beta-1 Receptor Antagonists - chemistry | Drug Design | Adrenergic beta-1 Receptor Antagonists - metabolism | Dobutamine - chemistry | Isoproterenol - chemistry | Binding Sites | Hydroxyquinolines - pharmacology | Amphetamines - chemistry | Drug Partial Agonism | Albuterol - metabolism | Hydroxyquinolines - metabolism | Isoproterenol - metabolism | Models, Molecular | Receptors, Adrenergic, beta-1 - metabolism | Serine - chemistry | Serine - metabolism | Dobutamine - pharmacology | Animals | Hydrogen Bonding | Amphetamines - metabolism | Isoproterenol - pharmacology | Protein Stability - drug effects | Albuterol - chemistry | Ligands | Protein Conformation | Adrenergic beta-1 Receptor Agonists - metabolism
Journal Article
Respiratory Care, ISSN 0020-1324, 06/2018, Volume 63, Issue 6, pp. 641 - 654
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2017, Volume 199, Issue 7, pp. 2503 - 2514
Heterodimeric IL-27 (p28/EBV-induced gene 3) is an important member of the IL-6/IL-12 cytokine family. IL-27 is predominantly synthesized by mononuclear... 
ENDOGENOUS CATECHOLAMINES | ALTERNATIVELY ACTIVATED MACROPHAGES | HUMAN DENDRITIC CELLS | CYTOKINE PRODUCTION | CELLULAR IMMUNE FUNCTIONS | FAMILY-MEMBERS | REGULATORY T-CELLS | GENE-EXPRESSION | KAPPA-B | IMMUNOLOGY | BLOOD-PRESSURE | Norepinephrine - pharmacology | Albuterol - pharmacology | Sympathetic Nervous System - immunology | Zymosan - pharmacology | Interleukins - metabolism | Interleukins - genetics | Sympathetic Nervous System - physiology | Receptors, Adrenergic - drug effects | Interleukins - immunology | Macrophages - immunology | Thiadiazoles - pharmacology | Interleukins - blood | Formoterol Fumarate - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Inflammation | Sulfonamides - pharmacology | Toll-Like Receptor 3 - metabolism | Anthracenes - pharmacology | Animals | Shock, Septic | Signal Transduction - drug effects | Poly I-C - metabolism | Lipopolysaccharides - pharmacology | Interleukin-10 - biosynthesis | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Interleukin-10 - immunology | Epinephrine - pharmacology | Shock | Adrenal glands | Glands | Nervous system | Leukocytes (mononuclear) | Activation | Feedback loops | Macrophages | Neuromodulation | Interleukin 27 | Neoplasms | Neuroendocrine system | Interleukin 6 | Cell activation | Autonomic nervous system | Modulation | Formoterol | Autocrine signalling | Noradrenaline | Endotoxemia | Epinephrine | CD11b antigen | Immune response | Immunoregulation | Interleukin 12 | Catecholamines | JNK protein | Pharmacology | Sympathetic nervous system | Catecholamine | Gene silencing | Interleukin 10 | Adrenergic receptors | Receptors (physiology) | Hypothermia
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 12/2012, Volume 303, Issue 11, pp. 956 - 966
Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause bronchodilation. The aim of this study was to extend the information... 
Bronchodilation | Prostaglandins | Airway smooth muscle | Asthma | ACTIVATION | PHYSIOLOGY | POTASSIUM CHANNELS | INDUCED BRONCHODILATION | airway smooth muscle | asthma | ANTAGONISM | RESPONSES | BK CHANNELS | TONE | RESPIRATORY SYSTEM | OBSTRUCTION | prostaglandins | bronchodilation | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Respiratory Mucosa - drug effects | Receptors, G-Protein-Coupled - metabolism | Albuterol - pharmacology | Male | Trachea - drug effects | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Trachea - metabolism | Receptors, G-Protein-Coupled - agonists | Chloroquine - pharmacology | Muscle, Smooth - drug effects | Large-Conductance Calcium-Activated Potassium Channels - physiology | Charybdotoxin - pharmacology | Trachea - physiology | Indoles - pharmacology | Muscle, Smooth - physiology | Cholinergic Agonists - pharmacology | Gene Expression | Guinea Pigs | Bronchodilator Agents - pharmacology | Indomethacin - pharmacology | Peptides - pharmacology | Carbachol - pharmacology | Animals | Muscle Contraction - drug effects | Receptors, G-Protein-Coupled - genetics | Muscle Relaxation - drug effects | In Vitro Techniques | Quaternary Ammonium Compounds - pharmacology | Physiological aspects | Taste | Genetic aspects | Research | Drug therapy | Trachea | Bronchodilator agents
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2013, Volume 36, Issue 6, pp. 966 - 973
Journal Article
Science, ISSN 0036-8075, 09/2017, Volume 357, Issue 6354, pp. 891 - 898
Journal Article
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, ISSN 1044-1549, 07/2000, Volume 23, Issue 1, pp. 79 - 85
We have previously reported that human airway smooth-muscle (ASM) cells produce abundant interleukin (IL)-8, a major neutrophil chemoattractant involved in... 
RESPONSIVENESS | MECHANISM | SPUTUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN-LUNG | INDUCTION | SALMETEROL | CELL BIOLOGY | EPITHELIAL-CELLS | INTERFERON-GAMMA | RESPIRATORY SYSTEM | INFLAMMATION | ASTHMA | Albuterol - pharmacology | Humans | Trachea - drug effects | Fluticasone | Adrenal Cortex Hormones - therapeutic use | Respiratory System - cytology | Adrenergic beta-Antagonists - pharmacology | Muscle, Smooth - drug effects | Dexamethasone - pharmacology | Adrenergic beta-Agonists - therapeutic use | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Interleukin-8 - metabolism | Rolipram - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Survival - drug effects | Salmeterol Xinafoate | Adrenergic beta-2 Receptor Antagonists | Trachea - cytology | Colforsin - pharmacology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Cells, Cultured | Adrenal Cortex Hormones - pharmacology | Adrenergic beta-Agonists - pharmacology | Albuterol - analogs & derivatives | Phosphodiesterase Inhibitors - pharmacology | Muscle, Smooth - metabolism | Asthma - drug therapy | Receptors, Adrenergic, beta-2 - metabolism | Drug Synergism | Tumor Necrosis Factor-alpha - pharmacology | Dexamethasone - therapeutic use | Androstadienes - pharmacology | Respiratory System - drug effects | Albuterol - therapeutic use | Androstadienes - therapeutic use | Muscle, Smooth - cytology | Propanolamines - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 04/2018, Volume 49, pp. 20 - 26
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2014, Volume 736, pp. 35 - 43
Journal Article
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 2012, Volume 25, Issue 2, pp. 178 - 184
Abstract The phosphodiesterase 4 inhibitor (PDE4i) roflumilast has been approved in the US and EU for treatment of GOLD stage 3 and 4 chronic obstructive... 
Medical Education | Pulmonary/Respiratory | Dexamethasone | Roflumilast | cAMP | PBMC | PDE4 | Salmeterol | CAMP | PROTEIN-KINASE | MONOCYTES | ADRENERGIC AGONISTS | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP | RESPIRATORY SYSTEM | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | INHIBITORS | POTENTIAL ROLE | PHOSPHODIESTERASE-4 | Ethanolamines - pharmacology | Leukocytes, Mononuclear - metabolism | Formoterol Fumarate | Glucocorticoids - administration & dosage | Albuterol - pharmacology | Humans | Male | Ethanolamines - administration & dosage | Adrenergic beta-2 Receptor Agonists - pharmacology | Lipopolysaccharides | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Dexamethasone - pharmacology | Cyclopropanes - administration & dosage | Inflammation - drug therapy | Phosphodiesterase 4 Inhibitors - administration & dosage | Albuterol - administration & dosage | Inhibitory Concentration 50 | Anti-Inflammatory Agents - administration & dosage | Benzamides - pharmacology | Drug Therapy, Combination | Cyclopropanes - pharmacology | Aminopyridines - administration & dosage | Salmeterol Xinafoate | Dexamethasone - administration & dosage | Leukocytes, Mononuclear - drug effects | Anti-Inflammatory Agents - pharmacology | Tumor Necrosis Factor-alpha - secretion | Albuterol - analogs & derivatives | Phosphodiesterase 4 Inhibitors - pharmacology | Aminopyridines - pharmacology | Glucocorticoids - pharmacology | Adrenergic beta-2 Receptor Agonists - administration & dosage | Inflammation - physiopathology | Lung diseases, Obstructive | Management science | Corticosteroids | Anti-inflammatory drugs | Respiratory agents | Respiratory tract diseases | Mitogens
Journal Article