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Journal of Clinical Investigation, ISSN 0021-9738, 12/2014, Volume 124, Issue 12, pp. 5368 - 5384
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain... 
INTESTINAL INFLAMMATION | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | INFLAMMATORY-BOWEL-DISEASE | SPHINGOSINE KINASE 1 | EPITHELIAL-CELLS | GENE | INDUCED COLITIS | CELL-PROLIFERATION | PERSISTENT STAT3 ACTIVATION | CANCER | Lysophospholipids - metabolism | Colonic Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Aldehyde-Lyases - biosynthesis | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | Inflammatory Bowel Diseases - metabolism | RNA, Neoplasm - metabolism | Colonic Neoplasms - metabolism | Neoplasms, Experimental - pathology | Cell Transformation, Neoplastic - genetics | Gene Deletion | Inflammatory Bowel Diseases - genetics | Neoplasms, Experimental - genetics | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Neoplasm Proteins - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Mice, Transgenic | Signal Transduction - genetics | Anion Transport Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Gene Expression Regulation, Enzymologic | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Animals | Biopsy | Colonic Neoplasms - pathology | RNA, Neoplasm - genetics | Sphingosine - genetics | Mice | MicroRNAs - genetics | Neoplasms, Experimental - metabolism | Anion Transport Proteins - genetics | Colon cancer | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Lyases | Research | Inflammatory bowel disease | Medical research | Kinases | Rodents | Colorectal cancer | Index Medicus | Abridged Index Medicus
Journal Article
The Plant Journal, ISSN 0960-7412, 04/2012, Volume 70, Issue 2, pp. 243 - 255
The MADS box transcription factor RIN is a global regulator of fruit ripening. However, the direct targets modulated by RIN and the mechanisms underlying the... 
transcription factor | tomato | proteomics | fruit ripening | MADS‐RIN | chromatin immunoprecipitation | MADS-RIN | FLAVOR COMPOUNDS | TOMATO FRUIT | PROTEIN | AROMA | PROTEOMICS ANALYSIS | VOLATILE COMPOUNDS | ETHYLENE BIOSYNTHESIS | PLANT SCIENCES | PATHWAY | GENE-EXPRESSION | BINDING | Proteome - genetics | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Electrophoresis, Gel, Two-Dimensional | Gene Expression Profiling | Gene Regulatory Networks | Promoter Regions, Genetic - genetics | Lipoxygenase - metabolism | Lycopersicon esculentum - growth & development | Gene Expression Regulation, Developmental | Mass Spectrometry | Gene Expression Regulation, Plant | Lycopersicon esculentum - genetics | Plant Proteins - metabolism | Aldehyde-Lyases - genetics | Proteomics - methods | Fruit - metabolism | Fruit - genetics | Alcohol Dehydrogenase - metabolism | Amino Acid Sequence | Lycopersicon esculentum - metabolism | Signal Transduction | MADS Domain Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | MADS Domain Proteins - metabolism | Fruit - growth & development | Plant Proteins - genetics | Alcohol Dehydrogenase - genetics | Lipoxygenase - genetics | Aldehyde-Lyases - metabolism | Cytochrome P-450 Enzyme System - genetics | Protein Binding | Mutation | Proteome - metabolism | Enzymes | Anopheles | Chromatin | Messenger RNA | RNA | Analysis | Genes | Genetic research | Gene expression | Plant biology | Molecular biology | Proteomics | Fruits | Index Medicus
Journal Article
Journal Article
Journal of Biotechnology, ISSN 0168-1656, 09/2017, Volume 258, pp. 69 - 78
Journal Article
Science, ISSN 0036-8075, 7/2004, Volume 305, Issue 5684, pp. 665 - 668
We transformed the native tobacco, Nicotiana attenuata, to silence its lipoxygenase, hydroperoxide lyase, and allene oxide synthase genes in order to inhibit... 
Transcriptional regulatory elements | Ecological genetics | Genes | Plant genetics | Reports | Plants | Herbivores | Infestation | Post hoc | Insect genetics | Phenotypic traits | RESPONSES | EVOLUTION | COSTS | NICOTIANA-ATTENUATA | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | VOLATILES | GENES | RESISTANCE | ARABIDOPSIS | EXPRESSION | Oligonucleotide Array Sequence Analysis | Hemiptera - physiology | Cytochrome P-450 Enzyme System - metabolism | Gene Expression Profiling | Oxylipins | Lipoxygenase - metabolism | Terpenes - metabolism | Ecosystem | Gene Expression Regulation, Plant | Female | Insecta - physiology | Aldehyde-Lyases - genetics | Intramolecular Oxidoreductases - metabolism | Manduca - physiology | Coleoptera - physiology | Tobacco - physiology | Transformation, Genetic | Signal Transduction | Tobacco - metabolism | Gene Silencing | Hexobarbital - metabolism | Cyclopentanes - pharmacology | Animals | Nicotine - metabolism | Intramolecular Oxidoreductases - genetics | Tobacco - genetics | Bridged Bicyclo Compounds - metabolism | Lipoxygenase - genetics | Aldehyde-Lyases - metabolism | Cytochrome P-450 Enzyme System - genetics | Cyclopentanes - metabolism | Acetates - pharmacology | Oviposition | Physiological aspects | Genetic aspects | Plant defenses | Nicotiana | Research | Tobacco | Ecosystem studies | Insects | Plant resistance | Genetics | Animal populations | Biological diversity | Index Medicus
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 2816 - 12
Journal Article
Oncogene, ISSN 0950-9232, 06/2014, Volume 33, Issue 26, pp. 3364 - 3373
Despite progress in the understanding of the biology and genetics of melanoma, no effective treatment against this cancer is available. The adjacent... 
migration | melanoma | dermal fibroblasts | sphingosine-1-phosphate | mice | Sphk1 | Sphk1(-/-) mice | METASTASIS | TUMOR PROGRESSION | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | CANCER | CELL BIOLOGY | INVASION | ONCOLOGY | CUTANEOUS MELANOMA | GROWTH | GENETICS & HEREDITY | STROMAL FIBROBLASTS | Lysophospholipids - metabolism | Fibroblasts - enzymology | Humans | Melanoma - enzymology | Myofibroblasts - enzymology | Gene Expression Profiling | Cell Differentiation - genetics | RNA, Messenger - biosynthesis | Skin Neoplasms - enzymology | RNA Interference | Cell Transformation, Neoplastic - genetics | HEK293 Cells | Female | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Matrix Metalloproteinase 2 - biosynthesis | Skin Neoplasms - pathology | Myofibroblasts - pathology | Matrix Metalloproteinase 9 - biosynthesis | Membrane Proteins - genetics | Mice, Inbred C57BL | Phosphotransferases (Alcohol Group Acceptor) - genetics | Cell Communication - genetics | Extracellular Signal-Regulated MAP Kinases | Melanoma - pathology | Fibroblasts - pathology | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - analogs & derivatives | Animals | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Mice | RNA, Small Interfering | Cell Movement | Cell interaction | Enzymes | Protein research | Oncology, Experimental | Melanoma | Genetic aspects | Regulation | Research | Properties | Phosphotransferases | Cancer | Oncology | Kinases | Cancer therapies | Cells | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 26078 - 26088
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2017, Volume 127, Issue 3, pp. 912 - 928
Journal Article
BMC Cancer, ISSN 1471-2407, 10/2015, Volume 15, Issue 1, pp. 762 - 762
Background: Resistance to chemotherapy is common in gastroesophageal cancer. Mechanisms of resistance are incompletely characterised and there are no... 
Gastroesophageal cancer | Sphingosine kinase 1 | Chemoresistance | Sphingosine-1-phopshate lyase | Sphingosine-1-phosphate | CELLS | ADVANCED ESOPHAGOGASTRIC CANCER | LABEL PHASE-3 TRIAL | CAPECITABINE | CISPLATIN | ONCOLOGY | ADVANCED GASTRIC-CANCER | PROSTATE-CANCER | DOUBLE-BLIND | 1ST-LINE THERAPY | 1-PHOSPHATE | Immunohistochemistry | Humans | Gene Expression Regulation, Neoplastic | Aldehyde-Lyases - biosynthesis | Stomach Neoplasms - metabolism | Male | Antineoplastic Agents - therapeutic use | Esophageal Neoplasms - metabolism | Lysophospholipids - biosynthesis | Female | Aldehyde-Lyases - genetics | Real-Time Polymerase Chain Reaction | Stomach Neoplasms - genetics | Signal Transduction | Phosphotransferases (Alcohol Group Acceptor) - genetics | Stomach Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Esophageal Neoplasms - genetics | Sphingosine - biosynthesis | Cell Line, Tumor | RNA, Neoplasm - genetics | Sphingosine - genetics | Esophageal Neoplasms - drug therapy | Phosphotransferases (Alcohol Group Acceptor) - biosynthesis | Complications and side effects | Care and treatment | Chemotherapy | Usage | Analysis | Sphingosine | Influence | Research | Gene expression | Stomach cancer | Health aspects | Cancer | Physiological aspects | Membrane lipids | Genes | Index Medicus
Journal Article