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Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7472, pp. 571 - 574
Journal Article
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 6, pp. 724 - 734
ABSTRACT—Sphingosine 1-phosphate (S1P), an evolutionarily conserved bioactive lipid mediator, is now recognized as a potent modulator of cell regulation. In... 
Sphingolipid mediators | Sphingosine kinase | Sphingosine 1-phosphate lyase | Sphingosine 1-phosphate receptors | Sphingosine 1-phosphate phosphatase | NOVO CERAMIDE SYNTHESIS | sphingosine 1-phosphate lyase | CARDIAC & CARDIOVASCULAR SYSTEMS | sphingosine kinase | LIPID PHOSPHATE PHOSPHATASES | LOW-DENSITY-LIPOPROTEIN | SACCHAROMYCES-CEREVISIAE | sphingosine 1-phosphate receptors | HUMAN ENDOTHELIAL-CELLS | LONG-CHAIN BASES | SPHINGOLIPID METABOLISM | SPHINGOSINE-1-PHOSPHATE LYASE | sphingolipid mediators | PROTEIN-COUPLED RECEPTOR | sphingosine 1-phosphate phosphatase | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Lysophospholipids - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Receptors, G-Protein-Coupled - metabolism | Species Specificity | Humans | Invertebrates - metabolism | Receptors, Lysophospholipid | Fungi - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Plants - metabolism | Sphingosine - analogs & derivatives | Animals | Cardiovascular System - metabolism | Endothelium, Vascular - metabolism | Myocardium - metabolism | Aldehyde-Lyases - metabolism | Second Messenger Systems - physiology | Membrane Proteins - metabolism | Sphingosine - metabolism | Phosphoric Monoester Hydrolases - metabolism | Receptors, G-Protein-Coupled - drug effects | Vertebrates - metabolism | Receptors, G-Protein-Coupled - physiology
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 08/2011, Volume 18, Issue 8, pp. 1356 - 1365
We have recently reported that the bioactive lipid sphingosine-1-phosphate (S1P), usually signaling proliferation and anti-apoptosis induces neuronal death... 
neurodegeneration | calpain | apoptosis | cis-4-methylsphingosine | release | Sphingosine-1-phosphate | Ca2+-release | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL-CHARACTERIZATION | SPHINGOSINE 1-PHOSPHATE | CELL BIOLOGY | SPHINGOLIPID METABOLISM | CYTOCHROME-C | POSTMITOTIC NEURONS | AMYLOID-BETA | CELL-CYCLE | MOLECULAR-CLONING | Lysophospholipids - metabolism | Neurons - pathology | Calpain - metabolism | Caspase 9 - metabolism | Calcium - metabolism | tau Proteins - metabolism | Calpain - genetics | Nerve Degeneration - chemically induced | Nerve Degeneration - metabolism | Neurons - physiology | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Neurons - drug effects | Mice, Inbred C57BL | Phosphotransferases (Alcohol Group Acceptor) - genetics | Mitochondria - metabolism | Caspase 12 - metabolism | Nerve Degeneration - pathology | Cyclin-Dependent Kinase 5 - metabolism | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Cerebellum - cytology | Aldehyde-Lyases - metabolism | Cell Cycle - physiology | Glycosphingolipids - metabolism | Signal Transduction - physiology | Mice | Apoptosis - physiology | Sphingosine - chemistry | Cerebellum | Phosphorylation | Calcium | Central nervous system | Cysteine proteinase | Caspase | Calpain | Lipids | Anatomy | Metabolism | Cyclin-dependent kinase 5 | Sphingosine 1-phosphate | Neurotoxicity | Glycosphingolipids | Tau protein | Neurodegeneration | Phosphate | Cell cycle | Endoplasmic reticulum | Index Medicus | Original Paper
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2014, Volume 124, Issue 12, pp. 5368 - 5384
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain... 
INTESTINAL INFLAMMATION | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | INFLAMMATORY-BOWEL-DISEASE | SPHINGOSINE KINASE 1 | EPITHELIAL-CELLS | GENE | INDUCED COLITIS | CELL-PROLIFERATION | PERSISTENT STAT3 ACTIVATION | CANCER | Lysophospholipids - metabolism | Colonic Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Aldehyde-Lyases - biosynthesis | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | Inflammatory Bowel Diseases - metabolism | RNA, Neoplasm - metabolism | Colonic Neoplasms - metabolism | Neoplasms, Experimental - pathology | Cell Transformation, Neoplastic - genetics | Gene Deletion | Inflammatory Bowel Diseases - genetics | Neoplasms, Experimental - genetics | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Neoplasm Proteins - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Mice, Transgenic | Signal Transduction - genetics | Anion Transport Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Gene Expression Regulation, Enzymologic | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Animals | Biopsy | Colonic Neoplasms - pathology | RNA, Neoplasm - genetics | Sphingosine - genetics | Mice | MicroRNAs - genetics | Neoplasms, Experimental - metabolism | Anion Transport Proteins - genetics | Colon cancer | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Lyases | Research | Inflammatory bowel disease | Medical research | Kinases | Rodents | Colorectal cancer | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0146410
L. pneumophila is the causative agent of Legionnaires' disease, a human illness characterized by severe pneumonia. In contrast to those derived from humans,... 
PHAGOSOME | TUMOR-NECROSIS-FACTOR | NUCLEOTIDE-EXCHANGE FACTOR | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | EFFECTOR PROTEIN DRRA | LEGIONNAIRES-DISEASE | INFECTION | NF-KAPPA-B | HUMAN-MONOCYTES | Caspase 7 - metabolism | Phagosomes - microbiology | Lysophospholipids - metabolism | Species Specificity | Humans | Caspase 3 - metabolism | Legionnaires' Disease - metabolism | Caspase 1 - metabolism | NF-kappa B - metabolism | Lysophospholipids - immunology | Legionnaires' Disease - immunology | Phagosomes - immunology | Lysosomes - metabolism | Caspase 3 - genetics | Apoptosis Regulatory Proteins - genetics | Legionnaires' Disease - microbiology | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Aldehyde-Lyases - immunology | Legionella pneumophila - pathogenicity | Disease Resistance - genetics | Macrophages - immunology | Macrophages - microbiology | Calcium-Binding Proteins - metabolism | Bacterial Secretion Systems - genetics | Legionnaires' Disease - genetics | Membrane Fusion | Signal Transduction | Caspase 7 - genetics | Phagosomes - metabolism | Gene Expression Regulation | Sphingosine - immunology | Apoptosis Regulatory Proteins - metabolism | Host-Pathogen Interactions | Macrophages - metabolism | Sphingosine - analogs & derivatives | Animals | Lysosomes - microbiology | NF-kappa B - genetics | Caspase 1 - genetics | Bacterial Secretion Systems - metabolism | Legionella pneumophila - physiology | Mice, Inbred NOD | Mice | Lysosomes - immunology | Calcium-Binding Proteins - genetics | Physiological aspects | Mitochondrial DNA | Macrophages | Analysis | Sphingosine | Phosphates | Phosphorylation | Pneumonia | Fuses | Flagellin | Legionella pneumophila | Homology | Biology | Infections | Activation | Legionnaires disease | Kinases | Caspase-3 | Cell adhesion & migration | Caspase-1 | Sphingosine 1-phosphate | Proteins | Sphingosine lyase | Mitochondria | Bone marrow | Tumor necrosis factor-TNF | Lipid metabolism | Strains (organisms) | Elongation | Pattern recognition systems | Enzymes | Pathogens | NF-κB protein | Bacterial infections | Cytokines | Secretion | Caspase | Inflammation | Metabolism | Mutants | Caspase-7 | Monocytes | Replication | Laboratory animals | Sphingosine 1-phosphate lyase
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 26078 - 26088
Journal Article
Marine Drugs, ISSN 1660-3397, 02/2017, Volume 15, Issue 2, pp. 37 - 37
Recently, we identified an alginate-assimilating gene cluster in the genome of Flavobacterium sp. strain UMI-01, a member of Bacteroidetes. Alginate lyase... 
2-keto-3-deoxy-D-gluconate (KDG) kinase/2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase | 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEH) metabolism | Proteobacteria | Flavobacterium | Alginate-derived products | Bacteroidetes | Alginate degradation | alginate-derived products | CHEMISTRY, MEDICINAL | alginate degradation | ENTNER-DOUDOROFF PATHWAY | APLYSIA-KURODAI | 2-keto-3-deoxy-D-gluconate (KDG) kinase | ESCHERICHIA-COLI | SULFOLOBUS-SOLFATARICUS | SACCHAROPHAGUS-DEGRADANS 2-40 | 4-DEOXY-L-ERYTHRO-5-HEXOSEULOSE URONIC-ACID | 2-keto-3deoxy-6-phosphogluconate (KDPG) aldolase | HALIOTIS-DISCUS-HANNAI | 2-KETO-3-DEOXYGLUCONATE KINASE | 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE KDPG ALDOLASE | OLIGOALGINATE LYASE | Amino Acid Sequence | Proteobacteria - metabolism | Oxidoreductases - metabolism | Glucuronic Acid - metabolism | Phylogeny | Uronic Acids - metabolism | Alginates - metabolism | Gluconates - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sequence Alignment | Bacteroidetes - metabolism | Escherichia coli - metabolism | Aldehyde-Lyases - metabolism | Hexuronic Acids - metabolism | Flavobacterium - metabolism | 4-deoxy | l-erythro-5-hexoseulose uronic acid (DEH) metabolism">">l-erythro-5-hexoseulose uronic acid (DEH) metabolism | d-gluconate (KDG) kinase">">d-gluconate (KDG) kinase | 2-keto-3-deoxy | 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase
Journal Article
Advances in Biological Regulation, ISSN 2212-4926, 01/2017, Volume 63, pp. 156 - 166
Cellular level of sphingosine-1-phosphate (S1P), the simplest bioactive sphingolipid, is tightly regulated by its synthesis catalyzed by sphingosine kinases... 
Acute lung injury | S1P signaling | S1P lyase | Sphingosine kinases | Histone acetylation | Histone deacetylases | Hexadecenal | Lysophospholipids - metabolism | Epigenesis, Genetic | Humans | Acute Lung Injury - genetics | Aldehydes - metabolism | Lipopolysaccharides | Receptors, Lysosphingolipid - genetics | Acute Lung Injury - metabolism | Membrane Proteins - metabolism | Sphingosine - metabolism | Acetylation | Aldehyde-Lyases - genetics | Receptors, Lysosphingolipid - metabolism | Cytokines - genetics | Histone Deacetylase 1 - genetics | Histone Deacetylase 2 - genetics | Phosphoric Monoester Hydrolases - genetics | Cytokines - metabolism | Signal Transduction | Membrane Proteins - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Acute Lung Injury - pathology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - analogs & derivatives | Animals | Histones - genetics | Acute Lung Injury - chemically induced | Aldehyde-Lyases - metabolism | Mice | Histone Deacetylase 2 - metabolism | Histones - metabolism | Phosphoric Monoester Hydrolases - metabolism | Histone Deacetylase 1 - metabolism | Phosphates | Acute respiratory distress syndrome | Epigenetic inheritance | Phosphatases | Cytokines | Lipids | Inflammation | Genetic transcription | Ethanolamines | Aldehydes | Endothelium | Sphingosine | Phosphotransferases | Sphingosine Kinases | S1P Lyase | Histone Deacetylases | Histone Acetylation | Acute Lung Injury
Journal Article
Journal Article