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Biochemical Journal, ISSN 0264-6021, 07/2011, Volume 437, Issue 1, pp. 53 - 61
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 12/2011, Volume 24, Issue 12, pp. 2153 - 2166
Journal Article
FEBS Letters, ISSN 0014-5793, 03/2018, Volume 592, Issue 6, pp. 1010 - 1019
Journal Article
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 10/2017, Volume 276, pp. 167 - 173
Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine... 
Enzyme inhibition | Sex hormones | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) | Short-chain dehydrogenases/reductases (SDR) | Carbonyl reduction | Aldo-keto reductases (AKR) | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-HYDROXYSTEROID DEHYDROGENASE | CARCINOGEN NNK | 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE NNK | CIGARETTE-SMOKING | PHARMACOLOGY & PHARMACY | HUMAN LIVER | F344 RATS | TOXICOLOGY | LUNG-CANCER RISK | TOBACCO-SPECIFIC NITROSAMINE | N-NITROSAMINES | Inactivation, Metabolic | Aldo-Keto Reductases - genetics | Liver - enzymology | Nitrosamines - metabolism | Humans | Gonadal Hormones - chemistry | Recombinant Proteins - biosynthesis | Carcinogens - metabolism | Recombinant Proteins - isolation & purification | Progesterone - chemistry | Short Chain Dehydrogenase-Reductases - antagonists & inhibitors | Carcinogens - chemistry | Aldo-Keto Reductases - antagonists & inhibitors | Estradiol - metabolism | Tobacco - metabolism | Nitrosamines - chemistry | Recombinant Proteins - chemistry | Short Chain Dehydrogenase-Reductases - genetics | Gonadal Hormones - metabolism | Androstenes - chemistry | Estradiol - chemistry | Aldo-Keto Reductases - metabolism | Progesterone - metabolism | Androstenes - metabolism | Tobacco - chemistry | Short Chain Dehydrogenase-Reductases - metabolism | Testosterone | Enzymes | Analysis | Lung cancer | Physiological aspects | Development and progression | Ethinyl estradiol | Progesterone | Hormones | Oral contraceptives | Nitrosoamines | Estradiol | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2311 - 2323
Aldo-keto reductase 1C3 (AKR1C3; type 5 17 beta-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated... 
TARGET | CHEMISTRY, MEDICINAL | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PURIFICATION | BIOLOGICAL EVALUATION | AKR1C3 | ABIRATERONE ACETATE | 17-BETA-HSD1 | RESISTANT PROSTATE-CANCER | EXPRESSION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Antineoplastic Agents - chemical synthesis | Humans | Male | Structure-Activity Relationship | Hydroxyprostaglandin Dehydrogenases - metabolism | Fenamates - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | 20-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | 3-Hydroxysteroid Dehydrogenases - metabolism | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Fenamates - chemistry | Testosterone - biosynthesis | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Hydroxyprostaglandin Dehydrogenases - genetics | Cyclooxygenase Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Testosterone - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Fenamates - chemical synthesis | Cyclooxygenase 1 - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Isoenzymes - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 234 - 242
Journal Article