X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (620) 620
index medicus (616) 616
aldo-keto reductases (608) 608
aldo-keto reductase (517) 517
animals (425) 425
biochemistry & molecular biology (416) 416
aldehyde reductase (379) 379
alcohol oxidoreductases - metabolism (316) 316
pharmacology & pharmacy (251) 251
expression (216) 216
female (205) 205
male (203) 203
enzymes (200) 200
aldehyde reductase - metabolism (199) 199
substrate specificity (197) 197
kinetics (188) 188
aldo-keto reductase family 1 member c3 (183) 183
toxicology (179) 179
alcohol oxidoreductases - genetics (166) 166
molecular sequence data (165) 165
metabolism (158) 158
amino acid sequence (155) 155
3-hydroxysteroid dehydrogenases - metabolism (147) 147
aldehyde reductase - genetics (147) 147
hydroxyprostaglandin dehydrogenases - metabolism (143) 143
article (135) 135
cell line, tumor (132) 132
mice (131) 131
cancer (127) 127
oxidative stress (127) 127
superfamily (126) 126
oxidation-reduction (121) 121
physiological aspects (121) 121
rats (121) 121
nadp - metabolism (117) 117
gene expression (116) 116
analysis (114) 114
alcohol oxidoreductases - chemistry (107) 107
models, molecular (106) 106
purification (106) 106
3-hydroxysteroid dehydrogenases - genetics (105) 105
proteins (104) 104
biotechnology & applied microbiology (102) 102
hydroxyprostaglandin dehydrogenases - genetics (102) 102
endocrinology & metabolism (98) 98
oncology (95) 95
cell biology (92) 92
liver - enzymology (91) 91
identification (90) 90
recombinant proteins - metabolism (90) 90
cloning, molecular (88) 88
gene (86) 86
base sequence (84) 84
3-alpha-hydroxysteroid dehydrogenase (82) 82
aldehyde reductase - chemistry (81) 81
biophysics (78) 78
enzyme inhibitors - pharmacology (78) 78
catalysis (77) 77
crystal-structure (77) 77
sequence homology, amino acid (76) 76
carbonyl reductase (75) 75
adult (74) 74
chemistry, medicinal (73) 73
gene-expression (71) 71
middle aged (71) 71
aldehydes (69) 69
research (69) 69
dihydrodiol dehydrogenase (67) 67
dehydrogenase (66) 66
alcohol oxidoreductases - isolation & purification (65) 65
cells (65) 65
binding sites (64) 64
cells, cultured (64) 64
site-directed mutagenesis (64) 64
genes (62) 62
protein (62) 62
crystallography, x-ray (61) 61
research article (61) 61
hydrogen-ion concentration (60) 60
immunohistochemistry (60) 60
aldose reductase (59) 59
microbiology (59) 59
tissue distribution (59) 59
aldo–keto reductase (58) 58
metabolites (58) 58
protein conformation (58) 58
akr1c3 (57) 57
keto reductase superfamily (56) 56
molecular structure (55) 55
mutagenesis, site-directed (55) 55
stereoisomerism (55) 55
alcohol oxidoreductases - antagonists & inhibitors (54) 54
protein binding (54) 54
escherichia coli - genetics (53) 53
structure-activity relationship (52) 52
aged (51) 51
cloning (51) 51
molecular-cloning (51) 51
mutation (51) 51
liver (50) 50
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Chemico-Biological Interactions, ISSN 0009-2797, 10/2017, Volume 276, pp. 167 - 173
Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine... 
Enzyme inhibition | Sex hormones | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) | Short-chain dehydrogenases/reductases (SDR) | Carbonyl reduction | Aldo-keto reductases (AKR) | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-HYDROXYSTEROID DEHYDROGENASE | CARCINOGEN NNK | 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE NNK | CIGARETTE-SMOKING | PHARMACOLOGY & PHARMACY | HUMAN LIVER | F344 RATS | TOXICOLOGY | LUNG-CANCER RISK | TOBACCO-SPECIFIC NITROSAMINE | N-NITROSAMINES | Inactivation, Metabolic | Aldo-Keto Reductases - genetics | Liver - enzymology | Nitrosamines - metabolism | Humans | Gonadal Hormones - chemistry | Recombinant Proteins - biosynthesis | Carcinogens - metabolism | Recombinant Proteins - isolation & purification | Progesterone - chemistry | Short Chain Dehydrogenase-Reductases - antagonists & inhibitors | Carcinogens - chemistry | Aldo-Keto Reductases - antagonists & inhibitors | Estradiol - metabolism | Tobacco - metabolism | Nitrosamines - chemistry | Recombinant Proteins - chemistry | Short Chain Dehydrogenase-Reductases - genetics | Gonadal Hormones - metabolism | Androstenes - chemistry | Estradiol - chemistry | Aldo-Keto Reductases - metabolism | Progesterone - metabolism | Androstenes - metabolism | Tobacco - chemistry | Short Chain Dehydrogenase-Reductases - metabolism | Testosterone | Enzymes | Analysis | Lung cancer | Physiological aspects | Development and progression | Ethinyl estradiol | Progesterone | Hormones | Oral contraceptives | Nitrosoamines | Estradiol
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 533 - 545
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This... 
DIHYDRODIOL DEHYDROGENASE ISOFORMS | QUINONE REDUCTASE | HUMAN CARBONYL REDUCTASE | ENZYMES | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SUPERFAMILY | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ALDEHYDE REDUCTASE | SINGLE NUCLEOTIDE POLYMORPHISMS | PROSTAGLANDIN-F SYNTHASE | Aldehyde Reductase - genetics | Humans | Polymorphism, Single Nucleotide - physiology | Mitochondrial Proteins - genetics | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Recombinant Proteins - isolation & purification | Mitochondrial Proteins - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Glyceraldehyde - metabolism | Phenanthrenes - metabolism | Recombinant Proteins - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Biocatalysis | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Frequency | Indans - metabolism | Models, Molecular | Alcohol Oxidoreductases - metabolism | Recombinant Proteins - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductases | Vitamin K 3 - metabolism | Aldo-Keto Reductase Family 1 Member C3 | NAD(P)H Dehydrogenase (Quinone) - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics
Journal Article
Biotechnology Progress, ISSN 8756-7938, 09/2017, Volume 33, Issue 5, pp. 1235 - 1242
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2015, Volume 234, pp. 309 - 319
Estrogens have important roles in the pathogenesis of endometrial cancer. They can have carcinogenic effects through stimulation of cell proliferation or... 
Aromatase pathway | Sulfatase pathway | Phase I and phase II estrogen metabolism | Aldo–keto reductase 1C3 (AKR1C3) | 17β-Hydroxysteroid dehydrogenases (17β-HSDs, HSD17B) | Catechol-O-methyl transferase (COMT) | 17b-Hydroxysteroid dehydrogenases | (17b-HSDs HSD17B)Aldoketo reductase 1C3 (AKR1C3) | 17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs, HSD17B) | DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | PROGESTERONE ACTION | 17-BETA-ESTRADIOL | BETA | HYDROXYTAMOXIFEN | Aldo-keto reductase 1C3 (AKR1C3) | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PHASE-I | CARCINOMA | PRE-RECEPTOR REGULATION | Sulfatases - genetics | Progesterone Reductase - metabolism | Humans | Endometrial Neoplasms - metabolism | Aromatase - metabolism | Catechol O-Methyltransferase - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Catechol O-Methyltransferase - metabolism | Aromatase - genetics | Endometrial Neoplasms - genetics | Sulfatases - metabolism | Estrogens - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Sulfotransferases - metabolism | Estrogens - metabolism | Quinones - pharmacology | Glutathione S-Transferase pi - genetics | Sulfotransferases - genetics | Estrone - genetics | Quinone Reductases - metabolism | Androstenedione - genetics | Glutathione S-Transferase pi - metabolism | Estrogens - biosynthesis | RNA, Messenger - genetics | Transcriptome - genetics | Progesterone Reductase - genetics | Arylsulfotransferase - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Estrone - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Cell Line, Tumor | Quinone Reductases - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Arylsulfotransferase - metabolism | Physiological aspects | Endometrial cancer | Sulfates | Genes | Estrogen | Steroids | Index Medicus
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 728 - 732
The gateway to morphine biosynthesis in opium poppy (Papaver somniferum) is the stereochemical inversion of (S)-reticuline since the enzyme yielding the first... 
SYNTHASE | (S)-TETRAHYDROPROTOBERBERINE OXIDASE | 1,2-DEHYDRORETICULINE | COPTIS-JAPONICA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BENZYLISOQUINOLINE ALKALOID METABOLISM | REDUCTASE | MOLECULAR-CLONING | NOSCAPINE BIOSYNTHESIS | CULTURED-CELLS | MORPHINE ALKALOIDS | Aldehyde Reductase - genetics | Exons | Saccharomyces cerevisiae - genetics | Stereoisomerism | Ligases - genetics | Open Reading Frames | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Morphine - biosynthesis | Carbohydrate Epimerases - antagonists & inhibitors | Papaver - genetics | Opium - chemistry | Benzylisoquinolines - chemistry | Saccharomyces cerevisiae - metabolism | Morphinans - metabolism | Bromoviridae - genetics | Base Sequence | Escherichia coli - metabolism | Gene Expression Regulation, Plant | Aldehyde Reductase - metabolism | Opium - metabolism | Plant Proteins - metabolism | Alkaloids - biosynthesis | Recombinant Proteins - metabolism | Morphinans - chemistry | Oxidation-Reduction | Introns | Morphine - chemistry | Ligases - metabolism | Gene Fusion | Recombinant Proteins - genetics | Aldo-Keto Reductases | Plant Proteins - genetics | Benzylisoquinolines - metabolism | Bromoviridae - metabolism | Escherichia coli - genetics | Cytochrome P-450 Enzyme System - genetics | Papaver - metabolism | Carbohydrate Epimerases - genetics | Alkaloids - chemistry | Carbohydrate Epimerases - metabolism | Plant biology | Enzymes | Biosynthesis | Flowers & plants | Narcotics
Journal Article
Enzyme and Microbial Technology, ISSN 0141-0229, 12/2017, Volume 107, pp. 32 - 40
−Butyl 6−cyano−(3 ,5 )−dihydroxyhexanoate ((3 ,5 )− ) is a valuable chiral synthon of atorvastatin calcium. A novel NADPH-specific aldo−keto reductase (AKR)... 
Kluyveromyces marxianus | Aldo−keto reductase | Site−saturation mutagenesis | t−Butyl 6−cyano−(3R,5R)−dihydroxyhexanoate | 6-cyano-(3R,5R)-dihydroxyhexanoate | LODDEROMYCES-ELONGISPORUS | CANDIDA-PARAPSILOSIS | ENANTIOSELECTIVITY |