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Journal Article
Toxicology, ISSN 0300-483X, 2007, Volume 238, Issue 2, pp. 111 - 118
Abstract In many cases, cancer chemotherapy still obtains unsatisfactory response rates, rare complete remissions and responses of relatively short duration.... 
Emergency | Aldo-keto reductases (AKR) | Carbonyl reduction | Biotransformation | Drug metabolism | Oracin | Stereospecificity | Chemotherapeutics | aldo-keto reductases (AKR) | HYDROXYSTEROID DEHYDROGENASES | POTENTIAL CYTOSTATIC DRUG | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | POLYCYCLIC AROMATIC-HYDROCARBONS | chemotherapeutics | DIHYDRODIOL DEHYDROGENASE | 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE NNK | carbonyl reduction | biotransformation | IN-VITRO | ENZYMES | drug metabolism | oracin | SUPERFAMILY | PHARMACOLOGY & PHARMACY | HUMAN LIVER | TOXICOLOGY | stereospecificity | Inactivation, Metabolic | Liver - enzymology | Hydroxysteroid Dehydrogenases - chemistry | Isoquinolines - pharmacokinetics | Stereoisomerism | Humans | 20-Hydroxysteroid Dehydrogenases - chemistry | Substrate Specificity | Oxidoreductases - chemistry | Antineoplastic Agents - metabolism | Cytosol - enzymology | Isoquinolines - chemistry | Ethanolamines - pharmacokinetics | Hydroxysteroid Dehydrogenases - metabolism | Antineoplastic Agents - pharmacokinetics | Molecular Structure | Catalysis | Isoquinolines - metabolism | Oxidation-Reduction | Oxidoreductases - metabolism | Electrophoresis, Polyacrylamide Gel | Liver - metabolism | Alcohol Oxidoreductases - metabolism | Aldehyde Reductase | 20-Hydroxysteroid Dehydrogenases - metabolism | Antineoplastic Agents - chemistry | Ethanolamines - chemistry | Aldo-Keto Reductases | Ethanolamines - metabolism | Cytosol - metabolism | Liver - cytology | Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 248, Issue 1, pp. 182 - 191
Human aldo-keto reductases (AKR) of the 1A, 1B, 1C and 1D subfamilies are involved in the pre-receptor regulation of nuclear (steroid hormone and orphan)... 
Nuclear receptors | Prostaglandin G/H synthase (cyclooxygenase) | Peroxisome proliferator activated receptor | Non-steroidal anti-inflammatory drugs | prostaglandin G/H synthase (cyclooxygenase) | HYDROXYSTEROID DEHYDROGENASES | ISOFORMS | CRYSTAL-STRUCTURE | peroxisome proliferator activated receptor | RECEPTOR | non-steroidal anti-inflammatory drugs | CELL-PROLIFERATION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | CELL BIOLOGY | nuclear receptors | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ENDOCRINOLOGY & METABOLISM | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | EXPRESSION | Humans | 3-Hydroxysteroid Dehydrogenases - analysis | Gonadal Steroid Hormones - biosynthesis | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | 3-Hydroxysteroid Dehydrogenases - physiology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Dinoprost - biosynthesis | Enzyme Inhibitors - chemistry | Drug Design | Transcription, Genetic | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Gonadal Steroid Hormones - metabolism | Enzyme Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - physiology | Testosterone - biosynthesis | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Prostatic Diseases - enzymology | Hydroxyprostaglandin Dehydrogenases - analysis | Prostate - enzymology | Prostatic Diseases - genetics | Immunohistochemistry | Enzymes | Care and treatment | Micropollutants | Wind-pressure | Estrogen | Hydrocarbons | Recombinant proteins | Prevention | Testosterone | Prostaglandins | Polycyclic aromatic hydrocarbons | Glycols | Progesterone | Mass spectrometry | Cancer | Index Medicus
Journal Article
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2012, Volume 3, pp. 193 - 193
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants. They are procarcinogens requiring metabolic activation to elicit their... 
O-quinones | Conjugation reactions | Phase II metabolism | Polycyclic aromatic hydrocarbons | Aldo-keto reductases | Redox-cycling | o-quinones | conjugation reactions | aldo-keto reductases | PHARMACOLOGY & PHARMACY | polycyclic aromatic hydrocarbons | phase II metabolism | redox-cycling | Redox cycling
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2011, Volume 437, Issue 1, pp. 53 - 61
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 10/2017, Volume 276, pp. 167 - 173
Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine... 
Enzyme inhibition | Sex hormones | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) | Short-chain dehydrogenases/reductases (SDR) | Carbonyl reduction | Aldo-keto reductases (AKR) | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-HYDROXYSTEROID DEHYDROGENASE | CARCINOGEN NNK | 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE NNK | CIGARETTE-SMOKING | PHARMACOLOGY & PHARMACY | HUMAN LIVER | F344 RATS | TOXICOLOGY | LUNG-CANCER RISK | TOBACCO-SPECIFIC NITROSAMINE | N-NITROSAMINES | Inactivation, Metabolic | Aldo-Keto Reductases - genetics | Liver - enzymology | Nitrosamines - metabolism | Humans | Gonadal Hormones - chemistry | Recombinant Proteins - biosynthesis | Carcinogens - metabolism | Recombinant Proteins - isolation & purification | Progesterone - chemistry | Short Chain Dehydrogenase-Reductases - antagonists & inhibitors | Carcinogens - chemistry | Aldo-Keto Reductases - antagonists & inhibitors | Estradiol - metabolism | Tobacco - metabolism | Nitrosamines - chemistry | Recombinant Proteins - chemistry | Short Chain Dehydrogenase-Reductases - genetics | Gonadal Hormones - metabolism | Androstenes - chemistry | Estradiol - chemistry | Aldo-Keto Reductases - metabolism | Progesterone - metabolism | Androstenes - metabolism | Tobacco - chemistry | Short Chain Dehydrogenase-Reductases - metabolism | Testosterone | Enzymes | Analysis | Lung cancer | Physiological aspects | Development and progression | Ethinyl estradiol | Progesterone | Hormones | Oral contraceptives | Nitrosoamines | Estradiol | Index Medicus
Journal Article
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2019, Volume 192, pp. 105283 - 105283
Drugs used for the treatment of castration resistant prostate cancer (CRPC) include Abiraterone acetate (Zytiga®) and Enzalutamide (XTANDI®). However, these... 
Adaptive androgen biosynthesis | Non-steroidal anti-inflammatory drugs (NSAIDs) | Abiraterone | N-Phenylanthranilic acids | Aldo-keto reductase (AKR) | Androgen receptor antagonist | Enzalutamide | Competitive inhibition | Index Medicus
Journal Article