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Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 07/2016, Volume 311, Issue 1, pp. E1 - E31
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2016, Volume 311, Issue 6, pp. H1360 - H1366
Anesthesia can affect respiratory, circulatory, and endocrine systems but is necessary for certain experimental procedures such as echocardiography and blood... 
Ketamine-xylazine | Pentobarbital sodium | Isoflurane | pentobarbital sodium | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | ketamine-xylazine | MECHANISMS | BODY-TEMPERATURE | COMBINATION | BLOOD-PRESSURE | INSULIN | IMPACT | PERIPHERAL VASCULAR DISEASE | MICE | isoflurane | STRESS | HYPERTENSIVE-RATS | Renin - metabolism | Anesthetics, Dissociative - pharmacology | Isoflurane - pharmacology | Pentobarbital - pharmacology | Male | Fatty Acids, Nonesterified - metabolism | Heart Rate - drug effects | Aldosterone - metabolism | Xylazine - pharmacology | Renin - drug effects | Blood Pressure - drug effects | Dopamine - metabolism | Anesthetics, Inhalation - pharmacology | Angiotensin II - drug effects | Echocardiography | Angiotensin II - metabolism | Cholesterol, HDL - drug effects | Cholesterol, HDL - metabolism | Aorta - drug effects | Insulin Resistance | Rats | Cholesterol, LDL - drug effects | Cholesterol - metabolism | Rats, Sprague-Dawley | Triglycerides - metabolism | Blood Glucose - drug effects | Insulin - metabolism | Animals | Norepinephrine - metabolism | Lipid Metabolism - drug effects | Cholesterol, LDL - metabolism | Glucose - metabolism | Renin-Angiotensin System - drug effects | Hemodynamics - drug effects | Hypnotics and Sedatives - pharmacology | Blood Glucose - metabolism | Ketamine - pharmacology | Epinephrine - metabolism
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 02/2013, Volume 65, Issue 2, pp. 243 - 252
Objectives To investigate the potential protective effects of captopril, the angiotensin-converting enzyme inhibitor, in diabetic rats exposed to... 
kidney | diabetes mellitus | ischaemia/reperfusion | rats | captopril | OXIDATIVE STRESS | OXIDANT STRESS | ISCHEMIA-REPERFUSION INJURY | RECEPTOR BLOCKER | CONVERTING ENZYME-INHIBITION | RENIN-ANGIOTENSIN SYSTEM | CARBON-MONOXIDE | PHARMACOLOGY & PHARMACY | HEME OXYGENASE-1 | DECREASES APOPTOSIS | BILIVERDIN REDUCTASE | Tumor Necrosis Factor-alpha - metabolism | Islets of Langerhans - drug effects | Diabetes Mellitus, Experimental - drug therapy | Fas Ligand Protein - metabolism | Kidney - blood supply | Captopril - pharmacology | Kidney - pathology | Glutathione - metabolism | Microtubule-Associated Proteins - metabolism | Caspase 3 - metabolism | Male | NF-kappa B - metabolism | Diabetes Mellitus, Type 2 - metabolism | Reperfusion Injury - blood | Creatinine - metabolism | Aldosterone - metabolism | Insulin-Secreting Cells - metabolism | Kidney - metabolism | Islets of Langerhans - metabolism | Hyperglycemia - pathology | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Diabetes Mellitus, Experimental - metabolism | Heme Oxygenase (Decyclizing) - metabolism | Reperfusion Injury - metabolism | Kidney Diseases - metabolism | Malondialdehyde - metabolism | Kidney - drug effects | Islets of Langerhans - pathology | Reperfusion Injury - pathology | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Aldosterone - blood | Rats | Rats, Sprague-Dawley | Hyperglycemia - metabolism | Insulin - metabolism | Animals | Reperfusion Injury - prevention & control | Hyperglycemia - blood | Insulin-Secreting Cells - drug effects | Creatinine - blood | Diabetes Mellitus, Experimental - pathology | Diabetes Mellitus, Type 2 - pathology | Insulin-Secreting Cells - pathology | Diabetes Mellitus, Type 2 - drug therapy | Nitric Oxide - metabolism | Enzymes | Pancreatic beta cells | Enzyme inhibitors | Ischemia | Captopril | Nitric oxide | Heme | Diabetes | Rodents
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e49036
We have previously shown that the eye is a mineralocorticoid-sensitive organ and we now question the role of mineralocorticoid receptor (MR) in ocular... 
CELLS | TUMOR-NECROSIS-FACTOR | NITRIC-OXIDE SYNTHASE | RAT OCULAR-TISSUES | INFLAMMATION | SPIRONOLACTONE | MULTIDISCIPLINARY SCIENCES | DIABETIC-NEPHROPATHY | INHIBITOR | EXPRESSION | CILIARY BODY | Microglia - metabolism | Receptors, Mineralocorticoid - genetics | Ciliary Body - pathology | Intravitreal Injections | Spironolactone - administration & dosage | Receptors, Mineralocorticoid - metabolism | Humans | Endotoxins | Rats, Inbred Lew | Receptors, Glucocorticoid - metabolism | Anti-Inflammatory Agents - metabolism | Aldosterone - administration & dosage | Lipopolysaccharides | Aqueous Humor - metabolism | Spironolactone - pharmacology | Inflammation Mediators - metabolism | Iris - drug effects | Iris - enzymology | Anti-Inflammatory Agents - therapeutic use | Microglia - pathology | Female | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Uveitis - metabolism | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Ciliary Body - enzymology | Uveitis - drug therapy | Rats | Aldosterone - pharmacology | Down-Regulation - drug effects | Iris - pathology | Down-Regulation - genetics | Animals | Signal Transduction - drug effects | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Receptors, Glucocorticoid - genetics | Chemokines - metabolism | Aqueous Humor - drug effects | Uveitis - chemically induced | Uveitis - pathology | Enzymes | Anti-inflammatory drugs | Corticosterone | Analysis | Uveitis | Inflammation | Aldosterone | Mitogens | Steroids | Glucocorticoids | Mortality | Adipocytes | Injection | Tumor necrosis factor-α | Macrophages | Gene expression | Microglia | Cell adhesion & migration | Eye | Iris | Rodents | Nitric oxide | γ-Interferon | Down-regulation | Structural damage | Tumor necrosis factor-TNF | Interferon | Diabetes
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2015, Volume 411, Issue C, pp. 146 - 154
Journal Article
Science, ISSN 0036-8075, 2/2011, Volume 331, Issue 6018, pp. 768 - 772
Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and... 
Depolarization | Hypertension | Somatic mutation | Cell growth | Hyperaldosteronism | REPORTS | Loss of heterozygosity | Adenoma | Genetic mutation | Sequencing | Tumors | REMEDIABLE ALDOSTERONISM | HUMAN BREAST | COLORECTAL CANCERS | ADRENOCORTICAL-CELLS | MULTIDISCIPLINARY SCIENCES | CONDUCTION | GLOMERULOSA CELLS | IDENTIFICATION | MOLECULAR-BASIS | SELECTIVITY | POTASSIUM CHANNEL | Adrenal Glands - pathology | Potassium - metabolism | Cell Proliferation | Humans | Hyperaldosteronism - pathology | Hyperplasia | Protein Multimerization | Zona Glomerulosa - pathology | Male | Hyperaldosteronism - metabolism | Sodium - metabolism | Aldosterone - metabolism | Adrenocortical Adenoma - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Female | Hypertension - genetics | Adrenal Cortex Neoplasms - metabolism | Cell Line | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Hyperaldosteronism - genetics | Mutant Proteins - genetics | Mutant Proteins - metabolism | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Hypertension - metabolism | Adrenal Cortex Neoplasms - genetics | Mutant Proteins - chemistry | Mutation | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 10/2016, Volume 5, Issue 10, p. n/a
Background Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1)... 
caveolin 1 | mineralocorticoid receptor | dyslipidemia | insulin resistance | aldosterone | eplerenone | Insulin resistance | Caveolin 1 | Eplerenone | Aldosterone | Mineralocorticoid receptor | Dyslipidemia | METABOLIC SYNDROME | OXIDATIVE STRESS | CAVEOLIN-1-DEFICIENT MICE | CARDIAC & CARDIOVASCULAR SYSTEMS | OXIDANT STRESS | VASCULAR RELAXATION | MINERALOCORTICOID RECEPTOR BLOCKADE | DIETARY-SODIUM | INSULIN-RESISTANCE | ADIPOCYTE DYSFUNCTION | ALDOSE REDUCTASE | Dyslipidemias - genetics | Aldehyde Reductase - genetics | Hypertriglyceridemia - genetics | Resistin - genetics | Receptors, Mineralocorticoid - metabolism | Humans | Middle Aged | Lipoproteins, HDL - metabolism | Homeostasis | Male | RNA, Messenger - metabolism | Young Adult | Adipose Tissue - metabolism | Aldosterone - metabolism | Spironolactone - pharmacology | Mineralocorticoid Receptor Antagonists - pharmacology | Adult | Aldehyde Reductase - metabolism | Female | Lipid Metabolism - genetics | Retinol-Binding Proteins, Plasma - metabolism | Spironolactone - analogs & derivatives | Resistin - metabolism | NADPH Oxidase 4 - genetics | Signal Transduction | Gene Frequency | Liver - metabolism | Caveolin 1 - genetics | Hypertriglyceridemia - metabolism | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Triglycerides - metabolism | Blood Glucose - drug effects | Insulin - metabolism | NADPH Oxidase 4 - metabolism | Animals | Adolescent | Insulin Resistance - genetics | Dyslipidemias - metabolism | Glucose - metabolism | Aged | Mice | Polymorphism, Single Nucleotide | Retinol-Binding Proteins, Plasma - genetics
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 238 - 247
Hyperaldosteronism is associated with hypertension, cardiac hypertrophy, and congestive heart failure. Steroidogenic factors facilitate aldosterone secretion... 
STEROIDOGENESIS | ALDOSTERONE RELEASE | STEROID-SECRETION | ENDOCRINOLOGY & METABOLISM | RAT ADRENALS | AMINOPEPTIDASE | MEDIUM FLOW-RATE | BLOOD-FLOW | RECEPTORS | GLAND | ENDOTHELIAL NITRIC-OXIDE | Endothelium, Vascular - cytology | Gene Expression Regulation, Enzymologic - drug effects | Abattoirs | Muscle, Smooth, Vascular - metabolism | Zona Glomerulosa - drug effects | Adrenal Cortex - metabolism | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Protease Inhibitors - pharmacology | Aldosterone - metabolism | Cattle | Adrenal Cortex - drug effects | Aminopeptidases - metabolism | Arterioles - cytology | Muscle, Smooth, Vascular - drug effects | Aminopeptidases - genetics | Angiotensin II - pharmacology | Peptide Fragments - metabolism | Angiotensin II - metabolism | Cells, Cultured | Zona Glomerulosa - metabolism | Adrenal Cortex - blood supply | Aminopeptidases - antagonists & inhibitors | Angiotensin II - analogs & derivatives | Angiotensin I - metabolism | Muscle, Smooth, Vascular - cytology | Arterioles - drug effects | Zona Glomerulosa - cytology | Angiotensin III - metabolism | Angiotensin II - chemistry | Animals | Arterioles - metabolism | Endothelium, Vascular - metabolism | Peptide Fragments - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Angiotensin I - antagonists & inhibitors | Heart | Enzyme activity | Angiotensin III | Adrenal glands | Eicosanoids | Congestive heart failure | Aldosterone | Arteries | Receptors | Metabolites | Enzymatic activity | Adrenal gland | Inhibition | Angiotensin II | Hypertension | Peptidase | Secretion | Cortex | Mass spectroscopy | Liquid chromatography | Metabolism | Blood flow | Angiotensin | Aminopeptidase | Mass spectrometry | Adrenal metabolism | Hypertrophy | Veins & arteries
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2014, Volume 734, Issue 1, pp. 23 - 34
Heart failure and related cardiac complications remains a great health challenge. We investigated the effects of upregulating heme-oxygenase (HO) on myocardial... 
Hypertension | Heme-arginate | Osteopontin | Osteoprotegerin oxidative stress | Inflammation | Heme oxygenase | IMPROVES INSULIN SENSITIVITY | OXIDATIVE STRESS | ATRIAL-NATRIURETIC-PEPTIDE | PHOSPHOLIPASE-C | BODY-COMPOSITION | RAT MODEL | SYSTOLIC BLOOD-PRESSURE | GLUCOSE-METABOLISM | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | INDUCED RENAL INJURY | Antioxidants - metabolism | Cardiotonic Agents - metabolism | Tumor Necrosis Factor-alpha - blood | Male | Dinoprost - metabolism | Tyrosine - analogs & derivatives | Interleukin-1beta - blood | Hypertension - blood | Heme - pharmacology | Aldosterone - metabolism | Heme Oxygenase (Decyclizing) - biosynthesis | Interleukin-6 - blood | Hypertension - chemically induced | Chemokine CCL3 - blood | Enzyme Induction - drug effects | Adiponectin - metabolism | Blood Pressure - drug effects | Dinoprost - analogs & derivatives | Heme Oxygenase (Decyclizing) - metabolism | Extracellular Matrix Proteins - metabolism | Biomarkers - metabolism | Cardiomyopathies - blood | Atrial Natriuretic Factor - metabolism | Endothelin-1 - metabolism | Rats | Cardiomyopathies - pathology | NG-Nitroarginine Methyl Ester - adverse effects | Heart Failure - metabolism | Chemokine CCL2 - blood | Rats, Sprague-Dawley | Hypertension - metabolism | Tyrosine - metabolism | Animals | Cyclic GMP - metabolism | Arginine - pharmacology | Cardiomyopathies - metabolism
Journal Article