Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (13609) 13609
Publication (796) 796
Newsletter (279) 279
Book Chapter (193) 193
Book Review (183) 183
Book / eBook (54) 54
Conference Proceeding (33) 33
Magazine Article (24) 24
Newspaper Article (14) 14
Dissertation (12) 12
Government Document (5) 5
Data Set (4) 4
Trade Publication Article (4) 4
Journal / eJournal (2) 2
Paper (2) 2
Web Resource (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
alkaloids (6697) 6697
animals (5594) 5594
index medicus (5492) 5492
humans (3856) 3856
pharmacology & pharmacy (2587) 2587
male (2446) 2446
rats (2078) 2078
chemistry, medicinal (2052) 2052
mice (1920) 1920
toxicity (1833) 1833
analysis (1715) 1715
alkaloids - pharmacology (1618) 1618
biochemistry & molecular biology (1561) 1561
female (1527) 1527
toxicology (1351) 1351
plant sciences (1333) 1333
cancer (1046) 1046
dose-response relationship, drug (968) 968
alkaloids - chemistry (963) 963
apoptosis (963) 963
research (957) 957
alkaloids - toxicity (919) 919
molecular structure (909) 909
in-vitro (878) 878
chemistry, organic (873) 873
cytotoxicity (872) 872
metabolites (811) 811
plants (775) 775
cell line, tumor (747) 747
chemistry, multidisciplinary (727) 727
plant extracts - pharmacology (715) 715
pyrrolizidine alkaloids (714) 714
derivatives (701) 701
chemistry (676) 676
mass spectrometry (673) 673
structure-activity relationship (665) 665
inhibition (657) 657
oncology (646) 646
health aspects (626) 626
chemistry, analytical (598) 598
life sciences (595) 595
physiological aspects (585) 585
cell survival - drug effects (579) 579
drugs (576) 576
alkaloid (572) 572
integrative & complementary medicine (571) 571
organic chemistry (565) 565
cells (554) 554
metabolism (549) 549
antineoplastic agents - pharmacology (540) 540
pharmacology (539) 539
food science & technology (537) 537
apoptosis - drug effects (534) 534
plant extracts - chemistry (513) 513
medicine (511) 511
alkaloids - isolation & purification (503) 503
article (500) 500
oxidative stress (491) 491
proteins (489) 489
rats, sprague-dawley (480) 480
cell proliferation - drug effects (456) 456
pyridine (454) 454
enzymes (450) 450
pyrrolizidine alkaloids - toxicity (445) 445
care and treatment (441) 441
flavonoids (441) 441
research article (441) 441
ecology (434) 434
cell line (422) 422
chemistry, applied (420) 420
cattle (419) 419
antioxidants (418) 418
cells, cultured (417) 417
chemotherapy (416) 416
expression (412) 412
liver (408) 408
chromatography (394) 394
medicine, herbal (392) 392
rats, wistar (392) 392
medicine, botanic (386) 386
identification (381) 381
growth (380) 380
neurosciences (376) 376
cell biology (373) 373
alkaloids - analysis (370) 370
biochemical research methods (368) 368
biosynthesis (366) 366
biotechnology & applied microbiology (366) 366
leaves (366) 366
fungi (362) 362
time factors (362) 362
adult (361) 361
chromatography, high pressure liquid (361) 361
alkaloids - therapeutic use (359) 359
biology (358) 358
biochemistry, general (357) 357
usage (355) 355
liver - drug effects (354) 354
multidisciplinary sciences (354) 354
medicinal plants (344) 344
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (20) 20
Chemistry (A D Allen) - Stacks (4) 4
Collection Dvlpm't (Acquisitions) - Closed Orders (3) 3
Earth Sciences (Noranda) - Stacks (3) 3
UofT at Mississauga - Stacks (3) 3
Chemistry (A D Allen) - In transit (1) 1
Gerstein Science - Not Returned (1) 1
Online Resources - Online (1) 1
UTL at Downsview - May be requested (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (13768) 13768
Chinese (102) 102
German (69) 69
French (65) 65
Russian (46) 46
Japanese (38) 38
Spanish (22) 22
Portuguese (21) 21
Italian (10) 10
Korean (6) 6
Polish (6) 6
Czech (3) 3
Dutch (3) 3
Hungarian (3) 3
Ukrainian (3) 3
Slovak (2) 2
Bulgarian (1) 1
Danish (1) 1
Finnish (1) 1
Indonesian (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Pyrrolizidine alkaloids
: structure and toxicity
by Wiedenfeld, Helmut
2008, ISBN 9783899714265, 143
"Pyrrolizidine alkaloids show only minor toxicity in their native state, but are metabolized in the human or animal organisms to carcinogenic, teratogenic and... 
Pyrrolizidine Alkaloids | chemistry | toxicity | Pyrrolizidines
Book
Details down arrow
2. Full Text Toxic constituents index: A toxicity-calibrated quantitative evaluation approach for the precise toxicity prediction of the hypertoxic phytomedicine-aconite
by Zhang, Ding-Kun and Li, Rui-Sheng and Han, Xue and Li, Chun-Yu and Zhao, Zhi-Hao and Zhang, Hai-zhu and Yang, Ming and Wang, Jia-Bo and Xiao, Xiao-He
Frontiers in Pharmacology, ISSN 1663-9812, 06/2016, Volume 7, p. 164
Complex chemical composition is an important reason for restricting herbal quality evaluation. Despite the multi-components determination method significantly... 
Toxicity calibration coefficient | Toxic potency | Multi-components determination | Toxic constituents index | Toxicity prediction | Aconite | toxic potency | toxicity calibration coefficient | aconite | toxicity prediction | STRATEGY | toxic constituents index | multi-components determination | HONG-KONG | CHEMOTYPE | PERFORMANCE LIQUID-CHROMATOGRAPHY | HERBS | FINGERPRINT | ROOTS | PHARMACOLOGY & PHARMACY | EXTRACTS | ALKALOIDS
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Toxicity potential of nutraceuticals
by Gupta, Ramesh C and Srivastava, Ajay and Lall, Rajiv
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1800, pp. 367 - 394
By the turn of the twenty-first century, the use of nutraceuticals became increasingly popular in both humans and animals due to their easy access,... 
Plant alkaloids | Safe nutraceuticals | Toxic potential | Metals | Mycotoxins | Pesticides | Toxicity testing models | Drugs of abuse | Nutraceuticals | Animals | Drug Interactions | Humans | Biomarkers | Perioperative Care - methods | Drug Discovery - methods | Dietary Supplements - adverse effects | Toxicity Tests
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Acute Methylenedioxypyrovalerone Toxicity
by Froberg, Blake A and Levine, Michael and Beuhler, Michael C and Judge, Bryan S and Moore, Philip W and Engebretsen, Kristin M and Mckeown, Nathanael J and Rosenbaum, Christopher D and Young, Amy C and Rusyniak, Daniel E and ACMT Toxicology Investigators Consortium (ToxIC) and On behalf of the ACMT Toxicology Investigators Consortium (ToxIC)
Journal of Medical Toxicology, ISSN 1556-9039, 6/2015, Volume 11, Issue 2, pp. 185 - 194
The objective of this study was to characterize the acute clinical effects, laboratory findings, complications, and disposition of patients presenting to the... 
Poisons | Toxicology | Biomedicine | Drug effects | Central nervous system stimulants | Designer drugs | Pharmacology/Toxicology | Biomedicine general | Street drugs | Age Factors | Humans | Middle Aged | Psychomotor Agitation - psychology | Male | Pyrrolidines - poisoning | Treatment Outcome | Hypnotics and Sedatives - therapeutic use | Lorazepam - therapeutic use | Street Drugs | Young Adult | Substance-Related Disorders - epidemiology | Adolescent | Substance-Related Disorders - psychology | Adult | Female | Registries | Benzodioxoles - poisoning | Retrospective Studies | Substance-Related Disorders - diagnosis | Alkaloids - poisoning | Diagnosis, Dual (Psychiatry) | Drugs | Analysis | Methyl groups | Ephedrine | Clinical trials | Dosage and administration | Chemical properties | Health aspects | Case studies | Drug abuse | Toxicity | Index Medicus | Toxicology Investigation
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines
by Rosenbaum, Christopher D and Carreiro, Stephanie P and Babu, Kavita M
Journal of Medical Toxicology, ISSN 1556-9039, 3/2012, Volume 8, Issue 1, pp. 15 - 32
Despite their widespread Internet availability and use, many of the new drugs of abuse remain unfamiliar to health care providers. The herbal marijuana... 
Drug abuse | Emerging drugs | Biomedicine | Designer drugs | Herbal | Legal highs | Pharmacology/Toxicology | Biomedicine general | Cyclohexylamines - toxicity | Humans | Psychotropic Drugs - analysis | Piperazines - toxicity | Mitragyna - toxicity | Psychotropic Drugs - therapeutic use | Cyclohexylamines - pharmacology | Cyclohexanones - therapeutic use | Psychotropic Drugs - pharmacology | Alkaloids - analysis | Cannabinoids - toxicity | Alkaloids - toxicity | Alkaloids - pharmacology | Cyclohexanones - toxicity | Piperazines - therapeutic use | Cyclohexanones - pharmacology | Salvia - toxicity | Piperazines - pharmacology | Cyclohexylamines - therapeutic use | Cannabinoids - pharmacology | Cyclohexylamines - analysis | Cannabinoids - therapeutic use | Piperazines - analysis | Cyclohexanones - analysis | Alkaloids - therapeutic use | Psychotropic Drugs - toxicity | Cannabinoids - analysis | Usage | Care and treatment | Health aspects | Index Medicus | Review
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text European medicinal and edible plants associated with subacute and chronic toxicity part I: Plants with carcinogenic, teratogenic and endocrine-disrupting effects
by Kristanc, Luka and Kreft, Samo
Food and Chemical Toxicology, ISSN 0278-6915, 06/2016, Volume 92, pp. 150 - 164
In recent decades, the use of herbal medicines and food products has been widely embraced in many developed countries. These products are generally highly... 
Carcinogenic | Phytoestrogen | Teratogenic | Pyrrolizidine alkaloid | Alkenylbenzene | European plants | ISOFLAVONE SUPPLEMENTS | DNA-ADDUCTS | POISONOUS PLANTS | PYRROLIZIDINE ALKALOIDS | FOOD SCIENCE & TECHNOLOGY | OVER-THE-COUNTER | ARISTOLOCHIC ACID | TRANS-ANETHOLE | PTERIDIUM-AQUILINUM | BRACKEN FERN | TOXICOLOGY | AQUILINUM L-KUHN | Carcinogenesis - drug effects | Teratogens - toxicity | Plants, Medicinal - toxicity | Europe | Humans | Plants, Toxic - toxicity | Plants, Edible - toxicity | Toxicity Tests - methods | Carcinogens - toxicity | Endocrine Disruptors - toxicity | Phytoestrogens - toxicity | Medicine, Herbal | Plants | Medicine, Botanic | Estrogen | Isoflavones | Food | Alkaloids | Medical research | Medicine, Experimental | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Norepinephrine protects against amyloid-β toxicity via TrkB
by Liu, Xia and Ye, Keqiang and Weinshenker, David
Journal of Alzheimer's Disease, ISSN 1387-2877, 2015, Volume 44, Issue 1, pp. 251 - 260
The locus coeruleus (LC), the brainstem noradrenergic nucleus that is the sole source of norepinephrine (NE) in the forebrain, is one of the first structures... 
Neuroprotection | Brain-derived neurotrophic factor | Tropomyosin-related kinase B | Norepinephrine | Amyloid-β | Alzheimer's disease | Locus coeruleus | norepinephrine | tropomyosin-related kinase B | OXIDATIVE STRESS | BDNF | ALZHEIMERS-DISEASE | NEUROTROPHIC FACTOR | MEMORY DEFICITS | TRANSGENIC MOUSE | LOCUS-CERULEUS | locus coeruleus | NEUROSCIENCES | amyloid-beta | neuroprotection | MOUSE MODEL | NEURONS | brain-derived neurotrophic factor | BRAIN | Animals, Newborn | Norepinephrine - pharmacology | Tyrosine 3-Monooxygenase - metabolism | Brain - cytology | Amyloid beta-Peptides - toxicity | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Cell Count | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Adrenergic Agents - pharmacology | Dose-Response Relationship, Drug | Animals | Caspases - metabolism | Neuroprotective Agents - pharmacology | Indole Alkaloids - pharmacology | Neurons - metabolism | Phosphorylation - drug effects | Carbazoles - pharmacology | Neurons - drug effects | Receptor, trkB - metabolism | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Plants containing pyrrolizidine alkaloids: toxicity and problems
by Wiedenfeld, H
Food Additives & Contaminants: Part A, ISSN 1944-0049, 03/2011, Volume 28, Issue 3, pp. 282 - 292
Pyrrolizidine alkaloids (PA) are toxic for human and livestock. They undergo a metabolic toxication process in the liver which is the first target organ for PA... 
toxicology | natural toxicants | risk assessment | gas chromatography/mass spectrometry | cytotoxicity | alkaloids | Alkaloids | Cytotoxicity | Toxicology | Natural toxicants | Gas chromatography/mass spectrometry | Risk assessment | RAGWORT SENECIO-JACOBAEA | METABOLIC CONVERSION | RAT | FOOD SCIENCE & TECHNOLOGY | N-OXIDES | gas chromatography | VENO-OCCLUSIVE DISEASE | HEPATIC VENOOCCLUSIVE DISEASE | LIVER | mass spectrometry | LC-MS ANALYSIS | HEPATOTOXICITY | CHEMISTRY, APPLIED | MEDICINAL-PLANTS | Inactivation, Metabolic | Liver - enzymology | Senecio - chemistry | Food Analysis - methods | Food Contamination - analysis | Humans | Cytochrome P-450 Enzyme System - metabolism | Pyrrolizidine Alkaloids - poisoning | Animals | Animal Feed - analysis | Biotransformation | Liver Failure - chemically induced | Livestock | Plants - chemistry | Ethiopia | Index Medicus | pyrrolizidine alkaloids | Toxicity | Food additives | Food contamination | Liver | Organs | Poisoning | Intoxication | Guanylate cyclase | High-performance liquid chromatography
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Psychoactive bath salts: Compounds, mechanisms, and toxicities
by Lehner, Kurt R and Baumann, Michael H
Neuropsychopharmacology, ISSN 0893-133X, 01/2013, Volume 38, Issue 1, pp. 243 - 244
MEPHEDRONE | PHARMACOLOGY & PHARMACY | PSYCHIATRY | NEUROSCIENCES | LEGAL HIGHS | Designer Drugs - chemistry | Alkaloids - toxicity | Designer Drugs - toxicity | Substance-Related Disorders - metabolism | Animals | Humans | Substance-Related Disorders - psychology | Psychotropic Drugs - chemistry | Psychotropic Drugs - toxicity | Street Drugs - toxicity | Alkaloids - chemistry | Street Drugs - chemistry | Index Medicus | Hot Topics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Comment on Amézquita et al. (2017) “Conspicuousness, color resemblance, and toxicity in geographically diverging mimicry: The pan‐Amazonian frog Allobates femoralis”
by Saporito, Ralph A and Grant, Taran
Evolution, ISSN 0014-3820, 04/2018, Volume 72, Issue 4, pp. 1009 - 1014
Amézquita et al. (2017) recently concluded that species of the Allobates femoralis group are toxic to mice at levels equivalent to syntopic alkaloid‐containing... 
chemical defense | toxicity | Alkaloid | benzocaine | poison frogs | anura | Frogs | Chemical defense | Toxicity | Oral administration | Casts | Secretions | Amphibians | Mimicry | Alkaloids | Oral cavity | Experimentation | Skin | Chemical composition | Species
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity
by Elnaggar, Yosra S.R and Etman, Samar M and Abdelmonsif, Doaa A and Abdallah, Ossama Y
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2015, Volume 104, Issue 10, pp. 3544 - 3556
Piperine (PIP) is a phytopharmaceutical with reported neuroprotective potential in Alzheimer's disease (AD). Oral PIP delivery suffers from its hydrophobicity... 
drug targeting | nanotechnology | chitosan | polymeric drug delivery systems | Alzheimer's disease | nasal drug delivery | EX-VIVO PERMEATION | RIVASTIGMINE | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | DEMENTIA | NANOCARRIERS | CHEMISTRY, MULTIDISCIPLINARY | NASAL DELIVERY-SYSTEM | RAT MODEL | COLCHICINE | IN-VITRO APPRAISAL | PHARMACOLOGY & PHARMACY | PROTEIN DELIVERY | Tumor Necrosis Factor-alpha - metabolism | Rats, Wistar | Apoptosis - drug effects | Caspase 3 - metabolism | Polyunsaturated Alkamides - therapeutic use | Male | Polyunsaturated Alkamides - toxicity | Benzodioxoles - administration & dosage | Brain Diseases - chemically induced | Drug Delivery Systems | Nanoparticles | Benzodioxoles - toxicity | Benzodioxoles - therapeutic use | Piperidines - toxicity | Alkaloids - toxicity | Piperidines - administration & dosage | Alzheimer Disease - drug therapy | Rats | Antioxidants - pharmacology | Cognition - drug effects | Administration, Intranasal | Particle Size | Polyunsaturated Alkamides - administration & dosage | Animals | Brain Diseases - pathology | Cholinesterase Inhibitors - pharmacology | Piperidines - therapeutic use | Alkaloids - administration & dosage | Alkaloids - therapeutic use | Chitosan | Drugs | Brain | Drug delivery systems | Drug therapy | Vehicles | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Elucidating cylindrospermopsin toxicity via synthetic analogues: An in vitro approach
by Evans, Daniel M and Hughes, Jack and Jones, Leigh F and Murphy, Patrick J and Falfushynska, Halina and Horyn, Oksana and Sokolova, Inna M and Christensen, Jeppe and Coles, Simon J and Rzymski, Piotr
Chemosphere, ISSN 0045-6535, 11/2019, Volume 234, pp. 139 - 147
Cylindrospermopsin (CYN) is an alkaloid biosynthesized by selected cyanobacteria, the cyto- and genotoxic properties of which have been studied extensively by... 
Oxidative stress | Hepatocytes | Mechanism of action | DNA damage | Cylindrospermopsin | Cyanobacteria | CELLS | THREAT | ENVIRONMENTAL SCIENCES | RACIBORSKII | INHIBITION | HEPATOTOXIN | FISH | MICE | CYANOBACTERIAL ALKALOID CYLINDROSPERMOPSIN | Pyrimidines | Hydroxides | Structure | Analysis | Fishes | Crystals | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights