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Cancer chemotherapy and pharmacology, ISSN 0344-5704, 8/2011, Volume 68, Issue 2, pp. 445 - 455
The natural flavonoid fisetin was recently identified as a lead compound that stabilizes endothelial cell microtubules. In this study, we investigated the... 
Fisetin | Lewis lung carcinoma | Angiogenesis | Antitumour activity | Cyclophosphamide | Medicine & Public Health | Cancer Research | Oncology | Cytotoxicity | EA·hy 926 endothelial cells | Pharmacology/Toxicology | Flavonoid | EA•hy 926 endothelial cells | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | NIH 3T3 Cells | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Tubulin Modulators - pharmacology | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antineoplastic Agents, Alkylating - pharmacology | Flavonoids - adverse effects | Antineoplastic Agents, Alkylating - administration & dosage | Cyclophosphamide - adverse effects | Cyclophosphamide - therapeutic use | Flavonoids - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Angiogenesis Inhibitors - administration & dosage | Antineoplastic Agents, Phytogenic - administration & dosage | Angiogenesis Inhibitors - therapeutic use | Flavonoids - administration & dosage | Tubulin Modulators - administration & dosage | Female | Flavonoids - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Angiogenesis Inhibitors - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Cell Line | Cell Survival - drug effects | Tubulin Modulators - adverse effects | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Tubulin Modulators - therapeutic use | Carcinoma, Lewis Lung - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Cell Movement - drug effects | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Cyclophosphamide - pharmacology | Carcinoma, Lewis Lung - pathology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Alkylating - adverse effects | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Endothelial Cells - drug effects | Antimitotic agents | Flavonoids | Flavones | Lung cancer | Bioflavonoids | Accountants | Drug therapy, Combination | Universities and colleges | Antineoplastic agents | Endothelium | Tumors | Index Medicus | cytology | Antineoplastic Agents, Phytogenic | pathology | Cell Proliferation | Endothelial Cells | Tubulin Modulators | Neovascularization, Pathologic | fisetin | administration & dosage | pharmacology | flavonoid | Carcinoma, Lewis Lung | Antineoplastic Agents, Alkylating | cytotoxicity | drug therapy | Cell Survival | angiogenesis | Antineoplastic Combined Chemotherapy Protocols | drug effects | Tumor Burden | Angiogenesis Inhibitors | EA.hy 926 | Cell Cycle | antitumour activity | adverse effects | therapeutic use | Cell Movement
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 50, pp. 47107 - 47115
Treatment with the DNA topoisomerase inhibitors etoposide, doxorubicin, and camptothecin, and with the alkylating agents cisplatin and melphalan, caused peroxide accumulation and apoptosis in U-937... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Buthionine Sulfoximine - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Reactive Oxygen Species | Glutathione - metabolism | Alkylating Agents - pharmacology | Humans | Topoisomerase I Inhibitors | Antineoplastic Agents, Alkylating - pharmacology | Immunoblotting | Monocytes - metabolism | Oxygen - metabolism | Antineoplastic Agents - toxicity | Necrosis | Dose-Response Relationship, Drug | Flow Cytometry | Time Factors | U937 Cells | Adenosine Triphosphate - metabolism | Cell Death | Radiation-Protective Agents - pharmacology | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Membrane Potentials - drug effects | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Etoposide - pharmacology | Spectrometry, Fluorescence | Glutathione - antagonists & inhibitors | Mitochondria - metabolism | Antioxidants - pharmacology | Cisplatin - pharmacology | Hypoxia | Antineoplastic Agents, Phytogenic - pharmacology | Camptothecin - pharmacology | Dose-Response Relationship, Radiation | Doxorubicin - pharmacology | Apoptosis | butylated hydroxyanisole | melphelan | N-Acetyl-L-cysteine | cisplatin | Index Medicus
Journal Article
Materials Science and Engineering: C, ISSN 0928-4931, 04/2016, Volume 61, pp. 1002 - 1017
Journal Article
Leukemia, ISSN 1476-5551, 01/2012, Volume 26, Issue 7, pp. 1594 - 1601
Journal Article
Neuroscience, ISSN 0306-4522, 2017, Volume 346, pp. 298 - 308
Highlights • GDC-0941 monotherapy induced cytotoxicity and showed pro-apoptotic effects in. • glioblastoma multiforme (GBM) cell lines. • GDC-0941 enhanced the... 
Neurology | TMZ | radiotherapy | glioma | GDC-0941 | chemotherapy | PI3K inhibitor | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Apoptosis - drug effects | Dacarbazine - therapeutic use | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Brain Neoplasms - pathology | Antineoplastic Agents, Alkylating - pharmacology | Antineoplastic Agents - therapeutic use | Glioblastoma - radiotherapy | Radiation-Sensitizing Agents - therapeutic use | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Antineoplastic Agents - pharmacology | Brain Neoplasms - radiotherapy | Phosphatidylinositol 3-Kinase - metabolism | Cell Survival - drug effects | Neoplasm Invasiveness | Radiation-Sensitizing Agents - pharmacology | Antineoplastic Combined Chemotherapy Protocols | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Antineoplastic Agents, Alkylating - therapeutic use | Glioblastoma - therapy | Indazoles - pharmacology | Cell Movement - drug effects | Signal Transduction - drug effects | Sulfonamides - therapeutic use | Glioblastoma - pathology | Brain Neoplasms - therapy | Cell Line, Tumor | Cell Cycle - drug effects | Glioblastoma - drug therapy | Indazoles - therapeutic use | Antimitotic agents | Tumor proteins | Antineoplastic agents | Chemotherapy | Gliomas | Analysis | Cancer | Index Medicus
Journal Article
Experimental Hematology, ISSN 0301-472X, 2017, Volume 52, pp. 65 - 71
.... We hypothesized that these structurally unrelated drugs affect the transport of DNA-alkylating agents... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | Life Sciences & Biomedicine | Hematology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cyclophosphamide - analogs & derivatives | Flow Cytometry - methods | Fluoresceins - metabolism | Humans | Ethacrynic Acid - pharmacology | Antineoplastic Agents, Alkylating - pharmacology | Chlorambucil - pharmacology | Ketoconazole - pharmacology | Drug Interactions | Everolimus - pharmacokinetics | Ethacrynic Acid - pharmacokinetics | Biological Transport - drug effects | Melphalan - pharmacology | Busulfan - pharmacology | Cell Survival - drug effects | Fluoresceins - chemistry | Reproducibility of Results | Busulfan - pharmacokinetics | Everolimus - pharmacology | Chlorambucil - pharmacokinetics | Ketoconazole - pharmacokinetics | Antineoplastic Agents, Alkylating - pharmacokinetics | Sirolimus - pharmacokinetics | Sirolimus - pharmacology | Cyclophosphamide - pharmacology | Cell Line, Tumor | Melphalan - pharmacokinetics | Cyclophosphamide - pharmacokinetics | Multidrug Resistance-Associated Proteins - metabolism | Antimitotic agents | Complications and side effects | Chemotherapy | Leukemia | Drug interactions | Lymphomas | Transplantation | Drug therapy, Combination | Antineoplastic agents | Ethacrynic acid | Hematopoietic stem cells | Cancer | Index Medicus | flow cytometry | drug interactions | carboxyfluorescein | drug transporter | drug efflux method | stem cell transplantation
Journal Article