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1. Full Text Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
by Getachew, Henok and Tadesse, Yewondwossen and Shibeshi, Workineh
BMC Nephrology, ISSN 1471-2369, 10/2015, Volume 16, Issue 1, p. 158
Background: Dose adjustment for certain drugs is required in patients with reduced renal function to avoid toxicity as many drugs are eliminated by the... 
Prospective | Dose adjustment | Renal impairment | DOSING ADJUSTMENTS | ERRORS | DIET | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | Prospective Studies | Spironolactone - administration & dosage | Humans | Middle Aged | Fluconazole - administration & dosage | Antihypertensive Agents - administration & dosage | Male | Young Adult | Drug Dosage Calculations | Aged, 80 and over | Adult | Female | Cimetidine - administration & dosage | Enalapril - administration & dosage | Pharmaceutical Preparations - administration & dosage | Medication Errors | Severity of Illness Index | Diuretics - administration & dosage | Vancomycin - administration & dosage | Cross-Sectional Studies | Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage | Hospitalization | Acute Kidney Injury - physiopathology | Anti-Arrhythmia Agents - administration & dosage | Creatinine - urine | Renal Insufficiency, Chronic - physiopathology | Anti-Ulcer Agents - administration & dosage | Gout Suppressants - administration & dosage | Drug Prescriptions - statistics & numerical data | Allopurinol - administration & dosage | Digoxin - administration & dosage | Adolescent | Ceftazidime - administration & dosage | Creatinine - blood | Aged | Anti-Bacterial Agents - administration & dosage | Antifungal Agents - administration & dosage | Ethiopia | Drugs | Prescribing | Medical research | Hospital patients | Prescription writing | Analysis | Medicine, Experimental | Medical care | Quality management
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2. Full Text GC–MS analysis of blood for the metabonomic investigation of the effects of physical exercise and allopurinol administration on rats
by Pechlivanis, Alexandros and Chatziioannou, Anastasia Chrysovalantou and Veskoukis, Aristidis S and Kouretas, Dimitrios and Mougios, Vassilis and Theodoridis, Georgios A
Journal of Chromatography B, ISSN 1570-0232, 09/2014, Volume 966, pp. 127 - 131
Exhaustive exercise is a generator of free radicals and reactive species in mammals. Allopurinol is a known inhibitor of xanthine oxidase, a source of free... 
Physical exercise | Metabolomics | GC–MS | Allopurinol | Metabonomics | GC-MS | CHEMISTRY, ANALYTICAL | LIVER | BIOCHEMICAL RESEARCH METHODS | METABOLIC FINGERPRINT | SYSTEMS BIOLOGY | Gas Chromatography-Mass Spectrometry - methods | Reproducibility of Results | Rats, Wistar | Metabolome - physiology | Rats | Male | Biomarkers - blood | Physical Conditioning, Animal - physiology | Metabolomics - methods | Animals | Allopurinol - administration & dosage | Analysis of Variance | Metabolome - drug effects | Allopurinol - pharmacology | Sports sciences | Exercise | Metabolites | Investigations | Oxidases | Care and treatment | Oxalic acid | Gout | Amino acids | Oxalates | Separation | Free radicals | Statistical analysis | Inhibitors | Samples | Exhaustion | Statistical methods
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3. Full Text Allopurinol Administration for the Prevention of Contrast-Induced Nephropathy: A Network Meta-analysis With Trial Sequential Analysis
by Bellos, Ioannis and Iliopoulos, Dimitrios C and Perrea, Despina N
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 05/2019, Volume 73, Issue 5, pp. 307 - 315
Contrast-induced nephropathy represents a major source of morbidity in patients undergoing coronary angiography. Various preventive measures have been... 
CARDIAC & CARDIOVASCULAR SYSTEMS | SCORE | meta-analysis | RISK | ACUTE-RENAL-FAILURE | angiography | PREDICTION | contrast-induced nephropathy | PERCUTANEOUS CORONARY INTERVENTION | ANGIOPLASTY | CLINICAL-TRIALS | PHARMACOLOGY & PHARMACY | acute kidney injury | allopurinol | URIC-ACID | Complications and side effects | Dosage and administration | Kidney diseases | Angiography | Allopurinol | Risk factors
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4. Full Text Lesinurad Combined With Allopurinol: A Randomized, Double‐Blind, Placebo‐Controlled Study in Gout Patients With an Inadequate Response to Standard‐of‐Care Allopurinol (a US‐Based Study)
by Saag, Kenneth G and Fitz‐Patrick, David and Kopicko, Jeff and Fung, Maple and Bhakta, Nihar and Adler, Scott and Storgard, Chris and Baumgartner, Scott and Becker, Michael A
Arthritis & Rheumatology, ISSN 2326-5191, 01/2017, Volume 69, Issue 1, pp. 203 - 212
Objective Lesinurad is a selective uric acid reabsorption inhibitor used for the treatment of gout in combination with a xanthine oxidase inhibitor. The... 
TRIAL | MORTALITY | URATE | HYPERURICEMIA | MANAGEMENT | SAFETY | GUIDELINES | PREVENTION | RHEUMATOLOGY | INHIBITOR | FEBUXOSTAT | Triazoles - administration & dosage | Double-Blind Method | United States | Humans | Middle Aged | Uricosuric Agents - administration & dosage | Gout - drug therapy | Male | Gout Suppressants - administration & dosage | Young Adult | Thioglycolates - administration & dosage | Allopurinol - administration & dosage | Adolescent | Aged, 80 and over | Adult | Female | Aged | Drug Combinations | Rheumatism | Creatinine | Therapy | Renal function | Allopurinol | Gout | Reabsorption | Uric acid | Xanthine | Patients | Randomization | Inhibitors | Flares | Xanthine oxidase | Safety
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5. Full Text Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial
by Kaandorp, Joepe J and Benders, Manon J N L and Schuit, Ewoud and Rademaker, Carin M A and Oudijk, Martijn A and Porath, Martina M and Oetomo, Sidarto Bambang and Wouters, Maurice G A J and van Elburg, Ruurd M and Franssen, Maureen T M and Bos, Arie F and de Haan, Timo R and Boon, Janine and de Boer, Inge P and Rijnders, Robbert J P and Jacobs, Corrie J W F M and Scheepers, Liesbeth H C J and Gavilanes, Danilo A W and Bloemenkamp, Kitty W M and Rijken, Monique and van Meir, Claudia A and von Lindern, Jeannette S and Huisjes, Anjoke J M and Bakker, Saskia C M J E R and Mol, Ben W J and Visser, Gerard H A and Van Bel, Frank and Derks, Jan B
Archives of Disease in Childhood - Fetal and Neonatal Edition, ISSN 1359-2998, 05/2015, Volume 100, Issue 3, pp. F216 - F223
Objective To determine whether maternal allopurinol treatment during suspected fetal hypoxia would reduce the release of biomarkers associated with neonatal... 
ENCEPHALOPATHY | REGRESSION | BLOOD-LEVELS | BIOMARKER | BIOLOGICAL-FLUIDS | BIRTH ASPHYXIA | PEDIATRICS | BRAIN-DAMAGE | S100B PROTEIN | CEREBRAL-ISCHEMIA | PERINATAL ASPHYXIA | Dinoprost - blood | Double-Blind Method | Maternal-Fetal Exchange | Humans | Male | Aldehydes - blood | Enzyme Inhibitors - therapeutic use | S100 Calcium Binding Protein beta Subunit - blood | Pregnancy | Allopurinol - therapeutic use | Oxypurinol - blood | Ketones - blood | Fetal Blood - chemistry | Fetal Hypoxia - drug therapy | Adult | Female | Dinoprost - analogs & derivatives | Allopurinol - blood | Xanthine Oxidase - antagonists & inhibitors | Complications and side effects | Care and treatment | Usage | Brain-damaged children | Allopurinol | Clinical trials | Dosage and administration | Fetal anoxia | Studies | Free radicals | Brain research | Womens health | Rodents | Fetuses | Brain damage | Hypoxia | Umbilical cord | Drug dosages
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6. Full Text Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia
by Fleischmann, Roy and Fleischmann, Roy and Kerr, Bradley and Baumgartner, Scott and Yeh, Li-Tain and Suster, Matt and Shen, Zancong and Polvent, Elizabeth and Hingorani, Vijay and Quart, Barry and Manhard, Kimberly and Miner, Jeffrey N and Baumgartner, Scott and RDEA591 111 Study Grp and RDEA594-111 Study Group
Rheumatology (Oxford, England), ISSN 1462-0324, 12/2014, Volume 53, Issue 12, pp. 2167 - 2174
Objective. The aim of this study was to evaluate the pharmacodynamics (PDs), pharmacokinetics (PKs) and safety of lesinurad (selective uric acid reabsorption... 
xanthine oxidase inhibitor | selective uric acid reabsorption inhibitor | drug–drug interaction | gout | pharmacodynamic | febuxostat | lesinurad | pharmacokinetic | Febuxostat | Gout | Pharmacodynamic | Selective uric acid reabsorption inhibitor | Xanthine oxidase inhibitor | Lesinurad | Drug-drug interaction | Pharmacokinetic | THERAPEUTICS | MEDICATION | BENZBROMARONE | MANAGEMENT | EVIDENCE BASED RECOMMENDATIONS | RHEUMATOLOGY | ALLOPURINOL | THERAPY | TASK-FORCE | REDUCTION | drug-drug interaction | URIC-ACID | Triazoles - administration & dosage | Triazoles - adverse effects | Thiazoles - blood | Triazoles - blood | Humans | Middle Aged | Gout - drug therapy | Male | Thiazoles - administration & dosage | Thiazoles - adverse effects | Dose-Response Relationship, Drug | Thioglycolates - administration & dosage | Thioglycolates - blood | Adult | Female | Uric Acid - blood | Drug Therapy, Combination | Gout - blood | Gout Suppressants - blood | Thioglycolates - adverse effects | Drug Administration Schedule | Gout Suppressants - adverse effects | Hyperuricemia - drug therapy | Gout Suppressants - administration & dosage | Hyperuricemia - blood | Colchicine - blood | Aged
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7. Full Text Split‐dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6‐MMP metabolism
by Shih, D. Q and Nguyen, M and Zheng, L and Ibanez, P and Mei, L and Kwan, L. Y and Bradford, K and Ting, C and Targan, S. R and Vasiliauskas, E. A
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 09/2012, Volume 36, Issue 5, pp. 449 - 458
Background Mercaptopurine and azathioprine (AZA) are efficacious in treating IBD. 6-tioguanine (6-TGN) levels correlate with therapeutic efficacy, whereas high... 
LONG-TERM | ALLOPURINOL | MERCAPTOPURINE | INFLAMMATORY-BOWEL-DISEASE | CROHNS-DISEASE | AZATHIOPRINE THERAPY | 6-MERCAPTOPURINE THERAPY | METHYLTRANSFERASE ACTIVITY | PHARMACOLOGY & PHARMACY | T-CELL LYMPHOMA | PHARMACOGENETICS | GASTROENTEROLOGY & HEPATOLOGY | Inflammatory Bowel Diseases - drug therapy | Azathioprine - administration & dosage | Humans | Middle Aged | Mercaptopurine - administration & dosage | Male | Treatment Outcome | Inflammatory Bowel Diseases - metabolism | Erythrocytes - drug effects | Dose-Response Relationship, Drug | Young Adult | Adolescent | Erythrocytes - metabolism | Mercaptopurine - metabolism | Adult | Female | Retrospective Studies | Mercaptopurine - analogs & derivatives | Immunosuppressive Agents - administration & dosage | Index Medicus
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8. Full Text Exacerbation of allopurinol‐induced drug reaction with eosinophilia and systemic symptoms by teicoplanin: A case report
by Taghvaye Masoumi, H and Hadjibabaie, M and Zarif‐Yeganeh, M and Arasteh, O
Journal of Clinical Pharmacy and Therapeutics, ISSN 0269-4727, 10/2017, Volume 42, Issue 5, pp. 642 - 645
Allopurinol is one of the most frequently reported drugs accounting for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome development.... 
teicoplanin | drug reaction with eosinophilia and systemic symptoms | allopurinol | RASH | PHARMACOLOGY & PHARMACY | DRESS SYNDROME | TOXIC EPIDERMAL NECROLYSIS | STEVENS-JOHNSON-SYNDROME | FEATURES | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Vidarabine - analogs & derivatives | Gout Suppressants - adverse effects | Cytarabine - administration & dosage | Gout Suppressants - administration & dosage | Teicoplanin - adverse effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Teicoplanin - administration & dosage | Allopurinol - administration & dosage | Allopurinol - adverse effects | Female | Anti-Bacterial Agents - adverse effects | Vidarabine - administration & dosage | Drug Hypersensitivity Syndrome - etiology | Anti-Bacterial Agents - administration & dosage | Granulocyte Colony-Stimulating Factor - administration & dosage | Drugs | Complications and side effects | Chemotherapy | Leukemia | Allopurinol | Dosage and administration | Eosinophilia | Cancer | Liver | Exanthema | Prophylaxis | Pruritus | Dosage | Drug development | Hydrocortisone | Cytarabine | Dyspnea | Granulocyte colony-stimulating factor | Colony-stimulating factor | Drug dosages | Enzymes | Limbs | Edema | Alanine | Acute lymphatic leukemia | Hypersensitivity | Abnormalities | Case reports | Fever | Side effects | Fludarabine | Lysis | Alanine transaminase | Respiration | Erythema | Tumors
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9. Full Text Prevalence of Contraindications and Prescription of Pharmacologic Therapies for Gout
by Keenan, Robert T., MD, MPH and O'Brien, William R., MD and Lee, Kristen H., MD and Crittenden, Daria B., MD and Fisher, Mark C., MD, MPH and Goldfarb, David S., MD and Krasnokutsky, Svetlana, MD, MS and Oh, Cheongeun, PhD and Pillinger, Michael H., MD
American Journal of Medicine, The, ISSN 0002-9343, 2011, Volume 124, Issue 2, pp. 155 - 163
Abstract Background Patients with gout have comorbidities, but the impact of these comorbidities on treatment has not been studied. Methods A total of 575... 
Internal Medicine | Treatment | Drug contraindication | Comorbidity | Gout | Quality of care | POPULATION | METABOLIC SYNDROME | MANAGEMENT | OLDER-ADULTS | NATIONAL-HEALTH | CLASSIFICATION | CARE | ALLOPURINOL | MEDICINE, GENERAL & INTERNAL | HYPERURICEMIA | NUTRITION EXAMINATION SURVEY | Severity of Illness Index | Glucocorticoids - administration & dosage | Prevalence | Humans | Middle Aged | Uricosuric Agents - administration & dosage | Gout - drug therapy | Probenecid - administration & dosage | Colchicine - administration & dosage | Male | Gastroesophageal Reflux - epidemiology | Drug Prescriptions - standards | Contraindications | Gout Suppressants - administration & dosage | Renal Insufficiency, Chronic - epidemiology | Allopurinol - administration & dosage | Gout - epidemiology | Hepatitis, Chronic - epidemiology | Diabetes Mellitus - epidemiology | Aged, 80 and over | Female | Aged | Hypertension - epidemiology
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10. Full Text Febuxostat administration for the prevention of tumour lysis syndrome: A meta‐analysis
by Bellos, Ioannis and Kontzoglou, Konstantinos and Psyrri, Amanda and Pergialiotis, Vasilios
Journal of Clinical Pharmacy and Therapeutics, ISSN 0269-4727, 08/2019, Volume 44, Issue 4, pp. 525 - 533
The present meta‐analysis suggests that febuxostat was able to prevent tumor lysis syndrome, by effectively reducing serum uric acid levels without increasing... 
tumour lysis syndrome | hyperuricemia | febuxostat | meta‐analysis | allopurinol | PLACEBO | MANAGEMENT | EFFICACY | SAFETY | PHASE-III | meta-analysis | RANDOMIZED CLINICAL-TRIALS | MALIGNANCIES | PHARMACOLOGY & PHARMACY | Prevention | Medicine, Experimental | Medical research | Uric acid | Analysis | Tumors | Scientific papers | Cytolysis | Acids | Allopurinol | Lysis | Clinical trials | Search engines | Safety | Incidence
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11. Full Text Behavioral and neurodevelopmental outcome of children after maternal allopurinol administration during suspected fetal hypoxia: 5-year follow up of the ALLO-trial
by Klumper, Job and Kaandorp, Joepe J and Schuit, Ewoud and Groenendaal, Floris and Koopman-Esseboom, Corine and Mulder, Eduard J. H and Van Bel, Frank and Benders, Manon J. N. L and Mol, Ben W. J and van Elburg, Ruurd M and Bos, Arend F and Derks, Jan B and ALLO-trial Study Grp and ALLO-trial study group and on behalf of the ALLO-trial study group
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0201063
Objective To evaluate the long-term neurodevelopmental and behavioral outcome of antenatal allopurinol treatment during suspected fetal hypoxia. Study design... 
PATHWAYS | NEONATAL ENCEPHALOPATHY | BLOOD-LEVELS | BIOMARKER | MULTIDISCIPLINARY SCIENCES | INJURY | BRAIN-DAMAGE | NEUROPROTECTION | PERINATAL ASPHYXIA | Child Behavior Disorders - prevention & control | Double-Blind Method | Follow-Up Studies | Developmental Disabilities - etiology | Humans | Child, Preschool | Developmental Disabilities - prevention & control | Free Radical Scavengers - administration & dosage | Male | Child Behavior Disorders - etiology | Pregnancy | Labor, Obstetric | Allopurinol - administration & dosage | Fetal Hypoxia - drug therapy | Female | Child Behavior - drug effects | Child Development - drug effects | Fetal Hypoxia - complications | Allopurinol | Dosage and administration | Research | Drug therapy | Health aspects | Risk factors | Fetal anoxia | Pediatrics | Traumatic brain injury | Broadband | Fetuses | Gender | Obstetrics | Narrowband | Confidence intervals | Studies | Ischemia | Biomarkers | Hypoxia | Brain damage | Children
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12. Full Text Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol
by Perez-Ruiz, Fernando and Sundy, John S and Miner, Jeffrey N and Cravets, Matthew and Storgard, Chris and RDEA594-203 Study Grp and RDEA594-203 Study Group
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2016, Volume 75, Issue 6, pp. 1074 - 1080
ObjectivesTo assess the efficacy and tolerability of lesinurad, an oral selective uric acid reabsorption inhibitor, in combination with allopurinol versus... 
HYPERURICEMIA | MANAGEMENT | TASK-FORCE | EFFICACY | KINETICS | EVIDENCE BASED RECOMMENDATIONS | RHEUMATOLOGY | FEBUXOSTAT | Triazoles - administration & dosage | Double-Blind Method | Humans | Middle Aged | Gout - drug therapy | Male | Treatment Outcome | Gout Suppressants - administration & dosage | Thioglycolates - administration & dosage | Allopurinol - administration & dosage | Adult | Female | Drug Therapy, Combination | Clinical trials | Care and treatment | Usage | Dosage and administration | Allopurinol | Gout | Clinical and Epidemiological Research | Inflammation | Treatment | Pharmacokinetics | 1506
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13. Full Text A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300–600 mg/day versus benzbromarone 100–200 mg/day in patients with gout
by Reinders, M K and Haagsma, C and Jansen, T L Th A and van Roon, E N and Delsing, J and van de Laar, M A F J and Brouwers, J R B J
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2009, Volume 68, Issue 6, pp. 892 - 897
Objectives:To compare the efficacy and tolerability of allopurinol 300–600 mg/day versus benzbromarone 100–200 mg/day used to attain a target serum urate... 
KIDNEY-DISEASE | URATE | ATTACKS | MANAGEMENT | HYPERURICEMIA | THERAPY | PREVENTION | OSTEOARTHRITIS | RHEUMATOLOGY | ARTHRITIS | URIC-ACID | Confidence Intervals | Prospective Studies | Humans | Middle Aged | Gout - drug therapy | Male | Dose-Response Relationship, Drug | Oxypurinol - blood | Drug-Related Side Effects and Adverse Reactions | Female | Uric Acid - blood | Gout - blood | Drug Administration Schedule | Uricosuric Agents - administration & dosage | Treatment Outcome | Gout Suppressants - adverse effects | Benzbromarone - administration & dosage | Gout Suppressants - administration & dosage | Gout Suppressants - therapeutic use | Allopurinol - therapeutic use | Benzbromarone - therapeutic use | Allopurinol - administration & dosage | Benzbromarone - adverse effects | Allopurinol - adverse effects | Uricosuric Agents - adverse effects | Aged | Patient Compliance | Uricosuric Agents - therapeutic use | Usage | Gout | Patient outcomes | Allopurinol | Dosage and administration | Drug therapy | Health aspects | Studies | Clinical medicine | Drug dosages | Success | Index Medicus
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