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Nature (London), ISSN 1476-4687, 05/2016, Volume 534, Issue 7605, pp. 129 - 132
..., an allosteric inhibitor that targets selected drug-resistant EGFR mutants but spares the wild-type receptor. The crystal structure shows that the compound binds... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Drug Resistance, Multiple - drug effects | Protein Conformation - drug effects | ErbB Receptors - genetics | Lung Neoplasms - pathology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Disease Models, Animal | Allosteric Regulation - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Drug Resistance, Multiple - genetics | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Lung Neoplasms - enzymology | Allosteric Site - drug effects | Mutant Proteins - genetics | Cetuximab - pharmacology | Mutant Proteins - metabolism | Drug Synergism | Drug Resistance, Neoplasm - genetics | Animals | ErbB Receptors - chemistry | Mutant Proteins - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Protein Multimerization - drug effects | Drug Resistance, Neoplasm - drug effects | Studies | Phosphorylation | Nuclear magnetic resonance--NMR | Epidermal growth factor | Mutation | Kinases | Enzyme kinetics | Tumors | Index Medicus
Journal Article
Plant physiology (Bethesda), ISSN 1532-2548, 03/2013, Volume 161, Issue 3, pp. 1501 - 1516
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 50, pp. 20785 - 20798
A key feature of acute myocardial infarction (AMI) is an alteration in cardiac architecture. Signaling events that result in the inhibition of glycogen... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neovascularization, Physiologic - drug effects | Apoptosis - drug effects | Atrial Remodeling - drug effects | Male | Aorta - metabolism | Angiogenesis Inducing Agents - therapeutic use | Ligation | Protein Processing, Post-Translational - drug effects | Thiadiazoles - therapeutic use | Myocardial Infarction - pathology | Female | Myocardial Infarction - physiopathology | Angiogenesis Inducing Agents - pharmacology | Phosphorylation - drug effects | Heart Ventricles - pathology | Disease Models, Animal | Thiadiazoles - pharmacology | Allosteric Regulation - drug effects | Coronary Vessels - drug effects | Coronary Vessels - pathology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Aorta - drug effects | Mice, Inbred C57BL | Myocardial Infarction - metabolism | Glycogen Synthase Kinase 3 - metabolism | Aorta - pathology | Animals | Myocardial Infarction - drug therapy | Heart Ventricles - physiopathology | Protein Kinase Inhibitors - therapeutic use | Aorta - surgery | Heart Ventricles - metabolism | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | In Vitro Techniques | Heart Ventricles - drug effects | Index Medicus | Gene Regulation | Wnt signaling | angiogenesis | endothelial cell | myocardial infarction | allosteric regulation | glycogen synthase kinase 3 (GSK-3)
Journal Article
PloS one, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0176800 - e0176800
...)(.-)concentration, revealed a new O-2(.-)-dependent regulation of IRP1 leading to the reduction of IRP1 protein level and in consequence to the diminution of IRP1 enzymatic and IRE-binding activities... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Superoxide Dismutase-1 - deficiency | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Liver - drug effects | Tumor Suppressor Proteins - deficiency | Receptors, LDL - deficiency | Superoxides - metabolism | Paraquat - pharmacology | Iron Regulatory Protein 1 - genetics | Tumor Suppressor Proteins - metabolism | Kidney - drug effects | Liver - metabolism | RNA, Messenger - genetics | Receptors, LDL - metabolism | Apoferritins - genetics | Macrophages - cytology | Down-Regulation - drug effects | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Iron Regulatory Protein 1 - metabolism | Macrophages - drug effects | RAW 264.7 Cells | Mice | Oxidative Stress - drug effects | Herbicides | Oxidative stress | Analysis | Physiological aspects | Superoxide dismutase | Chemical properties | Macrophages | Health aspects | Cell culture | Liver | Biochemistry | Electron spin | Blood | Proteins | Degradation | Animal breeding | Clusters | Bone marrow | Hydroxyl radicals | Biocompatibility | Genetics | Copper | Deoxyribonucleic acid--DNA | Binding | Enzymes | Paramagnetic resonance | Fluctuations | Breeding | Developmental biology | Fetuses | Gene expression | Metabolism | Embryos | Stem cells | Affinity | Residues | Hydrogen peroxide | Arches | Toxicity | Leukemia | Gene regulation | Homeostasis | Viruses | Iron | Biology | Neurotoxicity | Allosteric properties | Ethylenediaminetetraacetic acids | Clonal deletion | Uterus | E coli | Rodents | Biodegradation | Oxygen | Amyotrophic lateral sclerosis | Pharmacology | Biophysics | Ribonucleic acid--RNA | Citric acid | Cell death | In vivo methods and tests | Molecular biology | Females | Tumors | Peritoneum | Cancer | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 7/2014, Volume 111, Issue 29, pp. 10544 - 10549
Journal Article