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ChemBioChem, ISSN 1439-4227, 12/2019, Volume 20, Issue 23, pp. 2916 - 2920
Photocontrol of protein activity is an emerging field in biomedicine. For optical control of a mutant small GTPase K‐Ras(G12C), we developed small‐molecule... 
covalent inhibitors | photoswitches | azobenzenes | K-Ras(G12C) | allosterism
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 12/2019, Volume 17, Issue 12, pp. 2110 - 2122
Background Human factor XIa (FXIa) is an actively pursued target for development of safer anticoagulants. Our long‐standing hypothesis has been that... 
coagulation proteases | drug discovery | factor XIa | allosterism | antithrombotics
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 03/2019, Volume 9, Issue 1, pp. 4637 - 14
Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is... 
AFFINITY | MULTIDISCIPLINARY SCIENCES | LOOP | PARAMETERS | RECEPTORS | ALLOSTERISM | BINDING | Acetylcholine receptors (muscarinic)
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 11/2019
Journal Article
CELL CHEMICAL BIOLOGY, ISSN 2451-9448, 10/2019, Volume 26, Issue 10, pp. 1365 - 1365
Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to... 
MOLECULAR-DYNAMICS | READ ALIGNMENT | PRC2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHYLATED HISTONE H3 | DRUG DISCOVERY | METHYLTRANSFERASE ACTIVITY | FORCE-FIELD | H2A UBIQUITYLATION | GENOMIC TARGETS | WEB SERVER
Journal Article
ChemBioChem, ISSN 1439-4227, 10/2019, Volume 20, Issue 19, pp. 2485 - 2493
CD38 is a multi‐functional signaling enzyme that catalyzes the biosynthesis of two calcium‐mobilizing second messengers: cyclic ADP‐ribose and nicotinic acid... 
inhibitors | CD38 | HDX-MS | E-pharmacophores | allosterism | Deuterium | NADPH | Calcium | Nicotinic acid | Antibodies | Molecular dynamics | Biosynthesis | Drug development | ADP | Modulators | Second messengers | Allosteric properties | NAADP | Ribose | CD38 antigen | Aging | Binding | Adenine | Mass spectroscopy | Lead compounds | NAD | Organic chemistry | Inhibitors | Nicotinamide adenine dinucleotide | Surface plasmon resonance | Nicotinamide | Mass spectrometry
Journal Article
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 06/2019, Volume 75, pp. 461 - 469
Human liver pyruvate kinase (hLPYK) converts phosphoenolpyruvate to pyruvate in the final step of glycolysis. hLPYK is allosterically activated by... 
SYSTEM | BIOPHYSICS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | pyruvate kinase | BIOCHEMICAL RESEARCH METHODS | human liver isozyme | CRYSTALLOGRAPHY | allosterism
Journal Article
Acta Crystallographica Section F, ISSN 2053-230X, 06/2019, Volume 75, Issue 6, pp. 461 - 469
Human liver pyruvate kinase (hLPYK) converts phosphoenolpyruvate to pyruvate in the final step of glycolysis. hLPYK is allosterically activated by... 
human liver isozyme | pyruvate kinase | allosterism | Binding | Phosphates | Residues | Pyruvate kinase | Liver | Pyruvic acid | Activation | Glucose | Fructose | Covalent bonds | Allosteric properties | Breakage | Glycolysis | Cations | Crystal structure | Structure-function relationships
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2019, Volume 63, Issue 5
The quinazolinones are a new class of antibacterials with in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA). The quinazolinones... 
Synergy | Quinazolinone | Tazobactam | Allosterism | Piperacillin | MRSA | synergy | tazobactam | IN-VIVO | quinazolinone | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | piperacillin | BINDING PROTEIN 2A | allosterism
Journal Article
Journal of Inclusion Phenomena and Macrocyclic Chemistry, ISSN 1388-3127, 4/2019, Volume 93, Issue 3, pp. 127 - 143
Journal Article
Journal of Receptors and Signal Transduction, ISSN 1079-9893, 03/2019, Volume 39, Issue 2, pp. 106 - 113
Context: Drugs such as positive allosteric modulators (PAMs) produce complex behaviors when acting on tissues in different physiological contexts in vivo.... 
Receptor allosterism | Gq-coupled receptors | drug discovery and development | positive allosteric modulation | PHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | BINDING | MODULATION | CELL BIOLOGY
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 03/2019, Volume 11, Issue 6, pp. 599 - 610
Molecular dynamics is a state of the art computational tool for the investigation of biophysics phenomenon at a molecular scale, as it enables the modeling of... 
solvation | GPCRs | biased agonism | molecular dynamics | ligand binding | allosterism | class B GPCRs | STRUCTURAL INSIGHTS | CHEMISTRY, MEDICINAL | LIGAND-BINDING | CLASS-A GPCRS | AGONIST-BINDING | A(2A) ADENOSINE RECEPTOR | ALLOSTERIC COMMUNICATION PIPELINES | CLASS-B GPCRS | SODIUM-ION BINDING | TARGET RESIDENCE TIME | BETA-ADRENERGIC RECEPTOR
Journal Article
Biochemistry and Biophysics Reports, ISSN 2405-5808, 03/2019, Volume 17, pp. 127 - 131
While the binding of biotin by streptavidin does not appear to be cooperative in the traditional sense of altered binding strength, it has been suggested that... 
Tryptophan fluorescence | Protein-ligand binding | Allosterism | Streptavidin | Photobleaching
Journal Article