Journal of nuclear medicine : official publication, Society of Nuclear Medicine, ISSN 0161-5505, 09/2017, Volume 58, Issue Suppl 2, pp. 91S - 96S
In recent years, new α-particle-, β -particle-, and Auger electron-emitting radiometals-such as Cu, Sc, Ho, Tb, Tb, Pb/ Bi, Ac, and Bi-have been produced and...
Radiochemistry - methods | Animals | Radioisotopes - therapeutic use | Metals - chemistry | Humans | Beta Particles - therapeutic use | Alpha Particles - therapeutic use | Radioisotopes - chemistry | Electrons
Radiochemistry - methods | Animals | Radioisotopes - therapeutic use | Metals - chemistry | Humans | Beta Particles - therapeutic use | Alpha Particles - therapeutic use | Radioisotopes - chemistry | Electrons
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 2014, Volume 41, Issue 11, pp. 2106 - 2119
Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as (90)Y/(177)Lu-DOTATOC is a new therapeutic option in neuroendocrine...
DOTATOC | Targeted alpha therapy (TAT) | 225 Ac | 213 Bi | Humans | Alpha Particles - adverse effects | Male | Tomography, X-Ray Computed | Positron-Emission Tomography | Bismuth - therapeutic use | Octreotide - pharmacokinetics | Alpha Particles - therapeutic use | Neoplasm Metastasis | Neuroendocrine Tumors - diagnostic imaging | Treatment Failure | Adult | Female | Receptors, Somatostatin - metabolism | Retrospective Studies | Molecular Targeted Therapy - methods | Neuroendocrine Tumors - pathology | Molecular Targeted Therapy - adverse effects | Radioisotopes - therapeutic use | Octreotide - analogs & derivatives | Octreotide - adverse effects | Octreotide - therapeutic use | Octreotide - pharmacology | Neuroendocrine Tumors - radiotherapy | Beta Particles - therapeutic use | Index Medicus
DOTATOC | Targeted alpha therapy (TAT) | 225 Ac | 213 Bi | Humans | Alpha Particles - adverse effects | Male | Tomography, X-Ray Computed | Positron-Emission Tomography | Bismuth - therapeutic use | Octreotide - pharmacokinetics | Alpha Particles - therapeutic use | Neoplasm Metastasis | Neuroendocrine Tumors - diagnostic imaging | Treatment Failure | Adult | Female | Receptors, Somatostatin - metabolism | Retrospective Studies | Molecular Targeted Therapy - methods | Neuroendocrine Tumors - pathology | Molecular Targeted Therapy - adverse effects | Radioisotopes - therapeutic use | Octreotide - analogs & derivatives | Octreotide - adverse effects | Octreotide - therapeutic use | Octreotide - pharmacology | Neuroendocrine Tumors - radiotherapy | Beta Particles - therapeutic use | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2010, Volume 16, Issue 21, pp. 5303 - 5311
Purpose: Lintuzumab (HuM195), a humanized anti-CD33 antibody, targets myeloid leukemia cells and has modest single-agent activity against acute myeloid...
ANTI-CD33 MONOCLONAL-ANTIBODY | RETINOIC ACID | THERAPY | PHARMACOKINETICS | ONCOLOGY | RECOMMENDATIONS | BONE-MARROW-TRANSPLANTATION | INDUCTION | M195 ANTI-CD33 | CHEMOTHERAPY | REMISSION | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Alpha Particles - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Bismuth - therapeutic use | Cytarabine - adverse effects | Alpha Particles - therapeutic use | Bismuth - adverse effects | Antimetabolites, Antineoplastic - administration & dosage | Antibodies, Monoclonal, Humanized | Aged, 80 and over | Immunoconjugates - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Radioimmunotherapy - methods | Adult | Female | Antibodies, Monoclonal - chemistry | Immunoconjugates - adverse effects | Leukemia, Myeloid, Acute - radiotherapy | Radioisotopes - therapeutic use | Drug Administration Schedule | Radioisotopes - adverse effects | Remission Induction | Cytarabine - administration & dosage | Antimetabolites, Antineoplastic - adverse effects | Aged | Radioimmunotherapy - adverse effects | Index Medicus | Alpha-particles | Bismuth-213 | Monoclonal Antibodies | Acute myeloid leukemia | Radioimmunotherapy
ANTI-CD33 MONOCLONAL-ANTIBODY | RETINOIC ACID | THERAPY | PHARMACOKINETICS | ONCOLOGY | RECOMMENDATIONS | BONE-MARROW-TRANSPLANTATION | INDUCTION | M195 ANTI-CD33 | CHEMOTHERAPY | REMISSION | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Alpha Particles - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Bismuth - therapeutic use | Cytarabine - adverse effects | Alpha Particles - therapeutic use | Bismuth - adverse effects | Antimetabolites, Antineoplastic - administration & dosage | Antibodies, Monoclonal, Humanized | Aged, 80 and over | Immunoconjugates - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Radioimmunotherapy - methods | Adult | Female | Antibodies, Monoclonal - chemistry | Immunoconjugates - adverse effects | Leukemia, Myeloid, Acute - radiotherapy | Radioisotopes - therapeutic use | Drug Administration Schedule | Radioisotopes - adverse effects | Remission Induction | Cytarabine - administration & dosage | Antimetabolites, Antineoplastic - adverse effects | Aged | Radioimmunotherapy - adverse effects | Index Medicus | Alpha-particles | Bismuth-213 | Monoclonal Antibodies | Acute myeloid leukemia | Radioimmunotherapy
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 05/2013, Volume 133, Issue 5, pp. 1231 - 1239
Advances in nanotechnology have demonstrated potential application of nanoparticles (NPs) for effective and targeted drug delivery. Here we investigated the...
WATER-SOLUBLE CHITOSAN | ANTIBACTERIAL PROPERTIES | MICROSPHERES | ALPHA | ACNE-VULGARIS | RELEASE | MICROPARTICLES | NANOTECHNOLOGY | DELIVERY | DERMATOLOGY | Alginates - therapeutic use | Anti-Infective Agents - pharmacology | Humans | Hexuronic Acids - administration & dosage | Skin Diseases, Bacterial - drug therapy | Drug Delivery Systems | Feasibility Studies | Nanoparticles - therapeutic use | Chitosan - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Chitosan - pharmacology | Anti-Inflammatory Agents - administration & dosage | Glucuronic Acid - administration & dosage | Keratinocytes - microbiology | Alginates - pharmacology | Benzoyl Peroxide - pharmacology | Cell Line | Benzoyl Peroxide - administration & dosage | Benzoyl Peroxide - therapeutic use | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Propionibacterium acnes - physiology | Cells, Cultured | Chitosan - administration & dosage | Acne Vulgaris - drug therapy | Anti-Infective Agents - therapeutic use | Glucuronic Acid - therapeutic use | Alginates - administration & dosage | Glucuronic Acid - pharmacology | Anti-Infective Agents - administration & dosage | Keratinocytes - drug effects | Propionibacterium acnes - ultrastructure | Keratinocytes - metabolism | Nanoparticles - administration & dosage | Propionibacterium acnes - drug effects | Administration, Topical | Hexuronic Acids - pharmacology | Hexuronic Acids - therapeutic use | Index Medicus | Acne | Antimicrobial | Inflammation | Chitosan | Nanoparticle | Skin infection
WATER-SOLUBLE CHITOSAN | ANTIBACTERIAL PROPERTIES | MICROSPHERES | ALPHA | ACNE-VULGARIS | RELEASE | MICROPARTICLES | NANOTECHNOLOGY | DELIVERY | DERMATOLOGY | Alginates - therapeutic use | Anti-Infective Agents - pharmacology | Humans | Hexuronic Acids - administration & dosage | Skin Diseases, Bacterial - drug therapy | Drug Delivery Systems | Feasibility Studies | Nanoparticles - therapeutic use | Chitosan - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Chitosan - pharmacology | Anti-Inflammatory Agents - administration & dosage | Glucuronic Acid - administration & dosage | Keratinocytes - microbiology | Alginates - pharmacology | Benzoyl Peroxide - pharmacology | Cell Line | Benzoyl Peroxide - administration & dosage | Benzoyl Peroxide - therapeutic use | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Propionibacterium acnes - physiology | Cells, Cultured | Chitosan - administration & dosage | Acne Vulgaris - drug therapy | Anti-Infective Agents - therapeutic use | Glucuronic Acid - therapeutic use | Alginates - administration & dosage | Glucuronic Acid - pharmacology | Anti-Infective Agents - administration & dosage | Keratinocytes - drug effects | Propionibacterium acnes - ultrastructure | Keratinocytes - metabolism | Nanoparticles - administration & dosage | Propionibacterium acnes - drug effects | Administration, Topical | Hexuronic Acids - pharmacology | Hexuronic Acids - therapeutic use | Index Medicus | Acne | Antimicrobial | Inflammation | Chitosan | Nanoparticle | Skin infection
Journal Article
Advanced Drug Delivery Reviews, ISSN 0169-409X, 01/2017, Volume 109, pp. 102 - 118
Radioimmunotherapy (RIT) aims to selectively deliver radionuclides emitting α-particles, β-particles or Auger electrons to tumors by conjugation to monoclonal...
Monoclonal antibodies | Auger electrons | α-Particles | Radiation treatment | Radioimmunotherapy | Cancer | BONE-MARROW-TRANSPLANTATION | RADIOTHERAPEUTIC AGENT IN-111-NLS-TRASTUZUMAB | ACUTE MYELOGENOUS LEUKEMIA | ACUTE MYELOID-LEUKEMIA | GROWING OVARIAN-CANCER | MONOCLONAL-ANTIBODY MOV18 | DISSEMINATED INTRAPERITONEAL DISEASE | EPIDERMAL-GROWTH-FACTOR | alpha-Particles | PHARMACOLOGY & PHARMACY | DISSEMINATED PERITONEAL DISEASE | SITE-SPECIFIC CONJUGATION | Animals | Radioisotopes - therapeutic use | Humans | Radioisotopes - adverse effects | Electrons - therapeutic use | Immunoconjugates - therapeutic use | Neoplasms - radiotherapy | Linear Energy Transfer | Alpha Particles - therapeutic use | Radioimmunotherapy - adverse effects | Immunoconjugates - adverse effects
Monoclonal antibodies | Auger electrons | α-Particles | Radiation treatment | Radioimmunotherapy | Cancer | BONE-MARROW-TRANSPLANTATION | RADIOTHERAPEUTIC AGENT IN-111-NLS-TRASTUZUMAB | ACUTE MYELOGENOUS LEUKEMIA | ACUTE MYELOID-LEUKEMIA | GROWING OVARIAN-CANCER | MONOCLONAL-ANTIBODY MOV18 | DISSEMINATED INTRAPERITONEAL DISEASE | EPIDERMAL-GROWTH-FACTOR | alpha-Particles | PHARMACOLOGY & PHARMACY | DISSEMINATED PERITONEAL DISEASE | SITE-SPECIFIC CONJUGATION | Animals | Radioisotopes - therapeutic use | Humans | Radioisotopes - adverse effects | Electrons - therapeutic use | Immunoconjugates - therapeutic use | Neoplasms - radiotherapy | Linear Energy Transfer | Alpha Particles - therapeutic use | Radioimmunotherapy - adverse effects | Immunoconjugates - adverse effects
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 26, pp. 7635 - 7646
Abstract Development of multifunctional theranostic nanoplatforms for targeted cancer imaging and therapy still remains a great challenge. Herein, we report...
Advanced Basic Science | Dentistry | CT imaging | Dendrimers | Alpha-tocopheryl succinate | Targeted cancer therapy | Gold nanoparticles | IRON-OXIDE NANOPARTICLES | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | WALLED CARBON NANOTUBES | COMPUTED-TOMOGRAPHY | VITAMIN-E ANALOGS | IN-VIVO | MAGNETIC-RESONANCE | TOMOGRAPHY IMAGING APPLICATIONS | COMPLEX II | POLYETHYLENE-GLYCOL | Nanoparticles - chemistry | Dendrimers - therapeutic use | Humans | Tomography, X-Ray Computed - methods | Vitamin E - analogs & derivatives | Male | Polyethylene Glycols - chemistry | Neoplasms - diagnosis | Polyethylene Glycols - therapeutic use | Neoplasms - therapy | Nanoparticles - therapeutic use | Vitamin E - therapeutic use | Contrast Media - therapeutic use | Vitamin E - chemistry | Gold - chemistry | Folic Acid - chemistry | Nanoparticles - ultrastructure | Animals | Mice, Nude | Cell Line, Tumor | Dendrimers - chemistry | Folic Acid - metabolism | Gold - therapeutic use | Contrast Media - chemistry | Mice, Inbred BALB C | Nanoparticles | Fluorescein | Radiology | Radiology, Medical | Polyols | Folic acid | Cancer | Surgical implants | Therapy | Gold | Biomedical materials | Imaging | Nanostructure
Advanced Basic Science | Dentistry | CT imaging | Dendrimers | Alpha-tocopheryl succinate | Targeted cancer therapy | Gold nanoparticles | IRON-OXIDE NANOPARTICLES | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | WALLED CARBON NANOTUBES | COMPUTED-TOMOGRAPHY | VITAMIN-E ANALOGS | IN-VIVO | MAGNETIC-RESONANCE | TOMOGRAPHY IMAGING APPLICATIONS | COMPLEX II | POLYETHYLENE-GLYCOL | Nanoparticles - chemistry | Dendrimers - therapeutic use | Humans | Tomography, X-Ray Computed - methods | Vitamin E - analogs & derivatives | Male | Polyethylene Glycols - chemistry | Neoplasms - diagnosis | Polyethylene Glycols - therapeutic use | Neoplasms - therapy | Nanoparticles - therapeutic use | Vitamin E - therapeutic use | Contrast Media - therapeutic use | Vitamin E - chemistry | Gold - chemistry | Folic Acid - chemistry | Nanoparticles - ultrastructure | Animals | Mice, Nude | Cell Line, Tumor | Dendrimers - chemistry | Folic Acid - metabolism | Gold - therapeutic use | Contrast Media - chemistry | Mice, Inbred BALB C | Nanoparticles | Fluorescein | Radiology | Radiology, Medical | Polyols | Folic acid | Cancer | Surgical implants | Therapy | Gold | Biomedical materials | Imaging | Nanostructure
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 3, pp. 1009 - 1018
Recurrent prostate cancer presents a challenge to conventional treatment, particularly so to address micrometastatic and small-volume disease. Use of...
NUDE-MICE | MEMBRANE ANTIGEN | PEPTIDES | SOLID TUMORS | GRP | ONCOLOGY | PHASE-I TRIAL | RADIOIMMUNOTHERAPY | RADIOTHERAPY | MONOCLONAL-ANTIBODIES | DELIVERY | Prostatic Neoplasms - radiotherapy | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Humans | Oligopeptides - pharmacokinetics | Alpha Particles - adverse effects | Male | Radiopharmaceuticals - toxicity | Oligopeptides - toxicity | Alpha Particles - therapeutic use | Oligopeptides - therapeutic use | Bismuth - chemistry | Xenograft Model Antitumor Assays | Animals | Beta Particles - adverse effects | Mice, Nude | Beta Particles - therapeutic use | Female | Lutetium - chemistry | Mice | Oligopeptides - chemistry | Radioisotopes - chemistry | Radiopharmaceuticals - therapeutic use
NUDE-MICE | MEMBRANE ANTIGEN | PEPTIDES | SOLID TUMORS | GRP | ONCOLOGY | PHASE-I TRIAL | RADIOIMMUNOTHERAPY | RADIOTHERAPY | MONOCLONAL-ANTIBODIES | DELIVERY | Prostatic Neoplasms - radiotherapy | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Humans | Oligopeptides - pharmacokinetics | Alpha Particles - adverse effects | Male | Radiopharmaceuticals - toxicity | Oligopeptides - toxicity | Alpha Particles - therapeutic use | Oligopeptides - therapeutic use | Bismuth - chemistry | Xenograft Model Antitumor Assays | Animals | Beta Particles - adverse effects | Mice, Nude | Beta Particles - therapeutic use | Female | Lutetium - chemistry | Mice | Oligopeptides - chemistry | Radioisotopes - chemistry | Radiopharmaceuticals - therapeutic use
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 10/2016, Volume 57, Issue 10, pp. 1569 - 1575
Alpha-particle emitters have a high linear energy transfer and short range, offering the potential for treating micrometastases while sparing normal tissues....
Astatine | Oncology: GU | Prostate-specific membrane antigen | Radionuclide therapy | Radiation dosimetry | Radiopharmaceuticals | Alpha emitter | Prostate cancer | SURVIVAL | MALIGNANT HUMAN TISSUES | RADIOIMMUNOTHERAPY | RADICAL PROSTATECTOMY | oncology: GU | MEMBRANE ANTIGEN PSMA | alpha emitter | METASTATIC PROSTATE-CANCER | prostate-specific membrane antigen | radiopharmaceuticals | prostate cancer | F-18-DCFBC | radionuclide therapy | astatine | radiation dosimetry | RECURRENCE | INHIBITORS | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Urea - pharmacokinetics | Humans | Organometallic Compounds - pharmacokinetics | Alpha Particles - therapeutic use | Urea - chemistry | Tissue Distribution | Radiopharmaceuticals - metabolism | Kidney - metabolism | Maximum Tolerated Dose | Urea - therapeutic use | Animals | Glutamate Carboxypeptidase II - metabolism | Organometallic Compounds - metabolism | Urea - analogs & derivatives | Radiochemistry | Antigens, Surface - metabolism | Cell Line, Tumor | Organometallic Compounds - therapeutic use | Organometallic Compounds - chemistry | Urea - metabolism | Mice | Radiopharmaceuticals - therapeutic use | Basic Science Investigations
Astatine | Oncology: GU | Prostate-specific membrane antigen | Radionuclide therapy | Radiation dosimetry | Radiopharmaceuticals | Alpha emitter | Prostate cancer | SURVIVAL | MALIGNANT HUMAN TISSUES | RADIOIMMUNOTHERAPY | RADICAL PROSTATECTOMY | oncology: GU | MEMBRANE ANTIGEN PSMA | alpha emitter | METASTATIC PROSTATE-CANCER | prostate-specific membrane antigen | radiopharmaceuticals | prostate cancer | F-18-DCFBC | radionuclide therapy | astatine | radiation dosimetry | RECURRENCE | INHIBITORS | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Urea - pharmacokinetics | Humans | Organometallic Compounds - pharmacokinetics | Alpha Particles - therapeutic use | Urea - chemistry | Tissue Distribution | Radiopharmaceuticals - metabolism | Kidney - metabolism | Maximum Tolerated Dose | Urea - therapeutic use | Animals | Glutamate Carboxypeptidase II - metabolism | Organometallic Compounds - metabolism | Urea - analogs & derivatives | Radiochemistry | Antigens, Surface - metabolism | Cell Line, Tumor | Organometallic Compounds - therapeutic use | Organometallic Compounds - chemistry | Urea - metabolism | Mice | Radiopharmaceuticals - therapeutic use | Basic Science Investigations
Journal Article
Small, ISSN 1613-6810, 06/2013, Volume 9, Issue 11, pp. 1929 - 1938
Upconverting nanoparticles (UCNPs) have attracted considerable attention as potential photosensitizer carriers for photodynamic therapy (PDT) in deep tissues....
combinational therapy | fluorescence resonance energy transfer | upconversion | photodynamic therapy | red‐emitting upconverting nanoparticles | red-emitting upconverting nanoparticles | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | DRUG-DELIVERY | STRATEGY | MATERIALS SCIENCE, MULTIDISCIPLINARY | LIGHT | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | FLUORESCENT NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | NM LASER | QUANTUM DOTS | NAYF4 NANOCRYSTALS | DOPANT-CONTROLLED SYNTHESIS | IMAGING AGENT | UP-CONVERSION NANOPARTICLES | Lung Neoplasms - drug therapy | Photosensitizing Agents - chemistry | Porphyrins - therapeutic use | Nanoparticles - chemistry | Photosensitizing Agents - therapeutic use | Photochemotherapy - methods | Humans | Lung Neoplasms - metabolism | Porphyrins - chemistry | Rats | alpha-Cyclodextrins - chemistry | Singlet Oxygen - metabolism | Animals | Nanoparticles - therapeutic use | Fluorescence Resonance Energy Transfer | Organometallic Compounds - therapeutic use | Indoles - therapeutic use | Organometallic Compounds - chemistry | Mice | Indoles - chemistry | Nanoparticles | Anthracyclines | Chemotherapy | Active oxygen | Phthalocyanins | Cancer cells | Fluorescence | Cyclodextrins | Health aspects | Photochemotherapy | Nanotechnology | Cancer | Oxygen | Photodynamic therapy | Drugs | Nanomaterials | Nanostructure
combinational therapy | fluorescence resonance energy transfer | upconversion | photodynamic therapy | red‐emitting upconverting nanoparticles | red-emitting upconverting nanoparticles | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | DRUG-DELIVERY | STRATEGY | MATERIALS SCIENCE, MULTIDISCIPLINARY | LIGHT | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | FLUORESCENT NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | NM LASER | QUANTUM DOTS | NAYF4 NANOCRYSTALS | DOPANT-CONTROLLED SYNTHESIS | IMAGING AGENT | UP-CONVERSION NANOPARTICLES | Lung Neoplasms - drug therapy | Photosensitizing Agents - chemistry | Porphyrins - therapeutic use | Nanoparticles - chemistry | Photosensitizing Agents - therapeutic use | Photochemotherapy - methods | Humans | Lung Neoplasms - metabolism | Porphyrins - chemistry | Rats | alpha-Cyclodextrins - chemistry | Singlet Oxygen - metabolism | Animals | Nanoparticles - therapeutic use | Fluorescence Resonance Energy Transfer | Organometallic Compounds - therapeutic use | Indoles - therapeutic use | Organometallic Compounds - chemistry | Mice | Indoles - chemistry | Nanoparticles | Anthracyclines | Chemotherapy | Active oxygen | Phthalocyanins | Cancer cells | Fluorescence | Cyclodextrins | Health aspects | Photochemotherapy | Nanotechnology | Cancer | Oxygen | Photodynamic therapy | Drugs | Nanomaterials | Nanostructure
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 02/2010, Volume 51, Issue 2, pp. 311 - 328
The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and...
Human α-particle emitter dosimetry | Targeted α-particle emitter therapy | α-particle emitters | DIFFERENT IONIZING RADIATIONS | INCORPORATED RADIONUCLIDES | alpha-particle emitters | RELATIVE BIOLOGICAL EFFECTIVENESS | HUMAN-CELLS | ABSORBED FRACTIONS | ACCELERATED HEAVY-IONS | TISSUE-CULTURE | MAMMALIAN-CELLS | RADIOPROTECTORS IN-VIVO | targeted alpha-particle emitter therapy | human alpha-particle emitter dosimetry | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DOSE-RATE | Radiotherapy Dosage | Cell Death - radiation effects | Radioisotopes - therapeutic use | Humans | Neoplasms, Radiation-Induced - etiology | Radioisotopes - adverse effects | Alpha Particles - adverse effects | Male | Clinical Trials as Topic | Pamphlets | Alpha Particles - therapeutic use | Cell Survival - radiation effects | Radiobiology | Societies, Medical | Radiation-Protective Agents - therapeutic use | Female | Neoplasms - radiotherapy | Relative Biological Effectiveness | Dose-Response Relationship, Radiation | Radiotherapy Planning, Computer-Assisted | targeted α-particle emitter therapy | human α-particle emitter dosimetry
Human α-particle emitter dosimetry | Targeted α-particle emitter therapy | α-particle emitters | DIFFERENT IONIZING RADIATIONS | INCORPORATED RADIONUCLIDES | alpha-particle emitters | RELATIVE BIOLOGICAL EFFECTIVENESS | HUMAN-CELLS | ABSORBED FRACTIONS | ACCELERATED HEAVY-IONS | TISSUE-CULTURE | MAMMALIAN-CELLS | RADIOPROTECTORS IN-VIVO | targeted alpha-particle emitter therapy | human alpha-particle emitter dosimetry | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DOSE-RATE | Radiotherapy Dosage | Cell Death - radiation effects | Radioisotopes - therapeutic use | Humans | Neoplasms, Radiation-Induced - etiology | Radioisotopes - adverse effects | Alpha Particles - adverse effects | Male | Clinical Trials as Topic | Pamphlets | Alpha Particles - therapeutic use | Cell Survival - radiation effects | Radiobiology | Societies, Medical | Radiation-Protective Agents - therapeutic use | Female | Neoplasms - radiotherapy | Relative Biological Effectiveness | Dose-Response Relationship, Radiation | Radiotherapy Planning, Computer-Assisted | targeted α-particle emitter therapy | human α-particle emitter dosimetry
Journal Article
Radiation Research, ISSN 0033-7587, 09/2018, Volume 190, Issue 3, pp. 236 - 247
The use of targeted radionuclide therapy for cancer is on the rise. While beta-particle-emitting radionuclides have been extensively explored for targeted...
SURVIVAL | ELECTRON | NEUROENDOCRINE TUMORS | BETA-EMITTING RADIONUCLIDES | MAMMALIAN-CELLS | S-VALUES | RADIOLABELED SOMATOSTATIN ANALOG | BIOPHYSICS | THYROID-CANCER | BIOLOGY | IN-111 PENTETREOTIDE | RESISTANT PROSTATE-CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Lead Radioisotopes - therapeutic use | Radioisotopes - therapeutic use | Humans | Alpha Particles - adverse effects | Bismuth - therapeutic use | Alpha Particles - therapeutic use | Neoplasm Metastasis | Beta Particles - adverse effects | Actinium - therapeutic use | Beta Particles - therapeutic use | Neoplasms - radiotherapy | Lutetium - therapeutic use | Neoplasms - pathology | Dose-Response Relationship, Radiation | Yttrium Radioisotopes - therapeutic use
SURVIVAL | ELECTRON | NEUROENDOCRINE TUMORS | BETA-EMITTING RADIONUCLIDES | MAMMALIAN-CELLS | S-VALUES | RADIOLABELED SOMATOSTATIN ANALOG | BIOPHYSICS | THYROID-CANCER | BIOLOGY | IN-111 PENTETREOTIDE | RESISTANT PROSTATE-CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Lead Radioisotopes - therapeutic use | Radioisotopes - therapeutic use | Humans | Alpha Particles - adverse effects | Bismuth - therapeutic use | Alpha Particles - therapeutic use | Neoplasm Metastasis | Beta Particles - adverse effects | Actinium - therapeutic use | Beta Particles - therapeutic use | Neoplasms - radiotherapy | Lutetium - therapeutic use | Neoplasms - pathology | Dose-Response Relationship, Radiation | Yttrium Radioisotopes - therapeutic use
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2013, Volume 19, Issue 3, pp. 530 - 537
An alpha-particle, a He-4 nucleus, is exquisitely cytotoxic and indifferent to many limitations associated with conventional chemo-and radiotherapy. The...
IRRADIATION | PHARMACOKINETICS | ONCOLOGY | IMMUNOTHERAPY | RADIOIMMUNOTHERAPY | DOUBLE-STRAND BREAKS | MYELOID-LEUKEMIA | MECHANISMS | INDUCTION | DOSIMETRY | CELL-DEATH | Neoplasms - metabolism | Neoplasms - radiotherapy | Clinical Trials as Topic | Signal Transduction - radiation effects | Alpha Particles - therapeutic use | Humans | α-Radiation | Cancer therapy | DNA | DNA damage | Hematologic cancer | Clinical trials | Monoclonal antibodies | Radiation therapy | Metastasis | Targeted α-therapy | Ovarian cancer
IRRADIATION | PHARMACOKINETICS | ONCOLOGY | IMMUNOTHERAPY | RADIOIMMUNOTHERAPY | DOUBLE-STRAND BREAKS | MYELOID-LEUKEMIA | MECHANISMS | INDUCTION | DOSIMETRY | CELL-DEATH | Neoplasms - metabolism | Neoplasms - radiotherapy | Clinical Trials as Topic | Signal Transduction - radiation effects | Alpha Particles - therapeutic use | Humans | α-Radiation | Cancer therapy | DNA | DNA damage | Hematologic cancer | Clinical trials | Monoclonal antibodies | Radiation therapy | Metastasis | Targeted α-therapy | Ovarian cancer
Journal Article
Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23, pp. 8941 - 8948
alpha-Particles are suitable to treat cancer micrometastases because of their short range and very high linear energy transfer. alpha-Particle emitter...
Mammary Neoplasms, Experimental - immunology | Lung Neoplasms - metabolism | Lung Neoplasms - radiotherapy | Bismuth - therapeutic use | Alpha Particles - therapeutic use | Mammary Neoplasms, Experimental - metabolism | Bismuth - chemistry | Tissue Distribution | Lung Neoplasms - secondary | Actinium - therapeutic use | Isotope Labeling | Female | Receptor, ErbB-2 - immunology | Yttrium Radioisotopes - therapeutic use | Antibodies, Monoclonal - immunology | Radioisotopes - therapeutic use | Radioimmunotherapy | Rats | Mammary Neoplasms, Experimental - radiotherapy | Mice, Transgenic | Animals | Actinium - chemistry | Immunotoxins - therapeutic use | Immunotoxins - pharmacokinetics | Mice | Radioisotopes - chemistry | Yttrium Radioisotopes - chemistry | Index Medicus | radioimmunotherapy | metastasis | 213Bi | alpha-particle | 225Ac | rat HER-2 | neu
Mammary Neoplasms, Experimental - immunology | Lung Neoplasms - metabolism | Lung Neoplasms - radiotherapy | Bismuth - therapeutic use | Alpha Particles - therapeutic use | Mammary Neoplasms, Experimental - metabolism | Bismuth - chemistry | Tissue Distribution | Lung Neoplasms - secondary | Actinium - therapeutic use | Isotope Labeling | Female | Receptor, ErbB-2 - immunology | Yttrium Radioisotopes - therapeutic use | Antibodies, Monoclonal - immunology | Radioisotopes - therapeutic use | Radioimmunotherapy | Rats | Mammary Neoplasms, Experimental - radiotherapy | Mice, Transgenic | Animals | Actinium - chemistry | Immunotoxins - therapeutic use | Immunotoxins - pharmacokinetics | Mice | Radioisotopes - chemistry | Yttrium Radioisotopes - chemistry | Index Medicus | radioimmunotherapy | metastasis | 213Bi | alpha-particle | 225Ac | rat HER-2 | neu
Journal Article
Enzyme and Microbial Technology, ISSN 0141-0229, 12/2016, Volume 95, pp. 58 - 68
Nanobiomedicine and parasitology are facing a number of key challenges, which mostly deal with the paucity of effective preventive and curative tools against...
Plasmodium | Anopheles | Malaria | Mosquito vector control | Chloroquine | Dengue | Artemisinin | Tumor | Zika virus | Culex | Aedes | ANTIPLASMODIAL ACTIVITY | NECROSIS-FACTOR-ALPHA | Tumor Zika virus | SILVER NANOPARTICLES | AEGYPTI DIPTERA-CULICIDAE | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMODIUM-FALCIPARUM | VECTOR ANOPHELES-STEPHENSI | DENGUE VIRUS | ZIKA VIRUS | NONTARGET AQUATIC ORGANISMS | Insecticides - pharmacology | Green Chemistry Technology | Plant Extracts - chemistry | Nanoparticles - chemistry | Humans | Nanoparticles - ultrastructure | Culicidae - drug effects | Dengue - prevention & control | Malaria - prevention & control | Culicidae - virology | Neoplasms - therapy | Animals | Insecticides - chemical synthesis | Insect Vectors - drug effects | Nanoparticles - therapeutic use | Culicidae - parasitology | Zika Virus Infection - prevention & control | Insect Control - methods | Nanotechnology | Nanoparticles | Bites and stings | Mosquitoes | Animal behavior | Cancer | Dengue viruses | Cells | Index Medicus
Plasmodium | Anopheles | Malaria | Mosquito vector control | Chloroquine | Dengue | Artemisinin | Tumor | Zika virus | Culex | Aedes | ANTIPLASMODIAL ACTIVITY | NECROSIS-FACTOR-ALPHA | Tumor Zika virus | SILVER NANOPARTICLES | AEGYPTI DIPTERA-CULICIDAE | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMODIUM-FALCIPARUM | VECTOR ANOPHELES-STEPHENSI | DENGUE VIRUS | ZIKA VIRUS | NONTARGET AQUATIC ORGANISMS | Insecticides - pharmacology | Green Chemistry Technology | Plant Extracts - chemistry | Nanoparticles - chemistry | Humans | Nanoparticles - ultrastructure | Culicidae - drug effects | Dengue - prevention & control | Malaria - prevention & control | Culicidae - virology | Neoplasms - therapy | Animals | Insecticides - chemical synthesis | Insect Vectors - drug effects | Nanoparticles - therapeutic use | Culicidae - parasitology | Zika Virus Infection - prevention & control | Insect Control - methods | Nanotechnology | Nanoparticles | Bites and stings | Mosquitoes | Animal behavior | Cancer | Dengue viruses | Cells | Index Medicus
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