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SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9
It was recently suggested that beta-site amyloid precursor protein (APP)-cleaving enzyme 2 (BACE2) functions as an amyloid beta (A beta)-degrading enzyme; in... 
ALPHA-SECRETASE | IMPUTATION | MULTIDISCIPLINARY SCIENCES | MODEL
Journal Article
LANCET, ISSN 0140-6736, 07/2006, Volume 368, Issue 9533, pp. 387 - 403
Alzheimer's disease is the most common cause of dementia. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks... 
ESTROGEN REPLACEMENT THERAPY | MEDICINE, GENERAL & INTERNAL | PLACEBO-CONTROLLED-TRIAL | DOUBLE-BLIND TRIAL | AMYLOID PRECURSOR PROTEIN | RANDOMIZED CONTROLLED-TRIAL | MILD COGNITIVE IMPAIRMENT | QUALITY STANDARDS SUBCOMMITTEE | TRANSGENIC MOUSE MODEL | ACADEMY-OF-NEUROLOGY | ALPHA-SECRETASE CLEAVAGE
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2010, Volume 30, Issue 33, pp. 11157 - 11166
We discovered a nonpeptidic compound, TAK-070, that inhibited BACE1, a rate-limiting protease for the generation of A beta peptides that are considered... 
ALPHA-SECRETASE | CLEAVING ENZYME | APP | MEMORY DEFICITS | IN-VIVO | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | NEUROSCIENCES | BRAIN | TRANSGENIC MICE | PRESENILIN-1
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 05/2019, Volume 55, Issue 34, pp. 4933 - 4936
Inspired by the unique mechanism of proteolytic maturation of host cell factor-1, we designed small peptide-based constructs that selectively recognized... 
ALPHA-SECRETASE | PROTEIN | DISRUPTION | ALZHEIMERS-DISEASE | A-BETA | CLEAVAGE | CHEMISTRY, MULTIDISCIPLINARY | BETA PEPTIDE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2007, Volume 282, Issue 15, pp. 10873 - 10880
The incidence of Alzheimer disease (AD) and vascular dementia is greatly increased following cerebral ischemia and stroke in which hypoxic conditions occur in... 
APP | INDUCIBLE FACTOR-1-ALPHA | MESSENGER-RNA | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | HUMAN NEUROBLASTOMA SH-SY5Y | PRECURSOR PROTEIN | TRANSCRIPTIONAL REGULATION | CEREBRAL-ISCHEMIA | ALPHA-SECRETASE CLEAVAGE
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2010, Volume 30, Issue 47, pp. 15927 - 15942
Calcium is a key mediator controlling essential neuronal functions depending on electrical activity. Altered neuronal calcium homeostasis affects metabolism of... 
ALPHA-SECRETASE | INHIBITOR DOMAIN | RAT CEREBRAL-CORTEX | ALZHEIMERS-DISEASE | IN-VIVO | A-BETA | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | PARADIGM SHIFT | CELL-DEATH
Journal Article
Nature Reviews Neurology, ISSN 1759-4758, 03/2010, Volume 6, Issue 3, pp. 131 - 144
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2008, Volume 283, Issue 44, pp. 29615 - 29619
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2015, Volume 6, p. 221
Journal Article