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PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 15300 - 15300
Journal Article
Antioxidants & redox signaling, ISSN 1557-7716, 2017, Volume 26, Issue 1, pp. 28 - 43
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2015, Volume 5, Issue 1, p. 17935
Inflammasomes are cytoplasmic, multiprotein complexes that trigger caspase-1 activation and IL-1 beta maturation in response to diverse stimuli. Although... 
ASC | OXYGEN SPECIES PRODUCTION | STIMULATION | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SALMONELLA | IL-1-BETA | UNCOUPLING PROTEIN-2 | NALP3 INFLAMMASOME | CELL-DEATH | BETA | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Lipopolysaccharides - immunology | Autophagy - drug effects | Mitochondrial Proteins - metabolism | Flagellin - metabolism | Macrophages - immunology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Peritonitis - etiology | Flagellin - immunology | Pneumonia - etiology | Cytokines - metabolism | Macrophage Activation - immunology | Apoptosis Regulatory Proteins - chemistry | Peritonitis - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Ion Channels - metabolism | Iridoids - pharmacology | CARD Signaling Adaptor Proteins | Chemokines - metabolism | Mice | Uncoupling Protein 2 | Pneumonia - metabolism | Protein Multimerization - drug effects | Mitochondrial uncoupling protein 2 | Oligomerization | Neutrophils | Aluminum sulfate | Caspase | Flagellin | IL-1β | Autophagy | Inflammatory diseases | Caspase-1 | Lipopolysaccharides | Genipin | Lungs | Peritonitis | Phagocytosis
Journal Article
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, pp. 14078 - 14078
Journal Article
Journal Article
Trends in Immunology, ISSN 1471-4906, 2010, Volume 31, Issue 3, pp. 103 - 109
Aluminium adjuvants potentiate the immune response, thereby ensuring the potency and efficacy of typically sparingly available antigen. Their concomitant... 
Allergy and Immunology | MAGNESIUM | CELLS | ACTIVATION | CYTOKINE PRODUCTION | HYDROXIDE ADJUVANT | MECHANISM | IMMUNE-RESPONSES | MONOCLONAL-ANTIBODY | IMMUNOLOGY | BRAIN | NALP3 INFLAMMASOME | Adjuvants, Immunologic - pharmacology | Aluminum Compounds - adverse effects | Reactive Oxygen Species - metabolism | Humans | Muscle, Skeletal - metabolism | Magnesium Compounds - immunology | Vaccines - metabolism | Adjuvants, Immunologic - adverse effects | T-Lymphocytes - drug effects | Adenosine Triphosphate - metabolism | Inflammation Mediators - metabolism | Aluminum Hydroxide - pharmacology | Adaptive Immunity - immunology | Phosphates - pharmacology | Magnesium Compounds - pharmacology | Phosphates - immunology | Aluminum Hydroxide - metabolism | Antigen-Presenting Cells - metabolism | Immunity, Innate - drug effects | Oxidation-Reduction | Phagocytes - drug effects | Antigen-Presenting Cells - drug effects | Vaccines - immunology | Inflammation - immunology | Aluminum Compounds - immunology | Phagocytes - metabolism | Phagocytes - immunology | Antigen-Presenting Cells - immunology | Inflammation - etiology | Aluminum Compounds - metabolism | Magnesium Compounds - metabolism | B-Lymphocytes - drug effects | Immunity, Innate - immunology | Extracellular Fluid - metabolism | Models, Immunological | Phosphates - metabolism | Adaptive Immunity - drug effects | Aluminum Hydroxide - adverse effects | Animals | B-Lymphocytes - immunology | Phosphates - adverse effects | Aluminum Hydroxide - immunology | T-Lymphocytes - immunology | Aluminum Compounds - pharmacology | Ligands | Immunization | Vaccines | Fluorides | Molecular weight | Clinical Medicine | Neurologi | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Surgery | Klinisk medicin | Kirurgi
Journal Article