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1. Full Text Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives
by Mostafalou, Sara and Abdollahi, Mohammad
Toxicology and Applied Pharmacology, ISSN 0041-008X, 04/2013, Volume 268, Issue 2, pp. 157 - 177
Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the... 
Oxidative stress | Mitochondrial dysfunction | Proteotoxicity | Pesticides | Chronic diseases | Endocrine disruption | Systematic review | Amyotrophic lateral sclerosis | Cardiovascular disease | Birth defects | Alzheimer | Parkinson | Asthma | Endoplasmic reticulum stress | Genetic damage | Nephropathy | Reproductive toxicity | Epigenetics | Diabetes | Cancer | EPIGENETIC TRANSGENERATIONAL ACTIONS | PARENTAL OCCUPATIONAL-EXPOSURE | ENDOPLASMIC-RETICULUM STRESS | INDUCED OXIDATIVE STRESS | NON-HODGKINS-LYMPHOMA | PHARMACOLOGY & PHARMACY | ENVIRONMENTAL RISK-FACTORS | TOXICOLOGY | SISTER-CHROMATID EXCHANGES | PERSISTENT ORGANIC POLLUTANTS | AMYOTROPHIC-LATERAL-SCLEROSIS | SOFT-TISSUE SARCOMA | Unfolded Protein Response - drug effects | Humans | Mitochondria - drug effects | Reproduction - drug effects | Animals | Neoplasms - chemically induced | Pesticides - toxicity | Abnormalities, Drug-Induced - etiology | Epigenesis, Genetic - drug effects | Amyotrophic Lateral Sclerosis - chemically induced | Oxidative Stress - drug effects | Parkinson Disease, Secondary - chemically induced | Alzheimer Disease - chemically induced | Chronic Disease | Ubiquitin | Rheumatoid factor | Lung diseases, Obstructive | Analysis | Atherosclerosis | Amyloid beta-protein | Alzheimer's disease | Index Medicus | NEOPLASMS | MITOCHONDRIA | 60 APPLIED LIFE SCIENCES | ARTERIOSCLEROSIS | PESTICIDES | RHEUMATIC DISEASES | ENDOPLASMIC RETICULUM | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | LUPUS | CORONARIES | ENZYMES | ASTHMA | RECEPTORS | REPRODUCTIVE DISORDERS
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2. Full Text Benzodiazepine use and risk of Alzheimer's disease: case-control study
by Billioti de Gage, Sophie and Moride, Yola and Ducruet, Thierry and Kurth, Tobias and Verdoux, Hélène and Tournier, Marie and Pariente, Antoine and Bégaud, Bernard
BMJ (Clinical research ed.), ISSN 0959-8146, 2014, Volume 349, Issue sep09 2, pp. g5205 - g5205
Objectives To investigate the relation between the risk of Alzheimer's disease and exposure to benzodiazepines started at least five years before, considering... 
POPULATION | DEPRESSION | MEDICINE, GENERAL & INTERNAL | SLEEP | DEMENTIA | OLDER-ADULTS | NEUROPSYCHIATRIC SYMPTOMS | HUMAN-MEMORY | DRUGS | NESTED CASE-CONTROL | MILD COGNITIVE IMPAIRMENT | Quebec - epidemiology | Humans | Risk Factors | Male | Anxiety Disorders - chemically induced | Case-Control Studies | Sleep Initiation and Maintenance Disorders - chemically induced | Aged, 80 and over | Alzheimer Disease - epidemiology | Female | Aged | Benzodiazepines - adverse effects | Depressive Disorder - chemically induced | Alzheimer Disease - chemically induced
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3. Full Text Association between environmental exposure to pesticides and neurodegenerative diseases
by Parrón, Tesifón and Requena, Mar and Hernández, Antonio F and Alarcón, Raquel
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2011, Volume 256, Issue 3, pp. 379 - 385
Preliminary studies have shown associations between chronic pesticide exposure in occupational settings and neurological disorders. However, data on the... 
Multiple sclerosis | Environmental toxins | Affective psychosis | Polyneuropathy | Suicide | Alzheimer | Parkinson | DEPRESSION | OXIDATIVE STRESS | FARM RESIDENTS | AGRICULTURAL HEALTH | ALZHEIMERS-DISEASE | TOXICITY | INCREASED RISK | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PARKINSONS-DISEASE | OCCUPATIONAL-EXPOSURE | Parkinson Disease, Secondary - epidemiology | Confidence Intervals | Prevalence | Humans | Polyneuropathies - epidemiology | Risk Factors | Male | Multiple Sclerosis - epidemiology | Multiple Sclerosis - chemically induced | Affective Disorders, Psychotic - epidemiology | Environmental Exposure - adverse effects | Polyneuropathies - chemically induced | Agriculture - statistics & numerical data | Neurodegenerative Diseases - chemically induced | Pesticides - toxicity | Spain - epidemiology | Alzheimer Disease - epidemiology | Female | Affective Disorders, Psychotic - chemically induced | Parkinson Disease, Secondary - chemically induced | Alzheimer Disease - chemically induced | Environmental Exposure - statistics & numerical data | Odds Ratio | Neurodegenerative Diseases - epidemiology | Nervous system diseases | Parkinson's disease | Pesticides | Environmental aspects | Alzheimer's disease | Prevalence studies (Epidemiology) | Index Medicus | PUBLIC HEALTH | MULTIVARIATE ANALYSIS | NERVOUS SYSTEM DISEASES | AGRICULTURE | NERVE TISSUE | TOXINS | OCCUPATIONAL EXPOSURE | 60 APPLIED LIFE SCIENCES | ENVIRONMENTAL EXPOSURE | PESTICIDES
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4. Full Text Alzheimer's Disease-Like Pathology Induced by Amyloid-beta Oligomers in Nonhuman Primates
by Forny-Germano, L and Silva, NMLE and Batista, AF and Brito-Moreira, J and Gralle, M and Boehnke, SE and Coe, BC and Lablans, A and Marques, SA and Martinez, AMB and Klein, WL and Houzel, JC and Ferreira, ST and Munoz, DP and De Felice, FG
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 10/2014, Volume 34, Issue 41, pp. 13629 - 13643
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a major medical problem. Here, we have investigated the impact of amyloid-beta (A... 
amyloid-beta oligomers | TRUNCATED TAU | SYNAPTIC DYSFUNCTION | MEMORY IMPAIRMENT | COGNITIVE IMPAIRMENT | nonhuman primate | TRIPLE-TRANSGENIC MODEL | NEUROSCIENCES | TANGLE FORMATION | PAIRED HELICAL FILAMENTS | A-BETA | tau pathology | synapse loss | Alzheimer's disease | MOLECULAR-BASIS | TAU-PATHOLOGY | Neurofibrillary Tangles - pathology | Microinjections | Rats, Wistar | Amyloid beta-Peptides - toxicity | Apoptosis - drug effects | Peptide Fragments - toxicity | Synapses - physiology | Peptide Fragments - administration & dosage | Astrocytes - pathology | Injections, Intraventricular | Macaca fascicularis | Rats | Male | Synapses - ultrastructure | Synapses - pathology | Alzheimer Disease - pathology | Animals | Microglia - pathology | Amyloid beta-Peptides - administration & dosage | Alzheimer Disease - chemically induced | amyloid-β oligomers
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5. Full Text Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF- K B/JNK signaling pathway in aging mouse model
by Ali, Tahir and Badshah, Haroon and Kim, Tae Hyun and Kim, Myeong Ok
Journal of Pineal Research, ISSN 0742-3098, 2015, Volume 58, Issue 1, pp. 71 - 85
Melatonin acts as a pleiotropic agent in various age-related neurodegenerative diseases. In this study, we examined the underlying neuroprotective mechanism of... 
neurodegeneration | D-galactose | melatonin | neuroinflammation | memory impairment | reactive oxygen species | Inflammation - chemically induced | Memory Disorders - physiopathology | Aging - drug effects | Memory Disorders - metabolism | Male | Brain - metabolism | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Inflammation - drug therapy | Alzheimer Disease - chemically induced | Receptor for Advanced Glycation End Products | Disease Models, Animal | Alzheimer Disease - physiopathology | Brain - physiopathology | Alzheimer Disease - drug therapy | Antioxidants - pharmacology | Aging - pathology | Animals | Memory Disorders - drug therapy | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Alzheimer Disease - metabolism | Receptors, Immunologic | Galactose - toxicity | Mice | Melatonin - pharmacology | Aging - metabolism | Inflammation - physiopathology | Memory Disorders - chemically induced
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6. Animal Model of Aluminum-Induced Alzheimer's Disease
by Song, Jing
Advances in experimental medicine and biology, ISSN 0065-2598, 2018, Volume 1091, p. 113
Lack of a satisfactory animal model for Alzheimer's disease (AD) has limited the reach progress of the pathogenesis of the disease and of therapeutic agents... 
Rabbits | Animals | Aluminum - toxicity | Alzheimer Disease - chemically induced | Disease Models, Animal
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7. Full Text Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease
by Dongfeng Cao and Hailin Lu and Terry L. Lewis and Ling Li
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36275 - 36282
Compelling evidence indicates that excess consumption of sugar-sweetened beverages plays an important role in the epidemic of obesity, a major risk factor for... 
DIABETES-MELLITUS | HIGH-FAT | OBESITY | PRESENILINS | PROTEIN | DIET | LEARNING-DEFICITS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | MICE | US CHILDREN | Beverages - adverse effects | Glucose Intolerance - metabolism | Amyloid Precursor Protein Secretases - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Sweetening Agents - toxicity | Glucose Intolerance - pathology | Diabetes Mellitus, Type 2 - metabolism | Apolipoproteins E - metabolism | Obesity - genetics | Amyloidosis - chemically induced | Alzheimer Disease - pathology | Brain - metabolism | Hypercholesterolemia - pathology | Sucrose - toxicity | Amyloid beta-Peptides - genetics | Amyloidosis - genetics | Amyloid beta-Peptides - metabolism | Water - administration & dosage | Glucose Intolerance - chemically induced | Alzheimer Disease - chemically induced | Disease Models, Animal | Glucose Intolerance - genetics | Amyloidosis - pathology | Risk Factors | Insulin Resistance | Mice, Transgenic | Obesity - metabolism | Obesity - pathology | Amyloid Precursor Protein Secretases - metabolism | Animals | Apolipoproteins E - genetics | Obesity - epidemiology | Alzheimer Disease - metabolism | Brain - pathology | Mice | Diabetes Mellitus, Type 2 - chemically induced | Diabetes Mellitus, Type 2 - pathology | Hypercholesterolemia - chemically induced | Hypercholesterolemia - genetics | Alzheimer Disease - genetics | Hypercholesterolemia - metabolism | Amyloidosis - metabolism
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8. Full Text The olfactory vector hypothesis of neurodegenerative disease: Is it viable?
by Doty, Richard L
Annals of Neurology, ISSN 0364-5134, 01/2008, Volume 63, Issue 1, pp. 7 - 15
Environmental agents, including viruses, prions, and toxins, have been implicated in the cause of a number of neurodegenerative diseases, most notably... 
SPECIES SENSITIVITY | DOPAMINERGIC NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE | SUBCELLULAR-DISTRIBUTION | ALZHEIMERS-DISEASE | CENTRAL-NERVOUS-SYSTEM | CREUTZFELDT-JAKOB-DISEASE | IDIOPATHIC PARKINSONS-DISEASE | INTRANASAL INOCULATION | NEUROSCIENCES | HERPES-SIMPLEX VIRUS | ODOR IDENTIFICATION | CLINICAL NEUROLOGY | Alzheimer Disease - physiopathology | Axonal Transport | Dyskinesia, Drug-Induced - physiopathology | Olfaction Disorders - virology | Humans | Olfactory Mucosa - physiopathology | Olfactory Mucosa - virology | Parkinson Disease - physiopathology | Hazardous Substances - toxicity | Disease Progression | Alzheimer Disease - virology | Animals | Neurodegenerative Diseases - chemically induced | Neurodegenerative Diseases - physiopathology | Virus Diseases - physiopathology | Olfaction Disorders - chemically induced | Parkinson Disease - virology | Olfaction Disorders - physiopathology | Alzheimer Disease - chemically induced | Olfactory Mucosa - drug effects | Neurodegenerative Diseases - virology | Index Medicus
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9. Full Text Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers
by Lopez del Amo, Juan Miguel and Fink, Uwe and Dasari, Muralidhar and Grelle, Gerlinde and Wanker, Erich E and Bieschke, Jan and Reif, Bernd
Journal of Molecular Biology, ISSN 0022-2836, 08/2012, Volume 421, Issue 4-5, pp. 517 - 524
The green tea compound epigallocatechin-3-gallate (EGCG) inhibits Alzheimer's disease β-amyloid peptide (Aβ) neurotoxicity. Solution-state NMR allows probing... 
drug development | neurotoxicity | β-amyloid peptide | Alzheimer's disease | magic angle spinning (MAS) solid-state NMR spectroscopy | EXPERIMENTAL CONSTRAINTS | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | beta-amyloid peptide | TOXICITY | MODEL | PEPTIDE | GREEN TEA | AMYLOID FIBRILS | C-13 | (-)-EPIGALLOCATECHIN-3-GALLATE | INHIBITORS | Alzheimer Disease - physiopathology | Magnetic Resonance Spectroscopy | Humans | Protein Multimerization | Neuroprotective Agents - metabolism | Amyloid beta-Peptides - metabolism | Protein Denaturation | Protein Conformation | Catechin - analogs & derivatives | Amyloid beta-Peptides - chemistry | Neuroprotective Agents - adverse effects | Alzheimer Disease - chemically induced | Catechin - adverse effects | Catechin - metabolism | Index Medicus
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10. Full Text Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study
by Gray, Shelly L and Dublin, Sascha and Yu, Onchee and Walker, Rod and Anderson, Melissa and Hubbard, Rebecca A and Crane, Paul K and Larson, Eric B
BMJ, ISSN 0959-8146, 2/2016, Volume 352, p. i90
Objective To determine whether higher cumulative use of benzodiazepines is associated with a higher risk of dementia or more rapid cognitive... 
MEDICINE, GENERAL & INTERNAL | MEDICATIONS | ALZHEIMERS-DISEASE | OLDER-ADULTS | BIAS | SYMPTOMS | NESTED CASE-CONTROL | HEALTH | ASSOCIATION | CARE | PROSPECTIVE COHORT | Prospective Studies | Cognition Disorders - chemically induced | Humans | Risk Factors | Male | Dementia - epidemiology | Washington - epidemiology | Antidepressive Agents - therapeutic use | Dementia - chemically induced | Alzheimer Disease - epidemiology | Anti-Anxiety Agents - adverse effects | Female | Aged | Benzodiazepines - adverse effects | Anti-Anxiety Agents - therapeutic use | Antidepressive Agents - adverse effects | Alzheimer Disease - chemically induced | Benzodiazepines - therapeutic use | Cognition Disorders - epidemiology | Longitudinal Studies | Population Surveillance
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