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Trends in Neurosciences, ISSN 0166-2236, 2012, Volume 35, Issue 11, pp. 700 - 709
Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its... 
Neurology | synaptic plasticity | synaptic loss | Alzheimer's disease | long-term depression | neuronal differentiation | long-term potentiation | Neuronal differentiation | Synaptic loss | Long-term depression | Long-term potentiation | Synaptic plasticity | ALZHEIMERS-DISEASE | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | PROGRAMMED CELL-DEATH | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | PRECURSOR PROTEIN | HUNTINGTONS-DISEASE | PARKINSONS-DISEASE | Nerve Net - embryology | Mitochondria - enzymology | Caspase Inhibitors - pharmacology | Humans | Huntington Disease - pathology | Neurons - cytology | Nerve Net - enzymology | Molecular Targeted Therapy | Alzheimer Disease - pathology | Caspase 3 - physiology | Nervous System - growth & development | Nervous System - embryology | Huntington Disease - enzymology | Disease Models, Animal | Nerve Net - growth & development | Long-Term Synaptic Depression - physiology | Nerve Tissue Proteins - physiology | Nervous System - enzymology | Parkinson Disease - pathology | Embryonic Development - physiology | Neural Tube - physiology | Alzheimer Disease - enzymology | Receptors, N-Methyl-D-Aspartate - physiology | Mice, Knockout | Animals | Caspase Inhibitors - therapeutic use | Neurons - enzymology | Parkinson Disease - enzymology | Apoptosis Regulatory Proteins - physiology | Mice | Apoptosis - physiology | Enzyme Activation | Nervous system diseases | Neurosciences | Neural networks | Proteases | Neurons | Depression, Mental | Apoptosis | Nervous system | Mitochondria | Pharmacology | Neurodegeneration | Index Medicus | Neurodegenerative diseases | Proteinase | Central nervous system | Caspase-3 | Neurological diseases | Axons | Neural tube | Plasticity (synaptic) | Reviews | Differentiation
Journal Article
Nature, ISSN 0028-0836, 01/2013, Volume 493, Issue 7434, pp. 674 - 678
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 319 - 324
Journal Article
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7672, pp. 389 - 393
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells | Index Medicus
Journal Article
Nature medicine, ISSN 1078-8956, 11/2014, Volume 20, Issue 11, pp. 1254 - 1262
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 9, pp. 3537 - 3542
Mutations of GBA1, the gene encoding glucocerebrosidase, represent a common genetic risk factor for developing the synucleinopathies Parkinson disease (PD) and... 
Pathology | Enzymes | Gaucher disease | Lewy body disease | Central nervous system | Parkinson disease | Mice | Alzheimers disease | Genetic mutation | Dementia | Lysosomal storage diseases | Memory defect | MAPT | Mouse models | mouse models | TAU-SYNUCLEIN | lysosomal storage diseases | DEMENTIA | MULTIDISCIPLINARY SCIENCES | ALPHA-SYNUCLEIN | PATHOLOGY | CEREBROSPINAL-FLUID | DEFICIENCY | GENE | DISEASE | memory defect | MUTATIONS | LEWY BODIES | Glucosylceramidase - genetics | Humans | Memory | Brain - enzymology | tau Proteins - metabolism | Gaucher Disease - pathology | tau Proteins - chemistry | Psychosine - analogs & derivatives | Parkinsonian Disorders - drug therapy | Protein Structure, Quaternary | Gaucher Disease - physiopathology | alpha-Synuclein - genetics | Gaucher Disease - drug therapy | Disease Models, Animal | Gaucher Disease - enzymology | Parkinsonian Disorders - physiopathology | Dependovirus - metabolism | Brain - physiopathology | Psychosine - metabolism | Mice, Transgenic | Parkinsonian Disorders - enzymology | Glucosylceramidase - metabolism | Hippocampus - pathology | Hippocampus - metabolism | Animals | Glucosylceramidase - therapeutic use | Brain - pathology | Glucosylceramidase - administration & dosage | Hippocampus - physiopathology | alpha-Synuclein - metabolism | Parkinsonism | Care and treatment | Physiological aspects | Hydrolases | Gaucher's disease | Nervous system | Mutation | Risk factors | Parkinsons disease | Index Medicus | Biological Sciences
Journal Article