X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (106317) 106317
Book Review (21264) 21264
Publication (10821) 10821
Newsletter (5549) 5549
Newspaper Article (3576) 3576
Book Chapter (850) 850
Conference Proceeding (516) 516
Magazine Article (294) 294
Book / eBook (261) 261
Trade Publication Article (137) 137
Dissertation (126) 126
Web Resource (87) 87
Government Document (40) 40
Transcript (34) 34
Reference (26) 26
Report (22) 22
Data Set (19) 19
Streaming Video (6) 6
Paper (5) 5
Presentation (2) 2
Poster (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (88381) 88381
humans (64375) 64375
alzheimer's disease (48576) 48576
animals (48286) 48286
alzheimers-disease (47648) 47648
neurosciences (38884) 38884
male (30604) 30604
female (23262) 23262
alzheimer disease - metabolism (22069) 22069
mice (20254) 20254
brain (19964) 19964
aged (19102) 19102
biochemistry & molecular biology (17530) 17530
alzheimers disease (16157) 16157
rats (14771) 14771
brain - metabolism (14331) 14331
dementia (13406) 13406
alzheimer disease - pathology (13329) 13329
amyloid beta-peptides - metabolism (12815) 12815
oxidative stress (12587) 12587
middle aged (12501) 12501
clinical neurology (10992) 10992
neurology (10963) 10963
research (10585) 10585
proteins (10423) 10423
aged, 80 and over (10326) 10326
analysis (9624) 9624
disease models, animal (9250) 9250
neurons (9074) 9074
cell biology (8989) 8989
alzheimer disease - genetics (8782) 8782
neurons - metabolism (8756) 8756
neurodegenerative diseases (8726) 8726
brain - pathology (8475) 8475
neurodegeneration (8028) 8028
alzheimer’s disease (7996) 7996
physiological aspects (7849) 7849
pharmacology & pharmacy (7741) 7741
amyloid precursor protein (7731) 7731
mice, transgenic (7416) 7416
medical research (7238) 7238
article (7229) 7229
pathology (7180) 7180
aging (7085) 7085
alzheimer disease - drug therapy (6854) 6854
memory (6659) 6659
cells, cultured (6596) 6596
phosphorylation (6514) 6514
metabolism (6503) 6503
apoptosis (6209) 6209
alzheimer disease - physiopathology (6201) 6201
adult (6158) 6158
mild cognitive impairment (5933) 5933
tau proteins - metabolism (5933) 5933
geriatrics & gerontology (5757) 5757
risk factors (5748) 5748
expression (5741) 5741
medicine, experimental (5699) 5699
immunohistochemistry (5657) 5657
parkinsons-disease (5616) 5616
multidisciplinary sciences (5527) 5527
transgenic mice (5519) 5519
amyloid beta-protein (5473) 5473
psychiatry (5471) 5471
amyloid beta-protein precursor - metabolism (5433) 5433
mice, inbred c57bl (5413) 5413
rodents (5382) 5382
hippocampus - metabolism (5361) 5361
in-vivo (5261) 5261
protein (5200) 5200
hippocampus (5187) 5187
gene expression (5141) 5141
inflammation (5140) 5140
a-beta (5063) 5063
nervous system diseases (4920) 4920
medicine (4902) 4902
alzheimer disease (4891) 4891
mouse model (4882) 4882
research article (4835) 4835
central-nervous-system (4752) 4752
neurons - drug effects (4718) 4718
rats, sprague-dawley (4667) 4667
mutation (4522) 4522
health aspects (4357) 4357
nervous system (4313) 4313
studies (4263) 4263
amyloid beta-protein precursor - genetics (4229) 4229
disease (4198) 4198
parkinson's disease (4157) 4157
in-vitro (4144) 4144
neurons - pathology (4135) 4135
cells (4058) 4058
amyloid-beta (3928) 3928
amyloid (3919) 3919
peptide fragments - metabolism (3910) 3910
genetic aspects (3863) 3863
tau (3849) 3849
peptides (3837) 3837
cognitive ability (3830) 3830
signal transduction (3748) 3748
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (155) 155
Providence Healthcare - Stacks (37) 37
Baycrest Hospital - Stacks (24) 24
Online Resources - Online (24) 24
Collection Dvlpm't (Acquisitions) - Closed Orders (16) 16
UofT at Mississauga - Stacks (16) 16
Collection Dvlpm't (Acquisitions) - Vendor file (13) 13
UofT at Scarborough - Stacks (11) 11
Baycrest Hospital - Wellness Library (5) 5
Stacks (4) 4
West Park Healthcare Centre - Stacks (4) 4
Robarts - Stacks (3) 3
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (3) 3
UTL at Downsview - May be requested (3) 3
Providence Healthcare - Reference (2) 2
Scarborough Hospital - Online (2) 2
Architecture Landscape (Shore + Moffat) - Stacks (1) 1
Baycrest Hospital - Missing (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
Gerstein Science - Not Returned (1) 1
Gerstein Science - Reference (1) 1
Humber River Regional Hospital - Church Stacks (1) 1
Lakeridge Health Sciences - Oshawa (1) 1
Patient Education (1) 1
Royal Ontario Museum - Periodical Stacks (1) 1
St. Michael's Hospital - Stacks (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (115057) 115057
Japanese (496) 496
Chinese (316) 316
French (241) 241
Spanish (219) 219
German (212) 212
Russian (137) 137
Polish (82) 82
Hungarian (29) 29
Swedish (23) 23
Dutch (16) 16
Portuguese (16) 16
Italian (14) 14
Czech (11) 11
Korean (11) 11
Turkish (10) 10
Danish (8) 8
Finnish (7) 7
Norwegian (5) 5
Hebrew (4) 4
Serbian (4) 4
Greek (3) 3
Ukrainian (3) 3
Persian (2) 2
Slovak (2) 2
Arabic (1) 1
Catalan (1) 1
Corsican (1) 1
Croatian (1) 1
Icelandic (1) 1
Lithuanian (1) 1
Romanian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Disease | Transcription | Genes | Homeostasis | Sclerosis | Proteins | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | Plaques | Myeloid cells | Neurodegenerative diseases | Microglia | Neurological diseases | Molecular modelling | β-Amyloid | Phagocytosis | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 448 - 454
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are... 
LIFE-SPAN | CAENORHABDITIS-ELEGANS | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ANALYSIS | NEURONS | MILD COGNITIVE IMPAIRMENT | SEL-12 PRESENILIN | REPRESSOR | C. ELEGANS | Neurons - pathology | Up-Regulation | Humans | Oxidative Stress - physiology | Caenorhabditis elegans Proteins - metabolism | Phagosomes | Neurons - cytology | Cognition | Autophagy | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Brain - metabolism | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Young Adult | Cell Nucleus - metabolism | Aging - genetics | Cell Death - genetics | Chromatin Immunoprecipitation | Repressor Proteins - deficiency | Aged, 80 and over | Neurons - metabolism | Repressor Proteins - metabolism | Wnt Signaling Pathway | Frontotemporal Dementia - pathology | Brain - cytology | Amyloid beta-Peptides - toxicity | Cognitive Dysfunction - metabolism | Down-Regulation | Gene Expression Regulation | Lewy Body Disease - pathology | Oxidative Stress - genetics | Repressor Proteins - genetics | Longevity | Aging - pathology | Lewy Body Disease - metabolism | Transcription Factors - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Alzheimer Disease - metabolism | Brain - pathology | Aged | Mice | Alzheimer Disease - genetics | Aging - metabolism | Oxidative stress | Control | Transcription factors | Neurons | Aging | Physiological aspects | Genetic aspects | Research | Alzheimer's disease | Studies | Pathology | Cognitive ability | Epigenetics | Kinases | Stress response | Gene expression | Alzheimers disease | Age | Apoptosis | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 08/2017, Volume 170, Issue 4, pp. 649 - 663.e13
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 216 - U107
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 05/2016, Volume 139, Issue 5, pp. 1551 - 1567
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 11/2014, Volume 515, Issue 7526, pp. 274 - 278
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2010, Volume 30, Issue 9, pp. 3184 - 3198
Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and... 
BACKBONE DYNAMICS | MULTIPLE SYSTEM ATROPHY | INCLUSION FORMATION | BETA-SHEET | ALZHEIMERS-DISEASE | SERINE 129 | TAU-PHOSPHORYLATION | NEUROSCIENCES | LEWY BODIES | RAT MODEL | PARKINSONS-DISEASE | Phosphorylation | Rats, Wistar | Humans | Male | Brain - metabolism | Lewy Bodies - genetics | Lewy Body Disease - genetics | Protein Isoforms - metabolism | Multiple System Atrophy - metabolism | Cell Membrane - metabolism | Neurons - metabolism | Parkinson Disease - metabolism | Lewy Bodies - metabolism | Lewy Bodies - pathology | Disease Models, Animal | Alzheimer Disease - physiopathology | Rats | Mice, Transgenic | Neurodegenerative Diseases - genetics | Amino Acid Sequence - physiology | Multiple System Atrophy - genetics | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Parkinson Disease - physiopathology | Serine - metabolism | alpha-Synuclein - chemistry | Creatine Kinase - genetics | Lewy Body Disease - metabolism | Animals | Neurodegenerative Diseases - physiopathology | Alzheimer Disease - metabolism | Brain - pathology | Creatine Kinase - metabolism | Mice | Multiple System Atrophy - physiopathology | Alzheimer Disease - genetics | alpha-Synuclein - metabolism | Polymers - metabolism | Lewy Body Disease - physiopathology | Protein Isoforms - genetics | Index Medicus | serine 87 | phosphorylation | synucleinopathies | phosphomimics | Parkinson’s disease | α-synuclein
Journal Article