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Protein Science, ISSN 0961-8368, 01/2013, Volume 22, Issue 1, pp. 22 - 34
A variety of antiprion compounds have been reported that are effective in ex vivo and in vivo treatment experiments. However, the molecular mechanisms for most... 
anti‐prion compounds | action mechanism | medical chaperones | prion protein | Action mechanism | Anti-prion compounds | Medical chaperones | Prion protein | BIOCHEMISTRY & MOLECULAR BIOLOGY | INFECTIVITY | CONFORMATIONS | SCRAPIE | REPLICATION | INHIBITION | PRPSC | DISEASE | TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY | ACCUMULATION | anti-prion compounds | DERIVATIVES | Surface Plasmon Resonance | Carbazoles - chemistry | Molecular Chaperones - metabolism | Nitriles - pharmacology | Protein Conformation - drug effects | Molecular Chaperones - chemistry | Aminopyridines - chemistry | Pentosan Sulfuric Polyester - chemistry | Pentosan Sulfuric Polyester - pharmacology | Quinacrine - pharmacology | Piperidines - pharmacology | Quinacrine - chemistry | Molecular Structure | Catechin - pharmacology | Binding Sites - drug effects | Molecular Chaperones - pharmacology | Amides - pharmacology | Prions - metabolism | Piperidines - chemistry | Magnetic Resonance Spectroscopy | Congo Red - pharmacology | Prions - chemistry | Prions - antagonists & inhibitors | Animals | Aminopyridines - pharmacology | Nitriles - chemistry | Amides - chemistry | Catechin - analogs & derivatives | Mice | Carbazoles - pharmacology | Congo Red - chemistry | Catechin - chemistry | Nuclear magnetic resonance spectroscopy | Universities and colleges | Chemical properties | Precipitation (Meteorology) | Prions | Protein binding | Proteins | Binding sites
Journal Article
亚太热带医药杂志:英文版, ISSN 1995-7645, 2016, Volume 9, Issue 4, pp. 393 - 399
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2006, Volume 72, Issue 2, pp. 339 - 348
Objective: Hyaluronan (HA) is an important constituent of the extracellular matrix and is known to regulate cellular events through binding to CD44 and the... 
Signal transduction | Extracellular matrix | Smooth muscle | Receptors | G-proteins | CD44 INTERACTION | CARDIAC & CARDIOVASCULAR SYSTEMS | receptors | signal transduction | PROTEIN RHO | MOLECULAR-WEIGHT HYALURONAN | KINASE | smooth muscle | PROLIFERATION | INTRACELLULAR HYALURONAN | GENE-EXPRESSION | RHO-GTPASES | PROMOTES | BINDING | extracellular matrix | Muscle, Smooth, Vascular - metabolism | Recombinant Fusion Proteins - pharmacology | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Hyaluronic Acid - pharmacology | rhoA GTP-Binding Protein - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Simvastatin - pharmacology | Dose-Response Relationship, Drug | rac GTP-Binding Proteins - antagonists & inhibitors | RNA Interference | rac GTP-Binding Proteins - genetics | Escherichia coli Proteins - pharmacology | rho-Associated Kinases | Hyaluronan Receptors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Aorta | Chromones - pharmacology | Complement C3 - genetics | Extracellular Matrix Proteins - metabolism | Muscle, Smooth, Vascular - drug effects | Amides - pharmacology | Signal Transduction | Antibodies, Monoclonal - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Cells, Cultured | Morpholines - pharmacology | Rats | rhoA GTP-Binding Protein - antagonists & inhibitors | Muscle, Smooth, Vascular - cytology | Stimulation, Chemical | Cell Movement - drug effects | Animals | Bacterial Toxins - pharmacology | Cytoskeleton - metabolism | Hyaluronan Receptors - immunology | Pyridines - pharmacology | Genes, tat | Enterotoxins - pharmacology | Hyaluronic acid
Journal Article
Journal Article
Journal of Neuroendocrinology, ISSN 0953-8194, 05/2008, Volume 20, Issue 1, pp. 26 - 34
N ‐acylethanolamines, which include the endocannabinoid anandamide and the cannabinoid receptor‐inactive saturated compounds N ‐palmitoyl ethanolamine and N... 
fatty acid amides | endocannabinoid | inflammation | acylethanolamines | vanilloid receptor | cannabinoid receptors | stearoyl ethanolamine | palmitoyl ethanolamine | Endocannabinoid | N-acylethanolamines | Inflammation | Vanilloid receptor | Fatty acid amides | N-stearoyl ethanolamine | Cannabinoid receptors | N-palmitoyl ethanolamine | PALMITOYLETHANOLAMIDE | FOCAL CEREBRAL-ISCHEMIA | MAST-CELLS | ANANDAMIDE | CANNABINOID CB2 RECEPTOR | NEUROSCIENCES | CONTACT-DERMATITIS | VANILLOID RECEPTORS | ENDOCRINOLOGY & METABOLISM | FATTY-ACID AMIDE | MICE | Ethanolamines - pharmacology | Fatty Acids - therapeutic use | Body Temperature - drug effects | Cannabinoid Receptor Antagonists | Cannabinoids - antagonists & inhibitors | Palmitic Acids - therapeutic use | Bornanes - pharmacology | Ear Auricle - pathology | Passive Cutaneous Anaphylaxis - physiology | Piperidines - pharmacology | Time Factors | Inflammation - drug therapy | Anti-Inflammatory Agents - therapeutic use | Female | Palmitic Acids - pharmacology | Endocannabinoids | Pyrazoles - pharmacology | Passive Cutaneous Anaphylaxis - drug effects | Ear Auricle - drug effects | Anti-Inflammatory Agents - pharmacology | Morpholines - pharmacology | Ethanolamines - chemistry | Cannabinoids - pharmacology | Naphthalenes - pharmacology | Edema - etiology | Cannabinoid Receptor Agonists | Animals | Benzoxazines - pharmacology | Palmitic Acids - chemistry | Ethanolamines - therapeutic use | Mice | Mice, Inbred BALB C | Edema - pathology | Stearic Acids - pharmacology | Fatty Acids - pharmacology | Anti-inflammatory drugs | Ethanolamines | Fatty acids | Analysis
Journal Article
Cellular Signalling, ISSN 0898-6568, 12/2011, Volume 23, Issue 12, pp. 2086 - 2096
Endothelial cell (EC) barrier dysfunction induced by inflammatory agonists is a frequent pathophysiologic event in multiple diseases. The platelet-derived... 
ERM | Cytoskeleton | S1P | Rac1 | Barrier function | Endothelial cells | ERM PROTEINS | TYROSINE PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE | KINASE-C | PLASMA-MEMBRANE | CELL BIOLOGY | FOCAL ADHESION | RHO GTPASES | CYTOSKELETAL REARRANGEMENT | CORTICAL CYTOSKELETON | ACTIN CYTOSKELETON | Protein Kinase C - genetics | Phosphorylation | rho GTP-Binding Proteins - antagonists & inhibitors | Cadherins - metabolism | Cytoskeletal Proteins - genetics | Humans | Actins - metabolism | rho-Associated Kinases - antagonists & inhibitors | Antigens, CD - metabolism | Gene Knockdown Techniques | RNA Interference | rho-Associated Kinases - metabolism | Oxadiazoles - pharmacology | Protein Kinase C - metabolism | Egtazic Acid - analogs & derivatives | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Cytoskeletal Proteins - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Receptors, Lysosphingolipid - metabolism | Microfilament Proteins - genetics | Endothelial Cells - physiology | Amides - pharmacology | Endothelial Cells - metabolism | Membrane Proteins - genetics | Sphingosine - physiology | Cells, Cultured | Thiophenes - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Chelating Agents - pharmacology | Electric Impedance | Permeability | Pulmonary Artery - cytology | Pulmonary Artery - physiology | Sphingosine - pharmacology | Bacterial Proteins - pharmacology | Sphingosine - analogs & derivatives | Egtazic Acid - pharmacology | Bacterial Toxins - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | rho GTP-Binding Proteins - metabolism | Cytoskeleton - metabolism | Pyridines - pharmacology | Lysophospholipids - physiology | Phosphates | Proteins | Sphingosine | Endothelium
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 09/2012, Volume 51, Issue 18, pp. 9873 - 9882
N-Heterocyclic carbene (NHC) ligand precursors, namely, HIm(A)Cl [1,3-bis(2-ethoxy-2-oxoethyl)-1H-imidazol-3-ium chloride] and HIm(B)Cl... 
CANCER-CELLS | IN-VITRO | COPPER(I) COMPLEXES | ANTICANCER AGENTS | SILVER(I)-CARBENE COMPLEXES | GOLD(I) CHLORIDE ADDUCTS | STRUCTURAL-CHARACTERIZATION | THIOREDOXIN REDUCTASE | ANTITUMOR-ACTIVITY | PHOSPHINE COMPLEXES | CHEMISTRY, INORGANIC & NUCLEAR | Methane - analogs & derivatives | Antineoplastic Agents - chemical synthesis | Humans | Heterocyclic Compounds - pharmacology | Imidazoles - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Dose-Response Relationship, Drug | Salts - chemistry | Salts - pharmacology | Heterocyclic Compounds - chemistry | MCF-7 Cells | Esters - chemistry | HEK293 Cells | Water - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Cell Death - drug effects | Amides - pharmacology | Magnetic Resonance Spectroscopy | Methane - pharmacology | Solubility | Models, Molecular | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Organometallic Compounds - chemical synthesis | Amides - chemistry | Cell Line, Tumor | Methane - chemistry | Organometallic Compounds - chemistry | Cell Proliferation - drug effects | Esters - pharmacology | Organometallic Compounds - pharmacology | Drug Screening Assays, Antitumor | Usage | Nuclear magnetic resonance spectroscopy | Cell-mediated cytotoxicity | Research | Carbenes | Dichloropropane | Analysis | Chlorides | Imidazole | Cancer cells | Physiological aspects | Chemical bonds | Chemical properties
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 552, Issue 1, pp. 135 - 142
In guinea pigs, it is well-known that mechanical stretch of airway smooth muscle exhibits spontaneous tone which is mediated by cyclooxygenase (COX)... 
Mechanotransduction | Guinea pig | Mechanical stress | Trachea | Ca 2+ channel | TRP (transient receptor potential) channel | channel | guinea pig | CA2+ SENSITIZATION | CELLS | trachea | INTRINSIC TONE | mechanotransduction | SPONTANEOUS TONE | INVOLVEMENT | INCREASES | mechanical stress | RECEPTOR | GUINEA-PIG TRACHEALIS | Ca2+ channel | CALCIUM | PHARMACOLOGY & PHARMACY | MYOGENIC TONE | Gadolinium - pharmacology | Calcium - metabolism | Cations - metabolism | Stress, Mechanical | Male | Trachea - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | Ion Channels - physiology | Nitrobenzenes - pharmacology | Simvastatin - pharmacology | Dose-Response Relationship, Drug | Muscle, Smooth - drug effects | Methacholine Chloride - pharmacology | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Trachea - physiology | Muscle, Smooth - physiology | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Amides - pharmacology | Nifedipine - pharmacology | Calcium - pharmacology | Guinea Pigs | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Calcium Channels, L-Type - physiology | Imidazoles - pharmacology | Calcium Channel Blockers - pharmacology | Sulfonamides - pharmacology | Indomethacin - pharmacology | Ion Channels - antagonists & inhibitors | Cyclooxygenase Inhibitors - pharmacology | Animals | Muscle Contraction - drug effects | Muscle Contraction - physiology | Pyridines - pharmacology | In Vitro Techniques | Trachea - enzymology | Muscle, Smooth - enzymology | Tocolytic agents | COX-2 inhibitors | Universities and colleges | Indomethacin | Simvastatin | Nifedipine
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2011, Volume 45, Issue 4, pp. 704 - 710
Rho/Ras signaling pathways may play an important role in the mechanism of LPS-induced inflammation and bronchoconstriction. In this study, we investigated the... 
EFS | Rho/Ras signaling pathways | Human bronchi | LPS | Statins | human bronchi | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHO-KINASE INHIBITOR | LUNG INJURY | CONTRACTILE ACTIVITY | CELL BIOLOGY | LIPOPOLYSACCHARIDE EXPOSURE | IN-VITRO | RESPIRATORY SYSTEM | statins | NITRIC-OXIDE | INDUCED AIRWAY HYPERRESPONSIVENESS | INHALED ENDOTOXIN | TRACHEAL SMOOTH-MUSCLE | GERANYLGERANYLTRANSFERASE-I | Leucine - pharmacology | Electric Stimulation | Sesquiterpenes - metabolism | Humans | Middle Aged | Alkyl and Aryl Transferases - metabolism | Alkyl and Aryl Transferases - antagonists & inhibitors | ras Proteins - metabolism | Male | Methionine - pharmacology | Simvastatin - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Bronchi - drug effects | Methionine - analogs & derivatives | Time Factors | rho-Associated Kinases - metabolism | Bronchoconstriction - drug effects | Bronchi - metabolism | Female | Leucine - analogs & derivatives | Amides - pharmacology | Protein Prenylation - drug effects | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Polyisoprenyl Phosphates - metabolism | Naphthalenes - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Signal Transduction - drug effects | rho GTP-Binding Proteins - metabolism | Lipopolysaccharides - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | In Vitro Techniques
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 03/2015, Volume 54, Issue 3, pp. 203 - 215
Aggressive dissemination and metastasis of pancreatic ductal adenocarcinoma (PDAC) results in poor prognosis and marked lethality. Rho monomeric G protein... 
Rho | carcinoma metastasis | phosphodiesterase | protein kinase A | pancreas | Protein kinase A | Carcinoma metastasis | Pancreas | Phosphodiesterase | PROTEIN-KINASE-A | DUCTAL ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CERULEIN-INDUCED PANCREATITIS | MODEL | GTPASES | ONCOLOGY | GROWTH | INHIBITS RHOA ACTIVATION | CXCL12 EXPRESSION | PRECURSORS | PROGRESSION | Cell Proliferation | rho GTP-Binding Proteins - antagonists & inhibitors | Humans | Deoxycytidine - pharmacology | rhoA GTP-Binding Protein - metabolism | Quinolones - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Amides - pharmacology | Vasodilator Agents - pharmacology | Colforsin - pharmacology | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Enzyme Inhibitors - pharmacology | Phosphodiesterase Inhibitors - pharmacology | rhoA GTP-Binding Protein - antagonists & inhibitors | rhoC GTP-Binding Protein | Carcinoma, Pancreatic Ductal - pathology | 1-Methyl-3-isobutylxanthine - pharmacology | Cyclic AMP - pharmacology | Cell Movement - drug effects | rho GTP-Binding Proteins - metabolism | Cell Line, Tumor | Pyridines - pharmacology | Deoxycytidine - analogs & derivatives | Apoptosis | G proteins | Muscle proteins | Analysis | Pancreatic cancer | Cancer cells | Metastasis | Cells | Cell adhesion & migration
Journal Article
Nature, ISSN 0028-0836, 04/1997, Volume 386, Issue 6625, pp. 616 - 619
Journal Article