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1. Full Text Mononuclear iron enzymes are primary targets of hydrogen peroxide stress
by Anjem, Adil and Imlay, James A
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 19, pp. 15544 - 15556
This study tested whether nonredox metalloenzymes are commonly charged with iron in vivo and are primary targets of oxidative stress because of it. Indeed,... 
OXIDATIVE STRESS | L-THREONINE DEHYDROGENASE | BACILLUS-SUBTILIS | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CYTOSINE DEAMINASE | PROTEIN-TYROSINE PHOSPHATASES | CATALYTIC MECHANISM | TRANSCRIPTION FACTOR | Apoproteins - chemistry | Oxidants - pharmacology | Models, Chemical | Alcohol Oxidoreductases - genetics | Cytosine Deaminase - metabolism | Biocatalysis - drug effects | Cation Transport Proteins - metabolism | Cytosine Deaminase - chemistry | Escherichia coli - metabolism | Oxidation-Reduction - drug effects | Cation Transport Proteins - genetics | Cysteine - metabolism | Apoproteins - metabolism | Bacterial Outer Membrane Proteins - genetics | Cytosine Deaminase - genetics | Amidohydrolases - metabolism | Catalytic Domain | Escherichia coli - enzymology | Amidohydrolases - genetics | Iron - chemistry | Hydrogen Peroxide - pharmacology | Bacterial Outer Membrane Proteins - chemistry | Alcohol Oxidoreductases - metabolism | Escherichia coli Proteins - metabolism | Cysteine - chemistry | Manganese - chemistry | Amidohydrolases - chemistry | Iron - metabolism | Blotting, Western | Manganese - metabolism | Bacterial Outer Membrane Proteins - metabolism | Alcohol Oxidoreductases - chemistry | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Kinetics | Mutation | Cation Transport Proteins - chemistry | Escherichia coli Proteins - chemistry | Index Medicus | Oxidative stress | Fenton Reaction | Microbiology | Iron | Metalloenzymes | Peptide Deformylase | Manganese | Sulfhydryl | Sulfhydryl Oxidation
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2. Full Text Heparan Sulfate Structure in Mice with Genetically Modified Heparan Sulfate Production
by Johan Ledin and William Staatz and Jin-Ping Li and Martin Götte and Scott Selleck and Lena Kjellén and Dorothe Spillmann and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för medicinsk biokemi och mikrobiologi and Uppsala universitet
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 41, pp. 42732 - 42741
Using a high throughput heparan sulfate (HS) isolation and characterization protocol, we have analyzed HS structure in several tissues from mice/mouse embryos... 
SYNDECAN-1 | DEACETYLASE/N-SULFOTRANSFERASE ISOZYMES | TARGETED DISRUPTION | NEONATAL LETHALITY | LIGAND-BINDING | FINE-STRUCTURE | IDURONIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | DOMAIN-STRUCTURE | FIBROBLAST-GROWTH-FACTOR | Heparitin Sulfate - biosynthesis | Membrane Glycoproteins - metabolism | Models, Chemical | Chromatography, High Pressure Liquid | Disaccharides - chemistry | Glycosaminoglycans - chemistry | Tissue Distribution | Kidney - metabolism | Membrane Glycoproteins - physiology | Time Factors | Swine | Oligosaccharides - chemistry | Sulfotransferases - metabolism | Sulfotransferases - physiology | Amidohydrolases - metabolism | Sulfotransferases - genetics | Syndecans | Glycosaminoglycans - metabolism | Mice, Inbred C57BL | Proteoglycans - metabolism | Genotype | Mice, Transgenic | Carbohydrate Epimerases - chemistry | Membrane Glycoproteins - genetics | Animals | Heparitin Sulfate - chemistry | Proteoglycans - physiology | Syndecan-1 | Mice | Proteoglycans - genetics | Sulfotransferases - chemistry | Index Medicus | Models; Chemical | Mice; Transgenic | Glycosaminoglycans/chemistry/metabolism | Oligosaccharides/chemistry | Proteoglycans/genetics/metabolism/physiology | Heparitin Sulfate/biosynthesis/chemistry | Chromatography; High Pressure Liquid | Kidney/metabolism | Mice; Inbred C57BL | Disaccharides/chemistry | Carbohydrate Epimerases/chemistry | Sulfotransferases/chemistry/genetics/metabolism/physiology | Research Support; Non-U.S. Gov't | Amidohydrolases/metabolism | Membrane Glycoproteins/genetics/metabolism/physiology
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3. Full Text Selective Covalent Protein Modification by 4‐Halopyridines through Catalysis
by Schardon, Christopher L and Tuley, Alfred and Er, Joyce A. V and Swartzel, Jake C and Fast, Walter
ChemBioChem, ISSN 1439-4227, 08/2017, Volume 18, Issue 15, pp. 1551 - 1556
We have investigated 4‐halopyridines as selective, tunable, and switchable covalent protein modifiers for use in the development of chemical probes.... 
covalent inhibitors | halopyridines | covalent probes | enzyme inactivation | CHEMISTRY, MEDICINAL | INHIBITION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | Affinity Labels - chemistry | Pyridines - chemistry | Humans | Acrylamide - chemistry | Cysteine - chemistry | Amidohydrolases - chemistry | Proteome - chemistry | Escherichia coli - metabolism | Phenols - chemistry | Sulfhydryl Compounds - chemistry | Glutathione - chemistry | Pyridinium Compounds - chemistry | Proteome - metabolism | Iodoacetamide - chemistry | Enzymes | Cysteine | Thiols | Escherichia coli | Aspartate | Rankings | Catalysis | Protein kinase A | Stabilization | Pyridinium | Amino acids | Labels | Proteins | Acrylamide | Covalence | Reactivity | Reagents | Affinity | Probes | Dimethylargininase | Index Medicus | covalent inhibitor | halopyridine | covalent probe
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4. Full Text Synthesis and characterization of poly(2-ethyl 2-oxazoline)-conjugates with proteins and drugs: Suitable alternatives to PEG-conjugates?
by Mero, Anna and Pasut, Gianfranco and Via, Lisa Dalla and Fijten, Martin W.M and Schubert, Ulrich S and Hoogenboom, Richard and Veronese, Francesco M
Journal of Controlled Release, ISSN 0168-3659, 2008, Volume 125, Issue 2, pp. 87 - 95
Poly(2-ethyl-2-oxazoline) (POZ) was synthesized by living cationic ring-opening polymerization under microwave irradiation yielding polymers with low... 
Trypsin | Conjugate | Poly(2-oxazoline) | Poly(ethylene glycol) | Ara-C | conjugate | COPOLY(2-OXAZOLINE)S | ACID | poly(ethylene glycol) | poly(2-oxazoline) | LIVING POLYMERIZATION | PHARMACOLOGY & PHARMACY | trypsin | BIODISTRIBUTION | CHEMISTRY, MULTIDISCIPLINARY | PEGYLATION | Polymers - administration & dosage | Esterases - chemistry | Humans | Drug Carriers - administration & dosage | Polyethylene Glycols - chemistry | Antimetabolites, Antineoplastic - chemistry | Amidohydrolases - chemistry | Polyamines | Cytarabine - administration & dosage | Drug Carriers - chemistry | Oxazoles - chemistry | Polyethylene Glycols - administration & dosage | Antimetabolites, Antineoplastic - administration & dosage | Hydrolysis | Cytarabine - chemistry | Caseins - chemistry | Oxazoles - administration & dosage | Polymers - chemistry | Cell Proliferation - drug effects | HeLa Cells | Trypsin - chemistry | Microbiological synthesis | Polymerization | Glycols | Index Medicus
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5. Full Text An improved amperometric creatinine biosensor based on nanoparticles of creatininase, creatinase and sarcosine oxidase
by Kumar, Parveen and Jaiwal, Ranjana and Pundir, C.S
Analytical Biochemistry, ISSN 0003-2697, 11/2017, Volume 537, pp. 41 - 49
An improved amperometric biosensor for detection of creatinine was developed based on immobilization of nanoparticles (NPs) of creatininase (CA), creatinase... 
Creatinine | Glassy carbon electrode | Serum | Enzyme nanoparticles | Biosensor | CHEMISTRY, ANALYTICAL | ACID | GLUCOSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | ELECTRODE | UREA | Amidohydrolases - metabolism | Gold - chemistry | Enzymes, Immobilized - chemistry | Enzymes, Immobilized - metabolism | Limit of Detection | Microscopy, Electron, Scanning | Humans | Metal Nanoparticles - chemistry | Amidohydrolases - chemistry | Electrochemical Techniques - instrumentation | Ureohydrolases - chemistry | Sarcosine Oxidase - chemistry | Electrodes | Uric Acid - chemistry | Ascorbic Acid - chemistry | Creatinine - blood | Biosensing Techniques - instrumentation | Ureohydrolases - metabolism | Sarcosine Oxidase - metabolism | Dielectric Spectroscopy | Oxidases | Nanoparticles | Phosphates | Detectors | Electric properties | Index Medicus
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6. Full Text A Novel 43-kDa Protein as a Negative Regulatory Component of Phenoloxidase-induced Melanin Synthesis
by Mingyi Zhao and Irene Söderhäll and Ji Won Park and Young Gerl Ma and Tsukusa Osaki and Nam-Chul Ha and Chun Fu Wu and Kenneth Söderhäll and Bok Luel Lee and Teknisk-naturvetenskapliga vetenskapsområdet and Biologiska sektionen and Jämförande fysiologi and Uppsala universitet and Institutionen för fysiologi och utvecklingsbiologi and Institutionen för organismbiologi
Journal of Biological Chemistry, ISSN 0021-9258, 07/2005, Volume 280, Issue 26, pp. 24744 - 24751
The melanization reaction induced by activated phenoloxidase in arthropods is important in the multiple host defense innate immune reactions, leading to the... 
PROPHENOLOXIDASE-ACTIVATING ENZYME | MANDUCA-SEXTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOLOTRICHIA-DIOMPHALIA LARVAE | PRO-PHENOL-OXIDASE | SERINE-PROTEASE | COLEOPTERAN INSECT | MOLECULAR-CLONING | TENEBRIO-MOLITOR LARVAE | DROSOPHILA | INNATE IMMUNITY | Melanins - chemistry | Baculoviridae - metabolism | Insecta | Molecular Sequence Data | Immunoblotting | Candida albicans - metabolism | Melanins - metabolism | Melanins - biosynthesis | RNA Interference | Tenebrio | Base Sequence | Cloning, Molecular | Polymerase Chain Reaction | Protein Denaturation | Green Fluorescent Proteins - chemistry | Monophenol Monooxygenase - chemistry | Amidohydrolases - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Insect Proteins - physiology | Quinones - chemistry | Electrophoresis, Polyacrylamide Gel | Gene Silencing | Hemolymph - metabolism | Recombinant Proteins - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Sequence Homology, Amino Acid | DNA - chemistry | Animals | Vitellogenins - physiology | Insect Proteins - chemistry | Vitellogenins - chemistry | Protein Binding | Hemolymph - chemistry | DNA, Complementary - metabolism | Index Medicus | Candida albicans/metabolism | Baculoviridae/metabolism | Recombinant Proteins/chemistry | Hemolymph/chemistry/metabolism | Immunology | Green Fluorescent Proteins/chemistry | Vitellogenins/chemistry/physiology | Monophenol Monooxygenase/chemistry | Research Support; Non-U.S. Gov't | Natural Sciences | Insect Proteins/chemistry/physiology | Biological Sciences | Blotting; Western | Immunologi | Protein Structure; Tertiary | Sequence Homology; Amino Acid | Cloning; Molecular | Naturvetenskap | DNA/chemistry | Electrophoresis; Polyacrylamide Gel | Insects | DNA; Complementary/metabolism | Biologiska vetenskaper | Melanins/biosynthesis/chemistry/metabolism | Quinones/chemistry | Amidohydrolases/metabolism
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7. Full Text 1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability
by Sundermann, Tom and Fabian, Jörg and Hanekamp, Walburga and Lehr, Matthias
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2015, Volume 23, Issue 10, pp. 2579 - 2592
Cytosolic phospholipase A α (cPLA α) and fatty acid amide hydrolase (FAAH) are enzymes, which have emerged as attractive targets for the development of... 
Cytosolic phospholipase A2α | Indole-5-carboxylic acid | Metabolic stability | Inhibitors | Aldo–keto reductase | Cytochrome P450 | Short chain dehydrogenase/reductase | Fatty acid amide hydrolase | Carbonyl reductase | Benzotriazole | Aldo-keto reductase | Cytosolic phospholipase A | Group IV Phospholipases A2 - antagonists & inhibitors | Carboxylic Acids - chemical synthesis | Indoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Analgesics - chemical synthesis | Ketones - chemical synthesis | Swine | Biotransformation | Carboxylic Acids - chemistry | Enzyme Inhibitors - chemistry | Oxygen - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Sulfur - chemistry | Group IV Phospholipases A2 - chemistry | Drug Stability | Rats | Amidohydrolases - antagonists & inhibitors | Amidohydrolases - chemistry | Microsomes, Liver - chemistry | Animals | Nitrogen - chemistry | Analgesics - chemistry | Ketones - chemistry | Brain Chemistry | Indoles - chemistry | Index Medicus
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8. Full Text Biological evaluation of pyridone alkaloids on the endocannabinoid system
by Chicca, Andrea and Berg, Regina and Jessen, Henning J and Marck, Nicolas and Schmid, Fabian and Burch, Patrick and Gertsch, Jürg and Gademann, Karl
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2017, Volume 25, Issue 22, pp. 6102 - 6114
Naturally occurring pyridone alkaloids as well as synthetic derivatives were previously shown to induce neurite outgrowth. However, the molecular basis for... 
2-ARACHIDONOYLGLYCEROL | METABOLITES | CHEMISTRY, MEDICINAL | PAECILOMYCES-FARINOSUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANANDAMIDE CELLULAR UPTAKE | TRANSPORT | RICINUS-COMMUNIS | NEURITE OUTGROWTH | TENELLIN | INHIBITORS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | Amidohydrolases - metabolism | Endocannabinoids - metabolism | Polyunsaturated Alkamides - chemistry | Monoacylglycerol Lipases - antagonists & inhibitors | Humans | Amidohydrolases - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Arachidonic Acids - chemistry | Polyunsaturated Alkamides - metabolism | Monoacylglycerol Lipases - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Arachidonic Acids - metabolism | U937 Cells | Cyclooxygenase 2 - metabolism | Inhibitory Concentration 50 | Protein Binding | Pyridones - metabolism | Alkaloids - metabolism | Kinetics | Pyridones - chemistry | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Alkaloids - chemistry | Endocannabinoids - chemistry | Hydrolysis | Alkaloids | Lipase | Fatty acids | Analysis | Index Medicus
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9. Full Text Electrochemical Molecular Switch for the Selective Profiling of Cysteine in Live Cells and Whole Blood and for the Quantification of Aminoacylase-1
by Balamurugan, T.S.T and Huang, Chih-Hung and Chang, Pu-Chieh and Huang, Sheng-Tung
Analytical Chemistry, ISSN 0003-2700, 11/2018, Volume 90, Issue 21, pp. 12631 - 12638
A first-of-a-kind latent electrochemical redox probe, ferrocene carbamate phenyl acrylate (FCPA), was developed for the selective detection of cysteine (Cys)... 
HOMOCYSTEINE | CHEMISTRY, ANALYTICAL | CHEMOSENSOR | RATIOMETRIC PROBES | GLUTATHIONE | REDOX | CYS | FLUORESCENT-PROBE | Limit of Detection | Acrylates - chemistry | Acetylcysteine - chemistry | Humans | Enzyme Assays - methods | Electrochemical Techniques - methods | Metallocenes - chemistry | Amidohydrolases - blood | Amidohydrolases - chemistry | Cysteine - blood | Escherichia coli - chemistry | Cellular manufacture | Molecular machines | Chemical sensors | Cysteine | Transformation | Escherichia coli | Acetylcysteine | Dynamic range | Amino acids | Biochemistry | Aminoacylase | Blood | Electrocatalysis | Cellular biology | Electrochemistry | Index Medicus
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10. Full Text Structure and Activity of Two Metal Ion-dependent Acetylxylan Esterases Involved in Plant Cell Wall Degradation Reveals a Close Similarity to Peptidoglycan Deacetylases
by Edward J. Taylor and Tracey M. Gloster and Johan P. Turkenburg and Florence Vincent and A. Marek Brzozowski and Claude Dupont and François Shareck and Maria S. J. Centeno and José A. M. Prates and Vladimír Puchart and Luís M. A. Ferreira and Carlos M. G. A. Fontes and Peter Biely and Gideon J. Davies
Journal of Biological Chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 16, pp. 10968 - 10975
The enzymatic degradation of plant cell wall xylan requires the concerted action of a diverse enzymatic syndicate. Among these enzymes are xylan esterases,... 
STREPTOMYCES-LIVIDANS | ANGSTROM RESOLUTION | SUBSTRATE-SPECIFICITY | CRYSTAL-STRUCTURE | TRICHODERMA-REESEI | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBOHYDRATE ESTERASE | DENSITY-MODIFICATION | CLOSTRIDIUM-THERMOCELLUM | FERULOYL ESTERASE | MOLECULAR GRAPHICS | Acetylesterase - chemistry | Models, Chemical | Streptomyces lividans - metabolism | Peptidoglycan - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Metals - chemistry | Clostridium thermocellum - metabolism | Escherichia coli - metabolism | Catalysis | Binding Sites | Dimerization | Protein Structure, Tertiary | Nickel - chemistry | Carbohydrate Metabolism | Models, Molecular | Chitin - chemistry | Ions | Models, Statistical | Amidohydrolases - chemistry | Plants - metabolism | Xylans - chemistry | Carbohydrates - chemistry | Cell Wall - metabolism | Ligands | Protein Conformation | Aspartic Acid - chemistry | Histidine - chemistry | Cobalt - chemistry | Index Medicus
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11. Full Text 2012 division of medicinal chemistry award address. Trekking the cannabinoid road: A personal perspective
by Makriyannis, Alexandros
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2014, Volume 57, Issue 10, pp. 3891 - 3911
My involvement with the field of cannabinoids spans close to 3 decades and covers a major part of my scientific career. It also reflects the robust progress in... 
CB2 RECEPTORS | SELECTIVE ANANDAMIDE ANALOG | CHEMISTRY, MEDICINAL | ACID AMIDE HYDROLASE | PROTEIN-COUPLED RECEPTOR | MASS-SPECTROMETRIC CHARACTERIZATION | SOLID-STATE H-2-NMR | FOOD-REINFORCED BEHAVIOR | X-RAY-DIFFRACTION | AFFINITY IRREVERSIBLE PROBE | HUMAN MONOACYLGLYCEROL LIPASE | Endocannabinoids - metabolism | Analgesics - pharmacology | Receptor, Cannabinoid, CB2 - physiology | Endocannabinoids - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | Humans | Monoacylglycerol Lipases - physiology | Receptor, Cannabinoid, CB2 - drug effects | Awards and Prizes | Amidohydrolases - antagonists & inhibitors | Chemistry, Pharmaceutical | Receptor, Cannabinoid, CB1 - physiology | Cannabinoids - pharmacology | Animals | Amidohydrolases - physiology | Receptor, Cannabinoid, CB1 - drug effects | Index Medicus
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12. Full Text Biochemical and mutational studies of allantoinase from Bacillus licheniformis CECT 20T
by Martínez-Gómez, Ana Isabel and Soriano-Maldonado, Pablo and Andújar-Sánchez, Montserrat and Clemente-Jiménez, Josefa María and Rodríguez-Vico, Felipe and Neira, José L and Las Heras-Vázquez, Francisco Javier and Martínez-Rodríguez, Sergio
Biochimie, ISSN 0300-9084, 04/2014, Volume 99, Issue 1, pp. 178 - 188
Allantoinases (allantoin amidohydrolase, E.C. 3.5.2.5) catalyze the hydrolysis of the amide bond of allantoin to form allantoic acid, in those organisms where... 
Allantoinase | TIM-barrel | Amidohydrolase | PURINE CATABOLIC PATHWAY | D-AMINO ACIDS | AMPHIBIAN ALLANTOINASE | RECOMBINANT ESCHERICHIA-COLI | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTRATE-SPECIFICITY | FUNCTIONAL EXPRESSION | D-AMINOACYLASE | URIC-ACID | PHASEOLUS-VULGARIS | Allantoin - chemistry | Molecular Weight | Stereoisomerism | Allosteric Regulation | Bacterial Proteins - chemistry | Substrate Specificity | Hydrogen Peroxide - chemistry | Enzyme Inhibitors - chemistry | Uracil - chemistry | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Mutagenesis, Site-Directed | Amidohydrolases - genetics | Bacterial Proteins - genetics | Amidohydrolases - antagonists & inhibitors | Cysteine - chemistry | Manganese - chemistry | Amidohydrolases - chemistry | Hydrolysis | Bacillus - enzymology | Protein Binding | Kinetics | Hydantoins - chemistry | Transition Temperature | Cobalt - chemistry | Amino Acid Substitution | Hydrogen-Ion Concentration | Uracil - analogs & derivatives | Enzymes | Genetic aspects | Uric acid | Index Medicus
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13. Full Text A Trivalent Enzymatic System for Uricolytic Therapy of HPRT Deficiency and Lesch-Nyhan Disease
by Ronda, Luca and Marchetti, Marialaura and Piano, Riccardo and Liuzzi, Anastasia and Corsini, Romina and Percudani, Riccardo and Bettati, Stefano
Pharmaceutical Research, ISSN 0724-8741, 07/2017, Volume 34, Issue 7, pp. 1477 - 1490
Purpose Because of the evolutionary loss of the uricolytic pathway, humans accumulate poorly soluble urate as the final product of purine catabolism.... 
enzyme therapy | hyperuricemia | polyethylene glycol | purine degradation | gout | Lesch-Nyhan disease | THERMAL-STABILITY | URATE OXIDASE | PROTEIN | PEGLOTICASE | POLYMER CONJUGATION | CHEMISTRY, MULTIDISCIPLINARY | URIC-ACID DEGRADATION | TETRAMER DISSOCIATION | IN-VIVO | PHARMACOLOGY & PHARMACY | PEGYLATION | Enzyme Therapy | Uricosuric Agents - chemistry | Allantoin - chemistry | Molecular Weight | Stereoisomerism | Humans | Solubility | Recombinant Proteins - chemistry | Lesch-Nyhan Syndrome - drug therapy | Polyethylene Glycols - chemistry | Zebrafish | Carboxy-Lyases - chemistry | Amidohydrolases - chemistry | Hyperuricemia - drug therapy | Hypoxanthine Phosphoribosyltransferase - deficiency | Uric Acid - chemistry | Animals | Urate Oxidase - chemistry | Purines | Enzymes | Alkaloids | Biological products | Metabolites | Polyethylene glycol | Polyols | Therapy | Stability | Allantoin | In vitro testing | Uric acid | Conversion | Guanine | Hyperuricemia | Lesch-Nyhan syndrome | Enzymatic activity | Restoration | Hypoxanthine | Phosphoribosyltransferase | Catabolism | Conjugation | Freeze-drying | Recombinant | Index Medicus | Research Paper
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14. Full Text Activity Based Protein Profiling Leads to Identification of Novel Protein Targets for Nerve Agent VX
by Carmany, Dan and Walz, Andrew J and Hsu, Fu-Lian and Benton, Bernard and Burnett, David and Gibbons, Jennifer and Noort, Daan and Glaros, Trevor and Sekowski, Jennifer W
Chemical Research in Toxicology, ISSN 0893-228X, 04/2017, Volume 30, Issue 4, pp. 1076 - 1084
Organophosphorus (OP) nerve agents continue to be a threat at home and abroad during the war against terrorism. Human exposure to nerve agents such as VX... 
ACETYLCHOLINESTERASE ACTIVITY | CHEMISTRY, MEDICINAL | ISOCITRATE DEHYDROGENASE | SOMAN | RATS | TOXICITY | TOXICOLOGY | CHEMISTRY, MULTIDISCIPLINARY | BLOOD | Male | Chromatography, High Pressure Liquid | Organothiophosphorus Compounds - chemistry | Brain - metabolism | Tandem Mass Spectrometry | Kidney - metabolism | Organothiophosphorus Compounds - toxicity | Protein Isoforms - metabolism | Liver - drug effects | Protein Isoforms - chemistry | Nerve Agents - chemistry | Amidohydrolases - metabolism | Malate Dehydrogenase - metabolism | Kidney - drug effects | Liver - metabolism | Rats | Amidohydrolases - chemistry | Nerve Agents - toxicity | Rats, Sprague-Dawley | Brain - drug effects | Animals | Proteins - metabolism | Isocitrate Dehydrogenase - chemistry | Heart - drug effects | Isocitrate Dehydrogenase - metabolism | Malate Dehydrogenase - chemistry | Proteins - chemistry | Peptides - analysis | Index Medicus
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15. Full Text Enzyme-responsive amphiphilic PEG-dendron hybrids and their assembly into smart micellar nanocarriers
by Harnoy, Assaf J and Rosenbaum, Ido and Tirosh, Einat and Ebenstein, Yuval and Shaharabani, Rona and Beck, Roy and Amir, Roey J
Journal of the American Chemical Society, ISSN 0002-7863, 05/2014, Volume 136, Issue 21, pp. 7531 - 7534
Enzyme-responsive micelles have great potential as drug delivery platforms due to the high selectivity of the activating enzymes. Here we report a highly... 
NANOPARTICLES | DESIGN | RELEASE | CHEMISTRY, MULTIDISCIPLINARY | Amidohydrolases - metabolism | Micelles | Dendrimers - chemistry | Hydrophobic and Hydrophilic Interactions | Polyethylene Glycols - chemistry | Molecular Structure | Surface-Active Agents - chemistry | Nanostructures | Amidohydrolases - chemistry | Surface-Active Agents - chemical synthesis | Research | Chemical properties | Chemical synthesis | Polyethylene glycol | Analysis | Index Medicus
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