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1. Full Text Model-based Drug Development
by Lalonde, R L and Kowalski, K G and Hutmacher, M M and Ewy, W and Nichols, D J and Milligan, P A and Corrigan, B W and Lockwood, P A and Marshall, S A and Benincosa, L J and Tensfeldt, T G and Parivar, K and Amantea, M and Glue, P and Koide, H and Miller, R
Clinical pharmacology and therapeutics, ISSN 0009-9236, 07/2007, Volume 82, Issue 1, pp. 21 - 32
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Analgesics - pharmacology | Muscarinic Agonists - pharmacology | Cholesterol - blood | Humans | Glycoproteins - pharmacology | Caproates - therapeutic use | Amines - therapeutic use | Alzheimer Disease - psychology | Neutrophil Infiltration - drug effects | United States Food and Drug Administration | Glycoproteins - therapeutic use | Alzheimer Disease - drug therapy | gamma-Aminobutyric Acid - pharmacology | Stroke - drug therapy | Cognition - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Models, Biological | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Amines - pharmacology | Immunologic Factors - pharmacology | Clinical Trials as Topic - legislation & jurisprudence | Guidelines as Topic | Meta-Analysis as Topic | Clinical Trials as Topic - statistics & numerical data | United States | Caproates - pharmacology | Muscarinic Agonists - therapeutic use | Oximes - therapeutic use | Drug Approval | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Computer Simulation | Drug Design | gamma-Aminobutyric Acid - therapeutic use | Stroke - immunology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Hypercholesterolemia - blood | Reproducibility of Results | Neuralgia, Postherpetic - drug therapy | Pharmacology | Models, Statistical | Animals | Anticholesteremic Agents - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Oximes - pharmacology | Clinical Trials as Topic - methods | Pharmacokinetics | Research Design | Anticholesteremic Agents - pharmacology | Immunologic Factors - therapeutic use | Index Medicus | Abridged Index Medicus
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2. Full Text Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro
by Crawford, Devon C and Jiang, Xiaoping and Taylor, Amanda and Mennerick, Steven
The Journal of neuroscience, ISSN 0270-6474, 09/2012, Volume 32, Issue 38, pp. 13100 - 13110
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Electric Stimulation | Coculture Techniques | Culture Media, Conditioned - chemistry | Neuronal Plasticity - drug effects | Culture Media, Conditioned - pharmacology | Male | Excitatory Postsynaptic Potentials - drug effects | N-Methylaspartate - pharmacology | Thrombospondins - pharmacology | Quinoxalines - pharmacology | CREB-Binding Protein - metabolism | Cyclic AMP - analogs & derivatives | Potassium Chloride - pharmacology | Statistics, Nonparametric | Female | Phosphorylation - drug effects | Hippocampus - growth & development | Organ Culture Techniques | Receptors, AMPA - metabolism | Animals, Newborn | Synapses - drug effects | Presynaptic Terminals - drug effects | Vesicular Glutamate Transport Protein 1 - metabolism | Valine - analogs & derivatives | Rats | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Adenosine - pharmacology | Biophysics | Thionucleotides - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Cyclic AMP - pharmacology | Nerve Tissue Proteins - metabolism | Astrocytes - physiology | Patch-Clamp Techniques | Animals | Cyclohexanecarboxylic Acids - pharmacology | Adenosine - analogs & derivatives | Dynamin I - metabolism | Protein Kinase Inhibitors - pharmacology | Valine - pharmacology | Amines - pharmacology | Thrombospondins - metabolism | Index Medicus
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3. Full Text Neuropathic pain
by Colloca, Luana and Ludman, Taylor and Bouhassira, Didier and Baron, Ralf and Dickenson, Anthony H and Yarnitsky, David and Freeman, Roy and Truini, Andrea and Attal, Nadine and Finnerup, Nanna B and Eccleston, Christopher and Kalso, Eija and Bennett, David L and Dworkin, Robert H and Raja, Srinivasa N
Nature reviews. Disease primers, ISSN 2056-676X, 02/2017, Volume 3, Issue 1, pp. 17002 - 17002
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Analgesics - pharmacology | Lidocaine - pharmacology | Neuralgia - complications | Gabapentin | Nociceptive Pain - diagnosis | Pregabalin - therapeutic use | Humans | Tramadol - pharmacology | Lidocaine - therapeutic use | Narcotics - therapeutic use | Neoplasms - complications | Transcutaneous Electric Nerve Stimulation - standards | Amines - therapeutic use | Voltage-Gated Sodium Channel Blockers - therapeutic use | Neuralgia - diagnosis | Quality of Life - psychology | gamma-Aminobutyric Acid - therapeutic use | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Pregabalin - pharmacology | Pain Management - methods | gamma-Aminobutyric Acid - pharmacology | Nociceptive Pain - complications | Tramadol - therapeutic use | Drug Therapy, Combination - methods | Cyclohexanecarboxylic Acids - pharmacology | Voltage-Gated Sodium Channel Blockers - pharmacology | Narcotics - pharmacology | Neuralgia - epidemiology | Amines - pharmacology | Transcutaneous Electric Nerve Stimulation - methods | Index Medicus
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4. Full Text Monoamine transporter and receptor interaction profiles of a new series of designer cathinones
by Simmler, L.D and Rickli, A and Hoener, M.C and Liechti, M.E
Neuropharmacology, ISSN 0028-3908, 04/2014, Volume 79, pp. 152 - 160
Bath salts | Norepinephrine | Dopamine | Serotonin | Transporter | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Designer Drugs - pharmacology | Dopamine Uptake Inhibitors - pharmacology | Amphetamines - pharmacology | Humans | Propiophenones - pharmacology | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Receptors, Biogenic Amine - antagonists & inhibitors | Butyrophenones - pharmacology | HEK293 Cells | Pentanones - pharmacology | Receptors, Biogenic Amine - metabolism | Adrenergic Uptake Inhibitors - pharmacology | Biogenic Monoamines - metabolism | Serotonin Uptake Inhibitors - pharmacology | Methylamines - pharmacology | Cytokinins | Polymethylmethacrylate | Bath products | Ecstasy (Drug) | Index Medicus
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5. Full Text Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes
by Kammerer, M and Rassner, M P and Freiman, T M and Feuerstein, T J
Naunyn-Schmiedeberg's archives of pharmacology, ISSN 0028-1298, 7/2011, Volume 384, Issue 1, pp. 47 - 57
Neurosciences | Veratridine | Biomedicine | Epilepsy | GABA | Neocortical synaptosomes | Pharmacology/Toxicology | Antiepileptic drugs | Potassium | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Synaptosomes - drug effects | Gabapentin | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Child, Preschool | Infant | Male | Pregabalin | Synaptosomes - metabolism | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Calcium - deficiency | Young Adult | Calcium - antagonists & inhibitors | Neocortex - metabolism | Neocortex - drug effects | Piracetam - pharmacology | Adult | Female | Phenytoin - pharmacology | Tetrodotoxin - pharmacology | Nipecotic Acids - pharmacology | Child | Carbamazepine - pharmacology | Triazines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Tetanus Toxin - pharmacology | Potassium - pharmacology | Veratridine - pharmacology | GABA Antagonists - pharmacology | Animals | Cyclohexanecarboxylic Acids - pharmacology | Piracetam - analogs & derivatives | Adolescent | Oximes - pharmacology | Aged | gamma-Aminobutyric Acid - analogs & derivatives | Amines - pharmacology | Phenytoin - pharmacokinetics | Lamotrigine | Levetiracetam | Drugs | Brain | Anticonvulsants | Marine toxins | Neurons | Tetanus | Glutamate | Sodium channels | gamma -Aminobutyric acid | Calcium | lamotrigine | Cortex | veratridine | tetanus toxin | Antiepileptic agents | Exocytosis | Valproic acid | Etiracetam | Carbamazepine | Depolarization | Neurotransmitters | Neural networks | gabapentin | Synaptosomes | Phenytoin | Index Medicus
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6. Full Text Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model
by Booth, R and Kim, H
Annals of biomedical engineering, ISSN 0090-6964, 12/2014, Volume 42, Issue 12, pp. 2379 - 2391
Biomedical Engineering | Biochemistry, general | Microsystems | μ BBB | Biomedicine | BBB | Central nervous system | Mechanics | Biophysics and Biological Physics | Drug discovery | Biomedicine general | Endothelial cells | μBBB | Engineering | Technology | Engineering, Biomedical | Science & Technology | L-Lactate Dehydrogenase - metabolism | Coculture Techniques | Varenicline | Quinoxalines - pharmacology | Biological Transport | Piperidines - pharmacology | Indoles - pharmacology | Microfluidic Analytical Techniques | Cell Survival - drug effects | Sertraline - pharmacology | Endothelial Cells - metabolism | Valine - analogs & derivatives | Cells, Cultured | Rats | gamma-Aminobutyric Acid - pharmacology | Benzazepines - pharmacology | Permeability | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Pyrroles - pharmacology | Animals | Cyclohexanecarboxylic Acids - pharmacology | Tetrahydronaphthalenes - pharmacology | Neuroglia - metabolism | Mice | Valine - pharmacology | Amines - pharmacology | Ethosuximide - pharmacology | Drugs | Analysis | Microfluidics | Index Medicus | Surgical implants | Biomedical materials | Dynamics | In vivo tests | Mathematical models
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7. Full Text The nitric oxide-cyclic GMP-protein kinase G-K + channel pathway participates in the antiallodynic effect of spinal gabapentin
by Mixcoatl-Zecuatl, Teresa and Flores-Murrieta, Francisco J and Granados-Soto, Vinicio
European journal of pharmacology, ISSN 0014-2999, 2006, Volume 531, Issue 1, pp. 87 - 95
Pinacidil | Gabapentin | Nitric oxide | Protein kinase G | Diazoxide | Guanylyl cyclase | K + channel opener | Neuropathic pain | channel opener | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Analgesics - pharmacology | Okadaic Acid - pharmacology | Potassium Channels - physiology | Pinacidil - administration & dosage | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Glyburide - pharmacology | Time Factors | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channel Blockers - pharmacology | Spinal Nerves - injuries | Spinal Nerves - physiopathology | Enzyme Inhibitors - pharmacology | Cyclohexanecarboxylic Acids - administration & dosage | Rats | gamma-Aminobutyric Acid - pharmacology | Indazoles - pharmacology | NG-Nitroarginine Methyl Ester - chemistry | Cyclic GMP - metabolism | Signal Transduction - drug effects | Pain - physiopathology | Nitric Oxide Synthase - metabolism | Carbazoles - pharmacology | Amines - pharmacology | Diazoxide - administration & dosage | Cyclic GMP - antagonists & inhibitors | Diazoxide - pharmacology | Rats, Wistar | Stereoisomerism | Nitric Oxide Synthase - antagonists & inhibitors | gamma-Aminobutyric Acid - administration & dosage | Apamin - pharmacology | Cyclic GMP-Dependent Protein Kinases - metabolism | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Amines - administration & dosage | Female | Indoles - pharmacology | Injections, Spinal | NG-Nitroarginine Methyl Ester - pharmacology | Pinacidil - pharmacology | Vasodilator Agents - pharmacology | Pain - prevention & control | Nitric Oxide - antagonists & inhibitors | Analgesics - administration & dosage | Animals | Cyclohexanecarboxylic Acids - pharmacology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Index Medicus
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