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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2007, Volume 82, Issue 1, pp. 21 - 32
The low productivity and escalating costs of drug development have been well documented over the past several years. Less than 10% of new compounds that enter... 
TRIPTANS SEROTONIN | METAANALYSIS | PAIN | DOSE-RESPONSE | INTEGRATION | 5-HT1B/1D AGONISTS | CLINICAL-TRIALS | DISEASE | PHARMACOLOGY & PHARMACY | SIMULATION | MIGRAINE | Analgesics - pharmacology | Muscarinic Agonists - pharmacology | Cholesterol - blood | Humans | Glycoproteins - pharmacology | Caproates - therapeutic use | Amines - therapeutic use | Alzheimer Disease - psychology | Neutrophil Infiltration - drug effects | United States Food and Drug Administration | Glycoproteins - therapeutic use | Alzheimer Disease - drug therapy | gamma-Aminobutyric Acid - pharmacology | Stroke - drug therapy | Cognition - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Models, Biological | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Amines - pharmacology | Immunologic Factors - pharmacology | Clinical Trials as Topic - legislation & jurisprudence | Guidelines as Topic | Meta-Analysis as Topic | Clinical Trials as Topic - statistics & numerical data | United States | Caproates - pharmacology | Muscarinic Agonists - therapeutic use | Oximes - therapeutic use | Drug Approval | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Computer Simulation | Drug Design | gamma-Aminobutyric Acid - therapeutic use | Stroke - immunology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Hypercholesterolemia - blood | Reproducibility of Results | Neuralgia, Postherpetic - drug therapy | Pharmacology | Models, Statistical | Animals | Anticholesteremic Agents - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Oximes - pharmacology | Clinical Trials as Topic - methods | Pharmacokinetics | Research Design | Anticholesteremic Agents - pharmacology | Immunologic Factors - therapeutic use
Journal Article
Neuroendocrinology Letters, ISSN 0172-780X, 2010, Volume 31, Issue 5, pp. 645 - 656
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2012, Volume 32, Issue 38, pp. 13100 - 13110
Astrocytes contribute to many neuronal functions, including synaptogenesis, but their role in the development of synaptic plasticity remains unclear.... 
NEUROPATHIC PAIN | PYRAMIDAL CELLS | PROTEIN-KINASE | NECROSIS-FACTOR-ALPHA | SILENT SYNAPSES | ANTIEPILEPTIC DRUGS | GABAPENTIN | DIFFERENTIAL REGULATION | NEUROSCIENCES | CALCIUM-CHANNEL | GLIAL TNF-ALPHA | Electric Stimulation | Coculture Techniques | Culture Media, Conditioned - chemistry | Neuronal Plasticity - drug effects | Culture Media, Conditioned - pharmacology | Male | Excitatory Postsynaptic Potentials - drug effects | N-Methylaspartate - pharmacology | Thrombospondins - pharmacology | Quinoxalines - pharmacology | CREB-Binding Protein - metabolism | Cyclic AMP - analogs & derivatives | Potassium Chloride - pharmacology | Statistics, Nonparametric | Female | Phosphorylation - drug effects | Hippocampus - growth & development | Organ Culture Techniques | Receptors, AMPA - metabolism | Animals, Newborn | Synapses - drug effects | Presynaptic Terminals - drug effects | Vesicular Glutamate Transport Protein 1 - metabolism | Valine - analogs & derivatives | Rats | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Adenosine - pharmacology | Biophysics | Thionucleotides - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Cyclic AMP - pharmacology | Nerve Tissue Proteins - metabolism | Astrocytes - physiology | Patch-Clamp Techniques | Animals | Cyclohexanecarboxylic Acids - pharmacology | Adenosine - analogs & derivatives | Dynamin I - metabolism | Protein Kinase Inhibitors - pharmacology | Valine - pharmacology | Amines - pharmacology | Thrombospondins - metabolism
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 7/2011, Volume 384, Issue 1, pp. 47 - 57
In epilepsy, allegedly, a neurotransmitter imbalance between the inhibitory GABA and the excitatory glutamate prevails. Therefore, some antiepileptic drugs... 
Neurosciences | Veratridine | Biomedicine | Epilepsy | GABA | Neocortical synaptosomes | Pharmacology/Toxicology | Antiepileptic drugs | Potassium | ACTION-POTENTIALS | VOLTAGE-DEPENDENT LIMITATION | TEMPORAL-LOBE EPILEPSY | NEUROTRANSMITTER RELEASE | VALPROIC ACID | TRANSPORTER GAT-1 | MOUSE CENTRAL NEURONS | IN-VITRO | SODIUM VALPROATE | PHARMACOLOGY & PHARMACY | CALCIUM-CHANNEL | Synaptosomes - drug effects | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Child, Preschool | Infant | Male | Pregabalin | Synaptosomes - metabolism | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Calcium - deficiency | Young Adult | Calcium - antagonists & inhibitors | Neocortex - metabolism | Neocortex - drug effects | Piracetam - pharmacology | Adult | Female | Phenytoin - pharmacology | Tetrodotoxin - pharmacology | Nipecotic Acids - pharmacology | Child | Carbamazepine - pharmacology | Triazines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Tetanus Toxin - pharmacology | Potassium - pharmacology | Veratridine - pharmacology | GABA Antagonists - pharmacology | Animals | Cyclohexanecarboxylic Acids - pharmacology | Piracetam - analogs & derivatives | Adolescent | Oximes - pharmacology | Aged | gamma-Aminobutyric Acid - analogs & derivatives | Amines - pharmacology | Phenytoin - pharmacokinetics | Drugs | Brain | Anticonvulsants | Marine toxins | Neurons | Tetanus | Glutamate | Sodium channels | gamma -Aminobutyric acid | Calcium | lamotrigine | Cortex | veratridine | tetanus toxin | Antiepileptic agents | Exocytosis | Valproic acid | Etiracetam | Carbamazepine | Depolarization | Neurotransmitters | Neural networks | gabapentin | Synaptosomes | Phenytoin
Journal Article
Circulation research, ISSN 0009-7330, 2005, Volume 96, Issue 1, pp. 119 - 126
Remodeling of small arteries is essential in the long-term regulation of blood pressure and blood flow to specific organs or tissues. A large part of the... 
Vascular remodeling | Tissue transglutaminase | Vasoconstriction | Blood flow | INDUCED ACTIVATION | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | RESISTANCE ARTERIES | CROSS-LINKING | SPASM | tissue transglutaminase | vascular remodeling | FLOW | STRUCTURAL-CHANGES | ADAPTATION | PERIPHERAL VASCULAR DISEASE | vasoconstriction | HYPERTENSION | HEMATOLOGY | blood flow | Norepinephrine - pharmacology | GTP-Binding Proteins - pharmacology | Mesenteric Arteries - physiology | Cross-Linking Reagents - pharmacology | Endothelin-1 - pharmacology | Transglutaminases - pharmacology | Transglutaminases - genetics | Nitroprusside - pharmacology | Hemorheology | Cadaverine - pharmacology | GTP-Binding Proteins - genetics | Vasoconstriction - physiology | Enzyme Induction - drug effects | Cystamine - pharmacology | Female | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - cytology | Organ Culture Techniques | Muscle, Skeletal - blood supply | Tretinoin - pharmacology | Vasoconstrictor Agents - pharmacology | Extracellular Matrix Proteins - chemistry | GTP-Binding Proteins - physiology | Guinea Pigs | Vasodilator Agents - pharmacology | Gels | Cell Size - drug effects | Transglutaminases - biosynthesis | Rats | Nitric Oxide - physiology | Papaverine - pharmacology | Arteries - drug effects | Vasoconstriction - drug effects | Extracellular Matrix Proteins - drug effects | Extracellular Matrix - ultrastructure | Animals | Arteries - enzymology | Coronary Vessels - cytology | Vasomotor System - physiology | Collagen | Biotin - pharmacology | Transglutaminases - physiology | GTP-Binding Proteins - biosynthesis | Amines - pharmacology | Mesenteric Arteries - enzymology | Sus scrofa | Biotin - analogs & derivatives
Journal Article
Neuropharmacology, ISSN 0028-3908, 2005, Volume 48, Issue 5, pp. 658 - 672
To date, two cannabinoid receptors have been identified, CB1 and CB2. Activation of these receptors with non-selective cannabinoid receptor agonists reduces... 
CB2 | Rotarod | GW405833 | Radioligand binding | Incisional pain | Catalepsy | Anxiety | Cannabinoid | Pharmacokinetics | Inflammatory pain | Neuropathic pain | ACTIVATION | ANTIHYPERALGESIC ACTIVITY | MICE DEFICIENT | cannabinoid | radioligand binding | NEUROSCIENCES | RAT MODEL | incisional pain | catalepsy | anxiety | CB2 RECEPTORS | neuropathic pain | INHIBITION | pharmacokinetics | inflammatory pain | PHARMACOLOGY & PHARMACY | rotarod | EXPRESSION | CANNABINOIDS | Analgesics - pharmacology | Cricetulus | Receptor, Cannabinoid, CB2 - agonists | Humans | Catalepsy - metabolism | Male | Benzoxazines | Pain - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Time Factors | Inflammation - drug therapy | Reaction Time - drug effects | Behavior, Animal - drug effects | Indoles - pharmacology | Cyclohexanols - pharmacology | Anxiety - metabolism | Ataxia - metabolism | Cyclic AMP - metabolism | Immunosuppressive Agents - pharmacology | CHO Cells | Disease Models, Animal | Cricetinae | Morpholines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Psychomotor Performance - drug effects | Rats, Sprague-Dawley | Indomethacin - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Binding, Competitive - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Pain Measurement - methods | Animals | Cyclohexanecarboxylic Acids - pharmacology | Indoles - pharmacokinetics | Mice | Morpholines - pharmacokinetics | Amines - pharmacology | Receptor, Cannabinoid, CB2 - deficiency | Care and treatment | Pain | Analysis | Physiological aspects | Ataxia | Models | Chemical properties
Journal Article
by Booth, R and Kim, H
Annals of Biomedical Engineering, ISSN 0090-6964, 12/2014, Volume 42, Issue 12, pp. 2379 - 2391
Journal Article
Military Medicine, ISSN 0026-4075, 11/2017, Volume 182, Issue 11, pp. e2052 - e2055
Introduction: Over 5,300 inguinal hernia repairs (IHR) were performed in the Military Health System in 2015. Chronic pain can be a debilitating complication,... 
MEDICINE, GENERAL & INTERNAL | QUALITY-OF-LIFE | HERNIORRHAPHY | POSTOPERATIVE PAIN | Lidocaine - pharmacology | Adjuvants, Anesthesia - pharmacology | Ondansetron - pharmacology | Adjuvants, Anesthesia - therapeutic use | Fentanyl - therapeutic use | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Propofol - pharmacology | Lidocaine - therapeutic use | Male | Fentanyl - pharmacology | Hernia, Inguinal - drug therapy | Hypnotics and Sedatives - therapeutic use | Anesthetics, Local - pharmacology | Placebos - therapeutic use | Hernia, Inguinal - surgery | Antiemetics - therapeutic use | Amines - therapeutic use | Midazolam - therapeutic use | Adult | Androstanols - therapeutic use | Female | Anesthetics, Local - therapeutic use | Neuromuscular Depolarizing Agents - therapeutic use | Quality of Life - psychology | Succinylcholine - pharmacology | gamma-Aminobutyric Acid - therapeutic use | Neuromuscular Depolarizing Agents - pharmacology | Succinylcholine - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Double-Blind Method | Reconstructive Surgical Procedures - methods | gamma-Aminobutyric Acid - pharmacology | Treatment Outcome | Androstanols - pharmacology | Cyclohexanecarboxylic Acids - pharmacology | Ondansetron - therapeutic use | Hypnotics and Sedatives - pharmacology | Amines - pharmacology | Midazolam - pharmacology | Propofol - therapeutic use | Antiemetics - pharmacology | Cholecystectomy | Laparoscopy | FDA approval | Patients | Bone surgery | Quality of life | Studies | Airway management | Pain | Analgesics | Hernias | Surgeons | Anesthesia | Drug dosages
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 531, Issue 1, pp. 87 - 95
The possible participation of the nitric oxide (NO)-cyclic GMP-protein kinase G (PKG) pathway on gabapentin-induced spinal antiallodynic activity was assessed... 
Pinacidil | Gabapentin | Nitric oxide | Protein kinase G | Diazoxide | Guanylyl cyclase | K + channel opener | Neuropathic pain | channel opener | SENSITIVE POTASSIUM CHANNELS | nitric oxide | TACTILE ALLODYNIA | K+ channel opener | RANDOMIZED CONTROLLED-TRIAL | NERVE INJURY | VASCULAR SMOOTH-MUSCLE | guanylyl cyclase | neuropathic pain | gabapentin | diazoxide | pinacidil | RABBIT VENTRICULAR MYOCYTES | PHARMACOLOGY & PHARMACY | protein kinase G | UP-REGULATION | CALCIUM-CHANNEL | PERIPHERAL ANTINOCICEPTIVE ACTION | Analgesics - pharmacology | Okadaic Acid - pharmacology | Potassium Channels - physiology | Pinacidil - administration & dosage | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Glyburide - pharmacology | Time Factors | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channel Blockers - pharmacology | Spinal Nerves - injuries | Spinal Nerves - physiopathology | Enzyme Inhibitors - pharmacology | Cyclohexanecarboxylic Acids - administration & dosage | Rats | gamma-Aminobutyric Acid - pharmacology | Indazoles - pharmacology | NG-Nitroarginine Methyl Ester - chemistry | Cyclic GMP - metabolism | Signal Transduction - drug effects | Pain - physiopathology | Nitric Oxide Synthase - metabolism | Carbazoles - pharmacology | Amines - pharmacology | Diazoxide - administration & dosage | Cyclic GMP - antagonists & inhibitors | Diazoxide - pharmacology | Rats, Wistar | Stereoisomerism | Nitric Oxide Synthase - antagonists & inhibitors | gamma-Aminobutyric Acid - administration & dosage | Apamin - pharmacology | Cyclic GMP-Dependent Protein Kinases - metabolism | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Amines - administration & dosage | Female | Indoles - pharmacology | Injections, Spinal | NG-Nitroarginine Methyl Ester - pharmacology | Pinacidil - pharmacology | Vasodilator Agents - pharmacology | Pain - prevention & control | Nitric Oxide - antagonists & inhibitors | Analgesics - administration & dosage | Animals | Cyclohexanecarboxylic Acids - pharmacology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage
Journal Article