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Science, ISSN 0036-8075, 6/2003, Volume 300, Issue 5626, pp. 1763 - 1767
A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (M , also called ), which... 
Enzymes | Molecules | Coronavirus | Atoms | SARS | Reports | Dimers | Polyproteins | SARS virus | Monomers | Crystal structure | VIRUS-ENCODED PROTEINASES | 229E 3C-LIKE PROTEINASE | MULTIDISCIPLINARY SCIENCES | PROTEASES | Cysteine Endopeptidases - chemistry | Coronavirus 229E, Human - enzymology | Humans | Cysteine Proteinase Inhibitors - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Cysteine Endopeptidases - metabolism | Pyrrolidinones - metabolism | Pyrrolidinones - pharmacology | Drug Design | Amino Acid Chloromethyl Ketones - metabolism | Cysteine Proteinase Inhibitors - chemistry | Binding Sites | Dimerization | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Transmissible gastroenteritis virus - enzymology | Catalytic Domain | Protein Structure, Secondary | Amino Acid Chloromethyl Ketones - chemistry | Isoxazoles - metabolism | Crystallization | Models, Molecular | Recombinant Proteins - chemistry | SARS Virus - drug effects | Antiviral Agents | Isoxazoles - chemistry | Severe Acute Respiratory Syndrome - drug therapy | Pyrrolidinones - chemistry | Isoxazoles - pharmacology | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation | SARS Virus - enzymology | Severe acute respiratory syndrome | Research | Coronaviruses | Proteins | Viruses | Drug therapy
Journal Article
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 03/2006, Volume 26, Issue 6, pp. 2215 - 2225
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ALPHA-INDUCED APOPTOSIS | MITOCHONDRIAL PERMEABILITY TRANSITION | CYCLOPHILIN-D | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIP | DEATH-DOMAIN KINASE | NECROTIC CELL-DEATH | NF-KAPPA-B | ADENINE-NUCLEOTIDE TRANSLOCASE | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases | Humans | Intracellular Membranes | bcl-X Protein - genetics | Cysteine Proteinase Inhibitors - metabolism | Mitochondrial ADP, ATP Translocases - metabolism | Necrosis | Cyclophilins - pharmacology | Mitochondrial ADP, ATP Translocases - genetics | Amino Acid Chloromethyl Ketones - pharmacology | Adenosine Triphosphate - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Amino Acid Chloromethyl Ketones - metabolism | Biological Transport - drug effects | Cysteine - metabolism | Cell Death - drug effects | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Membrane Potentials - drug effects | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Permeability | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - antagonists & inhibitors | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Cell Death - physiology | Cysteine Proteinase Inhibitors - pharmacology | Adenosine Diphosphate - metabolism | bcl-X Protein - metabolism | Mitochondrial ADP, ATP Translocases - drug effects
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 2/2004, Volume 164, Issue 4, pp. 493 - 499
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 10/2003, Volume 10, Issue 10, pp. 1188 - 1203
Effective execution of apoptosis requires the activation of caspases. However, in many cases, broad-range caspase inhibitors such as Z-VAD.fmk do not inhibit... 
ER stress | Serine proteases | Caspase inhibition | IL-3 | Phagocytosis | Apoptosis | phagocytosis | CLEARANCE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | MITOCHONDRIA | FAMILY PROTEASES | apoptosis | CLEAVAGE | caspase inhibition | serine proteases | CELL BIOLOGY | BCL-2 | TNF-ALPHA | CYTOCHROME-C RELEASE | GRANZYME-B | Apoptosis - drug effects | Microscopy, Phase-Contrast | Humans | Brefeldin A - pharmacology | Sulfones - pharmacology | Interleukin-3 - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | fas Receptor - immunology | Caspases - metabolism | Flow Cytometry | Amino Acid Chloromethyl Ketones - pharmacology | U937 Cells | Amino Acid Chloromethyl Ketones - metabolism | Caspase 3 | Caspases - chemistry | Fibroblasts - metabolism | Phagocytosis - drug effects | Amino Acid Chloromethyl Ketones - chemistry | Antibodies, Monoclonal - pharmacology | Gene Expression Regulation | Phagocytosis - physiology | Rats | Interleukin-3 - deficiency | Cell Adhesion - drug effects | Caspase Inhibitors | Blotting, Western | Cycloheximide - pharmacology | Proto-Oncogene Proteins c-bcl-2 - pharmacology | Animals | Cell Adhesion - physiology | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Cell Line, Tumor | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Serine Endopeptidases - metabolism | Apoptosis - physiology | HeLa Cells | Proto-Oncogene Proteins c-bcl-2 - genetics | Microscopy, Fluorescence
Journal Article