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1. Full Text Amino Acid Homeostasis Modulates Salicylic Acid-Associated Redox Status and Defense Responses in Arabidopsis
by Guosheng Liu and Yuanyuan Ji and Nazmul H. Bhuiyan and Guillaume Pilot and Gopalan Selvaraj and Jitao Zou and Yangdou Wei
The Plant Cell, ISSN 1040-4651, 11/2010, Volume 22, Issue 11, pp. 3845 - 3863
The tight association between nitrogen status and pathogenesis has been broadly documented in plant-pathogen interactions. However, the interface between... 
Pathogens | Leaves | Disease resistance | Plant diseases | Chloroplasts | Homeostasis | Amino acids | Infections | Plants | Plant cells | OXYGEN GENE NETWORK | PATHOGEN INTERACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYSTEMIC ACQUIRED-RESISTANCE | CELL-DEATH | NEGATIVE REGULATOR | PLANT SCIENCES | CELL BIOLOGY | DEFICIENT MUTANTS | DOWNY MILDEW RESISTANCE | PLANT DEFENSE | GLUTAMINE-SYNTHETASE | DISEASE RESISTANCE | Amino Acid Transport Systems, Basic - genetics | Reactive Oxygen Species - metabolism | Salicylic Acid - metabolism | Plant Diseases - immunology | Immunity, Innate - genetics | Arabidopsis - immunology | Glutamine - metabolism | Recombinant Fusion Proteins - metabolism | Gene Knockdown Techniques | Arabidopsis Proteins - metabolism | Amino Acids - metabolism | Microarray Analysis | Plants, Genetically Modified | Gene Expression Regulation, Plant | Plant Diseases - genetics | Arabidopsis Proteins - genetics | Nitrogen - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Arabidopsis - genetics | Immunity, Innate - immunology | Arabidopsis - anatomy & histology | Recombinant Fusion Proteins - genetics | Amino Acid Transport Systems, Basic - metabolism | Arabidopsis thaliana | Salicylic acid | Plant immunology | Physiological aspects | Oxidation-reduction reaction | Research | Properties | Index Medicus
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2. Full Text Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle
by Forde, Niamh and Simintiras, Constantine A and Sturmey, Roger and Mamo, Solomon and Kelly, Alan K and Spencer, Thomas E and Bazer, Fuller W and Lonergan, Pat
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100010 - e100010
In cattle, conceptus-maternal interactions are critical for the establishment and maintenance of pregnancy. A major component of this early interaction... 
IN-VITRO CULTURE | SURVIVAL | SELECT NUTRIENTS | SYSTEMIC PROGESTERONE | EMBRYO | IMPLANTATION | ELONGATION | MULTIDISCIPLINARY SCIENCES | BOVINE ENDOMETRIUM | LUMEN | ESTROUS-CYCLE | Pregnancy, Animal | Amino Acid Transport Systems, Basic - genetics | Uterus - metabolism | Amino Acid Transport Systems, Acidic - metabolism | Embryo Implantation - genetics | Fertilization - genetics | Gene Expression Regulation | Amino Acid Transport Systems, Neutral - metabolism | Amino Acid Transport Systems - metabolism | Amino Acid Transport Systems, Neutral - genetics | Pregnancy | Amino Acids - metabolism | Animals | Time Factors | Cattle | Gene Expression Regulation, Developmental | Progesterone - metabolism | Amino Acid Transport Systems - genetics | Amino Acid Transport Systems, Acidic - genetics | Female | Amino Acid Transport Systems, Basic - metabolism | Endometrium - metabolism | Glutamic acid | Epithelial cells | Amino acids | Estrus cycle | Food science | Leucine | Polyamines | Signal transduction | Histidine | Arginine | Uterus | Rodents | Nutrients | Aspartic acid | Endometrium | Isoleucine | Tyrosine | Estrus | Phenylalanine | Secretion | Amino acid sequence | Implantation | Metabolism | Gene expression | Lysine | Valine | Asparagine | Progesterone | Transporter | Glutamine | Index Medicus
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3. Full Text Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth, and tumor development
by Wang, Qian and Tiffen, Jessamy and Bailey, Charles G and Lehman, Melanie L and Ritchie, William and Fazli, Ladan and Metierre, Cynthia and Feng, Yue Julie and Li, Estelle and Gleave, Martin and Buchanan, Grant and Nelson, Colleen C and Rasko, John E. J and Holst, Jeff
Journal of the National Cancer Institute, ISSN 0027-8874, 10/2013, Volume 105, Issue 19, pp. 1463 - 1473
Background L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into cells, stimulating mammalian target of rapamycin complex 1... 
ANDROGEN RECEPTOR | SIGNALING PATHWAYS | IN-VITRO | ACTIVATION | GENE | ONCOLOGY | TRANSFER-RNA SYNTHETASE | DISTINCT | EXPRESSION | PROGRESSION | REVEALS | Prostatic Neoplasms - metabolism | Amino Acid Transport Systems, Basic - genetics | TOR Serine-Threonine Kinases - metabolism | Humans | Receptors, Androgen - metabolism | Male | Prostatic Neoplasms - physiopathology | Luminescent Measurements | Neoplasms, Hormone-Dependent - physiopathology | Gene Knockdown Techniques | Mechanistic Target of Rapamycin Complex 1 | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Receptors, Androgen - drug effects | Antineoplastic Agents, Hormonal - therapeutic use | Computer Simulation | Biological Transport - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - drug therapy | Leucine - metabolism | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Activating Transcription Factor 4 - drug effects | Orchiectomy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Animals | Leucine - antagonists & inhibitors | Activating Transcription Factor 4 - metabolism | Signal Transduction - drug effects | Neoadjuvant Therapy - methods | Amino Acid Transport Systems, Basic - antagonists & inhibitors | Protein Array Analysis | Mice | Neoplasms, Hormone-Dependent - drug therapy | Amino Acid Transport Systems, Basic - metabolism | Cell Cycle - drug effects | Care and treatment | Usage | Cell cycle | Physiological aspects | Amino acids | Rapamycin | Research | Prostate cancer | Health aspects | Mens health | Medical research | Metastasis | Index Medicus
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4. Full Text Transporters in Arabidopsis roots mediating uptake of amino acids at naturally occurring concentrations
by Henrik Svennerstam and Sandra Jämtgård and Iftikhar Ahmad and Kerstin Huss-Danell and Torgny Näsholm and Ulrika Ganeteg and Sveriges lantbruksuniversitet
The New Phytologist, ISSN 0028-646X, 7/2011, Volume 191, Issue 2, pp. 459 - 467
Recent studies of Arabidopsis have identified several transporters as being important for amino acid uptake. We used Arabidopsis plants with altered expression... 
Plant roots | Amino acids | Plants | Kinetics | Acid soils | Soil solution | Nitrogen | Genetic mutation | Amino acid transport systems | Forest soils | lysine histidine transporter 1 (LHT1) | amino acid permease 5 (AAP5) | kinetics | amino acid permease 1 (AAP1) | mutants | Amino acid permease 5 (AAP5) | Amino acid permease 1 (AAP1) | Lysine histidine transporter 1 (LHT1) | Mutants | PLANT | SPECIFICITY | LYSINE | PERMEASE | PLANT SCIENCES | THALIANA | BARLEY | ORGANIC NITROGEN | EXPRESSION | SOIL SOLUTIONS | Arabidopsis Proteins - genetics | Gene Expression | Amino Acid Transport Systems, Basic - genetics | Plant Roots - metabolism | Amino Acid Transport Systems, Acidic - metabolism | Amino Acids - analysis | Plant Roots - genetics | Amino Acid Transport Systems, Neutral - metabolism | Amino Acid Transport Systems - metabolism | Amino Acid Transport Systems, Neutral - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Amino Acids - metabolism | Biological Transport | Amino Acid Transport Systems - genetics | Amino Acid Transport Systems, Acidic - genetics | Mutation | Amino Acid Transport Systems, Basic - metabolism | Arabidopsis thaliana | Histidine | Lysine | Analysis | Forest ecology | Plant genetics | Gene expression | Index Medicus | Genetik | Genetics | Botanik | Botany
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5. Full Text Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1
by Shushi Nagamori and Pattama Wiriyasermkul and Meritxell Espino Guarch and Hirohisa Okuyama and Saya Nakagomi and Kenjiro Tadagaki and Yumiko Nishinaka and Susanna Bodoy and Kazuaki Takafuji and Suguru Okuda and Junko Kurokawa and Ryuichi Ohgaki and Virginia Nunes and Manuel Palacín and Yoshikatsu Kanai
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2016, Volume 113, Issue 3, pp. 775 - 780
Heterodimeric amino acid transporters play crucial roles in epithelial transport, as well as in cellular nutrition. Among them, the heterodimer of a membrane... 
Cystine reabsorption | Amino acid transporter | Cystinuria | Kidney | C-TERMINUS | cystine reabsorption | RBAT | MULTIDISCIPLINARY SCIENCES | AFFINITY GLUTAMATE TRANSPORTER | EXPRESSION CLONING | amino acid transporter | FAMILY | kidney | AMINO-ACID TRANSPORTER | HEAVY-CHAIN | cystinuria | NA+/GLUCOSE COTRANSPORTER | INTRACELLULAR TRAFFICKING | Immunohistochemistry | Amino Acid Transport Systems - chemistry | Antibodies - metabolism | Humans | Protein Multimerization | Proteolipids - metabolism | Molecular Sequence Data | Male | RNA, Messenger - metabolism | Kidney - metabolism | In Situ Hybridization | HEK293 Cells | Female | Cell Membrane - metabolism | Cystinuria - metabolism | Response Elements - genetics | Amino Acid Sequence | Mice, Inbred C57BL | RNA, Messenger - genetics | Amino Acid Transport Systems, Neutral - metabolism | Amino Acid Transport Systems - metabolism | Blotting, Western | Animals | Excitatory Amino Acid Transporter 3 - metabolism | Kidney Tubules, Proximal - metabolism | Amino Acid Transport Systems - genetics | Protein Binding | Amino Acid Transport Systems, Basic - metabolism | Physiological aspects | Physiological research | Research | Biological transport | Cystine | Aminoaciduria, Renal | Proteins | Amino acids | Membranes | Mass spectrometry | Rodents | Index Medicus | Biological Sciences
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6. Full Text Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression
by Wang, Qian and Bailey, Charles G and Ng, Cynthia and Tiffen, Jessamy and Thoeng, Annora and Minhas, Vineet and Lehman, Melanie L and Hendy, Stephen C and Buchanan, Grant and Nelson, Colleen C and Rasko, John E. J and Holst, Jeff
Cancer Research, ISSN 0008-5472, 12/2011, Volume 71, Issue 24, pp. 7525 - 7536
L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the... 
RAG GTPASES | METABOLISM | ONCOLOGY | GROWTH | TRANSCRIPTION | PTEN | TUMOR-SUPPRESSOR | IDENTIFICATION | EXPRESSION | CARCINOMA | MTOR | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Amino Acid Transport Systems, Basic - genetics | TOR Serine-Threonine Kinases - metabolism | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Male | Transplantation, Heterologous | Amino Acids - metabolism | Prostatic Neoplasms - genetics | RNA Interference | HEK293 Cells | Biological Transport - drug effects | Prostatic Neoplasms - pathology | Amino Acids, Cyclic - pharmacology | Signal Transduction | Activating Transcription Factor 4 - genetics | Large Neutral Amino Acid-Transporter 1 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Disease Progression | Animals | Receptors, Androgen - genetics | Activating Transcription Factor 4 - metabolism | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Amino Acid Transport Systems, Basic - metabolism | Index Medicus
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7. Full Text LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis
by Bin Liu and Hongwei Du and Rachael Rutkowski and Anton Gartner and Xiaochen Wang
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6092, pp. 351 - 354
Defective catabolite export from lysosomes results in lysosomal storage diseases in humans. Mutations in the cystine transporter gene CTNS cause cystinosis,... 
Cystinosis | COS cells | Phenotypes | Protein synthesis | REPORTS | Disulfides | Lysosomes | Amino acids | Embryos | Amino acid transport systems | Freight | CYSTINE | CAENORHABDITIS-ELEGANS | PROTEIN | REMOVAL | MULTIDISCIPLINARY SCIENCES | KINASE | DEGRADATION | AUTOPHAGY | ENDOCYTOSIS | C. ELEGANS | FIBROBLASTS | Amino Acid Transport Systems, Basic - genetics | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Humans | Lysosomes - genetics | Caenorhabditis elegans Proteins - metabolism | Cercopithecus aethiops | Homeostasis | Lysosomal Storage Diseases - genetics | Amino Acid Transport Systems - metabolism | Animals | Lysosomes - metabolism | Amino Acid Transport Systems - genetics | Lysosomal Storage Diseases - metabolism | Cysteamine - metabolism | Lysine - metabolism | Amino Acid Transport Systems, Basic - metabolism | COS Cells | Caenorhabditis elegans Proteins - genetics | Arginine - metabolism | Metabolism, Inborn errors of | Gene mutations | Carrier proteins | Physiological aspects | Genetic aspects | Research | Cellular biology | Molecular biology | Metabolic disorders | Index Medicus | International trade | Lysine | Cysteamine | Transporter | Cystine
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8. Full Text Arabidopsis LHT1 Is a High-Affinity Transporter for Cellular Amino Acid Uptake in Both Root Epidermis and Leaf Mesophyll
by Axel Himer and Friederike Ladwig and Harald Stransky and Sakiko Okumoto and Melanie Keinath and Agnes Harms and Wolf B. Frommer and Wolfgang Koch
The Plant Cell, ISSN 1040-4651, 8/2006, Volume 18, Issue 8, pp. 1931 - 1946
Amino acid transport in plants is mediated by at least two large families of plasma membrane transporters. Arabidopsis thaliana, a nonmycorrhizal species, is... 
Leaves | Mesophyll | Plant growth | Plant roots | Protoplasts | Amino acids | Plants | Acid soils | Nitrogen | Amino acid transport systems | PLANT | SUGAR-BEET LEAVES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERMEASE | THLASPI-CAERULESCENS | PLANT SCIENCES | CELL BIOLOGY | YEAST | SUBSTRATE-SPECIFICITY | GENE | THALIANA | ORGANIC NITROGEN | EXPRESSION | Arabidopsis Proteins - genetics | Arabidopsis Proteins - physiology | Nitrogen - metabolism | Amino Acid Transport Systems, Basic - genetics | Plant Roots - metabolism | Arabidopsis - growth & development | Plant Roots - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Amino Acids - metabolism | Protoplasts - metabolism | Yeasts - genetics | Phenotype | Plant Leaves - genetics | Plant Leaves - metabolism | Amino Acid Transport Systems, Basic - physiology | Gene Expression Regulation, Plant | Biological Transport - physiology | Amino Acid Transport Systems, Basic - metabolism | Physiological aspects | Genetic aspects | Research | Arabidopsis | Amino acid metabolism | Index Medicus | s
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9. Full Text Structural basis for amino acid transport by the CAT family of SLC7 transporters
by Jungnickel, Katharina E. J and Parker, Joanne L and Newstead, Simon
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 550 - 12
Amino acids play essential roles in cell biology as regulators of metabolic pathways. Arginine in particular is a major signalling molecule inside the cell,... 
SYSTEM | OVEREXPRESSION | MECHANISM | MULTIDISCIPLINARY SCIENCES | PURIFICATION | APC SUPERFAMILY | ARGININE | OPTIMIZATION | CULTURED ANIMAL-CELLS | MEMBRANE-PROTEINS | MOLECULAR-BASIS | Nitric Oxide - biosynthesis | Animals | Amino Acid Transport Systems, Basic - chemistry | Crystallization | Ornithine - biosynthesis | Crystallography, X-Ray | Amino Acid Transport Systems, Basic - metabolism | Arginine - metabolism | Regulators | Amino acids | Homology | Mammals | Metabolism | Macrophages | Mammalian cells | Proteins | Signal transduction | Signaling | Cell activation | Arginine | Sodium | Nitric oxide | Metabolic pathways | Cations | Transport | Ornithine | Crystal structure | Structure-function relationships | Index Medicus
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10. Full Text Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases
by Ghaddar, Kassem and Merhi, Ahmad and Saliba, Elie and Krammer, Eva-Maria and Prévost, Martine and André, Bruno
Molecular and Cellular Biology, ISSN 0270-7306, 2014, Volume 34, Issue 24, pp. 4447 - 4463
Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and delivery to the lysosome in response to various stimuli. We report here... 
PROTEIN-TURNOVER | TRANSPORTERS | PATHWAY | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | CELL-SURFACE | CAN1 PERMEASE | QUALITY-CONTROL | SACCHAROMYCES-CEREVISIAE | GAP1 PERMEASE | CELL BIOLOGY | Amino Acid Transport Systems - chemistry | Saccharomyces cerevisiae - genetics | Endosomal Sorting Complexes Required for Transport - genetics | Ubiquitin-Protein Ligase Complexes - genetics | Lysosomes - physiology | Saccharomyces cerevisiae - metabolism | Amino Acids - metabolism | Endocytosis | Ubiquitination | Binding Sites | Gene Expression Regulation, Fungal | Protein Structure, Tertiary | Biocatalysis | Amino Acid Transport Systems, Basic - chemistry | Signal Transduction | Endosomal Sorting Complexes Required for Transport - metabolism | Models, Molecular | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Saccharomyces cerevisiae - cytology | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Protein Conformation | Mutation | Amino Acid Transport Systems, Basic - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus
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11. Full Text Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy
by Adrien Jézégou and Elisa Llinares and Christine Anne and Sylvie Kieffer-Jaquinod and Seana O’Regan and Joëlle Aupetit and Allel Chabli and Corinne Sagné and Cécile Debacker and Bernadette Chadefaux-Vekemans and Agnès Journet and Bruno André and Bruno Gasnier
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, pp. E3434 - E3443
Cystinosin, the lysosomal cystine exporter defective in cystinosis, is the founding member of a family of heptahelical membrane proteins related to... 
Lysosomal storage disease | Secondary active transporter | lysosomal storage disease | SHOTGUN PROTEOMICS | secondary active transporter | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL-CHARACTERIZATION | CONGENITAL DISORDER | NEPHROPATHIC CYSTINOSIS | SACCHAROMYCES-CEREVISIAE | MITOCHONDRIAL PYRUVATE CARRIER | GENE | ARGININE TRANSPORT | BATTEN-DISEASE | L-CANAVANINE | Amino Acid Transport Systems, Basic - genetics | Species Specificity | Saccharomyces cerevisiae - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | DNA, Complementary - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Cystinosis - drug therapy | Saccharomyces cerevisiae - metabolism | Base Sequence | Female | Genes, Fungal | Membrane Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Drosophila Proteins | DEAD-box RNA Helicases | Amino Acid Transport Systems, Basic - chemistry | Protein Structure, Secondary | Membrane Proteins - genetics | Oocytes - metabolism | Xenopus laevis | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Cystinosis - metabolism | Canavanine - metabolism | Amino Acid Motifs | Animals | Membrane Proteins - chemistry | Cysteamine - therapeutic use | Saccharomyces cerevisiae Proteins - metabolism | Vacuoles - metabolism | Electrophysiological Phenomena | Amino Acid Transport Systems, Basic - metabolism | Caenorhabditis elegans Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Eukaryotes | Yeast | Prokaryotes | Homeostasis | Amino acids | Cells | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Genomics | Biological Sciences | PNAS Plus
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